US1000075A
(en)
|
1910-07-27 |
1911-08-08 |
William R Collins |
Tunneling-machine.
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
ATE171185T1
(de)
|
1985-03-15 |
1998-10-15 |
Antivirals Inc |
Immunotestmittel für polynukleotid und verfahren
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
US4828971A
(en)
|
1988-03-24 |
1989-05-09 |
Eastman Kodak Company |
Thermally processable element comprising a backing layer
|
CA1251835A
(en)
|
1988-04-05 |
1989-03-28 |
Wai-Cheung Tang |
Dielectric image-resonator multiplexer
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
CA2093664C
(en)
|
1990-10-12 |
2003-07-29 |
Fritz Eckstein |
Modified ribozymes
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
KR100361933B1
(ko)
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
ATE247642T1
(de)
|
1994-06-17 |
2003-09-15 |
Hoffmann La Roche |
N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria- mittel
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
ATE373672T1
(de)
|
1996-01-16 |
2007-10-15 |
Sirna Therapeutics Inc |
Synthese von methoxynukleoside und enzymatische nukleisäure moleküle
|
CA2249195A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
ATE319855T1
(de)
|
1996-12-10 |
2006-03-15 |
Sequenom Inc |
Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
|
US20030073207A1
(en)
|
1997-01-31 |
2003-04-17 |
Saghir Akhtar |
Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
ES2532910T3
(es)
|
1998-04-02 |
2015-04-01 |
Genentech, Inc. |
Variantes de anticuerpos y fragmentos de los mismos
|
AU3751299A
(en)
|
1998-04-20 |
1999-11-08 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
EP1154756B1
(en)
|
1999-02-22 |
2007-01-03 |
Georgetown University |
Antibody fragment-targeted immunoliposomes for systemic gene delivery
|
US6849272B1
(en)
|
1999-04-21 |
2005-02-01 |
Massachusetts Institute Of Technology |
Endosomolytic agents and cell delivery systems
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
WO2001049698A1
(en)
|
1999-12-29 |
2001-07-12 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
IL151928A0
(en)
|
2000-03-30 |
2003-04-10 |
Whitehead Biomedical Inst |
Rna sequence-specific mediators of rna interference
|
ES2461765T3
(es)
|
2000-03-30 |
2014-05-21 |
The Whitehead Institute For Biomedical Research |
Procedimientos de producción de células silenciadas u organismos silenciados por medio de mediadores específicos de secuencia de ARN de interferencia de ARN y usos de los mismos.
|
WO2001083740A2
(en)
|
2000-05-04 |
2001-11-08 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
JP2002095476A
(ja)
*
|
2000-09-20 |
2002-04-02 |
Eisai Co Ltd |
トランスフェリン受容体を介した遺伝子導入法
|
RU2322500C2
(ru)
|
2000-12-01 |
2008-04-20 |
Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. |
Малые молекулы рнк, опосредующие интерференцию рнк
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
DE10133858A1
(de)
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
US6942972B2
(en)
|
2001-10-24 |
2005-09-13 |
Beckman Coulter, Inc. |
Efficient synthesis of protein-oligonucleotide conjugates
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
ES2280826T5
(es)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
EP2305812A3
(en)
*
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
EP1608733B1
(en)
|
2003-04-02 |
2011-12-07 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
WO2004100987A2
(en)
*
|
2003-05-06 |
2004-11-25 |
Regeneron Pharmaceuticals, Inc. |
Methods of using il-1 antagonists to treat neointimal hyperplasia
|
AU2004252442B2
(en)
|
2003-06-02 |
2010-04-08 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of FNAi
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
PT1633767T
(pt)
|
2003-06-02 |
2019-02-27 |
Univ Massachusetts |
Métodos e composições para controlar a eficácia do silenciamento de arn
|
EP1633770B1
(en)
|
2003-06-13 |
2015-04-29 |
Alnylam Europe AG |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
US8133733B2
(en)
|
2003-10-24 |
2012-03-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to target tissues
|
CA3062320C
(en)
|
2003-11-06 |
2022-11-15 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
US7494925B2
(en)
|
2004-02-23 |
2009-02-24 |
Micron Technology, Inc. |
Method for making through-hole conductors for semiconductor substrates
|
US8389710B2
(en)
|
2004-02-27 |
2013-03-05 |
Operational Technologies Corporation |
Therapeutic nucleic acid-3′-conjugates
|
JP5243789B2
(ja)
|
2004-03-15 |
2013-07-24 |
シティ・オブ・ホープ |
二本鎖rnaによる遺伝子発現の特異的阻害のための方法及び組成物
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
US7928217B2
(en)
|
2004-05-27 |
2011-04-19 |
Alnylam Pharmaceuticals, Inc. |
Nuclease resistant double-stranded ribonucleic acid
|
HUE028632T2
(en)
|
2004-06-28 |
2016-12-28 |
Univ Western Australia |
To skip an antisense oligonucleotide exon and use it for procedures
|
EP1817336B1
(en)
|
2004-11-12 |
2019-01-09 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
US7429482B2
(en)
*
|
2005-01-13 |
2008-09-30 |
United States Of America As Represented By The Department Of Veterans Affairs |
Screening tools for discovery of novel anabolic agents
|
KR101363120B1
(ko)
|
2005-02-10 |
2014-02-13 |
베일러 리서치 인스티튜트 |
항-인터페론 알파 모노클로날 항체 및 사용 방법
|
BRPI0611474A2
(pt)
|
2005-05-26 |
2010-09-14 |
Ensemble Discovery Corp |
biodetecção por quìmica modelada com ácido nucléico
|
US20070054259A1
(en)
*
|
2005-06-17 |
2007-03-08 |
City Of Hope |
Modulation of hnRNP H and treatment of DM1
|
AU2006280600B2
(en)
|
2005-08-17 |
2012-01-19 |
Bioneer Corporation |
Sirna-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
US8158364B2
(en)
*
|
2006-04-11 |
2012-04-17 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions involving nucleotide repeat disorders
|
HUE035799T2
(en)
|
2006-05-10 |
2018-05-28 |
Sarepta Therapeutics Inc |
Cationic oligonucleotide analogues containing subunits
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
US7521232B2
(en)
|
2006-05-31 |
2009-04-21 |
Icx Nomadics, Inc. |
Emissive species for clinical imaging
|
JP4560582B2
(ja)
|
2006-06-02 |
2010-10-13 |
アベオ ファーマシューティカルズ, インコーポレイテッド |
肝細胞成長因子(hgf)結合蛋白質
|
CN101563105B
(zh)
|
2006-07-10 |
2013-01-23 |
拜奥根Idec马萨诸塞公司 |
用于抑制smad4-缺陷癌症的组合物和方法
|
PL2049664T3
(pl)
|
2006-08-11 |
2012-02-29 |
Biomarin Tech Bv |
Jednoniciowe oligonukleotydy komplementarne do powtarzalnych elementów do leczenia chorób genetycznych związanych z niestabilnością powtórzeń DNA
|
WO2008022309A2
(en)
|
2006-08-18 |
2008-02-21 |
F. Hoffmann-La Roche Ag |
Polyconjugates for in vivo delivery of polynucleotides
|
JP2010537640A
(ja)
|
2007-08-27 |
2010-12-09 |
ボストン バイオメディカル, インコーポレイテッド |
マイクロrna模倣剤または阻害剤としての非対称性rna二重鎖の組成物
|
CN101809283B
(zh)
|
2007-08-29 |
2012-07-25 |
维斯塔斯风力系统集团公司 |
用于离岸风力发电机的单桩地基
|
US20100286241A1
(en)
|
2007-09-18 |
2010-11-11 |
Intradigm Corporation |
Compositions comprising k-ras sirna and methods of use
|
DK2548962T3
(en)
|
2007-09-19 |
2016-04-11 |
Applied Biosystems Llc |
Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof
|
CA2704049A1
(en)
|
2007-10-26 |
2009-04-30 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
US20110065774A1
(en)
|
2008-01-31 |
2011-03-17 |
Alnylam Pharmaceuticals |
Chemically modified oligonucleotides and uses thereof
|
WO2009099991A2
(en)
|
2008-01-31 |
2009-08-13 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
SI2237799T1
(sl)
|
2008-02-01 |
2019-07-31 |
Ascendis Pharma A/S |
Predzdravilo, ki obsega samo-cepljiv linker
|
JP5697993B2
(ja)
|
2008-02-11 |
2015-04-08 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
修飾RNAiポリヌクレオチドおよびその使用
|
CA2718942A1
(en)
|
2008-03-18 |
2009-09-24 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
AU2009234266B2
(en)
|
2008-04-11 |
2015-08-06 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
CA2720363A1
(en)
|
2008-04-15 |
2009-10-22 |
Bira Arya |
Compositions and methods for delivering inhibitory oligonucleotides
|
US8248352B2
(en)
|
2008-04-25 |
2012-08-21 |
Lg Display Co., Ltd. |
Driving circuit of liquid crystal display
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
AU2009279458B2
(en)
|
2008-08-08 |
2015-07-02 |
Code Biotherapeutics, Inc. |
Long-acting DNA dendrimers and methods thereof
|
EP2323628B1
(en)
|
2008-08-13 |
2022-04-13 |
California Institute of Technology |
Carrier nanoparticles and related compositions, methods and systems
|
EP3208337A1
(en)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions for combined inhibition of mutant egfr and il-6 expression
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
US8796443B2
(en)
|
2008-09-22 |
2014-08-05 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
TR201902952T4
(tr)
|
2008-10-24 |
2019-03-21 |
Sarepta Therapeutics Inc |
Dmd için ekson atlama bileşimleri.
|
CA2741629C
(en)
|
2008-10-27 |
2022-07-05 |
Academisch Ziekenhuis Leiden |
Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mrna
|
KR101602431B1
(ko)
|
2008-11-05 |
2016-03-10 |
삼성전자 주식회사 |
냉장고
|
KR101881596B1
(ko)
|
2008-12-02 |
2018-07-24 |
웨이브 라이프 사이언시스 재팬 인코포레이티드 |
인 원자 변형된 핵산의 합성 방법
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
US8481698B2
(en)
|
2009-03-19 |
2013-07-09 |
The President And Fellows Of Harvard College |
Parallel proximity ligation event analysis
|
CA2757354A1
(en)
|
2009-04-02 |
2010-10-07 |
Laura P.W. Ranum |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
CN102459298A
(zh)
|
2009-05-05 |
2012-05-16 |
阿尔特姆恩科技责任有限公司 |
化学可编程免疫
|
CN106117348A
(zh)
|
2009-06-04 |
2016-11-16 |
诺华公司 |
识别IgG结合位点的方法
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
SG177560A1
(en)
|
2009-07-06 |
2012-03-29 |
Hoffmann La Roche |
Bi-specific digoxigenin binding antibodies
|
US20120258104A1
(en)
|
2009-07-22 |
2012-10-11 |
Cenix Bioscience Gmbh |
Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes
|
WO2011024077A2
(en)
|
2009-08-31 |
2011-03-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Exon skipping therapy for functional amelioration of semi functional dystrophin in becker and duchenne muscular dystrophy
|
TR201804897T4
(tr)
|
2009-10-07 |
2018-06-21 |
Macrogenics Inc |
Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler
|
KR20230137491A
(ko)
|
2009-11-12 |
2023-10-04 |
더 유니버시티 오브 웨스턴 오스트레일리아 |
안티센스 분자 및 이를 이용한 질환 치료방법
|
CA2789560A1
(en)
|
2010-02-12 |
2011-08-18 |
Solulink, Inc. |
Preparation and/or purification of oligonucleotide conjugates
|
KR101671360B1
(ko)
|
2010-04-15 |
2016-11-01 |
시애틀 지네틱스, 인크. |
표적화된 피롤로벤조디아제핀 접합체
|
NZ602933A
(en)
|
2010-04-15 |
2014-09-26 |
Seattle Genetics Inc |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
KR20200133284A
(ko)
|
2010-05-28 |
2020-11-26 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
WO2011154542A1
(en)
|
2010-06-11 |
2011-12-15 |
Artisense Pharma Gmbh |
Method for selective oligonucleotide modification
|
KR101900770B1
(ko)
|
2010-07-19 |
2018-09-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
근육긴장성 이영양증-단백질 키나제(dmpk) 발현의 조절 방법
|
US20130195799A1
(en)
|
2010-08-19 |
2013-08-01 |
Peg Biosciences, Inc. |
Synergistic biomolecule-polymer conjugates
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
KR20130136494A
(ko)
|
2010-12-29 |
2013-12-12 |
애로우헤드 리서치 코오포레이션 |
효소 민감성 결합을 갖는 In Vivo 폴리뉴클레오티드 전달 컨쥬게이트
|
MX2013009191A
(es)
|
2011-02-08 |
2013-11-04 |
Charlotte Mecklenburg Hospital |
Oligonucleotidos antisentido.
|
US9045750B2
(en)
|
2011-03-18 |
2015-06-02 |
Yuelong Ma |
Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3
|
CN103476795B
(zh)
|
2011-03-29 |
2016-07-06 |
罗切格利卡特公司 |
抗体Fc变体
|
US10100305B2
(en)
|
2011-07-15 |
2018-10-16 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
|
EP3248982A1
(en)
|
2011-07-19 |
2017-11-29 |
Wave Life Sciences Ltd. |
Thiosulfonate reagents for the synthesis of functionalized nucleic acids
|
US9418216B2
(en)
|
2011-07-21 |
2016-08-16 |
Microsoft Technology Licensing, Llc |
Cloud service authentication
|
EP3453761A1
(en)
|
2011-08-29 |
2019-03-13 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
JP6393617B2
(ja)
|
2011-10-14 |
2018-09-19 |
シアトル ジェネティクス,インコーポレーテッド |
ピロロベンゾジアゼピンおよび標的コンジュゲート
|
WO2013071079A1
(en)
|
2011-11-09 |
2013-05-16 |
President And Fellows Of Harvard College |
Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
|
ES2923787T3
(es)
|
2011-11-18 |
2022-09-30 |
Alnylam Pharmaceuticals Inc |
Agentes de iARN modificados
|
GB201121069D0
(en)
*
|
2011-12-07 |
2012-01-18 |
Isis Innovation |
Delivery system
|
WO2013103800A1
(en)
|
2012-01-06 |
2013-07-11 |
Bioalliance C.V. |
Anti-transferrin receptor antibodies and methods using same
|
WO2013121175A1
(en)
|
2012-02-16 |
2013-08-22 |
Ucl Business Plc |
Lysosome-cleavable linker
|
RU2582259C2
(ru)
|
2012-02-24 |
2016-04-20 |
Алтеоген Инк. |
Модифицированные антитела, с которыми связан мотив, включающий остаток цистеина, конъюгаты этих модифицированных антител с лекарственными веществами и способ их получения
|
CA2907072A1
(en)
|
2012-03-16 |
2013-09-19 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of dmpk
|
EP3272868A1
(en)
|
2012-05-02 |
2018-01-24 |
Arrowhead Pharmaceuticals, Inc. |
Organic compositions to treat kras-related diseases
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
ES2887208T3
(es)
|
2012-05-15 |
2021-12-22 |
Concortis Biosystems Corp |
Conjugados de fármacos y usos de los mismos
|
EP2872147B1
(en)
|
2012-07-13 |
2022-12-21 |
Wave Life Sciences Ltd. |
Method for making chiral oligonucleotides
|
CA2880869A1
(en)
|
2012-08-20 |
2014-02-27 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
CA2885340C
(en)
|
2012-10-12 |
2016-11-08 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
BR112015010116A2
(pt)
|
2012-11-15 |
2017-08-22 |
Roche Innovation Ct Copenhagen As |
COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB
|
EP2922818B1
(en)
|
2012-11-24 |
2018-09-05 |
Hangzhou Dac Biotech Co., Ltd |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
SG11201504887TA
(en)
|
2012-12-21 |
2015-07-30 |
Bioalliance Cv |
Hydrophilic self-immolative linkers and conjugates thereof
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
US9319764B2
(en)
|
2013-03-08 |
2016-04-19 |
Merry Electronics Co., Ltd. |
MEMS microphone packaging structure
|
CN117844807A
(zh)
|
2013-03-14 |
2024-04-09 |
萨勒普塔医疗公司 |
用于治疗肌营养不良的外显子跳跃组合物
|
EP3662912A1
(en)
|
2013-03-15 |
2020-06-10 |
Sarepta Therapeutics, Inc. |
Improved dosages of eteplirsen for treating duchenne muscular dystrophy
|
MX2015011348A
(es)
|
2013-03-15 |
2016-01-15 |
Regeneron Pharma |
Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
US9577459B2
(en)
|
2013-03-15 |
2017-02-21 |
Sequana Medical Ag |
Systems and methods for regulating inductive energy transfer to an implantable system
|
EA201591590A1
(ru)
|
2013-03-27 |
2016-05-31 |
Исарна Терапьютикс Гмбх |
Модифицированные олигонуклеотиды трф-бета
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
US9861574B2
(en)
|
2013-04-09 |
2018-01-09 |
Duke University |
2-fluoro-modified RNAs as immunostimulators
|
WO2014177042A1
(zh)
|
2013-04-28 |
2014-11-06 |
Qin Gang |
一种新型的连接子及其制备方法和用途
|
KR102293064B1
(ko)
*
|
2013-05-20 |
2021-08-23 |
제넨테크, 인크. |
항-트랜스페린 수용체 항체 및 사용 방법
|
EP3004174B1
(en)
|
2013-05-31 |
2019-04-17 |
Zymeworks Inc. |
Heteromultimers with reduced or silenced effector function
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
EA201690780A1
(ru)
|
2013-10-15 |
2016-08-31 |
Сиэтл Дженетикс, Инк. |
Пегилированные лекарственные средства-линкеры для улучшенной фармакокинетики конъюгатов лиганд-лекарственное средство
|
SG11201604879QA
(en)
|
2013-10-15 |
2016-07-28 |
Sorrento Therapeutics Inc |
Drug-conjugates with a targeting molecule and two different drugs
|
EP3610884B1
(en)
|
2013-11-06 |
2021-08-18 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
US10378017B2
(en)
|
2013-12-02 |
2019-08-13 |
Brandeis University |
High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
|
US10160969B2
(en)
|
2014-01-16 |
2018-12-25 |
Wave Life Sciences Ltd. |
Chiral design
|
EP3099797B1
(en)
|
2014-01-30 |
2019-08-21 |
F. Hoffmann-La Roche AG |
Poly oligomer compound with biocleavable conjugates
|
BR112016029369B1
(pt)
|
2014-06-17 |
2020-12-08 |
Nippon Shinyaku Co., Ltd. |
oligômero antissentido, composição farmacêutica uso de um oligômero antissentido ou um sal ou hidrato farmaceuticamente aceitável do mesmo, e, métodos para fabricação e para triagem de um oligômero antissentido
|
TWI695011B
(zh)
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗her2表位之單株抗體及其使用之方法
|
WO2015200223A1
(en)
|
2014-06-23 |
2015-12-30 |
Monsanto Technology Llc |
Compositions and methods for regulating gene expression via rna interference
|
US10233448B2
(en)
|
2014-08-20 |
2019-03-19 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded RNA agents
|
WO2016170348A2
(en)
|
2015-04-22 |
2016-10-27 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
DK3289076T3
(da)
|
2015-05-01 |
2022-01-17 |
Prec Biosciences Inc |
Præcis sletning af kromosomale sekvenser in vivo
|
MA42134A
(fr)
|
2015-05-19 |
2018-03-28 |
Sarepta Therapeutics Inc |
Conjugués peptides/oligonucléotides
|
PE20221007A1
(es)
|
2015-06-24 |
2022-06-15 |
Hoffmann La Roche |
Anticuerpos anti-receptor de transferrina con afinidad disenada
|
EP3423490A1
(en)
|
2016-03-01 |
2019-01-09 |
H. Hoffnabb-La Roche Ag |
Obinutuzumab and rituximab variants having reduced adcp
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
EP4212176A1
(en)
|
2016-06-20 |
2023-07-19 |
Genahead Bio, Inc. |
Antibody-drug conjugate
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
US20190256868A1
(en)
|
2016-10-28 |
2019-08-22 |
Genethon |
Compositions and methods for the treatment of myotonic dystrophy
|
JP7157052B2
(ja)
|
2016-10-28 |
2022-10-19 |
ジェネトン |
筋緊張性ジストロフィーの治療のための組成物および方法
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
IT201700008383A1
(it)
*
|
2017-01-26 |
2018-07-26 |
Explea S R L |
Dispositivo per la produzione di energia elettrica utilizzante l’azione combinata di campi magnetici pulsati e di correnti fluidodinamiche agenti su una lamina flessibile dotata di un elemento piezoelettrico ed impianto formato da più elementi modulari collegati elettricamente fra loro e composti ciascuno da una pluralità di tali dispositivi
|
BR112019023249A8
(pt)
|
2017-05-05 |
2021-02-23 |
Centre For Probe Dev And Commercialization |
anticorpos monoclonais igf-1r e usos dos mesmos
|
AU2018335880A1
(en)
|
2017-09-22 |
2020-04-16 |
Avidity Biosciences, Inc. |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
EP3691657A4
(en)
*
|
2017-10-04 |
2021-07-21 |
Avidity Biosciences, Inc. |
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
|
CA3083526A1
(en)
|
2017-12-06 |
2019-06-13 |
Andrew John Geall |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
US20210261680A1
(en)
|
2018-08-02 |
2021-08-26 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof
|
EP4126066A4
(en)
|
2020-03-27 |
2024-04-24 |
Avidity Biosciences, Inc. |
COMPOSITIONS AND METHODS FOR TREATING MUSCULAR DYSTROPHY
|