JP4284071B2 - イソインドール−イミド化合物、組成物、およびそれらの使用 - Google Patents
イソインドール−イミド化合物、組成物、およびそれらの使用 Download PDFInfo
- Publication number
- JP4284071B2 JP4284071B2 JP2002559408A JP2002559408A JP4284071B2 JP 4284071 B2 JP4284071 B2 JP 4284071B2 JP 2002559408 A JP2002559408 A JP 2002559408A JP 2002559408 A JP2002559408 A JP 2002559408A JP 4284071 B2 JP4284071 B2 JP 4284071B2
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- Japan
- Prior art keywords
- alkyl
- dioxo
- mmol
- piperidyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **Cc1cccc2c1CN(C(*)(CCC(*1)=O)C1=O)C2=O Chemical compound **Cc1cccc2c1CN(C(*)(CCC(*1)=O)C1=O)C2=O 0.000 description 18
- QKDOBPDBHLFIFU-UHFFFAOYSA-N CC(c1c(C(OC)=O)c(NCc2cc(cccc3)c3[o]2)ccc1)=O Chemical compound CC(c1c(C(OC)=O)c(NCc2cc(cccc3)c3[o]2)ccc1)=O QKDOBPDBHLFIFU-UHFFFAOYSA-N 0.000 description 1
- HLPIHRDZBHXTFJ-UHFFFAOYSA-N CCc1ccc[o]1 Chemical compound CCc1ccc[o]1 HLPIHRDZBHXTFJ-UHFFFAOYSA-N 0.000 description 1
- UPFVWOHVUXLBHG-UHFFFAOYSA-N COC(c1c(C(OC)=O)c(NCc2ccc(CO)[o]2)ccc1)=O Chemical compound COC(c1c(C(OC)=O)c(NCc2ccc(CO)[o]2)ccc1)=O UPFVWOHVUXLBHG-UHFFFAOYSA-N 0.000 description 1
- SCKHHFCGUUBILP-UHFFFAOYSA-N COC(c1cccc(NCc2ccc[s]2)c1C(OC)=O)=O Chemical compound COC(c1cccc(NCc2ccc[s]2)c1C(OC)=O)=O SCKHHFCGUUBILP-UHFFFAOYSA-N 0.000 description 1
- DBFWANUUPKGPFE-UHFFFAOYSA-N COc1cccc(C(Nc(cccc2C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)=O)c1 Chemical compound COc1cccc(C(Nc(cccc2C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)=O)c1 DBFWANUUPKGPFE-UHFFFAOYSA-N 0.000 description 1
- NKROBHZPWIGLHK-UHFFFAOYSA-N Cc1c(C)[o]c(CNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)c1 Chemical compound Cc1c(C)[o]c(CNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)c1 NKROBHZPWIGLHK-UHFFFAOYSA-N 0.000 description 1
- VQKFNUFAXTZWDK-UHFFFAOYSA-N Cc1ccc[o]1 Chemical compound Cc1ccc[o]1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 description 1
- XQQBUAPQHNYYRS-UHFFFAOYSA-N Cc1ccc[s]1 Chemical compound Cc1ccc[s]1 XQQBUAPQHNYYRS-UHFFFAOYSA-N 0.000 description 1
- LWMOTIQKAURFAC-UHFFFAOYSA-N N#Cc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O Chemical compound N#Cc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O LWMOTIQKAURFAC-UHFFFAOYSA-N 0.000 description 1
- UTVVREMVDJTZAC-UHFFFAOYSA-N Nc1ccc[o]1 Chemical compound Nc1ccc[o]1 UTVVREMVDJTZAC-UHFFFAOYSA-N 0.000 description 1
- ZNSIEKYJZZEJNA-UHFFFAOYSA-N O=C(C1CC1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(C1CC1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O ZNSIEKYJZZEJNA-UHFFFAOYSA-N 0.000 description 1
- GYBAWNXMPZVXFQ-UHFFFAOYSA-N O=C(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)NC1CCCCC1 Chemical compound O=C(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)NC1CCCCC1 GYBAWNXMPZVXFQ-UHFFFAOYSA-N 0.000 description 1
- VWZVRHSJOPXCKC-UHFFFAOYSA-N O=C(c1c(C2)c(NCc3ccccc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(NCc3ccccc3)ccc1)N2C(CCC(N1)=O)C1=O VWZVRHSJOPXCKC-UHFFFAOYSA-N 0.000 description 1
- ZGYJSLXLVBIKGT-UHFFFAOYSA-N O=C(c1ccc[s]1)Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(c1ccc[s]1)Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O ZGYJSLXLVBIKGT-UHFFFAOYSA-N 0.000 description 1
- XINHPRLSYHOFAX-UHFFFAOYSA-N O=C(c1cccc(F)c1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(c1cccc(F)c1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O XINHPRLSYHOFAX-UHFFFAOYSA-N 0.000 description 1
- AKRSPVWONKMEHP-UHFFFAOYSA-N OC(c1c(C(O)=O)c(NCCOCc2ccccc2)ccc1)=O Chemical compound OC(c1c(C(O)=O)c(NCCOCc2ccccc2)ccc1)=O AKRSPVWONKMEHP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25837200P | 2000-12-27 | 2000-12-27 | |
US09/972,487 US20030045552A1 (en) | 2000-12-27 | 2001-10-05 | Isoindole-imide compounds, compositions, and uses thereof |
PCT/US2001/050401 WO2002059106A1 (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions, and uses thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005321049A Division JP4648822B2 (ja) | 2000-12-27 | 2005-11-04 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004525889A JP2004525889A (ja) | 2004-08-26 |
JP2004525889A5 JP2004525889A5 (US20030045552A1-20030306-C00110.png) | 2006-01-05 |
JP4284071B2 true JP4284071B2 (ja) | 2009-06-24 |
Family
ID=26946597
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002559408A Expired - Fee Related JP4284071B2 (ja) | 2000-12-27 | 2001-12-21 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
JP2005321049A Expired - Fee Related JP4648822B2 (ja) | 2000-12-27 | 2005-11-04 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
JP2010110388A Pending JP2010195824A (ja) | 2000-12-27 | 2010-05-12 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005321049A Expired - Fee Related JP4648822B2 (ja) | 2000-12-27 | 2005-11-04 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
JP2010110388A Pending JP2010195824A (ja) | 2000-12-27 | 2010-05-12 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
Country Status (20)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006089495A (ja) * | 2000-12-27 | 2006-04-06 | Celgene Corp | イソインドール−イミド化合物、組成物、およびそれらの使用 |
Families Citing this family (220)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228879B1 (en) * | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
DE60130799T2 (de) * | 2000-11-30 | 2008-07-17 | Children's Medical Center Corp., Boston | Synthese von 4-aminothalidomid enantiomeren |
DE10137163A1 (de) * | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
DE60231989D1 (de) * | 2001-08-06 | 2009-05-28 | Childrens Medical Center | Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga |
EP1475632B1 (en) * | 2002-02-14 | 2013-05-22 | Ajinomoto Co., Inc. | Method of analyzing aminofunctional compound and analytical reagent |
CA2481387A1 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
NZ549175A (en) | 2002-05-17 | 2007-12-21 | Celgene Corp | Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases |
US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
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Cited By (3)
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JP2006089495A (ja) * | 2000-12-27 | 2006-04-06 | Celgene Corp | イソインドール−イミド化合物、組成物、およびそれらの使用 |
JP2010195824A (ja) * | 2000-12-27 | 2010-09-09 | Celgene Corp | イソインドール−イミド化合物、組成物、およびそれらの使用 |
JP4648822B2 (ja) * | 2000-12-27 | 2011-03-09 | セルジーン コーポレイション | イソインドール−イミド化合物、組成物、およびそれらの使用 |
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