EP2229578A4 - Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use - Google Patents

Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use

Info

Publication number
EP2229578A4
EP2229578A4 EP08869969A EP08869969A EP2229578A4 EP 2229578 A4 EP2229578 A4 EP 2229578A4 EP 08869969 A EP08869969 A EP 08869969A EP 08869969 A EP08869969 A EP 08869969A EP 2229578 A4 EP2229578 A4 EP 2229578A4
Authority
EP
European Patent Office
Prior art keywords
methods
optical detection
array device
detection array
integrated microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08869969A
Other languages
German (de)
French (fr)
Other versions
EP2229578A1 (en
Inventor
Pao-Lin Shen
Li Jiang
Kejun Jiang
Zhongzhong Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynamic Throughput Inc
Original Assignee
Dynamic Throughput Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/970,451 external-priority patent/US7952705B2/en
Priority claimed from US12/191,812 external-priority patent/US20090097022A1/en
Application filed by Dynamic Throughput Inc filed Critical Dynamic Throughput Inc
Publication of EP2229578A1 publication Critical patent/EP2229578A1/en
Publication of EP2229578A4 publication Critical patent/EP2229578A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/0074—Production of other optical elements not provided for in B29D11/00009- B29D11/0073
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP08869969A 2008-01-07 2008-10-31 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use Withdrawn EP2229578A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/970,451 US7952705B2 (en) 2007-08-24 2008-01-07 Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US12/191,812 US20090097022A1 (en) 2007-08-24 2008-08-14 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use
PCT/US2008/012369 WO2009088408A1 (en) 2008-01-07 2008-10-31 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use

Publications (2)

Publication Number Publication Date
EP2229578A1 EP2229578A1 (en) 2010-09-22
EP2229578A4 true EP2229578A4 (en) 2011-02-23

Family

ID=40854774

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08869969A Withdrawn EP2229578A4 (en) 2008-01-07 2008-10-31 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use

Country Status (6)

Country Link
EP (1) EP2229578A4 (en)
JP (1) JP2011511933A (en)
CN (1) CN101978248A (en)
AU (1) AU2008347152A1 (en)
CA (1) CA2710828A1 (en)
WO (1) WO2009088408A1 (en)

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US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
CN102713621B (en) 2009-11-23 2016-10-19 西维克公司 For the method and apparatus implementing chemical examination
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9216412B2 (en) 2009-11-23 2015-12-22 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
JP2013528379A (en) * 2010-05-21 2013-07-11 オームクス コーポレーション Detection of cancer by PSA enzyme activity assay
ES2710908T3 (en) 2011-03-15 2019-04-29 Nat Res Council Canada System for microfluidics that has monolithic nanoplasmonic structures
CA2837463C (en) * 2011-05-29 2016-08-09 Korea Research Institute Of Chemical Technology High-speed screening apparatus for a raman analysis-based high-speed multiple drug
KR102070469B1 (en) 2012-03-08 2020-01-28 싸이벡, 아이엔씨 Microfluidic assay assemblies and methods of manufacture
TWI695151B (en) * 2012-11-30 2020-06-01 美商凱特伊夫公司 Gas enclosure system
US20160003732A1 (en) * 2013-03-14 2016-01-07 Hewlett-Packard Development Company, L.P. Devices to detect a substance and methods of producing such a device
CN103499534B (en) * 2013-07-25 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 Highly sensitive Terahertz microfluidic channel sensor and preparation method thereof
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JP6491425B2 (en) * 2014-05-21 2019-03-27 Ｔｏｗａ株式会社 Electronic parts package side view photographing device
KR101626045B1 (en) * 2014-07-29 2016-06-01 경희대학교 산학협력단 A method and device for diagnosis of viral infection using tear drop
JP6441172B2 (en) * 2015-06-12 2018-12-19 浜松ホトニクス株式会社 Surface-enhanced Raman scattering unit
JP6441174B2 (en) * 2015-06-18 2018-12-19 浜松ホトニクス株式会社 Surface-enhanced Raman scattering unit
CN104880391B (en) * 2015-06-23 2018-03-06 好来化工(中山)有限公司 For detecting the device of particulate matter in saliva
EP3347694B8 (en) * 2015-07-01 2021-04-21 Horiba Instruments Incorporated Cuvette assembly for optical microscopy of nanoparticles in liquids
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
EP3449242A4 (en) 2016-07-22 2019-12-11 Hewlett-Packard Development Company, L.P. Substrate supported sel stage and housing
CN107144620A (en) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 Diabetic nephropathy detects mark
CN107179309B (en) * 2017-05-22 2019-06-07 厦门大学 A kind of detection method of arginine kinase
WO2019164962A1 (en) * 2018-02-20 2019-08-29 EMULATE, Inc. Human microphysiological cell system for liver disease conversion with prov 1-18585 and prov 2-19154
CN108982826B (en) * 2018-09-28 2024-03-26 广东工业大学 Test device and test method for detecting embryotoxicity of nano particles by zebra fish
US20210404967A1 (en) * 2018-12-14 2021-12-30 Hewlett-Packard Development Company, L.P. An analysis chip
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Also Published As

Publication number Publication date
JP2011511933A (en) 2011-04-14
CA2710828A1 (en) 2009-07-16
EP2229578A1 (en) 2010-09-22
WO2009088408A1 (en) 2009-07-16
CN101978248A (en) 2011-02-16
AU2008347152A1 (en) 2009-07-16

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