JP6575950B2 - Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 - Google Patents
Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 Download PDFInfo
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- JP6575950B2 JP6575950B2 JP2015524400A JP2015524400A JP6575950B2 JP 6575950 B2 JP6575950 B2 JP 6575950B2 JP 2015524400 A JP2015524400 A JP 2015524400A JP 2015524400 A JP2015524400 A JP 2015524400A JP 6575950 B2 JP6575950 B2 JP 6575950B2
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675303P | 2012-07-24 | 2012-07-24 | |
| US61/675,303 | 2012-07-24 | ||
| US201261682688P | 2012-08-13 | 2012-08-13 | |
| US61/682,688 | 2012-08-13 | ||
| US201361780652P | 2013-03-13 | 2013-03-13 | |
| US61/780,652 | 2013-03-13 | ||
| PCT/US2013/051741 WO2014018567A1 (en) | 2012-07-24 | 2013-07-23 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Division JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530080A JP2015530080A (ja) | 2015-10-15 |
| JP2015530080A5 JP2015530080A5 (cg-RX-API-DMAC7.html) | 2016-10-13 |
| JP6575950B2 true JP6575950B2 (ja) | 2019-09-18 |
Family
ID=48948511
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524400A Active JP6575950B2 (ja) | 2012-07-24 | 2013-07-23 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10954567B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2877598A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6575950B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20150032340A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104704129A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013293087B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015001690A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2879570A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1206073A1 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2015001081A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014018567A1 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ601278A (en) | 2006-09-22 | 2013-09-27 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| US8809273B2 (en) | 2007-03-28 | 2014-08-19 | Pharmacyclics, Inc. | Inhibitors of Bruton's tyrosine kinase |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX2010007418A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
| MX2011000661A (es) | 2008-07-16 | 2011-05-25 | Pharmacyclics Inc | Inhibidores de tirosina cinasa de bruton para el tratamiento de tumores solidos. |
| EP2350071B1 (en) | 2008-10-22 | 2014-01-08 | Array Biopharma, Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
| EP2575818A4 (en) | 2010-06-03 | 2013-11-06 | Pharmacyclics Inc | USE OF BRUTON TYROSINE KINASE INHIBITORS (BTK) |
| EP2663309B1 (en) | 2011-01-10 | 2017-03-15 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| EP3409278B8 (en) | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
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| MX375194B (es) | 2012-11-01 | 2025-03-06 | Infinity Pharmaceuticals Inc | Tratamiento de cánceres utilizando moduladores de las isoformas de pi3 cinasa. |
| KR20150084923A (ko) | 2012-11-15 | 2015-07-22 | 파마시클릭스, 인코포레이티드 | 키나제 억제제로서의 피롤로피리미딘 화합물 |
| HUE044558T2 (hu) | 2013-03-14 | 2019-11-28 | Tolero Pharmaceuticals Inc | JAK és ALK2 inhibitorok és eljárások alkalmazásukra |
| DK3003309T3 (da) * | 2013-05-30 | 2020-12-14 | Infinity Pharmaceuticals Inc | Behandling af cancer med PI3-kinase-isoform modulatorer |
| CA2920534A1 (en) | 2013-08-12 | 2015-02-19 | Pharmacyclics Llc | Methods for the treatment of her2 amplified cancer |
| US20150238490A1 (en) * | 2014-02-21 | 2015-08-27 | Pharmacyclics, Inc. | Biomarkers for predicting response of dlbcl to treatment with ibrutinib |
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| SG11201700774UA (en) * | 2014-08-01 | 2017-02-27 | Pharmacyclics Llc | Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor |
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| EP3550031A1 (en) | 2019-10-09 |
| JP2015530080A (ja) | 2015-10-15 |
| MX2015001081A (es) | 2015-10-14 |
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| EP2877598A1 (en) | 2015-06-03 |
| US10954567B2 (en) | 2021-03-23 |
| US20150184249A1 (en) | 2015-07-02 |
| AU2013293087A1 (en) | 2015-03-05 |
| HK1206073A1 (en) | 2015-12-31 |
| JP2020000239A (ja) | 2020-01-09 |
| WO2014018567A1 (en) | 2014-01-30 |
| KR20150032340A (ko) | 2015-03-25 |
| AU2013293087B2 (en) | 2017-08-31 |
| BR112015001690A2 (pt) | 2017-11-07 |
| CN104704129A (zh) | 2015-06-10 |
| MX2020006151A (es) | 2020-08-13 |
| CA2879570A1 (en) | 2014-01-30 |
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