CN1243740C - 乙酰替苯胺衍生物的α型或β型结晶 - Google Patents

乙酰替苯胺衍生物的α型或β型结晶 Download PDF

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Publication number
CN1243740C
CN1243740C CNB02821370XA CN02821370A CN1243740C CN 1243740 C CN1243740 C CN 1243740C CN B02821370X A CNB02821370X A CN B02821370XA CN 02821370 A CN02821370 A CN 02821370A CN 1243740 C CN1243740 C CN 1243740C
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China
Prior art keywords
type
crystallization
ethyl
amino
phenylethyl
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Expired - Lifetime
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CNB02821370XA
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English (en)
Chinese (zh)
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CN1575287A (zh
Inventor
川添聪一郎
坂元健一郎
粟村勇治
丸山龙也
铃木贵之
恩田健一
高须俊行
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Astellas Pharma Inc
Yamanouchi Pharmaceutical Co Ltd
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Astellas Pharma Inc
Yamanouchi Pharmaceutical Co Ltd
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Publication of CN1575287A publication Critical patent/CN1575287A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CNB02821370XA 2001-10-30 2002-10-29 乙酰替苯胺衍生物的α型或β型结晶 Expired - Lifetime CN1243740C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001332914 2001-10-30
JP332914/2001 2001-10-30

Publications (2)

Publication Number Publication Date
CN1575287A CN1575287A (zh) 2005-02-02
CN1243740C true CN1243740C (zh) 2006-03-01

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ID=19148268

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CNB02821370XA Expired - Lifetime CN1243740C (zh) 2001-10-30 2002-10-29 乙酰替苯胺衍生物的α型或β型结晶

Country Status (17)

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US (2) US7342117B2 (OSRAM)
EP (3) EP2298752B1 (OSRAM)
JP (1) JP3800220B2 (OSRAM)
KR (1) KR100908796B1 (OSRAM)
CN (1) CN1243740C (OSRAM)
AU (1) AU2002344419C1 (OSRAM)
BR (1) BRPI0213570B8 (OSRAM)
CA (1) CA2464068C (OSRAM)
ES (1) ES2404071T3 (OSRAM)
HU (1) HU230481B1 (OSRAM)
MX (1) MXPA04003936A (OSRAM)
NO (1) NO326965B1 (OSRAM)
PL (1) PL218982B1 (OSRAM)
RU (1) RU2303033C2 (OSRAM)
TW (1) TW200300020A (OSRAM)
WO (1) WO2003037881A1 (OSRAM)
ZA (1) ZA200403044B (OSRAM)

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CN104230840A (zh) * 2014-09-05 2014-12-24 安徽联创药物化学有限公司 米拉贝隆的合成方法
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KR102398639B1 (ko) 2017-06-20 2022-05-17 (주) 성운파마코피아 아미드 유도체의 염 및 그 제조방법
CN108658797A (zh) * 2018-06-19 2018-10-16 安徽德信佳生物医药有限公司 一种米拉贝隆中间体(r)-2-(4-硝基苯乙基氨基)-1-苯基乙醇盐酸盐的合成
CN108947853A (zh) * 2018-06-29 2018-12-07 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成米拉贝隆中间体的方法
KR101928987B1 (ko) * 2018-08-28 2018-12-13 (주) 성운파마코피아 신규한 고순도 미라베그론의 결정질 일수화물, 이의 제조방법 또는 용도
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KR20200117091A (ko) 2019-04-02 2020-10-14 제이투에이치바이오텍 (주) 미라베그론 전구체 약물 화합물 및 이의 과민성 방광 질환의 치료 또는 개선을 위한 의약 용도
CN110590699B (zh) * 2019-09-29 2022-11-15 广东先强药业有限公司 一种米拉贝隆的精制方法
EP3722285B1 (en) 2020-04-08 2022-03-30 Alfred E. Tiefenbacher (GmbH & Co. KG) Process for preparing mirabegron enacarbil
CN113816864B (zh) * 2020-06-18 2024-03-29 南京正大天晴制药有限公司 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法
CN114539084B (zh) * 2020-11-24 2024-04-02 威智医药股份有限公司 米拉贝隆及其中间体的制备方法
CN114539182B (zh) * 2020-11-24 2024-08-09 威智医药股份有限公司 转晶溶剂及其应用和米拉贝隆α晶型的制备方法
KR20220081033A (ko) 2020-12-08 2022-06-15 주식회사 한서켐 미라베그론 α형 결정의 제조방법
CN112574137A (zh) * 2021-01-19 2021-03-30 南京美瑞制药有限公司 一种α晶型米拉贝隆的制备方法
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Also Published As

Publication number Publication date
BRPI0213570B8 (pt) 2021-05-25
RU2004116313A (ru) 2005-03-27
US20050004190A1 (en) 2005-01-06
BR0213570A (pt) 2004-10-26
BRPI0213570B1 (pt) 2018-02-27
EP1440969A1 (en) 2004-07-28
HUP0401665A1 (hu) 2004-11-29
US7982049B2 (en) 2011-07-19
ES2404071T3 (es) 2013-05-23
EP1932838A2 (en) 2008-06-18
NO326965B1 (no) 2009-03-23
HU230481B1 (hu) 2016-07-28
KR100908796B1 (ko) 2009-07-22
EP2298752B1 (en) 2013-03-27
KR20050040837A (ko) 2005-05-03
JPWO2003037881A1 (ja) 2005-02-17
US7342117B2 (en) 2008-03-11
PL369874A1 (en) 2005-05-02
JP3800220B2 (ja) 2006-07-26
EP2298752A1 (en) 2011-03-23
AU2002344419B2 (en) 2007-12-13
EP1932838A3 (en) 2008-07-30
PL218982B1 (pl) 2015-02-27
RU2303033C2 (ru) 2007-07-20
CA2464068A1 (en) 2003-05-08
NO20042227L (no) 2004-05-28
US20080214633A1 (en) 2008-09-04
AU2002344419C1 (en) 2024-02-01
CA2464068C (en) 2007-10-16
ZA200403044B (en) 2005-06-29
TW200300020A (en) 2003-05-01
WO2003037881A1 (en) 2003-05-08
TWI322805B (OSRAM) 2010-04-01
EP1440969A4 (en) 2005-01-19
MXPA04003936A (es) 2004-06-18
HUP0401665A3 (en) 2008-05-28
KR100908796B9 (ko) 2024-07-17
CN1575287A (zh) 2005-02-02

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