JPS54128598A - Antibiotic c-15003pdm - Google Patents

Antibiotic c-15003pdm

Info

Publication number
JPS54128598A
JPS54128598A JP3464578A JP3464578A JPS54128598A JP S54128598 A JPS54128598 A JP S54128598A JP 3464578 A JP3464578 A JP 3464578A JP 3464578 A JP3464578 A JP 3464578A JP S54128598 A JPS54128598 A JP S54128598A
Authority
JP
Japan
Prior art keywords
pdm
antibiotic
formula
15003pdm
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3464578A
Other languages
Japanese (ja)
Inventor
Mitsuko Asai
Kazuo Nakahama
Mikio Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP3464578A priority Critical patent/JPS54128598A/en
Priority to GR58533A priority patent/GR63147B/en
Priority to ES478706A priority patent/ES478706A1/en
Priority to AU45246/79A priority patent/AU519911B2/en
Priority to CA000323717A priority patent/CA1144096A/en
Priority to ZA791350A priority patent/ZA791350B/en
Priority to PT69382A priority patent/PT69382A/en
Priority to PL1979214307A priority patent/PL124051B1/en
Priority to DE7979300469T priority patent/DE2961940D1/en
Priority to EP79300469A priority patent/EP0004466B1/en
Priority to DK121279A priority patent/DK121279A/en
Priority to AT0219179A priority patent/AT362872B/en
Publication of JPS54128598A publication Critical patent/JPS54128598A/en
Priority to US06/153,522 priority patent/US4307016A/en
Priority to US06/290,943 priority patent/US4361650A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An antibiotic C-15003PDM of formula I: (R is H or ≤5C alkanoyl group). General term of PDM-0, PDM-1, PDM-2, PDM-3, and PDM-4.
USE: Antibiotics having antimicrobic and oncostatic activities.
PROCESS: An antibiotic C-15003 of formula II is brought into contact with cultured or treated substances of microorganisms, e.g. Bacillus megaterium IFO12108 (FERM-P No.12108), which belong to the genuses Bacillus, Streptomyces, or Actinomycetes, and have an ability to convert the -OCH3 group of the 20-position of the antibiotic C-15003 into a hydroxyl group, and their variation strains, to prepare the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP3464578A 1978-03-24 1978-03-24 Antibiotic c-15003pdm Pending JPS54128598A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP3464578A JPS54128598A (en) 1978-03-24 1978-03-24 Antibiotic c-15003pdm
GR58533A GR63147B (en) 1978-03-24 1979-03-07 Preparation process of demethyl maytansinoids
ES478706A ES478706A1 (en) 1978-03-24 1979-03-16 Demethyl maytansinoids and methods for producing them.
AU45246/79A AU519911B2 (en) 1978-03-24 1979-03-19 Demethyl maytansinoids
CA000323717A CA1144096A (en) 1978-03-24 1979-03-19 Demethyl maytansinoids
ZA791350A ZA791350B (en) 1978-03-24 1979-03-21 Demethyl maytansinoids
PL1979214307A PL124051B1 (en) 1978-03-24 1979-03-22 Process for preparing novel demethylmaytansynoidic compounds
PT69382A PT69382A (en) 1978-03-24 1979-03-22 Demethyl maytansinoids
DE7979300469T DE2961940D1 (en) 1978-03-24 1979-03-23 Demethyl maytansinoids and methods for producing them
EP79300469A EP0004466B1 (en) 1978-03-24 1979-03-23 Demethyl maytansinoids and methods for producing them
DK121279A DK121279A (en) 1978-03-24 1979-03-23 DEMETHYLMAYTANSINOIDS AND METHODS FOR MANUFACTURE THEREOF
AT0219179A AT362872B (en) 1978-03-24 1979-03-23 METHOD FOR PRODUCING NEW DEMETHYLMAYTANSINOIDS
US06/153,522 US4307016A (en) 1978-03-24 1980-05-27 Demethyl maytansinoids
US06/290,943 US4361650A (en) 1978-03-24 1981-08-07 Fermentation process of preparing demethyl maytansinoids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3464578A JPS54128598A (en) 1978-03-24 1978-03-24 Antibiotic c-15003pdm

Publications (1)

Publication Number Publication Date
JPS54128598A true JPS54128598A (en) 1979-10-05

Family

ID=12420166

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3464578A Pending JPS54128598A (en) 1978-03-24 1978-03-24 Antibiotic c-15003pdm

Country Status (2)

Country Link
JP (1) JPS54128598A (en)
ZA (1) ZA791350B (en)

Also Published As

Publication number Publication date
ZA791350B (en) 1980-04-30

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