JP5701894B2 - アッセイを行う方法及び装置 - Google Patents

アッセイを行う方法及び装置 Download PDF

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Publication number
JP5701894B2
JP5701894B2 JP2012540157A JP2012540157A JP5701894B2 JP 5701894 B2 JP5701894 B2 JP 5701894B2 JP 2012540157 A JP2012540157 A JP 2012540157A JP 2012540157 A JP2012540157 A JP 2012540157A JP 5701894 B2 JP5701894 B2 JP 5701894B2
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assay
microfluidic
reaction vessel
channel
sample
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Japanese (ja)
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JP2013511731A (ja
JP2013511731A5 (cg-RX-API-DMAC7.html
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マーティン・エイ・パトナム
アラン・ディー・カージー
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サイヴェク・インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2012540157A 2009-11-23 2010-11-23 アッセイを行う方法及び装置 Active JP5701894B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26357209P 2009-11-23 2009-11-23
US61/263,572 2009-11-23
PCT/US2010/057860 WO2011063408A1 (en) 2009-11-23 2010-11-23 Method and apparatus for performing assays

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015029544A Division JP5996014B2 (ja) 2009-11-23 2015-02-18 アッセイを行う方法及び装置

Publications (3)

Publication Number Publication Date
JP2013511731A JP2013511731A (ja) 2013-04-04
JP2013511731A5 JP2013511731A5 (cg-RX-API-DMAC7.html) 2013-05-16
JP5701894B2 true JP5701894B2 (ja) 2015-04-15

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JP2012540157A Active JP5701894B2 (ja) 2009-11-23 2010-11-23 アッセイを行う方法及び装置
JP2015029544A Active JP5996014B2 (ja) 2009-11-23 2015-02-18 アッセイを行う方法及び装置

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Country Status (7)

Country Link
US (1) US9229001B2 (cg-RX-API-DMAC7.html)
EP (1) EP2504701B1 (cg-RX-API-DMAC7.html)
JP (2) JP5701894B2 (cg-RX-API-DMAC7.html)
CN (1) CN102713621B (cg-RX-API-DMAC7.html)
CA (1) CA2781556C (cg-RX-API-DMAC7.html)
ES (1) ES2649559T3 (cg-RX-API-DMAC7.html)
WO (1) WO2011063408A1 (cg-RX-API-DMAC7.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2013142847A1 (en) * 2012-03-22 2013-09-26 Cyvek, Inc Pdms membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them
WO2013134741A2 (en) * 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
WO2012129455A2 (en) 2011-03-22 2012-09-27 Cyvek, Inc Microfluidic devices and methods of manufacture and use
DE102012205171B3 (de) 2012-03-29 2013-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Integriertes Einweg-Chipkartuschensystem für mobile Multiparameteranalysen chemischer und/oder biologischer Substanzen
US9458488B2 (en) 2013-03-15 2016-10-04 Nanomix, Inc. Point of care sensor systems
JP6625519B2 (ja) * 2013-03-15 2019-12-25 イナノベイト， インコーポレイテッド アッセイシステムおよびカートリッジデバイス
KR20170016915A (ko) * 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
CN104568537A (zh) * 2014-11-05 2015-04-29 华文蔚 一种处理生物微流体样本的方法
CN108136388A (zh) * 2015-04-30 2018-06-08 奥菲迪亚有限公司 微流阀和装置
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
DK3523448T3 (da) * 2016-10-07 2021-06-28 Boehringer Ingelheim Vetmedica Gmbh Fremgangsmåde og analysesystem til at teste en prøve
US20200245898A1 (en) * 2019-01-31 2020-08-06 Hound Labs, Inc. Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath
JP2022523799A (ja) * 2019-03-01 2022-04-26 ヴィディア・ホールディングス・リミテッド 光学要素における、または関連した改善
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
US12392769B1 (en) 2021-01-12 2025-08-19 Hound Labs, Inc. Ambient contamination in breath analyte detection and measurement
CN114345430B (zh) * 2022-01-14 2022-10-28 北京工商大学 一种通过纸基微流控芯片同时检测多种抗生素残留的便携式装置
US20250128256A1 (en) * 2022-01-25 2025-04-24 President And Fellows Of Harvard College Microfluidic devices with autonomous directional valves

Family Cites Families (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
SE343949B (cg-RX-API-DMAC7.html) 1966-06-02 1972-03-20 Pharmacia Ab
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3876376A (en) 1974-05-09 1975-04-08 American Cyanamid Co Linear determination of hemolytic complement activity in undiluted serum
US4222744A (en) 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
US4254096A (en) 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4425438A (en) 1981-03-13 1984-01-10 Bauman David S Assay method and device
US4368047A (en) 1981-04-27 1983-01-11 University Of Utah Research Foundation Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection
NZ201901A (en) 1981-09-25 1986-11-12 Commw Serum Lab Commission An apparatus suitable for performing automated heterogeneous immunoassays in a plurality of samples
DE3226407C2 (de) 1982-07-15 1985-05-15 Volker Dr. 6900 Heidelberg Daniel Mikro-Analyse-Kapillar-System
US4447546A (en) 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
CA1237645A (en) 1982-12-21 1988-06-07 John H. Fisher Assay technique
DE3484505D1 (de) 1983-12-19 1991-05-29 Daiichi Pure Chemicals Co Ltd Immuntest.
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
JPH06105261B2 (ja) * 1984-03-05 1994-12-21 株式会社東芝 濃度勾配測定装置
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5004923A (en) 1985-08-05 1991-04-02 Biotrack, Inc. Capillary flow device
US4844869A (en) 1985-09-09 1989-07-04 Ord, Inc. Immunoassay apparatus
US4716121A (en) 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
US5500350A (en) 1985-10-30 1996-03-19 Celltech Limited Binding assay device
US4820490A (en) 1986-09-11 1989-04-11 Miles Inc. Device and method for chemical analysis of fluids with a reagent coated light source
US4717545A (en) 1986-09-11 1988-01-05 Miles Inc. Device and method for chemical analysis of fluids with a reagent coated light source
US4797259A (en) 1986-12-15 1989-01-10 Pall Corporation Well-type diagnostic plate device
US4923819A (en) 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
ATE86386T1 (de) 1987-04-29 1993-03-15 Celltech Ltd Vorrichtung fuer bindungstest.
US5009998A (en) 1987-06-26 1991-04-23 E. I. Du Pont De Nemours And Company Method for performing heterogeneous immunoassay
US5041181A (en) 1987-10-06 1991-08-20 Integrated Fluidics Company Method of bonding plastics
US4908116A (en) 1989-06-01 1990-03-13 The Board Of Trustees At The Leland Stanford Junior University Capillary electrophoretic device employing structure permitting electrical contact through ionic movement
US5302349A (en) 1989-06-13 1994-04-12 Diatron Corporation Transient-state luminescence assay apparatus
US6008057A (en) 1989-08-25 1999-12-28 Roche Diagnostics Corporation Immunoassay system
US5183740A (en) 1990-02-23 1993-02-02 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor method and apparatus
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
JPH06501099A (ja) 1990-09-11 1994-01-27 ヴォアヒーズ・テクノロジース・インコーポレーテッド 被覆された毛管
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US6019944A (en) * 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
JPH06108242A (ja) 1992-09-25 1994-04-19 Minolta Camera Co Ltd 薄膜電極および薄膜製造装置
US5508200A (en) 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5534328A (en) 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
US5493802A (en) 1993-05-26 1996-02-27 Simson; Anton K. Scroll displaying device
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
ATE224053T1 (de) 1993-11-12 2002-09-15 Inverness Medical Switzerland Vorrichtung zum ablesen von teststreifen
US5976896A (en) 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US5624850A (en) 1994-06-06 1997-04-29 Idetek, Inc. Immunoassays in capillaries
US5593290A (en) 1994-12-22 1997-01-14 Eastman Kodak Company Micro dispensing positive displacement pump
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
JPH09288089A (ja) 1996-04-23 1997-11-04 Hitachi Ltd 毛細管電気泳動装置
JP2000510582A (ja) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
US7341727B1 (en) 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US20030054376A1 (en) 1997-07-07 2003-03-20 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
DE19635646C1 (de) 1996-09-03 1997-12-04 Bruker Franzen Analytik Gmbh Korrektur der Massenbestimmung mit MALDI-Flugzeitmassenspektrometern
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US6507989B1 (en) 1997-03-13 2003-01-21 President And Fellows Of Harvard College Self-assembly of mesoscale objects
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
WO1998049548A1 (en) 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US6020209A (en) 1997-04-28 2000-02-01 The United States Of America As Represented By The Secretary Of The Navy Microcapillary-based flow-through immunosensor and displacement immunoassay using the same
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6082185A (en) 1997-07-25 2000-07-04 Research International, Inc. Disposable fluidic circuit cards
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
JP3938982B2 (ja) 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
AU9673198A (en) 1997-10-02 1999-04-27 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5965237A (en) 1997-10-20 1999-10-12 Novartis Ag Microstructure device
US6143152A (en) 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6719868B1 (en) 1998-03-23 2004-04-13 President And Fellows Of Harvard College Methods for fabricating microfluidic structures
JPH11307604A (ja) 1998-04-17 1999-11-05 Toshiba Corp プロセスモニタ方法及びプロセス装置
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6366924B1 (en) 1998-07-27 2002-04-02 Caliper Technologies Corp. Distributed database for analytical instruments
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6497155B1 (en) 1999-02-09 2002-12-24 Pharmacopeia, Inc. Article comprising a particle retrieval device
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
EP1185871A4 (en) 1999-06-01 2003-01-15 Caliper Techn Corp MICRO-SCALE ASSAYS AND MICROFLUIDIC DEVICES FOR THE CONTROL OF TRANSPORTER, INDUCED GRADIENT AND BINDING ACTIVITIES
US6520753B1 (en) 1999-06-04 2003-02-18 California Institute Of Technology Planar micropump
US7601270B1 (en) 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
AU6366200A (en) * 1999-07-27 2001-02-13 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6762059B2 (en) * 1999-08-13 2004-07-13 U.S. Genomics, Inc. Methods and apparatuses for characterization of single polymers
JP4119649B2 (ja) * 1999-08-25 2008-07-16 カリパー・ライフ・サイエンシズ・インコーポレーテッド 単一真空源を有する高スループットシステムにおける稀釈
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
JP3441058B2 (ja) 1999-12-03 2003-08-25 理化学研究所 キャピラリーゲル電気泳動用マイクロチップおよびその製造方法
CA2364381C (en) 1999-12-22 2009-03-10 Gene Logic, Inc. Flow-thru chip cartridge, chip holder, system and method thereof
ATE403145T1 (de) 2000-01-31 2008-08-15 Univ Texas Tragbare vorrichtung mit einer sensor-array- anordnung
CA2399027C (en) 2000-01-31 2010-06-22 Joel S. Rossier Method for fabricating micro-structures with various surface properties in multilayer body by plasma etching
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
AU2001284700B2 (en) 2000-08-03 2005-12-08 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
US7189358B2 (en) 2000-08-08 2007-03-13 California Institute Of Technology Integrated micropump analysis chip and method of making the same
US7998746B2 (en) 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
US6994826B1 (en) 2000-09-26 2006-02-07 Sandia National Laboratories Method and apparatus for controlling cross contamination of microfluid channels
JP2002122596A (ja) * 2000-10-16 2002-04-26 Mitsubishi Rayon Co Ltd 生体関連物質検出用マイクロアレイ
US20050221385A1 (en) 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
EP1343973B2 (en) 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
GB0028647D0 (en) 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
EP1350029B1 (en) 2001-01-08 2014-09-10 President and Fellows of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US20060207877A1 (en) 2001-01-30 2006-09-21 Walter Schmidt Microfluidic device with various surface properties fabricated in multilayer body by plasma etching
JP2002286717A (ja) * 2001-03-23 2002-10-03 Central Res Inst Of Electric Power Ind 無蛍光担体およびこれを固相に用いた測定用セル、ならびに無蛍光担体を利用する濃度測定方法
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
JP2002340900A (ja) * 2001-05-18 2002-11-27 Mitsubishi Rayon Co Ltd バイオセンサー、バイオセンサーアレイ及び検出方法
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
US6881579B2 (en) 2001-07-30 2005-04-19 Agilent Technologies, Inc. Sample processing apparatus and methods
US7192629B2 (en) 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US6750661B2 (en) 2001-11-13 2004-06-15 Caliper Life Sciences, Inc. Method and apparatus for controllably effecting samples using two signals
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048736A2 (en) 2001-12-05 2003-06-12 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
US7622083B2 (en) 2002-01-28 2009-11-24 Biocal Technology, Inc. Multi-capillary electrophoresis cartridge interface mechanism
AU2003218132A1 (en) 2002-03-12 2003-09-29 Syngenta Participations Ag Microcapillary hybridization chamber
US7524462B2 (en) 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
US8211657B2 (en) 2002-04-29 2012-07-03 The Board Of Trustees Of The University Of Arkansas Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens
US7125510B2 (en) 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
EP2093565B1 (en) 2002-05-22 2014-11-19 Platypus Technologies, Inc. Uses of devices and methods for cellular assays
EP1513953A1 (en) 2002-06-03 2005-03-16 PamGene B.V. Method for high-throughput integrated chemical and biochemical reactions
US20060086309A1 (en) 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
US20040101444A1 (en) 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US20040126875A1 (en) 2002-09-12 2004-07-01 Putnam Martin A. Assay stick
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US20040110199A1 (en) 2002-08-28 2004-06-10 Montemagno Carlo D. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP1540591A1 (en) 2002-09-12 2005-06-15 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
US7186383B2 (en) 2002-09-27 2007-03-06 Ast Management Inc. Miniaturized fluid delivery and analysis system
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
WO2004034028A2 (en) 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US20050266582A1 (en) 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
AU2003297214A1 (en) 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
CA2772050C (en) 2002-12-26 2016-09-06 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US7445926B2 (en) 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
US7033476B2 (en) 2002-12-31 2006-04-25 Ut-Battelle, Llc Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection
US7122153B2 (en) 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
TW579430B (en) 2003-05-02 2004-03-11 Dr Chip Biotechnology Inc Automatic micro-fluid hybridization chip platform
AU2004240944A1 (en) 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
FR2857099B1 (fr) 2003-07-04 2005-10-07 Jean Marie Billiotte Procede et dispositif d'analyse chimique ou biologique par senseur a chambre monolithique en gerbe multi-micro-tubulaire et transducteur lateral de mesure integrale
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US7028536B2 (en) 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US20050098750A1 (en) 2003-11-06 2005-05-12 Daniel Sobek Electrostatic sealing device and method of use thereof
JP4073023B2 (ja) 2003-11-07 2008-04-09 財団法人新産業創造研究機構 微小流路デバイスおよびその作製方法
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
WO2005066613A1 (en) 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
EP1716404A4 (en) * 2004-02-20 2010-05-05 Univ New York State Res Found METHOD AND DEVICE FOR MANIPULATING LIQUIDS IN MICROFLUID SYSTEMS
JP4362532B2 (ja) 2004-04-07 2009-11-11 ウォードロウ パートナーズ エルピー 生体液を分析する使い捨てチャンバ
EP1796824A4 (en) 2004-05-02 2016-10-19 Fluidigm Corp DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE
US7887750B2 (en) 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
US7419639B2 (en) 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
EP1776581B1 (en) 2004-07-19 2015-05-06 ProteinSimple Method for protein detection
JP2006098169A (ja) * 2004-09-29 2006-04-13 Fujitsu Ltd 被検体定量デバイスおよび被検体定量方法
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
CA2578550A1 (en) 2004-10-29 2006-05-04 Itoham Foods Inc. Reaction vessel
EP1838431A4 (en) 2004-12-03 2012-08-22 California Inst Of Techn MICROFLUIDIC DEVICES WITH CIRCUITRY OF CHEMICAL REACTIONS
US7682817B2 (en) 2004-12-23 2010-03-23 Kimberly-Clark Worldwide, Inc. Microfluidic assay devices
US20060228734A1 (en) * 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
DE102005049365A1 (de) 2005-03-18 2006-09-21 BAM Bundesanstalt für Materialforschung und -prüfung Kalibriereinrichtung und Farbstoffkit sowie ihre Verwendung zur Charakterisierung von Lumineszenzmesssystemen
AU2006226744B2 (en) * 2005-03-23 2012-02-23 Velocys, Inc. Surface features in microprocess technology
US7507588B2 (en) 2005-04-20 2009-03-24 Becton, Dickinson And Company Multiplex microparticle system
CA2505657A1 (en) 2005-04-28 2006-10-28 York University Method for mixing inside a capillary and device for achieving same
WO2006122310A2 (en) 2005-05-11 2006-11-16 The Trustess Of The University Of Pennsylvania System for testing
EP1882950A4 (en) 2005-05-19 2012-08-15 Konica Minolta Med & Graphic TEST CHIP FOR ANALYZING TARGET SUBSTANCE IN SUBSTANCE TO BE ANALYZED AND ANALYTICAL SYSTEM AT MICROSCOPIC SCALE
AU2006246598B2 (en) * 2005-05-20 2010-04-01 Hitachi Chemical Company, Ltd. Method of analyzing biochemical
US20060263818A1 (en) * 2005-05-23 2006-11-23 Axel Scherer High throughput multi-antigen microfluidic fluorescence immunoassays
WO2007044091A2 (en) 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
WO2007021813A2 (en) 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic system and methods
RO122612B1 (ro) 2005-08-29 2009-09-30 Institutul Naţional De Cercetare-Dezvoltare Pentru Microtehnologie Procedeu de realizare a unui biocip cu funcţia de amplificare a unor fragmente specifice de adn prin reacţia polimerazică în lan
JP3116709U (ja) * 2005-09-13 2005-12-15 有限会社メタボスクリーン 微小流路チップ
EP1938101A2 (en) 2005-09-13 2008-07-02 Fluidigm Corporation Microfluidic assay devices and methods
US20080311585A1 (en) 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
JP4253323B2 (ja) * 2005-12-05 2009-04-08 株式会社東芝 マイクロ化学チップ
US8182767B2 (en) 2005-12-27 2012-05-22 Honeywell International Inc. Needle-septum interface for a fluidic analyzer
WO2007092713A2 (en) 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
EP1987275A1 (en) * 2006-02-13 2008-11-05 Koninklijke Philips Electronics N.V. Microfluidic device for molecular diagnostic applications
CN101067642A (zh) * 2006-02-24 2007-11-07 丹尼斯·B·歇尔 电子器件测试装置及其所使用的触头
US7639026B2 (en) 2006-02-24 2009-12-29 Johnstech International Corporation Electronic device test set and contact used therein
ES2393758T3 (es) 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
BRPI0711047A2 (pt) 2006-05-01 2011-08-23 Konink Philips Eletronics N V dispositivo de transporte de amostra de fluido, e, uso do mesmo
EP2032722B1 (en) 2006-05-16 2013-08-21 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
AU2007265628B2 (en) 2006-06-23 2012-12-06 Revvity Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
CA2656686A1 (en) 2006-07-05 2008-01-10 Aida Engineering, Ltd. Micro passage chip and fluid transferring method
US7794665B2 (en) * 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
US20080017512A1 (en) 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
GR1006447B (el) 2006-09-15 2009-06-19 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος" Μεθοδος συγκολλησης
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US20080131327A1 (en) 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
EP2074341A4 (en) 2006-10-04 2013-04-10 Fluidigm Corp MICROFLUIDIC CHECK VALVES
US8101403B2 (en) 2006-10-04 2012-01-24 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
WO2008052363A1 (en) 2006-11-03 2008-05-08 Mcgill University Electrical microvalve and method of manufacturing thereof
WO2008075253A1 (en) 2006-12-19 2008-06-26 Koninklijke Philips Electronics N.V. Micro fluidic device
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
KR20100017126A (ko) 2007-04-25 2010-02-16 쓰리엠 이노베이티브 프로퍼티즈 컴파니 화학적 요소 및 처리 장치 조립체
ES2453107T3 (es) 2007-06-11 2014-04-04 Wako Pure Chemical Industries, Ltd. Procedimiento de amplificación de ácidos nucleicos usando una PCR sobre microchip con detección integrada de CE en tiempo real
EP2167633A4 (en) * 2007-07-16 2014-12-24 California Inst Of Techn MICROFLUIDIC DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES
JP2009041984A (ja) * 2007-08-07 2009-02-26 Arkray Inc 分析装置、分析用具、および光学検知システム
WO2009029177A1 (en) 2007-08-24 2009-03-05 Dynamic Throughput Inc. Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US7736891B2 (en) 2007-09-11 2010-06-15 University Of Washington Microfluidic assay system with dispersion monitoring
KR20090030084A (ko) 2007-09-19 2009-03-24 삼성전자주식회사 미세유동장치
US8202722B2 (en) 2007-09-21 2012-06-19 Nec Corporation Temperature control method and system
US20090087884A1 (en) 2007-09-27 2009-04-02 Timothy Beerling Microfluidic nucleic acid amplification and separation
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
CN101978248A (zh) 2008-01-07 2011-02-16 动态通量生命科学仪器有限公司 具有整合微流化生物标记物光学检测阵列装置的发现工具和使用方法
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
JP2009178078A (ja) * 2008-01-30 2009-08-13 Hitachi Engineering & Services Co Ltd 微生物検査チップ及び微生物検査装置
CA2715985A1 (en) 2008-02-21 2009-08-27 Avantra Biosciences Corporation Assays based on liquid flow over arrays
KR100952056B1 (ko) 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
WO2009111461A2 (en) 2008-03-04 2009-09-11 University Of Utah Research Foundation Microfluidic flow cell
WO2009126826A1 (en) 2008-04-11 2009-10-15 Fluidigm Corporation Multilevel microfluidic systems and methods
US8303910B2 (en) 2008-05-07 2012-11-06 Panasonic Corporation Biosensor
US20090325171A1 (en) 2008-05-13 2009-12-31 Thomas Hirt Vesicles for use in biosensors
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
US7947492B2 (en) * 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US20110151479A1 (en) 2008-08-25 2011-06-23 University Of Washington Microfluidic systems incorporating flow-through membranes
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2010042784A2 (en) 2008-10-10 2010-04-15 Massachusetts Institute Of Technology Method of hydrolytically stable bonding of elastomers to substrates
US20110300570A1 (en) 2008-11-14 2011-12-08 The Brigham And Women's Hospital, Inc. Method and system for generating spatially and temporally controllable concentration gradients
GB0821636D0 (en) 2008-11-26 2008-12-31 Ucl Business Plc Device
CN102281950B (zh) 2008-12-08 2015-05-06 富鲁达公司 可编程微流体数字阵列
WO2010071045A1 (ja) 2008-12-19 2010-06-24 公立大学法人大阪府立大学 イムノアッセイ用キャピラリー及びそれを用いたキャピラリーイムノアッセイ法
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US8017409B2 (en) 2009-05-29 2011-09-13 Ecolab Usa Inc. Microflow analytical system
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
WO2010148252A1 (en) 2009-06-17 2010-12-23 Jody Vykoukal Method and apparatus for quantitative microimaging
US20120164036A1 (en) 2009-07-21 2012-06-28 Seth Stern Microfluidic devices and uses thereof
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
EP2490812B1 (en) 2009-10-21 2016-05-11 Biocartis NV Microfluidic cartridge with parallel pneumatic interface plate
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
WO2012129455A2 (en) 2011-03-22 2012-09-27 Cyvek, Inc Microfluidic devices and methods of manufacture and use

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