CN105833358B - 一种颅内药物洗脱支架系统及其制备方法 - Google Patents
一种颅内药物洗脱支架系统及其制备方法 Download PDFInfo
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- CN105833358B CN105833358B CN201610283341.3A CN201610283341A CN105833358B CN 105833358 B CN105833358 B CN 105833358B CN 201610283341 A CN201610283341 A CN 201610283341A CN 105833358 B CN105833358 B CN 105833358B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
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- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
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- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
PLGA含量 | 雷帕霉素含量 | 氯仿 |
5克 | 0.5克 | 600ml |
时间(小时) | 0 | 1 | 6 | 24 | 72 |
全身血药浓度 | 0.10±0.33 | 10.46±2.43 | 4.26±0.22 | 1.88±0.78 | 2.36±0.57 |
时间(天) | 1 | 3 | 8 | 14 | 28 |
药物浓度 | 0.4±0.1 | 0.2±0.0 | 5.9 | 7.6±0.5 | 0.4±0.2 |
时间(天) | 1 | 3 | 8 | 14 | 28 |
支架残留药物 | 0.074±0.023 | 0.073±0.005 | 0.046 | 0.050±0.012 | 0.012±0.017 |
Claims (4)
Priority Applications (1)
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CN201610283341.3A CN105833358B (zh) | 2016-04-28 | 2016-04-28 | 一种颅内药物洗脱支架系统及其制备方法 |
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CN201610283341.3A CN105833358B (zh) | 2016-04-28 | 2016-04-28 | 一种颅内药物洗脱支架系统及其制备方法 |
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CN105833358A CN105833358A (zh) | 2016-08-10 |
CN105833358B true CN105833358B (zh) | 2020-12-04 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL265511B (en) * | 2016-12-22 | 2022-07-01 | Sino Medical Sciences Tech Inc | A stent containing a drug for elution and a method for using it to enable restoration of endothelial cell layer function |
CN112741720A (zh) * | 2021-01-21 | 2021-05-04 | 北京久事神康医疗科技有限公司 | 一种可回收颅内药物洗脱支架系统 |
CN113101024A (zh) * | 2021-04-08 | 2021-07-13 | 哈尔滨医科大学 | 肺动脉药物洗脱支架和支架套件 |
CN115671407B (zh) * | 2022-10-25 | 2024-01-30 | 赛诺神畅医疗科技有限公司 | 一种自膨式药物洗脱支架系统及其制备方法 |
CN115487410A (zh) * | 2022-11-18 | 2022-12-20 | 山东瑞安泰医疗技术有限公司 | 一种预防增生和血栓药物洗脱支架的制备方法 |
CN116712620B (zh) * | 2023-04-27 | 2023-12-12 | 雅伦生物科技(北京)有限公司 | 药物涂层、含有其的药物洗脱支架及其制备方法 |
CN116832228B (zh) * | 2023-07-10 | 2024-05-03 | 上海心玮医疗科技股份有限公司 | 一种药物洗脱支架涂层及其制备方法和药物洗脱支架 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
CN101264351B (zh) * | 2008-04-07 | 2011-08-24 | 易生科技(北京)有限公司 | 复合涂层心血管药物洗脱支架及其制备方法 |
CN102091355A (zh) * | 2011-01-11 | 2011-06-15 | 南京大学 | 一种复合涂层冠脉药物洗脱支架及其制备方法 |
CN103536971A (zh) * | 2012-07-12 | 2014-01-29 | 赛诺医疗科学技术有限公司 | 药物可控释放的药物洗脱医疗器械及其制备方法 |
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Address after: 300457 the 2 layer of B area, TEDA biological medicine research and development building 5, Fourth Avenue, Tianjin development zone. Applicant after: Sano medical science and technology Limited by Share Ltd Address before: 300457 Tianjin Binhai New Area Development Zone Fourth Avenue 5, TEDA Biomedical Research and development building B 2 floor. Applicant before: Sainuo Medical Sicience and Technology Co,. Ltd. |
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Inventor after: Jiu Zhongrong Inventor after: Sun Jianhua Inventor after: Kang Xiaoran Inventor after: Cao Yishun Inventor after: Li Tianzhu Inventor after: Wu Xiangfen Inventor before: Sun Jianhua Inventor before: Kang Xiaoran Inventor before: Cao Yishun Inventor before: Li Tianzhu Inventor before: Wu Xiangfen |
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Effective date of registration: 20210402 Address after: Room 501, Shilu Jinling Plaza, 88 Nanxijiang Road, Yuexi, Wuzhong District, Suzhou City, Jiangsu Province, 215104 Patentee after: Sano Shenchang Medical Technology Co.,Ltd. Address before: 300457 TEDA TEDA biological medicine research and development building No. 2, No. fourth, 5 Avenue, Tianjin Development Zone, B Patentee before: SINO MEDICAL SCIENCES TECHNOLOGY Inc. |
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