JP5238159B2 - エクジソン受容体複合体を通して外因性遺伝子の発現を調節するための生物学的利用能のあるジアシルヒドラジン・リガンド - Google Patents

エクジソン受容体複合体を通して外因性遺伝子の発現を調節するための生物学的利用能のあるジアシルヒドラジン・リガンド Download PDF

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JP5238159B2
JP5238159B2 JP2006508884A JP2006508884A JP5238159B2 JP 5238159 B2 JP5238159 B2 JP 5238159B2 JP 2006508884 A JP2006508884 A JP 2006508884A JP 2006508884 A JP2006508884 A JP 2006508884A JP 5238159 B2 JP5238159 B2 JP 5238159B2
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phenyl
gene
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ホーマン，ロバート，ユージン
ポーター，デイビッド，ダブリュー．
チョルティク，オレステス
タイス，コリン，エム．
カールソン，グレン，リチャード
マイヤー，アンドリュー
オピエ，トーマス，アール．
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イントレクソン コーポレイション
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014111634A (ja) * 2003-02-28 2014-06-19 Intrexon Corp エクジソン受容体複合体を通して外因性遺伝子の発現を調節するための生物学的利用能のあるジアシルヒドラジン・リガンド

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
MXPA03007493A (es) 2001-02-20 2004-10-15 Rheogene Holdings Inc Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
EP2374891B1 (en) * 2001-02-20 2013-05-08 Intrexon Corporation Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system
JP4994563B2 (ja) 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
CA2445796C (en) 2001-02-20 2014-09-16 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP2005532781A (ja) * 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
AU2013204101B2 (en) * 2007-05-29 2015-07-02 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP3357904B1 (en) * 2007-05-29 2022-07-06 Precigen, Inc. Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
MX2010001993A (es) * 2007-08-23 2010-03-11 Intrexon Corp Metodos y composiciones para diagnosticar una enfermedad.
US20090136465A1 (en) * 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
HUE035406T2 (en) * 2007-10-08 2018-05-02 Intrexon Corp Modified dendritic cells and uses for cancer treatment
BRPI0908747A2 (pt) 2008-03-14 2023-04-18 Intrexon Corp Ligantes esteróides e seu uso em modulação de comutador genético
DE102008038222A1 (de) * 2008-08-18 2010-02-25 Merck Patent Gmbh Indazol-5-carbonsäurehydrazid-derivate
BRPI0920679A2 (pt) * 2008-10-08 2022-05-17 Intrexon Corp Células construídas expressando múltiplos imunomoduladores e usos das mesmas
NZ595163A (en) * 2009-03-05 2013-04-26 Rohm & Haas Control of key ethylene hormone signaling pathway proteins in plants
JP2013527753A (ja) 2010-03-23 2013-07-04 イントレキソン コーポレーション 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用
DE102010055499A1 (de) * 2010-12-22 2011-06-16 W.C. Heraeus Gmbh Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon
JP6189754B2 (ja) 2011-03-04 2017-08-30 イントレキソン コーポレーション タンパク質を条件的に発現するベクター
BR112014005509B1 (pt) 2011-09-08 2022-11-29 Intrexon Corporation Diacil-hidrazina cristalina e composição, uso, método para produzir e kit da mesma
WO2014144380A1 (en) 2013-03-15 2014-09-18 Intrexon Corporation Boron-containing diacylhydrazines
CA2918452A1 (en) 2013-07-15 2015-01-22 Donald Danforth Plant Science Center Enhanced oil production and stress tolerance in plants
JP6567657B2 (ja) 2014-09-17 2019-08-28 イントレキソン コーポレーション ホウ素含有ジアシルヒドラジン化合物
AR105359A1 (es) * 2015-07-17 2017-09-27 Bayer Cropscience Ag Hidrazidas de ácido carboxílico arilo y heteroarilo sustituidas o sus sales y su uso para aumentar la tolerancia al estrés en plantas
AU2016334401A1 (en) 2015-10-10 2018-04-26 Intrexon Corporation Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
EP3387010A1 (en) 2015-11-11 2018-10-17 Intrexon Corporation Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
CN106565531A (zh) * 2016-10-31 2017-04-19 苏州汉德创宏生化科技有限公司 烷基肼的药学可接受盐的合成方法
CA3042706A1 (en) 2016-11-09 2018-05-17 Intrexon Corporation Frataxin expression constructs
IL267865B1 (en) 2017-01-10 2024-03-01 Intrexon Corp Modulation of expression of polypeptides through a new system for changing gene expression
AU2019231652A1 (en) 2018-03-06 2020-10-01 Precigen, Inc. Hepatitis B vaccines and uses of the same
CN109134354B (zh) * 2018-09-19 2022-03-25 天津科技大学 2-吡啶甲基硫醚的合成方法及相关药物的合成工艺
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
CN110423210B (zh) * 2019-07-19 2021-07-27 暨南大学 一种苄基芳基硫醚衍生物及其制备方法和应用
CN114150032A (zh) * 2021-11-01 2022-03-08 丁庆 一种基于蝗虫特有肽的蝗虫水解物的制造方法及应用

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
DK483586A (da) * 1985-10-21 1987-04-22 Rohm & Haas Insecticide n'-substituerede-n,n'-diacylhydraziner
US5354762A (en) 1986-07-14 1994-10-11 Rohm And Haas Company Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US5424333A (en) * 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
US4985461A (en) * 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US4814349A (en) * 1985-12-09 1989-03-21 American Cyanamid Company Insecticidal substituted and unsubstituted benzoic acid 1-alkyl, 2 alkyl and 2-cycloalkylhydrazides
ES2027953T3 (es) * 1985-12-09 1992-07-01 American Cyanamid Company Procedimiento para preparar una composicion insecticida.
CA1338289C (en) 1986-01-22 1996-04-30 Raymond August Murphy Insecticidal n'-substituted-n-alkylcarbonyl- n'-acylhydrazines
CA1295618C (en) 1986-02-28 1992-02-11 Adam Chi-Tung Hsu Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines
JPH0820680B2 (ja) 1986-03-04 1996-03-04 ミノルタ株式会社 複写機の露光量制御方法
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
CA1281716C (en) 1986-05-01 1991-03-19 Raymond August Murphy Insecticidal n-substituted-n'-substituted-n,n'- diacylhydrazines
US5225443A (en) * 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
JPS62293150A (ja) 1986-06-13 1987-12-19 Amada Co Ltd 同期整流回路
ES2037709T3 (es) * 1986-07-14 1996-07-16 Rohm & Haas Derivados heterociclicos de seis miembros de n,n'-diacilhidrazinas n'-sustituidas.
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
ATE61044T1 (de) 1987-04-15 1991-03-15 Rohm & Haas Insektizide n-(gegebenenfalls substituierte)-n'substituierte-n,n'-disubstituierte hydrazine.
US4906280A (en) * 1987-10-14 1990-03-06 Pennwalt Corporation Tertiary butylhydrazides as plant growth regulators
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5429952A (en) 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5110986A (en) 1988-04-26 1992-05-05 Rohm And Haas Company Synthesis of n-t-alkyl-1,2-diacylhydrazines
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0413763B1 (en) 1988-06-13 1996-11-06 American Biogenetic Sciences, Inc. Method for the production of monoclonal antibodies utilizing a germfree animal
NZ229536A (en) 1988-06-15 1992-05-26 Rohm & Haas N'-substituted-n'-substituted carbonyl-n-substituted carbonyl-hydrazines and pesticidal compositions
ZA894508B (en) 1988-06-16 1990-03-28 Rohm & Haas Pharmaceutical compounds
US4857550A (en) * 1988-08-29 1989-08-15 American Cyanamid Company Novel insecticidal dibenzoyl-tert-butylcarbazonitrile compounds and method for the preparation thereof
JPH02207066A (ja) 1989-02-07 1990-08-16 Ishihara Sangyo Kaisha Ltd ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US4950666A (en) * 1989-03-30 1990-08-21 Fmc Corporation Difluoroalkane and difluoroalkenylalkane pesticides
US4954655A (en) * 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
EP0395581A1 (de) 1989-04-27 1990-10-31 Ciba-Geigy Ag N-Sulfenyl- und N-sulfinyl-N,N'-diacylhydrazide
NZ228936A (en) 1989-05-01 1992-04-28 Rohm & Haas Method for treating insect infestation in rice plants comprising applying diacylhydrazine derivatives
JPH03141245A (ja) 1989-10-24 1991-06-17 Ishihara Sangyo Kaisha Ltd ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤
JPH03145447A (ja) 1989-10-31 1991-06-20 Nissan Chem Ind Ltd ジベンゾイルヒドラジン化合物および殺虫剤
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
CA2075182C (en) 1990-02-09 2003-03-25 David J. Mangelsdorf Retinoid receptor compositions and methods
ES2180529T3 (es) * 1990-02-26 2003-02-16 Univ Leland Stanford Junior Identificacion y expresion de secuencias de adn de un receptor de esteroides de insectos.
WO1991014695A1 (en) 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US5641652A (en) 1990-03-22 1997-06-24 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) * 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
JPH0539252A (ja) 1990-08-01 1993-02-19 Nippon Kayaku Co Ltd Ｎ，Ｎ’−ジベンゾイル−ｔｅｒｔ−ブチルヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JP3068846B2 (ja) 1990-08-01 2000-07-24 日本化薬株式会社 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JP2885902B2 (ja) 1990-08-01 1999-04-26 日本化薬株式会社 Ｎ’―ｔｅｒｔ―ブチル―Ｎ―ハロゲノメチルスルフェニル―Ｎ，Ｎ’―ジベンゾイルヒドラジン誘導体およびそれを有効成分とする殺虫組成物
US5075471A (en) * 1990-10-09 1991-12-24 Rohm And Haas Company Insecticidal ferrocenoyl acylhydrazines
JP3087854B2 (ja) 1991-01-09 2000-09-11 日本化薬株式会社 新規ヒドラジン誘導体及びそれを有効成分とする殺虫組成物
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
DE69232188T2 (de) 1991-08-23 2002-06-20 Salk Inst For Biolog Studies L Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
AU2579692A (en) 1991-09-17 1993-04-27 Salk Institute For Biological Studies, The Receptor of the thyroid/steroid hormone receptor superfamily
JPH0539252U (ja) 1991-10-31 1993-05-28 株式会社 神戸鋳鉄所 樹木保護構造体
EP0619842A1 (en) 1991-12-06 1994-10-19 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors
US6013836A (en) * 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
US5530028A (en) * 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5344958A (en) * 1992-11-23 1994-09-06 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
JPH06172342A (ja) 1992-12-07 1994-06-21 Nippon Kayaku Co Ltd 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JP3298954B2 (ja) 1992-12-16 2002-07-08 三共株式会社 新規ｎ，ｎ’−ジベンゾイルヒドラジン誘導体及び殺虫組成物
JPH06298755A (ja) * 1993-04-20 1994-10-25 Nippon Kayaku Co Ltd 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
KR0149048B1 (ko) 1993-05-21 1998-08-17 박성희 인체의 피질흉선세포에 표현되는 단백질
ES2289194T3 (es) 1993-05-27 2008-02-01 Aventis Pharmaceuticals Inc. Bibliotecas en fase solida codificadas, segregadas topologicamente.
US5358966A (en) * 1993-06-08 1994-10-25 Rohm And Haas Company Turfgrass insecticides
ES2109613T3 (es) 1993-08-19 1998-01-16 Rohm & Haas Preparacion de 1,2-diacil-2-(t-alquil)hidrazinas.
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US5482962A (en) * 1994-07-22 1996-01-09 Rohm And Haas Company Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
EP0809509A4 (en) 1995-01-13 2000-02-02 Salk Inst For Biological Studi ALLOSTERIC REGULATION OF NUCLEAR HORMONE RECEPTORS
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
JP3600298B2 (ja) 1995-02-27 2004-12-15 日本化薬株式会社 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JPH08231529A (ja) 1995-02-27 1996-09-10 Nippon Kayaku Co Ltd ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
ATE293699T1 (de) * 1995-03-03 2005-05-15 Syngenta Participations Ag Kontrolle der pflanzengenexpression durch rezeptor-vermittelte transaktivation in gegenwart von einem chemischen ligand
AU711391B2 (en) 1995-05-26 1999-10-14 Syngenta Limited A gene switch comprising an ecdysone receptor
JPH09100262A (ja) 1995-06-06 1997-04-15 Rohm & Haas Co Ｎ，Ｎ’−ジアシル−Ｎ’−ｔ−アルキルヒドラジン化合物の製造方法
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6723531B2 (en) * 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
CN1215432A (zh) 1996-04-05 1999-04-28 索尔克生物学研究所 调节外源性基因在哺乳动物系统中表达的激素介导的方法及其相关产物
US6025483A (en) 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
US5948406A (en) * 1996-08-12 1999-09-07 Rohm And Haas Company Immunogens, antibodies formed therefrom, and coating antigens useful in a diacylhydrazine immunoassay method
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
EP0998560A1 (en) 1997-07-10 2000-05-10 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
DE19837620A1 (de) 1997-08-22 1999-02-25 Novartis Ag Organische Verbindungen
WO1999010510A2 (en) 1997-08-26 1999-03-04 Ariad Gene Therapeutics, Inc. Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6333318B1 (en) * 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) * 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP2000026423A (ja) 1998-07-09 2000-01-25 Otsuka Chem Co Ltd イソニコチノイルヒドラジン誘導体及び該誘導体を有効成分として含有する害虫防除剤
DE19831710A1 (de) * 1998-07-15 2000-01-20 Merck Patent Gmbh Diacylhydrazinderivate
EP0984009A1 (en) 1998-08-25 2000-03-08 Rohm And Haas Company Benzodioxincarboxylic acid hydrazides as insecticides
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
CN1177813C (zh) 1999-09-06 2004-12-01 华东理工大学 1,2-烷(芳)酰基芳酰基肼类昆虫生长调节剂及制备和应用
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
IL146010A0 (en) * 2000-02-18 2002-07-25 Arch Dev Corp Polyhydroxylated benzene-containing compounds
AU2001241682A1 (en) 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
EP1266015B1 (en) 2000-03-22 2006-08-30 RheoGene Holdings Inc. Ecdysone receptor-based inducible gene expression system
DE20012351U1 (de) 2000-07-14 2001-11-15 Siegenia Frank Kg Fenster oder Tür mit Entlastungseinrichtung
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
BR0207284B1 (pt) 2001-02-16 2014-10-14 Evonik Degussa Gmbh BACTÉRIAS CORINEFORMES COM GENE rpsL SUPEREXPRESSO E PROCESSO PARA A PREPARAÇÃO FERMENTADORA DE L-LISINA
MXPA03007493A (es) 2001-02-20 2004-10-15 Rheogene Holdings Inc Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
EP2374891B1 (en) * 2001-02-20 2013-05-08 Intrexon Corporation Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system
CA2445796C (en) * 2001-02-20 2014-09-16 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP4994563B2 (ja) 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
CN1161325C (zh) 2001-03-26 2004-08-11 江苏省农药研究所 作为杀虫剂的二酰基肼类化合物及制备此种化合物的中间体以及它们的制备方法
FR2827678B1 (fr) 2001-07-23 2003-12-12 Photonetics Attenuateur optique multicanal pour signal multiplexe
JP2005507247A (ja) * 2001-09-26 2005-03-17 レオジーン・ホールディングス，インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
JP2005532781A (ja) * 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
DE10324799A1 (de) * 2003-06-02 2004-12-23 Bayer Cropscience Ag Ligandenbindedomäne des Ecdyson-Rezeptors
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP4412051B2 (ja) * 2004-05-10 2010-02-10 パナソニック株式会社 電子部品装着装置および電子部品装着方法
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
EP3357904B1 (en) 2007-05-29 2022-07-06 Precigen, Inc. Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP5508625B2 (ja) 2009-12-14 2014-06-04 トヨタ自動車株式会社 車両の制御装置及び車両の制御方法
US9331524B1 (en) 2010-07-03 2016-05-03 Best Energy Reduction Technologies, Llc Method, system and apparatus for monitoring and measuring power usage
US9814215B2 (en) 2014-03-11 2017-11-14 Little Big Cat, Inc. Pet toy with telescoping wand with metallic wire

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014111634A (ja) * 2003-02-28 2014-06-19 Intrexon Corp エクジソン受容体複合体を通して外因性遺伝子の発現を調節するための生物学的利用能のあるジアシルヒドラジン・リガンド

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