JP3963020B2 - 血管内ステントを製造する方法、及びこの方法で製造されたステント - Google Patents
血管内ステントを製造する方法、及びこの方法で製造されたステント Download PDFInfo
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- JP3963020B2 JP3963020B2 JP2005034233A JP2005034233A JP3963020B2 JP 3963020 B2 JP3963020 B2 JP 3963020B2 JP 2005034233 A JP2005034233 A JP 2005034233A JP 2005034233 A JP2005034233 A JP 2005034233A JP 3963020 B2 JP3963020 B2 JP 3963020B2
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- stent
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- therapeutic substance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
Description
Gianturco に発行された米国特許明細書第4,800,882 号、及び、Wiktorに発行された米国特許明細書第4,886,062 号に開示されたもののような金属製のステントが、ステントの外表面に適用された物質と治療されるための血管の組織との間で、親密な接触を維持する能力があるので、ドラッグデリバリーのためにふさわしいということができる。
−lactic acid)) 、ポリカプロラクトン(polycaprolactone)、ポリ(ラクチド−コ−グリコライド)(poly(lactide−co−glycolide))、ポリ(ハイドロキシブチラート)(poly(hydroxybutyrate)) 、ポリ(ハイドロキシブチラート−コ−バリレート)(poly(hydroxybutyrate−co−valerate)) 、ポリジオキサノン(polydioxanone) 、ポリオルソエステル(polyorthoester)、ポリアンハイドライド(polyanhydride) 、ポリ(グリコーリックアシッド)(poly(glycolic acid)) 、ポリ(D,L−ラクティックアシッド)(poly(D, L−lactic acid))、ポリ(グリコーリックアシッド−コ−トリメチレンカーボネート)(poly(glycolicacid−co−trimethylene carbonate))、ポリフォスフォエステル(polyphosphoester)、ポリフォスフォエステルウレタン(polyphosphoester urethne) 、ポリ(アミノアシッド)(poly(amino acids)) 、シアノアクリレート(cyanoacrylates)、ポリ(トリメチレンカーボネート)(poly(trimethylene carbonate))、ポリ(イミノカーボネート)(poly(iminocarbonate))、コポリ(エーテル−エステル)(copoly(ether−esters))( 例えばPEO/PLA)、ポリアルキレンオギザレート(polyalkylene oxalates) 、ポリフォスファゼン(polyphosphazenes)、及び、フィブリン(fibrin)、フィブリノーゲン(fibrinogen)、セルロース(cellulose) 、スターチ(starch)、コラーゲン(collagen)及びヒアルロニックアシッド(hyaluronicacid)等の生体分子を含む。
Claims (9)
- 以下に挙げるステップを含んでいることを特徴とする、再狭窄防止のための血管内ステントを製造する方法:
(a)円筒形で、径方向に拡張可能なステント本体を与える;
(b)溶媒と、該溶媒に溶解されたポリマーと、該溶媒に分散された治療物質と、を含む溶液を上記ステント本体にスプレーにより噴霧する;
(c)上記溶媒を蒸発させる;
(d)上記ステップ(b)、(c)を繰り返し適用して複数の層を形成する;
(e)上記複数の層は、該層中の上記ポリマーに対する上記薬剤の割合を変えて上記治療物質の放出率を可変制御するために、上記複数の層のうちで外側の層における上記治療物質の上記ポリマーに対する割合を高くし、より高く早い投与量を与える。 - 上記ステント本体が金属表面を有している請求項1に記載の方法。
- 上記ステント本体が高分子表面を有している請求項1に記載の方法。
- 上記ポリマーが生体吸収性のポリマーである請求項1に記載の方法。
- 上記ポリマーが、ポリ(L−ラクティックアシッド)、ポリ(ラクタイド−コ−グリコライド)及びポリ(ハイドロキシブチレート−コ−バリレート)よりなる群から選択されたものである請求項1に記載の方法。
- 上記ポリマーが生体安定性のポリマーである請求項1に記載の方法。
- 上記ポリマーが、シリコン、ポリウレタン、ポリエステル、ビニルホモポリマー及びコポリマー、アクリレートホモポリマー及びコポリマー、ポリエーテル及びセルロース誘導体よりなる群から選択されたものである請求項6に記載の方法。
- 上記治療物質が、グルココルチコイド、デキサメサゾン、デキサメサゾンソジウムフォスフェート、抗凝固剤、ヘパリン、ヒルジン、ダニ抗凝固性たんぱく質、アンジオペプチン、抗有糸分裂剤及びオリゴヌクレオチドよりなる群から選択されたものである請求項1に記載の方法。
- 請求項1ないし8のいずれかに記載の方法で製造されたステント。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/052,878 US5464650A (en) | 1993-04-26 | 1993-04-26 | Intravascular stent and method |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10920694A Division JP3673973B2 (ja) | 1993-04-26 | 1994-04-26 | 血管内ステントを製造する方法、及びこの方法で製造されたステント |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005199079A JP2005199079A (ja) | 2005-07-28 |
JP3963020B2 true JP3963020B2 (ja) | 2007-08-22 |
Family
ID=21980501
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10920694A Expired - Lifetime JP3673973B2 (ja) | 1993-04-26 | 1994-04-26 | 血管内ステントを製造する方法、及びこの方法で製造されたステント |
JP2005034233A Expired - Lifetime JP3963020B2 (ja) | 1993-04-26 | 2005-02-10 | 血管内ステントを製造する方法、及びこの方法で製造されたステント |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10920694A Expired - Lifetime JP3673973B2 (ja) | 1993-04-26 | 1994-04-26 | 血管内ステントを製造する方法、及びこの方法で製造されたステント |
Country Status (4)
Country | Link |
---|---|
US (5) | US5464650A (ja) |
EP (2) | EP1181943A1 (ja) |
JP (2) | JP3673973B2 (ja) |
DE (2) | DE69431457T3 (ja) |
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1993
- 1993-04-26 US US08/052,878 patent/US5464650A/en not_active Expired - Lifetime
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1994
- 1994-04-20 EP EP01126059A patent/EP1181943A1/en not_active Withdrawn
- 1994-04-20 DE DE69431457T patent/DE69431457T3/de not_active Expired - Lifetime
- 1994-04-20 DE DE9422438U patent/DE9422438U1/de not_active Expired - Lifetime
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- 1994-04-26 JP JP10920694A patent/JP3673973B2/ja not_active Expired - Lifetime
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DE69431457T2 (de) | 2003-06-26 |
EP0623354B1 (en) | 2002-10-02 |
JP3673973B2 (ja) | 2005-07-20 |
DE9422438U1 (de) | 2002-04-25 |
US5837008A (en) | 1998-11-17 |
JP2005199079A (ja) | 2005-07-28 |
US5679400A (en) | 1997-10-21 |
JPH0833718A (ja) | 1996-02-06 |
US5464650A (en) | 1995-11-07 |
DE69431457D1 (de) | 2002-11-07 |
EP0623354B2 (en) | 2010-12-01 |
US5624411A (en) | 1997-04-29 |
US5776184A (en) | 1998-07-07 |
EP0623354A1 (en) | 1994-11-09 |
DE69431457T3 (de) | 2011-09-01 |
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