JP6067221B2 - 微生物プロテアーゼ変異種を含有する組成物と方法 - Google Patents

微生物プロテアーゼ変異種を含有する組成物と方法 Download PDF

Info

Publication number
JP6067221B2
JP6067221B2 JP2011512603A JP2011512603A JP6067221B2 JP 6067221 B2 JP6067221 B2 JP 6067221B2 JP 2011512603 A JP2011512603 A JP 2011512603A JP 2011512603 A JP2011512603 A JP 2011512603A JP 6067221 B2 JP6067221 B2 JP 6067221B2
Authority
JP
Japan
Prior art keywords
sequence
protease
detergent
cleaning
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011512603A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011522537A (ja
Inventor
バスラー、ジョシュア・アール
カスカオ−ペレイラ、ルイス・ジー
エステル、デイビッド・エー
ケリス、ジェイムズ・ティー
Original Assignee
ダニスコ・ユーエス・インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ダニスコ・ユーエス・インク filed Critical ダニスコ・ユーエス・インク
Publication of JP2011522537A publication Critical patent/JP2011522537A/ja
Application granted granted Critical
Publication of JP6067221B2 publication Critical patent/JP6067221B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2011512603A 2008-06-06 2009-06-03 微生物プロテアーゼ変異種を含有する組成物と方法 Active JP6067221B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5969508P 2008-06-06 2008-06-06
US61/059,695 2008-06-06
PCT/US2009/046066 WO2009149144A2 (en) 2008-06-06 2009-06-03 Compositions and methods comprising variant microbial proteases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013120358A Division JP2013240327A (ja) 2008-06-06 2013-06-07 微生物プロテアーゼ変異種を含有する組成物と方法
JP2015083842A Division JP2015211671A (ja) 2008-06-06 2015-04-16 微生物プロテアーゼ変異種を含有する組成物と方法

Publications (2)

Publication Number Publication Date
JP2011522537A JP2011522537A (ja) 2011-08-04
JP6067221B2 true JP6067221B2 (ja) 2017-01-25

Family

ID=41009802

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2011512621A Expired - Fee Related JP5647976B2 (ja) 2008-06-06 2009-06-03 変異体微生物プロテアーゼを含む組成物及び方法
JP2011512604A Pending JP2011524166A (ja) 2008-06-06 2009-06-03 変異体微生物プロテアーゼを含む組成物及び方法
JP2011512603A Active JP6067221B2 (ja) 2008-06-06 2009-06-03 微生物プロテアーゼ変異種を含有する組成物と方法
JP2013120406A Pending JP2013223499A (ja) 2008-06-06 2013-06-07 変異体微生物プロテアーゼを含む組成物及び方法
JP2013120358A Pending JP2013240327A (ja) 2008-06-06 2013-06-07 微生物プロテアーゼ変異種を含有する組成物と方法
JP2014148791A Expired - Fee Related JP6426391B2 (ja) 2008-06-06 2014-07-22 変異体微生物のプロテアーゼを含む組成物及び方法
JP2015083842A Pending JP2015211671A (ja) 2008-06-06 2015-04-16 微生物プロテアーゼ変異種を含有する組成物と方法
JP2017172877A Pending JP2018050618A (ja) 2008-06-06 2017-09-08 変異体微生物のプロテアーゼを含む組成物及び方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011512621A Expired - Fee Related JP5647976B2 (ja) 2008-06-06 2009-06-03 変異体微生物プロテアーゼを含む組成物及び方法
JP2011512604A Pending JP2011524166A (ja) 2008-06-06 2009-06-03 変異体微生物プロテアーゼを含む組成物及び方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2013120406A Pending JP2013223499A (ja) 2008-06-06 2013-06-07 変異体微生物プロテアーゼを含む組成物及び方法
JP2013120358A Pending JP2013240327A (ja) 2008-06-06 2013-06-07 微生物プロテアーゼ変異種を含有する組成物と方法
JP2014148791A Expired - Fee Related JP6426391B2 (ja) 2008-06-06 2014-07-22 変異体微生物のプロテアーゼを含む組成物及び方法
JP2015083842A Pending JP2015211671A (ja) 2008-06-06 2015-04-16 微生物プロテアーゼ変異種を含有する組成物と方法
JP2017172877A Pending JP2018050618A (ja) 2008-06-06 2017-09-08 変異体微生物のプロテアーゼを含む組成物及び方法

Country Status (13)

Country Link
US (12) US20110256609A1 (enExample)
EP (10) EP2947147A3 (enExample)
JP (8) JP5647976B2 (enExample)
KR (3) KR20110015006A (enExample)
CN (7) CN102057043B (enExample)
AU (3) AU2009256295A1 (enExample)
BR (3) BRPI0915681A2 (enExample)
CA (3) CA2726370A1 (enExample)
DK (2) DK2578680T3 (enExample)
MX (6) MX2010013100A (enExample)
RU (2) RU2010153866A (enExample)
WO (3) WO2009149144A2 (enExample)
ZA (1) ZA201008169B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018050618A (ja) * 2008-06-06 2018-04-05 ダニスコ・ユーエス・インク 変異体微生物のプロテアーゼを含む組成物及び方法

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE450606T1 (de) * 2002-01-16 2009-12-15 Genencor Int Mehrfachsubstituierte proteasevarianten
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
CN102209775A (zh) 2008-11-11 2011-10-05 丹尼斯科美国公司 包含一种或多种可组合的突变的芽孢杆菌属枯草杆菌蛋白酶
AR073420A1 (es) * 2008-11-11 2010-11-03 Danisco Us Inc Variantes de serina proteasas, composiciones y metodos de limpieza que las comprenden
SG177601A1 (en) * 2009-07-16 2012-02-28 Glaxo Group Ltd Improved anti-serum albumin binding single variable domains
AU2010299800B2 (en) * 2009-09-25 2014-08-07 Novozymes A/S Use of protease variants
ES2746931T3 (es) 2009-12-09 2020-03-09 Danisco Us Inc Composiciones y métodos comprendiendo variantes de proteasa
CN102652175B (zh) 2009-12-09 2016-02-10 宝洁公司 织物和家居护理产品
US20120067373A1 (en) * 2010-04-15 2012-03-22 Philip Frank Souter Automatic Dishwashing Detergent Composition
ES2745011T3 (es) * 2010-05-06 2020-02-27 Procter & Gamble Productos de consumo con variantes de proteasa
WO2012151480A2 (en) * 2011-05-05 2012-11-08 The Procter & Gamble Company Compositions and methods comprising serine protease variants
ES2707869T3 (es) * 2011-05-05 2019-04-05 Danisco Us Inc Composiciones y métodos comprendiendo variantes de serina proteasa
US20140342433A1 (en) * 2011-11-25 2014-11-20 Novozymes A/S Subtilase Variants and Polynucleotides Encoding Same
EP2607468A1 (en) 2011-12-20 2013-06-26 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
MX2014007446A (es) * 2011-12-20 2014-08-01 Novozymes As Variantes de subtilasa y polinucleotidos que las codifican.
WO2013120948A1 (en) * 2012-02-17 2013-08-22 Novozymes A/S Subtilisin variants and polynucleotides encoding same
EP2628785B1 (en) * 2012-02-17 2016-05-18 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
WO2014099525A1 (en) 2012-12-21 2014-06-26 Danisco Us Inc. Paenibacillus curdlanolyticus amylase, and methods of use, thereof
EP3354728B1 (en) 2012-12-21 2020-04-22 Danisco US Inc. Alpha-amylase variants
US20160017305A1 (en) 2013-03-11 2016-01-21 Danisco Us Inc. Alpha-amylase combinatorial variants
US20160160202A1 (en) 2013-05-29 2016-06-09 Danisco Us Inc. Novel metalloproteases
WO2014194054A1 (en) 2013-05-29 2014-12-04 Danisco Us Inc. Novel metalloproteases
EP3110833B1 (en) 2013-05-29 2020-01-08 Danisco US Inc. Novel metalloproteases
US20160108387A1 (en) 2013-05-29 2016-04-21 Danisco Us Inc. Novel metalloproteases
WO2014207228A1 (en) 2013-06-27 2014-12-31 Novozymes A/S Subtilase variants and polynucleotides encoding same
US20160145596A1 (en) 2013-06-27 2016-05-26 Novozymes A/S Subtilase Variants and Polynucleotides Encoding Same
US20160222368A1 (en) * 2013-09-12 2016-08-04 Danisco Us Inc. Compositions and Methods Comprising LG12-CLADE Protease Variants
WO2015057619A1 (en) 2013-10-15 2015-04-23 Danisco Us Inc. Clay granule
DK3068879T3 (da) 2013-11-14 2020-03-16 Danisco Us Inc Stabile enzymer opnået ved glykeringsreduktion
EP3080262B1 (en) 2013-12-13 2019-02-06 Danisco US Inc. Serine proteases of bacillus species
US10533165B2 (en) 2013-12-13 2020-01-14 Danisco Us Inc Serine proteases of the bacillus gibsonii-clade
CA2932498C (en) 2013-12-16 2023-03-14 E. I. Du Pont De Nemours And Company Use of poly alpha-1,3-glucan ethers as viscosity modifiers
EP3789407B1 (en) 2013-12-18 2024-07-24 Nutrition & Biosciences USA 4, Inc. Cationic poly alpha-1,3-glucan ethers
EP3097174A1 (en) 2014-01-22 2016-11-30 The Procter & Gamble Company Method of treating textile fabrics
WO2015112341A1 (en) 2014-01-22 2015-07-30 The Procter & Gamble Company Fabric treatment composition
WO2015112338A1 (en) 2014-01-22 2015-07-30 The Procter & Gamble Company Method of treating textile fabrics
EP3097173B1 (en) 2014-01-22 2020-12-23 The Procter and Gamble Company Fabric treatment composition
CN105992796A (zh) 2014-02-14 2016-10-05 纳幕尔杜邦公司 用于粘度调节的聚-α-1,3-1,6-葡聚糖
MX2016011467A (es) 2014-03-11 2016-11-16 Du Pont Poli alfa-1,3-glucano oxidado como mejorador de detergente.
EP4155398A1 (en) 2014-03-21 2023-03-29 Danisco US Inc. Serine proteases of bacillus species
US9714403B2 (en) 2014-06-19 2017-07-25 E I Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
EP3158043B1 (en) 2014-06-19 2021-03-10 Nutrition & Biosciences USA 4, Inc. Compositions containing one or more poly alpha-1,3-glucan ether compounds
WO2016001450A2 (en) * 2014-07-04 2016-01-07 Novozymes A/S Subtilase variants and polynucleotides encoding same
US20170233710A1 (en) 2014-10-17 2017-08-17 Danisco Us Inc. Serine proteases of bacillus species
BR112017007949A2 (pt) 2014-10-24 2018-01-23 Danisco Us Inc método para produção de álcool pelo uso de uma tripeptidil-peptidase
CN107148472A (zh) 2014-10-27 2017-09-08 丹尼斯科美国公司 芽孢杆菌属物种的丝氨酸蛋白酶
WO2016069544A1 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases
EP3212662B1 (en) 2014-10-27 2020-04-08 Danisco US Inc. Serine proteases
EP3212782B1 (en) 2014-10-27 2019-04-17 Danisco US Inc. Serine proteases
EP3212781B1 (en) 2014-10-27 2019-09-18 Danisco US Inc. Serine proteases
BR112017010239A2 (pt) 2014-11-17 2018-01-02 Procter & Gamble composições para liberação de agente de benefício
US10260024B2 (en) * 2014-12-04 2019-04-16 Novozymes A/S Liquid cleaning compositions comprising protease variants
CN107075493B (zh) 2014-12-04 2020-09-01 诺维信公司 枯草杆菌酶变体以及编码它们的多核苷酸
WO2016096711A2 (en) * 2014-12-15 2016-06-23 Novozymes A/S Subtilase variants
EP3741848A3 (en) * 2014-12-19 2021-02-17 Novozymes A/S Protease variants and polynucleotides encoding same
CN107109450A (zh) 2014-12-23 2017-08-29 纳幕尔杜邦公司 酶促产生的纤维素
EP3611259A1 (en) * 2015-03-12 2020-02-19 Danisco US Inc. Compositions and methods comprising lg12-clade protease variants
EP3088504B1 (en) 2015-04-29 2021-07-21 The Procter & Gamble Company Method of treating a fabric
PL3088502T3 (pl) 2015-04-29 2018-10-31 The Procter & Gamble Company Sposób obróbki tkaniny
EP3088506B1 (en) 2015-04-29 2018-05-23 The Procter and Gamble Company Detergent composition
PL3088503T3 (pl) 2015-04-29 2018-10-31 The Procter & Gamble Company Sposób prania tkanin
EP3088505B1 (en) 2015-04-29 2020-06-03 The Procter and Gamble Company Method of treating a fabric
US20180112204A1 (en) 2015-05-13 2018-04-26 Danisco Us Inc. AprL-CLADE PROTEASE VARIANTS AND USES THEREOF
EP3307427B1 (en) 2015-06-09 2023-08-16 Danisco US Inc. Osmotic burst encapsulates
WO2016201069A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc Low-density enzyme-containing particles
WO2016201040A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc. Water-triggered enzyme suspension
US11499146B2 (en) 2015-06-17 2022-11-15 Danisco Us Inc. Bacillus gibsonii-clade serine proteases
CN109072208A (zh) 2015-11-05 2018-12-21 丹尼斯科美国公司 类芽孢杆菌属物种甘露聚糖酶
CN108603183B (zh) 2015-11-05 2023-11-03 丹尼斯科美国公司 类芽孢杆菌属物种和芽孢杆菌属物种甘露聚糖酶
JP7045313B2 (ja) 2015-11-13 2022-03-31 ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物
WO2017083229A1 (en) 2015-11-13 2017-05-18 E. I. Du Pont De Nemours And Company Glucan fiber compositions for use in laundry care and fabric care
JP6997706B2 (ja) 2015-11-13 2022-01-18 ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物
WO2017089093A1 (en) 2015-11-25 2017-06-01 Unilever N.V. A liquid detergent composition
JP2019500058A (ja) 2015-12-09 2019-01-10 ダニスコ・ユーエス・インク α−アミラーゼ組み合わせ変異体
EP3390625B1 (en) 2015-12-18 2023-09-06 Danisco US Inc. Polypeptides with endoglucanase activity and uses thereof
DE102016205670A1 (de) * 2016-04-06 2017-10-12 Henkel Ag & Co. Kgaa Neue Protease mit verbesserter Waschleistung
BR112018072530A2 (pt) 2016-05-03 2019-03-26 Danisco Us Inc variantes de protease e usos das mesmas
CN109477112B (zh) 2016-05-31 2024-09-06 丹尼斯科美国公司 蛋白酶变体及其用途
MX2018015559A (es) 2016-06-17 2019-06-06 Danisco Us Inc Variantes de proteasa y sus usos.
US20190264138A1 (en) 2016-11-07 2019-08-29 Danisco Us Inc. Laundry detergent composition
DK3330349T3 (da) 2016-12-02 2024-07-15 Procter & Gamble Rengøringssammensætninger, der indbefatter enzymer
US10550443B2 (en) 2016-12-02 2020-02-04 The Procter & Gamble Company Cleaning compositions including enzymes
CA3044415C (en) 2016-12-02 2022-06-07 The Procter & Gamble Company Cleaning compositions including enzymes
WO2018118917A1 (en) 2016-12-21 2018-06-28 Danisco Us Inc. Protease variants and uses thereof
EP3559226B1 (en) 2016-12-21 2023-01-04 Danisco US Inc. Bacillus gibsonii-clade serine proteases
US11453871B2 (en) 2017-03-15 2022-09-27 Danisco Us Inc. Trypsin-like serine proteases and uses thereof
EP3601515A1 (en) 2017-03-31 2020-02-05 Danisco US Inc. Delayed release enzyme formulations for bleach-containing detergents
CA3067837A1 (en) 2017-06-30 2019-01-03 Danisco Us Inc Low-agglomeration, enzyme-containing particles
RU2718554C1 (ru) * 2017-09-25 2020-04-08 Георгий Георгиевич Чумбуридзе Термостабильная композиция, обладающая антивирусной и антибактериальной активностью и ее использование
CN111373039A (zh) 2017-11-29 2020-07-03 丹尼斯科美国公司 具有改善的稳定性的枯草杆菌蛋白酶变体
MX2020006518A (es) 2017-12-21 2020-10-28 Danisco Us Inc Gránulos de fusión en caliente, que contienen enzimas, que comprenden un desecante termotolerante.
MX2020008302A (es) 2018-02-08 2020-10-14 Danisco Us Inc Partículas de matriz de cera térmicamente resistentes para encapsulación de enzimas.
WO2019245704A1 (en) 2018-06-19 2019-12-26 Danisco Us Inc Subtilisin variants
US20210363470A1 (en) 2018-06-19 2021-11-25 Danisco Us Inc Subtilisin variants
WO2020047215A1 (en) 2018-08-30 2020-03-05 Danisco Us Inc Enzyme-containing granules
EP3856882A1 (en) 2018-09-27 2021-08-04 Danisco US Inc. Compositions for medical instrument cleaning
CN111019925B (zh) * 2018-10-10 2022-08-23 上饶市康可得生物科技有限公司 筛选蛋白酶变体的方法以及获得的蛋白酶变体
EP3851524A4 (en) * 2018-10-10 2022-05-18 Shangrao Concord Pharmaceutical Co., Ltd. METHOD OF SCREENING A PROTEASE VARIANT AND OBTAINED PROTEASE VARIANT
WO2020112599A1 (en) 2018-11-28 2020-06-04 Danisco Us Inc Subtilisin variants having improved stability
CN109481336B (zh) * 2018-12-19 2021-10-26 广州立白企业集团有限公司 口腔护理组合物及其应用
CN114174504A (zh) 2019-05-24 2022-03-11 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
EP3980517A1 (en) 2019-06-06 2022-04-13 Danisco US Inc. Methods and compositions for cleaning
IT201900023433A1 (it) 2019-12-10 2021-06-10 Lonati Spa Dispositivo prelevatore per operare il prelievo di un manufatto tubolare a maglia da una macchina circolare per maglieria, calzetteria o simile
US20240034960A1 (en) 2020-08-27 2024-02-01 Danisco Us Inc Enzymes and enzyme compositions for cleaning
WO2022165107A1 (en) 2021-01-29 2022-08-04 Danisco Us Inc Compositions for cleaning and methods related thereto
KR20230144058A (ko) * 2021-02-12 2023-10-13 프레제니우스 카비 입섬 에스. 알. 엘. 서브틸리신 변이체 및 그의 용도
CN112877304B (zh) * 2021-03-15 2022-07-26 合肥师范学院 一种细菌漆酶突变体LacAt及其表达菌株的构建和应用
EP4363565A1 (en) 2021-06-30 2024-05-08 Danisco US Inc. Variant lipases and uses thereof
US20240384205A1 (en) 2021-09-03 2024-11-21 Danisco Us Inc. Laundry compositions for cleaning
CN117957318A (zh) 2021-09-13 2024-04-30 丹尼斯科美国公司 含有生物活性物质的颗粒
CN118715318A (zh) 2021-12-16 2024-09-27 丹尼斯科美国公司 枯草杆菌蛋白酶变体及其用途
EP4448749A2 (en) 2021-12-16 2024-10-23 Danisco US Inc. Subtilisin variants and methods of use
US20250051748A1 (en) 2021-12-16 2025-02-13 Danisco Us Inc. Subtilisin variants and methods of use
US20250163396A1 (en) 2022-03-01 2025-05-22 Danisco Us Inc. Enzymes and enzyme compositions for cleaning
CN114733656B (zh) * 2022-04-25 2024-01-23 江苏泓润生物质能科技有限公司 一种用于预处理后的餐厨垃圾同步分相除渣及除杂系统
PE20251535A1 (es) 2022-05-14 2025-06-05 Novozymes As Composiciones y metodos para prevenir, tratar, suprimir y/o eliminar infecciones e infestaciones fitopatogenas
WO2023250301A1 (en) 2022-06-21 2023-12-28 Danisco Us Inc. Methods and compositions for cleaning comprising a polypeptide having thermolysin activity
CN120112635A (zh) 2022-09-02 2025-06-06 丹尼斯科美国公司 枯草杆菌蛋白酶变体及其相关方法
CN119855892A (zh) 2022-09-02 2025-04-18 丹尼斯科美国公司 洗涤剂组合物及其相关方法
EP4581137A1 (en) 2022-09-02 2025-07-09 Danisco Us Inc Mannanase variants and methods of use
CN120303400A (zh) 2022-11-09 2025-07-11 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
EP4658776A1 (en) 2023-02-01 2025-12-10 Danisco US Inc. Subtilisin variants and methods of use
US20240263162A1 (en) * 2023-02-01 2024-08-08 The Procter & Gamble Company Detergent compositions containing enzymes
WO2024163600A1 (en) * 2023-02-01 2024-08-08 Danisco Us Inc. Subtilisin variants and methods of use
WO2024186819A1 (en) 2023-03-06 2024-09-12 Danisco Us Inc. Subtilisin variants and methods of use
CN120813242A (zh) 2023-03-16 2025-10-17 营养与生物科学美国第四公司 用于清洁和臭味控制的短芽孢杆菌发酵物提取物及其用途
WO2025072144A1 (en) * 2023-09-27 2025-04-03 Osprey Biopharmaceuticals, Inc. Polypeptides having human igg cleavage activity
WO2025071996A1 (en) 2023-09-28 2025-04-03 Danisco Us Inc. Variant cutinase enzymes with improved solubility and uses thereof
WO2025085351A1 (en) 2023-10-20 2025-04-24 Danisco Us Inc. Subtilisin variants and methods of use
CN117417922B (zh) * 2023-12-13 2024-03-15 北京科为博生物科技有限公司 一种耐高温碱性蛋白酶及其基因和应用
CN120197407B (zh) * 2025-05-27 2025-08-12 南京华洲药业有限公司 一种除草剂悬浮剂分散稳定性预估优化方法及系统

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296839A (enExample) 1969-05-29 1972-11-22
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
GR76237B (enExample) 1981-08-08 1984-08-04 Procter & Gamble
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5972682A (en) 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5411873A (en) * 1984-05-29 1995-05-02 Genencor, Inc. Process for producing heterologous polypeptides
US5763257A (en) * 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
DK154572C (da) 1985-08-07 1989-04-24 Novo Industri As Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler
JPH0697997B2 (ja) 1985-08-09 1994-12-07 ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ 新規の酵素的洗浄剤添加物
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
DE3750916T2 (de) * 1986-04-30 1995-06-01 Genencor Int Mutante einer nicht menschlichen Carbonyl-Hydrolase, für diese kodierende DNS-Sequenzen und Vektoren und durch diese Vektoren transformierte Wirte.
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
EP0258068B1 (en) 1986-08-29 1994-08-31 Novo Nordisk A/S Enzymatic detergent additive
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
EP0322429B1 (en) 1987-05-29 1994-10-19 Genencor International, Inc. Cutinase cleaning composition
ES2076939T3 (es) 1987-08-28 1995-11-16 Novo Nordisk As Lipasa recombinante de humicola y procedimiento para la produccion de lipasas recombinantes de humicola.
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
JP2624859B2 (ja) 1988-01-07 1997-06-25 ノボ‐ノルディスク アクティーゼルスカブ 酵素洗剤
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
US4977252A (en) 1988-03-11 1990-12-11 National Starch And Chemical Investment Holding Corporation Modified starch emulsifier characterized by shelf stability
WO1990009446A1 (en) 1989-02-17 1990-08-23 Plant Genetic Systems N.V. Cutinase
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
DK316989D0 (da) * 1989-06-26 1989-06-26 Novo Nordisk As Enzymer
JPH04500385A (ja) * 1989-06-26 1992-01-23 ユニリーバー・ナームローゼ・ベンノートシヤープ 酵素洗剤組成物
DE4111321A1 (de) 1990-04-14 1991-10-17 Kali Chemie Ag Alkalische bacillus-lipasen, hierfuer codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren
US5354559A (en) 1990-05-29 1994-10-11 Grain Processing Corporation Encapsulation with starch hydrolyzate acid esters
US5766898A (en) * 1990-12-05 1998-06-16 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
EP0495257B1 (en) 1991-01-16 2002-06-12 The Procter & Gamble Company Compact detergent compositions with high activity cellulase
US5340735A (en) 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
PT717778E (pt) * 1992-07-17 2008-01-16 Genencor Int Serina proteases resistentes a alcalinidade elevada
DE4231726A1 (de) * 1992-09-23 1994-03-24 Cognis Bio Umwelt Mutierte subtilisinartige Serinproteasen
CA2145420C (en) * 1992-09-24 2005-01-04 Stanley E. Mainzer Cleaning compositions containing novel alkaline proteases
KR100303620B1 (ko) 1992-12-01 2001-11-22 피아 스타르 효소반응의증강법
CA2154157C (en) 1993-01-18 1999-08-03 Fiona Susan Macbeath Machine dishwashing detergent compositions
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
US5698504A (en) 1993-07-01 1997-12-16 The Procter & Gamble Company Machine dishwashing composition containing oxygen bleach and paraffin oil and benzotriazole compound silver tarnishing inhibitors
US5486303A (en) 1993-08-27 1996-01-23 The Procter & Gamble Company Process for making high density detergent agglomerates using an anhydrous powder additive
US6436690B1 (en) * 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
EP0719339B1 (en) 1993-09-15 2006-10-25 The Procter & Gamble Company Subtilisin bpn' variants with decreased adsorption and increased hydrolysis
ATE361355T1 (de) * 1993-10-14 2007-05-15 Procter & Gamble Proteasehaltige reinigungsmittel
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
CN1177921C (zh) * 1993-10-14 2004-12-01 普罗格特-甘布尔公司 含有蛋白酶的漂白组合物
DE4342680A1 (de) 1993-12-15 1995-06-22 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5691295A (en) 1995-01-17 1997-11-25 Cognis Gesellschaft Fuer Biotechnologie Mbh Detergent compositions
ES2364774T3 (es) 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
DK0701605T3 (da) 1994-02-24 2008-07-28 Henkel Ag & Co Kgaa Forbedrede enzymer og detergenter indeholdende disse
US5686014A (en) 1994-04-07 1997-11-11 The Procter & Gamble Company Bleach compositions comprising manganese-containing bleach catalysts
ES2180645T3 (es) 1994-06-17 2003-02-16 Genencor Int Metodo de limpieza basado en composiciones que contienen una enzima capaz de degradar las paredes celulares de las plantas y su uso en metodos de limpieza.
GB2294268A (en) 1994-07-07 1996-04-24 Procter & Gamble Bleaching composition for dishwasher use
GB9416841D0 (en) * 1994-08-19 1994-10-12 Finnfeeds Int Ltd An enzyme feed additive and animal feed including it
US5879584A (en) 1994-09-10 1999-03-09 The Procter & Gamble Company Process for manufacturing aqueous compositions comprising peracids
US5691297A (en) 1994-09-20 1997-11-25 The Procter & Gamble Company Process for making a high density detergent composition by controlling agglomeration within a dispersion index
US5489392A (en) 1994-09-20 1996-02-06 The Procter & Gamble Company Process for making a high density detergent composition in a single mixer/densifier with selected recycle streams for improved agglomerate properties
US5516448A (en) 1994-09-20 1996-05-14 The Procter & Gamble Company Process for making a high density detergent composition which includes selected recycle streams for improved agglomerate
ATE190090T1 (de) 1994-12-09 2000-03-15 Procter & Gamble Diacylperoxydteilchen enthaltende zusammensetzungen für automatische geschirreinigung
US5534179A (en) 1995-02-03 1996-07-09 Procter & Gamble Detergent compositions comprising multiperacid-forming bleach activators
US5574005A (en) 1995-03-07 1996-11-12 The Procter & Gamble Company Process for producing detergent agglomerates from high active surfactant pastes having non-linear viscoelastic properties
US5569645A (en) 1995-04-24 1996-10-29 The Procter & Gamble Company Low dosage detergent composition containing optimum proportions of agglomerates and spray dried granules for improved flow properties
US5597936A (en) 1995-06-16 1997-01-28 The Procter & Gamble Company Method for manufacturing cobalt catalysts
ES2158320T3 (es) 1995-06-16 2001-09-01 Procter & Gamble Composiciones para lavavajillas automaticos que comprenden catalizadores de cobalto.
US5565422A (en) 1995-06-23 1996-10-15 The Procter & Gamble Company Process for preparing a free-flowing particulate detergent composition having improved solubility
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
US5576282A (en) 1995-09-11 1996-11-19 The Procter & Gamble Company Color-safe bleach boosters, compositions and laundry methods employing same
ATE214729T1 (de) 1995-09-18 2002-04-15 Procter & Gamble Freisetzungssysteme
US5879564A (en) 1995-11-14 1999-03-09 Cytec Technology Corp. High performance polymer flocculating agents
MA24137A1 (fr) 1996-04-16 1997-12-31 Procter & Gamble Fabrication d'agents de surface ramifies .
JP4044143B2 (ja) * 1996-11-04 2008-02-06 ノボザイムス アクティーゼルスカブ ズブチラーゼ変異体及び組成物
CN1136311C (zh) * 1996-11-04 2004-01-28 诺沃奇梅兹有限公司 枯草杆菌酶变异体和组合物
CA2282466C (en) 1997-03-07 2005-09-20 The Procter & Gamble Company Bleach compositions containing metal bleach catalyst, and bleach activators and/or organic percarboxylic acids
CN1134443C (zh) 1997-03-07 2004-01-14 普罗格特-甘布尔公司 制备交联桥大环化合物的改进方法
EP1007646A1 (en) * 1997-08-29 2000-06-14 Novo Nordisk A/S Protease variants and compositions
RU2252254C2 (ru) * 1997-10-23 2005-05-20 Джененкор Интернэшнл, Инк. Вариант субтилизина bacillus (варианты), кодирующая его днк, экспрессирующий вектор и очищающая композиция
MA24811A1 (fr) 1997-10-23 1999-12-31 Procter & Gamble Compositions de lavage contenant des variantes de proteases multisubstituees
US5935826A (en) 1997-10-31 1999-08-10 National Starch And Chemical Investment Holding Corporation Glucoamylase converted starch derivatives and their use as emulsifying and encapsulating agents
US6773907B2 (en) * 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
CN1279715A (zh) 1997-11-21 2001-01-10 诺沃挪第克公司 蛋白酶变体及组合物
DK1042501T3 (da) 1997-12-24 2007-08-13 Genencor Int Fremgangsmåde til analyse af vaskeevnen af et enzym
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP2284272B1 (en) 1998-06-10 2014-08-13 Novozymes A/S Mannanases
US6461849B1 (en) * 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
US6376450B1 (en) 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
WO2000032601A2 (en) 1998-11-30 2000-06-08 The Procter & Gamble Company Process for preparing cross-bridged tetraaza macrocycles
WO2000037621A1 (en) * 1998-12-18 2000-06-29 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having an additional amino acid residue in an active site loop region
JP4647787B2 (ja) * 1998-12-18 2011-03-09 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
ATE355355T1 (de) * 1998-12-18 2006-03-15 Novozymes As Subtilasen der i-s1 und i-s2 untergruppen mit einem zusätzlichen aminosäurerest in der aktiven seitenschleifenregion
MXPA01011836A (es) * 1999-05-20 2002-06-21 Novozymes As Enzimas subtilasas de los sub-grupos i-s1 e i-s2 que tienen al menos un residuo de un aminoacido adicional entre las posiciones 97 y 98.
BR0012660A (pt) * 1999-07-22 2002-04-09 Procter & Gamble Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
BR0108513A (pt) * 2000-02-23 2002-12-17 Procter & Gamble Composições detergentes lìquidos para a lavagem de tecidos tendo vantagens melhoradas de remoção de argila
WO2001075087A2 (en) * 2000-04-03 2001-10-11 Maxygen, Inc. Subtilisin variants
EP2258853B1 (en) * 2000-04-28 2016-06-08 Novozymes A/S Lipolytic enzyme variant
ATE400648T1 (de) 2000-08-11 2008-07-15 Genencor Int Transformation von bacillus, transformanten und mutanten-bibliotheken
US6541235B1 (en) * 2000-09-29 2003-04-01 University Of Maryland Biotechnology Institute Calcium free subtilisin mutants
US6440991B1 (en) 2000-10-02 2002-08-27 Wyeth Ethers of 7-desmethlrapamycin
US6582914B1 (en) 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations
PL210859B1 (pl) * 2001-03-23 2012-03-30 Genencor Int Odmiana subtylizyny zawierająca zmieniony epitop limfocytów T, kwas nukleinowy kodujący tę odmianę subtylizyny, wektor ekspresyjny i komórka gospodarza zawierająca kwas nukleinowy oraz kompozycje zawierające tę odmianę subtylizyny
CN1612723A (zh) * 2001-11-13 2005-05-04 宝洁公司 包含由抑制剂稳定化的酶的局部组合物
US7332320B2 (en) * 2001-12-31 2008-02-19 Genencor International, Inc. Protease producing an altered immunogenic response and methods of making and using the same
JP2005514026A (ja) * 2001-12-31 2005-05-19 ジェネンコー・インターナショナル・インク 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
ATE450606T1 (de) * 2002-01-16 2009-12-15 Genencor Int Mehrfachsubstituierte proteasevarianten
ATE457352T1 (de) * 2002-02-26 2010-02-15 Genencor Int Subtilisin-carlsberg-proteine mit verminderter immunogenität
US7888093B2 (en) * 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
TWI319007B (en) * 2002-11-06 2010-01-01 Novozymes As Subtilase variants
US20040214737A1 (en) * 2003-04-25 2004-10-28 John Billman Foamy composition for pretreatment of stains on fabrics
US7910115B2 (en) * 2003-04-30 2011-03-22 Shigekazu Nakatsugawa Polypeptide absorbable into digestive organs
JP5244317B2 (ja) 2003-11-19 2013-07-24 ジェネンコー・インターナショナル・インク セリンプロテアーゼ、セリン酵素をコードする核酸、およびこれらを取り込んだベクターおよび宿主細胞
WO2005056782A2 (en) 2003-12-03 2005-06-23 Genencor International, Inc. Perhydrolase
US20060014265A1 (en) 2004-04-08 2006-01-19 Eugenio Ferrari Mutant alpha-amylases
DE102004027091A1 (de) * 2004-06-02 2005-12-29 Henkel Kgaa Leistungsverbesserte Alkalische Protease-Varianten und Wasch- und Reinigungsmittel, enthaltend diese leistungsverbesserten Alkalische Protease-Varianten
CN103555697A (zh) * 2005-07-08 2014-02-05 诺维信公司 枯草蛋白酶变体
JP5507843B2 (ja) 2005-10-12 2014-05-28 ジェネンコー・インターナショナル・インク 保存安定的な中性金属プロテアーゼの使用及び生産
CN101460618A (zh) * 2006-04-20 2009-06-17 诺维信公司 对蛋渍具有改进的洗涤性能的洒维奈斯变体
US20080009431A1 (en) * 2006-06-05 2008-01-10 Jean-Pol Boutique Enzyme stabilization
NZ573467A (en) * 2006-07-18 2012-02-24 Danisco Us Inc Genencor Div Subtilisin variants active over a broad temperature range
BRPI0915681A2 (pt) * 2008-06-06 2015-08-04 Danisco Us Inc Composições e métodos compreendendo proteases microbianas variantes
AR073420A1 (es) * 2008-11-11 2010-11-03 Danisco Us Inc Variantes de serina proteasas, composiciones y metodos de limpieza que las comprenden
CN102652175B (zh) * 2009-12-09 2016-02-10 宝洁公司 织物和家居护理产品
ES2746931T3 (es) * 2009-12-09 2020-03-09 Danisco Us Inc Composiciones y métodos comprendiendo variantes de proteasa
EP2551335A1 (en) * 2011-07-25 2013-01-30 The Procter & Gamble Company Enzyme stabilized liquid detergent composition
US20130123162A1 (en) * 2011-11-10 2013-05-16 The Procter & Gamble Company Consumer products

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018050618A (ja) * 2008-06-06 2018-04-05 ダニスコ・ユーエス・インク 変異体微生物のプロテアーゼを含む組成物及び方法

Also Published As

Publication number Publication date
US12448616B2 (en) 2025-10-21
EP2647702A3 (en) 2013-12-25
EP2578680A1 (en) 2013-04-10
EP2947147A2 (en) 2015-11-25
MX383345B (es) 2025-03-13
EP2297316A2 (en) 2011-03-23
US20150247140A1 (en) 2015-09-03
BRPI0915681A2 (pt) 2015-08-04
MX2010013121A (es) 2011-01-21
RU2010153866A (ru) 2012-07-20
CN103382421B (zh) 2016-01-20
CA2726370A1 (en) 2009-12-10
JP2013240327A (ja) 2013-12-05
EP2578679A1 (en) 2013-04-10
US20240309352A1 (en) 2024-09-19
KR20110015004A (ko) 2011-02-14
RU2010153864A (ru) 2012-07-20
WO2009149145A3 (en) 2010-01-28
US20150064767A1 (en) 2015-03-05
EP3095859A1 (en) 2016-11-23
MX2010013100A (es) 2010-12-21
WO2009149145A2 (en) 2009-12-10
JP2018050618A (ja) 2018-04-05
JP2015012864A (ja) 2015-01-22
US10563189B2 (en) 2020-02-18
AU2009256169A1 (en) 2009-12-10
DK2297314T3 (en) 2015-07-13
WO2009149144A3 (en) 2010-04-15
US20180223269A1 (en) 2018-08-09
CN104130993A (zh) 2014-11-05
CN104130993B (zh) 2018-10-23
US20110251073A1 (en) 2011-10-13
CN102112607A (zh) 2011-06-29
CN104694519B (zh) 2023-10-27
WO2009149200A3 (en) 2010-07-29
RU2541786C2 (ru) 2015-02-20
US20110256610A1 (en) 2011-10-20
EP2647702A2 (en) 2013-10-09
KR20110020245A (ko) 2011-03-02
CA2726451A1 (en) 2009-12-10
AU2009256295A1 (en) 2009-12-10
AU2009256294A1 (en) 2009-12-10
BRPI0915073A2 (pt) 2019-09-24
RU2010154103A (ru) 2012-07-20
US20150056682A1 (en) 2015-02-26
JP2011524166A (ja) 2011-09-01
JP2011522539A (ja) 2011-08-04
WO2009149144A2 (en) 2009-12-10
US20200190497A1 (en) 2020-06-18
BRPI0913623A2 (pt) 2015-08-04
WO2009149200A2 (en) 2009-12-10
KR20110015006A (ko) 2011-02-14
EP2647701A2 (en) 2013-10-09
EP2578680B1 (en) 2016-04-27
BRPI0913623A8 (pt) 2017-10-03
MX360255B (es) 2018-10-26
CA2726450A1 (en) 2009-12-10
CN102046783A (zh) 2011-05-04
CN102057043B (zh) 2015-03-04
CN102112607B (zh) 2014-08-20
US20220025350A1 (en) 2022-01-27
EP3173479A1 (en) 2017-05-31
US20110256609A1 (en) 2011-10-20
EP2297314A2 (en) 2011-03-23
EP2297315A2 (en) 2011-03-23
CN103382420B (zh) 2015-10-28
US12410420B2 (en) 2025-09-09
CN103382420A (zh) 2013-11-06
CN102057043A (zh) 2011-05-11
EP2947147A3 (en) 2015-12-23
JP6426391B2 (ja) 2018-11-21
DK2578680T3 (en) 2016-08-15
EP2297314B1 (en) 2015-04-15
JP5647976B2 (ja) 2015-01-07
EP2647701A3 (en) 2013-12-25
ZA201008169B (en) 2012-02-29
US20180051269A1 (en) 2018-02-22
JP2015211671A (ja) 2015-11-26
MX2010013101A (es) 2010-12-21
JP2011522537A (ja) 2011-08-04
CN103382421A (zh) 2013-11-06
CN104694519A (zh) 2015-06-10
MX350188B (es) 2017-08-30
JP2013223499A (ja) 2013-10-31
US20150159147A1 (en) 2015-06-11

Similar Documents

Publication Publication Date Title
JP6067221B2 (ja) 微生物プロテアーゼ変異種を含有する組成物と方法
KR20110091671A (ko) 세린 프로테아제 변이체를 포함하는 조성물 및 방법
AU2014201928A1 (en) Compositions and methods comprising variant microbial proteases
AU2014202897A1 (en) Compositions and methods comprising variant microbial proteases

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110128

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130319

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130617

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130624

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130712

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130807

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130819

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130913

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140422

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140718

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140728

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140822

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150416

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150611

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150617

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20150821

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160711

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160817

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160920

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161019

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161221

R150 Certificate of patent or registration of utility model

Ref document number: 6067221

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250