JPS5529972A - Preparation of maytansinol - Google Patents

Preparation of maytansinol

Info

Publication number
JPS5529972A
JPS5529972A JP10354778A JP10354778A JPS5529972A JP S5529972 A JPS5529972 A JP S5529972A JP 10354778 A JP10354778 A JP 10354778A JP 10354778 A JP10354778 A JP 10354778A JP S5529972 A JPS5529972 A JP S5529972A
Authority
JP
Japan
Prior art keywords
maytansinol
maytanacine
ansamitocin
antibiotics
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10354778A
Other languages
Japanese (ja)
Inventor
Kazuo Nakahama
Mikio Izawa
Makoto Kida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP10354778A priority Critical patent/JPS5529972A/en
Publication of JPS5529972A publication Critical patent/JPS5529972A/en
Pending legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare maytansinol, by treating maytanacine, maytansinol propionate or ansamitocin antibiotics with microorganisms which belong to the genus Streptomyces.
CONSTITUTION: Maytanacine, maytansinol propionate, or ansamitocin antibiotics are brought into contact with a culture of microorganisms, e.g. Streptomyces coelicolor ATCC-13405 (IFO 3807), which belong to the genus Streptomyces, and have the ability to convert the acyloxy group at the 3-position into the hydroxy group, or its treated substance.
COPYRIGHT: (C)1980,JPO&Japio
JP10354778A 1978-08-24 1978-08-24 Preparation of maytansinol Pending JPS5529972A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10354778A JPS5529972A (en) 1978-08-24 1978-08-24 Preparation of maytansinol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10354778A JPS5529972A (en) 1978-08-24 1978-08-24 Preparation of maytansinol

Publications (1)

Publication Number Publication Date
JPS5529972A true JPS5529972A (en) 1980-03-03

Family

ID=14356843

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10354778A Pending JPS5529972A (en) 1978-08-24 1978-08-24 Preparation of maytansinol

Country Status (1)

Country Link
JP (1) JPS5529972A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5818323A (en) * 1981-07-27 1983-02-02 Sumitomo Chem Co Ltd Preparation of alcohol
USRE39151E1 (en) 2000-08-18 2006-06-27 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
WO2021107133A1 (en) 2019-11-29 2021-06-03 日本マイクロバイオファーマ株式会社 Method for enzymatically producing maytansinol

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5818323A (en) * 1981-07-27 1983-02-02 Sumitomo Chem Co Ltd Preparation of alcohol
USRE39151E1 (en) 2000-08-18 2006-06-27 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
WO2021107133A1 (en) 2019-11-29 2021-06-03 日本マイクロバイオファーマ株式会社 Method for enzymatically producing maytansinol

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