JP3800220B2 - 酢酸アニリド誘導体のα型又はβ型結晶 - Google Patents

酢酸アニリド誘導体のα型又はβ型結晶 Download PDF

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Publication number
JP3800220B2
JP3800220B2 JP2003540162A JP2003540162A JP3800220B2 JP 3800220 B2 JP3800220 B2 JP 3800220B2 JP 2003540162 A JP2003540162 A JP 2003540162A JP 2003540162 A JP2003540162 A JP 2003540162A JP 3800220 B2 JP3800220 B2 JP 3800220B2
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ethyl
amino
acetic acid
crystals
hydroxy
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Japanese (ja)
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JPWO2003037881A1 (ja
Inventor
聡一郎 川添
健一郎 坂元
勇治 粟村
龍也 丸山
貴之 鈴木
健一 恩田
俊行 高須
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Astellas Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
JP2003540162A 2001-10-30 2002-10-29 酢酸アニリド誘導体のα型又はβ型結晶 Expired - Lifetime JP3800220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001332914 2001-10-30
JP2001332914 2001-10-30
PCT/JP2002/011217 WO2003037881A1 (en) 2001-10-30 2002-10-29 α-FORM OR ß-FORM CRYSTAL OF ACETANILIDE DERIVATIVE

Publications (2)

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JPWO2003037881A1 JPWO2003037881A1 (ja) 2005-02-17
JP3800220B2 true JP3800220B2 (ja) 2006-07-26

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JP2003540162A Expired - Lifetime JP3800220B2 (ja) 2001-10-30 2002-10-29 酢酸アニリド誘導体のα型又はβ型結晶

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US (2) US7342117B2 (OSRAM)
EP (3) EP1440969A4 (OSRAM)
JP (1) JP3800220B2 (OSRAM)
KR (1) KR100908796B1 (OSRAM)
CN (1) CN1243740C (OSRAM)
AU (1) AU2002344419C1 (OSRAM)
BR (1) BRPI0213570B8 (OSRAM)
CA (1) CA2464068C (OSRAM)
ES (1) ES2404071T3 (OSRAM)
HU (1) HU230481B1 (OSRAM)
MX (1) MXPA04003936A (OSRAM)
NO (1) NO326965B1 (OSRAM)
PL (1) PL218982B1 (OSRAM)
RU (1) RU2303033C2 (OSRAM)
TW (1) TW200300020A (OSRAM)
WO (1) WO2003037881A1 (OSRAM)
ZA (1) ZA200403044B (OSRAM)

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KR101928987B1 (ko) * 2018-08-28 2018-12-13 (주) 성운파마코피아 신규한 고순도 미라베그론의 결정질 일수화물, 이의 제조방법 또는 용도
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CN110590699B (zh) * 2019-09-29 2022-11-15 广东先强药业有限公司 一种米拉贝隆的精制方法
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CN113816864B (zh) * 2020-06-18 2024-03-29 南京正大天晴制药有限公司 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法
CN114539084B (zh) * 2020-11-24 2024-04-02 威智医药股份有限公司 米拉贝隆及其中间体的制备方法
CN114539182B (zh) * 2020-11-24 2024-08-09 威智医药股份有限公司 转晶溶剂及其应用和米拉贝隆α晶型的制备方法
KR20220081033A (ko) 2020-12-08 2022-06-15 주식회사 한서켐 미라베그론 α형 결정의 제조방법
CN112574137A (zh) * 2021-01-19 2021-03-30 南京美瑞制药有限公司 一种α晶型米拉贝隆的制备方法
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Publication number Publication date
EP1440969A4 (en) 2005-01-19
HUP0401665A1 (hu) 2004-11-29
EP1932838A2 (en) 2008-06-18
US7342117B2 (en) 2008-03-11
EP2298752A1 (en) 2011-03-23
CN1575287A (zh) 2005-02-02
KR100908796B9 (ko) 2024-07-17
BR0213570A (pt) 2004-10-26
US7982049B2 (en) 2011-07-19
KR100908796B1 (ko) 2009-07-22
CA2464068A1 (en) 2003-05-08
WO2003037881A1 (en) 2003-05-08
BRPI0213570B8 (pt) 2021-05-25
BRPI0213570B1 (pt) 2018-02-27
US20050004190A1 (en) 2005-01-06
AU2002344419C1 (en) 2024-02-01
EP1932838A3 (en) 2008-07-30
HU230481B1 (hu) 2016-07-28
CA2464068C (en) 2007-10-16
EP1440969A1 (en) 2004-07-28
NO20042227L (no) 2004-05-28
ZA200403044B (en) 2005-06-29
JPWO2003037881A1 (ja) 2005-02-17
AU2002344419B2 (en) 2007-12-13
TWI322805B (OSRAM) 2010-04-01
MXPA04003936A (es) 2004-06-18
NO326965B1 (no) 2009-03-23
RU2303033C2 (ru) 2007-07-20
PL369874A1 (en) 2005-05-02
EP2298752B1 (en) 2013-03-27
CN1243740C (zh) 2006-03-01
TW200300020A (en) 2003-05-01
US20080214633A1 (en) 2008-09-04
PL218982B1 (pl) 2015-02-27
KR20050040837A (ko) 2005-05-03
ES2404071T3 (es) 2013-05-23
HUP0401665A3 (en) 2008-05-28
RU2004116313A (ru) 2005-03-27

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