JP4493655B2 - 薬物ポリマコーティングをステントに施す方法 - Google Patents
薬物ポリマコーティングをステントに施す方法 Download PDFInfo
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- JP4493655B2 JP4493655B2 JP2006518945A JP2006518945A JP4493655B2 JP 4493655 B2 JP4493655 B2 JP 4493655B2 JP 2006518945 A JP2006518945 A JP 2006518945A JP 2006518945 A JP2006518945 A JP 2006518945A JP 4493655 B2 JP4493655 B2 JP 4493655B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Description
本発明の様々な実施形態は、添付の図によって解説される。
送出カテーテルは、ブロック640に示すように、コーティングステントに連結することができる。送出カテーテルには、コーティングステントとカテーテルの間に位置決めされて体内にコーティングステントを配備するのに用いられる膨張可能なバルーンを含むことができる。代替的に、送出カテーテルには、自己拡張型のコーティングステントを配備するために引込む鞘を含むことができる。
本明細書に開示した本発明の実施形態は、現時点で好ましいと考えられるものであるが、本発明の精神及び範囲から逸脱することなく様々な変更及び修正を行うことができる。本発明の範囲は、特許請求の範囲に示されており、均等物の意味及び範囲に該当する全ての変更は、本発明に含まれるものとする。
Claims (15)
- 薬物ポリマコーティングをステントに施す方法であって、
ステントフレームワークを第1のポリマと、第1の治療薬剤と、第1の溶媒とを含む第1のポリマ溶液に浸漬するステップと、
前記第1のポリマ溶液を乾燥させて、前記ステントフレームワークに薄い薬物ポリマ層を形成するステップと、
前記薄い薬物ポリマ層を含むステントフレームワークを、第2のポリマ溶液に浸漬するステップとを備え、前記第2のポリマ溶液は第2のポリマと第2の溶媒とを含み、前記薄い薬物ポリマ層が前記第2のポリマ溶液内で不溶性であり、前記方法はさらに、
前記第2のポリマ溶液を乾燥させて、前記第1の薄い薬物ポリマ層上に薄い障壁層を形成するステップと、
前記ステントフレームワークを前記第1のポリマ溶液に浸漬するステップと、該第1のポリマ溶液を乾燥させるステップと、該ステントフレームワークを前記第2のポリマ溶液に浸漬するステップと、該第2のポリマ溶液を乾燥させるステップとを、ターゲット薬物ポリマコーティング厚さが該ステントフレームワーク上に配置されるまで繰り返すステップと、
を含むことを特徴とする方法。 - 前記第1のポリマは、ポリ(エチレン−ビニルアセテート)を含む、
請求項1に記載の方法。 - 前記第1のポリマ溶液が、前記第1のポリマを固形物換算で0.05ないし1.0重量パーセント含有する、
請求項1に記載の方法。 - 前記第1の治療薬剤は、カンプトテシンを含む、
請求項1に記載の方法。 - 前記第1の治療薬剤は、ラパマイシン、ラパマイシン誘導体、又はラパマイシン類似物のうちの1つを含む、
請求項1に記載の方法。 - 前記第1の溶媒は、クロロホルム及びメタノールの混合物を含む、
請求項1に記載の方法。 - 前記第1の溶媒は、濃度が80ないし90パーセントのクロロホルムを含む、
請求項6に記載の方法。 - 前記第2のポリマは、ポリウレタン、ポリカプロラクトン、又はポリウレタンとポリカプロラクトンの配合ポリマのうちの1つを含む、
請求項1に記載の方法。 - 前記第2の溶媒は、テトラヒドロフランを含む、
請求項1に記載の方法。 - 前記第2のポリマ溶液は、第2の治療薬剤を含む、
請求項1に記載の方法。 - 前記第2の治療薬剤は、カンプトテシンを含む、
請求項10に記載の方法。 - 前記薄い障壁層は、前記第1のポリマ溶液に不溶性である、
請求項1に記載の方法。 - 前記第1のポリマ溶液を乾燥させるステップは、前記ステントフレームワークを前記第1のポリマ溶液に浸漬した後に該浸漬したステントフレームワークを空気中に配置し、前記第1の溶媒を蒸発させるステップを含む、
請求項1に記載の方法。 - 前記第2のポリマ溶液を乾燥させるステップは、前記ステントフレームワークを前記第2のポリマ溶液に浸漬した後に該浸漬したステントフレームワークを空気中に配置し、前記第2の溶媒を蒸発させるステップを含む、
請求項1に記載の方法。 - 前記薄い薬物ポリマ層中の前記第1の治療薬剤の濃度を調節して、所定の薬物放出プロフィールを形成するステップを更に含む、
請求項1に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48576603P | 2003-07-09 | 2003-07-09 | |
PCT/US2004/022139 WO2005016187A1 (en) | 2003-07-09 | 2004-07-08 | Laminated drug-polymer coated stent and method therof |
Publications (2)
Publication Number | Publication Date |
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JP2007528753A JP2007528753A (ja) | 2007-10-18 |
JP4493655B2 true JP4493655B2 (ja) | 2010-06-30 |
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Application Number | Title | Priority Date | Filing Date |
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JP2006518945A Expired - Fee Related JP4493655B2 (ja) | 2003-07-09 | 2004-07-08 | 薬物ポリマコーティングをステントに施す方法 |
Country Status (5)
Country | Link |
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US (2) | US7318945B2 (ja) |
EP (1) | EP1651140B1 (ja) |
JP (1) | JP4493655B2 (ja) |
AT (1) | ATE531339T1 (ja) |
WO (1) | WO2005016187A1 (ja) |
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JP3476604B2 (ja) * | 1995-08-22 | 2003-12-10 | 鐘淵化学工業株式会社 | 薬剤を付着・コーティングしたステントの製造方法 |
US5980972A (en) * | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
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CA2337534C (en) * | 1998-07-21 | 2008-05-06 | Biocompatibles Limited | Coating |
US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6251136B1 (en) * | 1999-12-08 | 2001-06-26 | Advanced Cardiovascular Systems, Inc. | Method of layering a three-coated stent using pharmacological and polymeric agents |
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WO2002026271A1 (en) * | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices and sterilization thereof |
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ES2329973T3 (es) * | 2000-11-30 | 2009-12-03 | Kabushiki Kaisha Kyoto Iryo Sekkei | Stent para vaso sanguineo y material para stent para vaso sanguineo. |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
AU2002252372A1 (en) | 2001-03-16 | 2002-10-03 | Sts Biopolymers, Inc. | Stent with medicated multi-layer hydrid polymer coating |
US6517889B1 (en) * | 2001-11-26 | 2003-02-11 | Swaminathan Jayaraman | Process for coating a surface of a stent |
CN1612804A (zh) | 2001-12-03 | 2005-05-04 | C·R·巴德公司 | 抗微生物医用器材、抗微生物聚合物涂层及其制备方法 |
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US7318945B2 (en) | 2008-01-15 |
JP2007528753A (ja) | 2007-10-18 |
EP1651140B1 (en) | 2011-11-02 |
US20050010282A1 (en) | 2005-01-13 |
US7955640B2 (en) | 2011-06-07 |
EP1651140A1 (en) | 2006-05-03 |
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