JP4922535B2 - チオール含有メイタンシノイド類の製造および精製方法 - Google Patents

チオール含有メイタンシノイド類の製造および精製方法 Download PDF

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Publication number
JP4922535B2
JP4922535B2 JP2002521468A JP2002521468A JP4922535B2 JP 4922535 B2 JP4922535 B2 JP 4922535B2 JP 2002521468 A JP2002521468 A JP 2002521468A JP 2002521468 A JP2002521468 A JP 2002521468A JP 4922535 B2 JP4922535 B2 JP 4922535B2
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Prior art keywords
methyl
maytansinol
alanine
maytansinoid
thiol
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Expired - Lifetime
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JP2002521468A
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Japanese (ja)
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JP2004506738A5 (enExample
JP2004506738A (ja
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チャーリー，ラヴィ，ヴァンキープラム，ジャガンナサ
ウィディソン，ウェイン，チャールズ
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イムノージェン インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002521468A 2000-08-18 2001-04-26 チオール含有メイタンシノイド類の製造および精製方法 Expired - Lifetime JP4922535B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/641,348 2000-08-18
US09/641,348 US6333410B1 (en) 2000-08-18 2000-08-18 Process for the preparation and purification of thiol-containing maytansinoids
PCT/US2001/010816 WO2002016368A1 (en) 2000-08-18 2001-04-26 Process for the preparation and purification of thiol-containing maytansinoids

Publications (3)

Publication Number Publication Date
JP2004506738A JP2004506738A (ja) 2004-03-04
JP2004506738A5 JP2004506738A5 (enExample) 2005-03-03
JP4922535B2 true JP4922535B2 (ja) 2012-04-25

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JP2002521468A Expired - Lifetime JP4922535B2 (ja) 2000-08-18 2001-04-26 チオール含有メイタンシノイド類の製造および精製方法

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Country Link
US (2) US6333410B1 (enExample)
EP (1) EP1313738B1 (enExample)
JP (1) JP4922535B2 (enExample)
AT (1) ATE313545T1 (enExample)
AU (1) AU763107B2 (enExample)
CA (2) CA2373554C (enExample)
DE (1) DE60116113T2 (enExample)
DK (1) DK1313738T3 (enExample)
ES (1) ES2253371T3 (enExample)
WO (1) WO2002016368A1 (enExample)

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DE60116113D1 (de) 2006-01-26
WO2002016368A1 (en) 2002-02-28
USRE39151E1 (en) 2006-06-27
CA2678754C (en) 2013-08-27
CA2373554A1 (en) 2002-02-28
AU5311801A (en) 2002-03-04
ES2253371T3 (es) 2006-06-01
ATE313545T1 (de) 2006-01-15
EP1313738B1 (en) 2005-12-21
EP1313738A1 (en) 2003-05-28
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