ATE426598T1 - Epothilonderivate - Google Patents
EpothilonderivateInfo
- Publication number
- ATE426598T1 ATE426598T1 AT04021059T AT04021059T ATE426598T1 AT E426598 T1 ATE426598 T1 AT E426598T1 AT 04021059 T AT04021059 T AT 04021059T AT 04021059 T AT04021059 T AT 04021059T AT E426598 T1 ATE426598 T1 AT E426598T1
- Authority
- AT
- Austria
- Prior art keywords
- epothilone derivatives
- epothilone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5195197P | 1997-07-08 | 1997-07-08 | |
US6752497P | 1997-12-04 | 1997-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE426598T1 true ATE426598T1 (de) | 2009-04-15 |
Family
ID=26729990
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04021059T ATE426598T1 (de) | 1997-07-08 | 1998-06-16 | Epothilonderivate |
AT98930300T ATE309236T1 (de) | 1997-07-08 | 1998-06-16 | Epothilonderivate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98930300T ATE309236T1 (de) | 1997-07-08 | 1998-06-16 | Epothilonderivate |
Country Status (33)
Country | Link |
---|---|
US (10) | US6605599B1 (de) |
EP (4) | EP1526133A1 (de) |
JP (2) | JP4090514B2 (de) |
KR (1) | KR100569041B1 (de) |
CN (1) | CN100384834C (de) |
AR (1) | AR013358A1 (de) |
AT (2) | ATE426598T1 (de) |
AU (1) | AU731497B2 (de) |
BG (1) | BG64952B1 (de) |
BR (1) | BRPI9810555A8 (de) |
CA (1) | CA2296012C (de) |
CO (1) | CO4940501A1 (de) |
CZ (1) | CZ297904B6 (de) |
DE (2) | DE69840693D1 (de) |
DK (1) | DK1019389T3 (de) |
EE (1) | EE04566B1 (de) |
EG (1) | EG24464A (de) |
ES (2) | ES2251088T3 (de) |
GE (1) | GEP20032897B (de) |
HK (2) | HK1026905A1 (de) |
HU (1) | HU227444B1 (de) |
ID (1) | ID23771A (de) |
IL (1) | IL133613A (de) |
LV (1) | LV12569B (de) |
MY (1) | MY124151A (de) |
NO (1) | NO322494B1 (de) |
NZ (1) | NZ501198A (de) |
PE (1) | PE104599A1 (de) |
PL (1) | PL197404B1 (de) |
RO (1) | RO120340B1 (de) |
TR (1) | TR200000065T2 (de) |
TW (1) | TW562802B (de) |
WO (1) | WO1999002514A2 (de) |
Families Citing this family (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
HU229833B1 (en) | 1996-11-18 | 2014-09-29 | Biotechnolog Forschung Gmbh | Epothilone d production process, and its use as cytostatic as well as phytosanitary agents |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP1386922B1 (de) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthese von Epitholonen, Zwischenprodukte, Analoga und ihre Verwendung |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
EP1005465B1 (de) | 1997-08-09 | 2007-07-25 | Bayer Schering Pharma Aktiengesellschaft | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
US6365749B1 (en) * | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
US6302838B1 (en) | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
US6380395B1 (en) * | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
KR100716272B1 (ko) | 1998-11-20 | 2007-05-09 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
WO2000037473A1 (en) * | 1998-12-22 | 2000-06-29 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
IL144370A0 (en) * | 1999-02-11 | 2002-05-23 | Schering Ag | Epothilon derivatives, method for the production and the use thereof as pharmaceuticals |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
MXPA01010292A (es) | 1999-04-15 | 2002-10-23 | Squibb Bristol Myers Co | Inhibidores ciclicos de la proteina tirosina cinasa. |
US7125893B1 (en) | 1999-04-30 | 2006-10-24 | Schering Ag | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations |
EP2289549A3 (de) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
US6518421B1 (en) | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
DE10020899A1 (de) * | 2000-04-20 | 2001-10-25 | Schering Ag | 9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten |
US6489314B1 (en) | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
AU2001266583A1 (en) * | 2000-05-26 | 2001-12-11 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
UA75365C2 (en) | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
JP2005500974A (ja) | 2000-10-13 | 2005-01-13 | ザ ユニバーシテイ オブ ミシシッピー | エポシロン類及び関連類似体の合成 |
NZ526871A (en) * | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
PL207720B1 (pl) * | 2001-01-25 | 2011-01-31 | Bristol Myers Squibb Co | Sposób przygotowania preparatu farmaceutycznego i jego zastosowanie, farmaceutyczny produkt oraz sposób wytwarzania kompozycji farmaceutycznej |
SK288098B6 (sk) | 2001-01-25 | 2013-07-02 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
HUP0302567A2 (hu) * | 2001-01-25 | 2003-12-29 | Bristol-Myers Squibb Co. | Epotilon analógokat tartalmazó parenterális adagolási formák és eljárás az előállításukra |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
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DE60213884T2 (de) | 2001-02-27 | 2007-02-22 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Verfahren zur Herstellung von Epothilonen |
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CA2471509A1 (en) | 2002-01-14 | 2003-07-17 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
EP1340498A1 (de) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Verwendung von Epothilonen zur Behandlung von mit proliferativen Prozessen assoziierten Gehirnerkrankungen |
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US7211593B2 (en) * | 2002-03-12 | 2007-05-01 | Bristol-Myers Squibb Co. | C12-cyano epothilone derivatives |
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US7008936B2 (en) | 2002-06-14 | 2006-03-07 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
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CN101600728A (zh) | 2006-12-04 | 2009-12-09 | 伊利诺斯大学理事会 | 使用铜氧还蛋白和富含CpG的DNA治疗癌症的组合物和方法 |
BRPI0806451A2 (pt) | 2007-02-08 | 2014-07-15 | Univ Illinois | Composições e métodos para a prevenção do câncer com cupredoxinas |
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- 1998-06-16 AT AT98930300T patent/ATE309236T1/de active
- 1998-06-16 JP JP50867399A patent/JP4090514B2/ja not_active Expired - Fee Related
- 1998-06-16 DE DE69832294T patent/DE69832294T2/de not_active Expired - Lifetime
- 1998-06-16 ES ES04021059T patent/ES2322807T3/es not_active Expired - Lifetime
- 1998-06-16 KR KR1020007000120A patent/KR100569041B1/ko active IP Right Grant
- 1998-06-16 CZ CZ20000058A patent/CZ297904B6/cs not_active IP Right Cessation
- 1998-06-16 WO PCT/US1998/012550 patent/WO1999002514A2/en active IP Right Grant
- 1998-06-16 AU AU79720/98A patent/AU731497B2/en not_active Ceased
- 1998-06-16 CA CA002296012A patent/CA2296012C/en not_active Expired - Lifetime
- 1998-07-02 TW TW087110722A patent/TW562802B/zh not_active IP Right Cessation
- 1998-07-07 PE PE1998000604A patent/PE104599A1/es not_active Application Discontinuation
- 1998-07-07 CO CO98038387A patent/CO4940501A1/es unknown
- 1998-07-07 EG EG79298A patent/EG24464A/xx active
- 1998-07-08 MY MYPI98003121A patent/MY124151A/en unknown
- 1998-07-08 AR ARP980103322A patent/AR013358A1/es active IP Right Grant
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2000
- 2000-01-07 NO NO20000076A patent/NO322494B1/no not_active IP Right Cessation
- 2000-01-10 BG BG104068A patent/BG64952B1/bg unknown
- 2000-02-02 LV LVP-00-17A patent/LV12569B/en unknown
- 2000-09-26 HK HK00106086A patent/HK1026905A1/xx not_active IP Right Cessation
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2001
- 2001-04-02 HK HK01102362.5A patent/HK1031731A1/xx not_active IP Right Cessation
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2003
- 2003-04-03 US US10/405,886 patent/US7125899B2/en not_active Expired - Lifetime
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2006
- 2006-08-30 US US11/512,623 patent/US7241755B2/en not_active Expired - Lifetime
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2007
- 2007-06-13 JP JP2007156260A patent/JP4885067B2/ja not_active Expired - Fee Related
- 2007-06-15 US US11/763,636 patent/US8536327B2/en not_active Expired - Fee Related
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2009
- 2009-08-11 US US12/539,498 patent/USRE41893E1/en not_active Expired - Lifetime
- 2009-08-11 US US12/539,496 patent/USRE41895E1/en not_active Expired - Lifetime
- 2009-08-11 US US12/539,492 patent/USRE41911E1/en not_active Expired - Lifetime
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2010
- 2010-09-15 US US12/882,769 patent/USRE43003E1/en not_active Expired - Fee Related
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2013
- 2013-08-14 US US13/966,613 patent/US8921542B2/en not_active Expired - Fee Related
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2014
- 2014-11-25 US US14/553,081 patent/US20150080440A1/en not_active Abandoned
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