EP2229578A4 - Outil de découverte avec dispositif de réseau de détection optique de biomarqueurs microfluidique et intégré, et procédés d'utilisation - Google Patents

Outil de découverte avec dispositif de réseau de détection optique de biomarqueurs microfluidique et intégré, et procédés d'utilisation

Info

Publication number
EP2229578A4
EP2229578A4 EP08869969A EP08869969A EP2229578A4 EP 2229578 A4 EP2229578 A4 EP 2229578A4 EP 08869969 A EP08869969 A EP 08869969A EP 08869969 A EP08869969 A EP 08869969A EP 2229578 A4 EP2229578 A4 EP 2229578A4
Authority
EP
European Patent Office
Prior art keywords
methods
optical detection
array device
detection array
integrated microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08869969A
Other languages
German (de)
English (en)
Other versions
EP2229578A1 (fr
Inventor
Pao-Lin Shen
Li Jiang
Kejun Jiang
Zhongzhong Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynamic Throughput Inc
Original Assignee
Dynamic Throughput Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/970,451 external-priority patent/US7952705B2/en
Priority claimed from US12/191,812 external-priority patent/US20090097022A1/en
Application filed by Dynamic Throughput Inc filed Critical Dynamic Throughput Inc
Publication of EP2229578A1 publication Critical patent/EP2229578A1/fr
Publication of EP2229578A4 publication Critical patent/EP2229578A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/0074—Production of other optical elements not provided for in B29D11/00009- B29D11/0073
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Mechanical Engineering (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP08869969A 2008-01-07 2008-10-31 Outil de découverte avec dispositif de réseau de détection optique de biomarqueurs microfluidique et intégré, et procédés d'utilisation Withdrawn EP2229578A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/970,451 US7952705B2 (en) 2007-08-24 2008-01-07 Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US12/191,812 US20090097022A1 (en) 2007-08-24 2008-08-14 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use
PCT/US2008/012369 WO2009088408A1 (fr) 2008-01-07 2008-10-31 Outil de découverte avec dispositif de réseau de détection optique de biomarqueurs microfluidique et intégré, et procédés d'utilisation

Publications (2)

Publication Number Publication Date
EP2229578A1 EP2229578A1 (fr) 2010-09-22
EP2229578A4 true EP2229578A4 (fr) 2011-02-23

Family

ID=40854774

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08869969A Withdrawn EP2229578A4 (fr) 2008-01-07 2008-10-31 Outil de découverte avec dispositif de réseau de détection optique de biomarqueurs microfluidique et intégré, et procédés d'utilisation

Country Status (6)

Country Link
EP (1) EP2229578A4 (fr)
JP (1) JP2011511933A (fr)
CN (1) CN101978248A (fr)
AU (1) AU2008347152A1 (fr)
CA (1) CA2710828A1 (fr)
WO (1) WO2009088408A1 (fr)

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US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
WO2013134744A2 (fr) 2012-03-08 2013-09-12 Cyvek, Inc Ensembles d'analyse microfluidique et leurs procédés de fabrication
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
CA2798812A1 (fr) * 2010-05-21 2011-11-24 Ohmx Corporation Detection du cancer par dosage de l'activite enzymatique du psa
EP2686154B1 (fr) * 2011-03-15 2018-11-14 National Research Council of Canada Système microfluidique ayant des structures monolithiques nanoplasmoniques
WO2012129455A2 (fr) 2011-03-22 2012-09-27 Cyvek, Inc Dispositifs micro-fluidiques et leurs procédés de fabrication et d'utilisation
EP2717052A4 (fr) * 2011-05-29 2014-10-29 Korea Res Inst Chem Tech Appareil de criblage à haute vitesse de plusieurs médicaments par analyse raman
TWI618901B (zh) * 2012-11-30 2018-03-21 凱特伊夫公司 用於維護工業用列印系統的方法
US20160003732A1 (en) * 2013-03-14 2016-01-07 Hewlett-Packard Development Company, L.P. Devices to detect a substance and methods of producing such a device
CN103499534B (zh) * 2013-07-25 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
EP2878373A1 (fr) 2013-11-29 2015-06-03 IMEC vzw Capteur plasmonique à écoulement capillaire
ES2645631T3 (es) * 2014-05-07 2017-12-07 Commissariat A L'energie Atomique Et Aux Energies Alternatives Microalgas verdes que carecen del gen funcional DYRKP-1, para uso en el aumento de la producción de materias primas
JP6491425B2 (ja) * 2014-05-21 2019-03-27 Ｔｏｗａ株式会社 電子部品パッケージ側面撮影装置
KR101626045B1 (ko) * 2014-07-29 2016-06-01 경희대학교 산학협력단 눈물 방울을 이용한 바이러스 감염진단 방법 및 기기
JP6441172B2 (ja) * 2015-06-12 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
JP6441174B2 (ja) * 2015-06-18 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
CN104880391B (zh) * 2015-06-23 2018-03-06 好来化工(中山)有限公司 用于检测唾液中颗粒物质的装置
EP3347694B8 (fr) * 2015-07-01 2021-04-21 Horiba Instruments Incorporated Ensemble cuvette pour une microscopie optique de nanoparticules dans des liquides
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
EP3449242A4 (fr) 2016-07-22 2019-12-11 Hewlett-Packard Development Company, L.P. Platine sel supportée sur substrat et boîtier
CN107144620A (zh) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 糖尿病肾病检测标志物
CN107179309B (zh) * 2017-05-22 2019-06-07 厦门大学 一种精氨酸激酶的检测方法
GB2618001B (en) * 2018-02-20 2024-01-31 Emulate Inc Human microphysiological cell system for liver disease
CN108982826B (zh) * 2018-09-28 2024-03-26 广东工业大学 一种斑马鱼检测纳米颗粒对胚胎毒性的测试装置和测试方法
US20210404967A1 (en) * 2018-12-14 2021-12-30 Hewlett-Packard Development Company, L.P. An analysis chip
DE102019100256A1 (de) 2019-01-07 2020-07-09 Als Automated Lab Solutions Gmbh Probengefäß mit einer Kavität zur Aufnahme einer Probe
GB2582619A (en) * 2019-03-28 2020-09-30 Sumitomo Chemical Co Enzyme linked assay methods and apparatuses
CN110327996B (zh) * 2019-09-03 2019-12-24 中国科学院上海高等研究院 微流控芯片、微流控系统及红外微流控分析方法
CN112626200B (zh) * 2021-01-12 2022-07-22 复旦大学附属妇产科医院 血清微囊泡-天冬酰胺内肽酶假基因1在子宫内膜异位症诊断及复发预测中的用途
US20220236261A1 (en) * 2021-01-26 2022-07-28 IceMos Technology Limited Semiconductor Device Providing a Biosensor to Test for Pathogen
CN114034683A (zh) * 2021-12-01 2022-02-11 吉林大学 一种快速诊断1型糖尿病的多重免疫芯片及其制备方法和应用
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See also references of WO2009088408A1 *
SEPANIAK M ET AL: "Chemical and biochemical analysis using microfluidic-localized field platforms", SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY V, vol. 6759, 675902, 26 September 2007 (2007-09-26), PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE USA, pages 1 - 10, XP002614597, ISSN: 0277-786X *
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Also Published As

Publication number Publication date
CN101978248A (zh) 2011-02-16
AU2008347152A1 (en) 2009-07-16
EP2229578A1 (fr) 2010-09-22
CA2710828A1 (fr) 2009-07-16
JP2011511933A (ja) 2011-04-14
WO2009088408A1 (fr) 2009-07-16

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