JP4090514B2 - エポチロン誘導体 - Google Patents

エポチロン誘導体 Download PDF

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Publication number
JP4090514B2
JP4090514B2 JP50867399A JP50867399A JP4090514B2 JP 4090514 B2 JP4090514 B2 JP 4090514B2 JP 50867399 A JP50867399 A JP 50867399A JP 50867399 A JP50867399 A JP 50867399A JP 4090514 B2 JP4090514 B2 JP 4090514B2
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methyl
compound
formula
alkyl
group
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Expired - Fee Related
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JP50867399A
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Japanese (ja)
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JP2002512634A5 (enExample
JP2002512634A (ja
Inventor
バイト，グレゴリー・ディ
ボルジレリ，ロバート・エム
キム，スーン−フーン
ジョンソン，ジェイムズ・エイ
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ブリストル−マイヤーズ・スクイブ・カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP50867399A 1997-07-08 1998-06-16 エポチロン誘導体 Expired - Fee Related JP4090514B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5195197P 1997-07-08 1997-07-08
US60/051,951 1997-07-08
US6752497P 1997-12-04 1997-12-04
US60/067,524 1997-12-04
PCT/US1998/012550 WO1999002514A2 (en) 1997-07-08 1998-06-16 Epothilone derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007156260A Division JP4885067B2 (ja) 1997-07-08 2007-06-13 エポチロン誘導体

Publications (3)

Publication Number Publication Date
JP2002512634A JP2002512634A (ja) 2002-04-23
JP2002512634A5 JP2002512634A5 (enExample) 2007-12-06
JP4090514B2 true JP4090514B2 (ja) 2008-05-28

Family

ID=26729990

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50867399A Expired - Fee Related JP4090514B2 (ja) 1997-07-08 1998-06-16 エポチロン誘導体
JP2007156260A Expired - Fee Related JP4885067B2 (ja) 1997-07-08 2007-06-13 エポチロン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007156260A Expired - Fee Related JP4885067B2 (ja) 1997-07-08 2007-06-13 エポチロン誘導体

Country Status (32)

Country Link
US (10) US6605599B1 (enExample)
EP (4) EP1019389B1 (enExample)
JP (2) JP4090514B2 (enExample)
KR (1) KR100569041B1 (enExample)
CN (1) CN100384834C (enExample)
AR (1) AR013358A1 (enExample)
AT (2) ATE309236T1 (enExample)
AU (1) AU731497B2 (enExample)
BG (1) BG64952B1 (enExample)
BR (1) BRPI9810555A8 (enExample)
CA (1) CA2296012C (enExample)
CO (1) CO4940501A1 (enExample)
CZ (1) CZ297904B6 (enExample)
DE (2) DE69832294T2 (enExample)
DK (1) DK1019389T3 (enExample)
EE (1) EE04566B1 (enExample)
EG (1) EG24464A (enExample)
ES (2) ES2251088T3 (enExample)
GE (1) GEP20032897B (enExample)
HU (1) HU227444B1 (enExample)
ID (1) ID23771A (enExample)
IL (1) IL133613A (enExample)
LV (1) LV12569B (enExample)
MY (1) MY124151A (enExample)
NO (1) NO322494B1 (enExample)
NZ (1) NZ501198A (enExample)
PE (1) PE104599A1 (enExample)
PL (1) PL197404B1 (enExample)
RO (1) RO120340B1 (enExample)
TR (1) TR200000065T2 (enExample)
TW (1) TW562802B (enExample)
WO (1) WO1999002514A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007291121A (ja) * 1997-07-08 2007-11-08 Bristol Myers Squibb Co エポチロン誘導体

Families Citing this family (168)

* Cited by examiner, † Cited by third party
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JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
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USRE41893E1 (en) 2010-10-26
HK1031731A1 (zh) 2001-06-22
ES2251088T3 (es) 2006-04-16
EG24464A (en) 2009-07-16
HU227444B1 (en) 2011-06-28
CZ297904B6 (cs) 2007-04-25
EE200000013A (et) 2000-08-15
DE69832294T2 (de) 2006-05-24
AU731497B2 (en) 2001-03-29
NO322494B1 (no) 2006-10-16
US6605599B1 (en) 2003-08-12
AR013358A1 (es) 2000-12-27
MY124151A (en) 2006-06-30
CN1270589A (zh) 2000-10-18
TW562802B (en) 2003-11-21
ID23771A (id) 2000-05-11
KR20010021562A (ko) 2001-03-15
USRE41911E1 (en) 2010-11-02
CN100384834C (zh) 2008-04-30
AU7972098A (en) 1999-02-08
LV12569B (en) 2001-04-20
US8921542B2 (en) 2014-12-30
EP1531153A1 (en) 2005-05-18
NO20000076D0 (no) 2000-01-07
ES2322807T3 (es) 2009-06-29
DK1019389T3 (da) 2006-01-16
US8536327B2 (en) 2013-09-17
CA2296012A1 (en) 1999-01-21
US20060287371A1 (en) 2006-12-21
ATE426598T1 (de) 2009-04-15
USRE43003E1 (en) 2011-12-06
TR200000065T2 (tr) 2000-11-21
PL197404B1 (pl) 2008-03-31
EP1493738A1 (en) 2005-01-05
US20150080440A1 (en) 2015-03-19
JP2007291121A (ja) 2007-11-08
IL133613A (en) 2005-11-20
CZ200058A3 (cs) 2001-01-17

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