ATE247642T1 - N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria- mittel - Google Patents
N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria- mittelInfo
- Publication number
- ATE247642T1 ATE247642T1 AT95922495T AT95922495T ATE247642T1 AT E247642 T1 ATE247642 T1 AT E247642T1 AT 95922495 T AT95922495 T AT 95922495T AT 95922495 T AT95922495 T AT 95922495T AT E247642 T1 ATE247642 T1 AT E247642T1
- Authority
- AT
- Austria
- Prior art keywords
- diyl
- pct
- bis
- phenylene
- cyclohexane
- Prior art date
Links
- 239000003430 antimalarial agent Substances 0.000 title 1
- -1 cyclohexane-1,3-diyl Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960003677 chloroquine Drugs 0.000 abstract 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH192894 | 1994-06-17 | ||
| PCT/EP1995/002123 WO1995035287A1 (en) | 1994-06-17 | 1995-06-03 | N,n'-bis(quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE247642T1 true ATE247642T1 (de) | 2003-09-15 |
Family
ID=4221871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95922495T ATE247642T1 (de) | 1994-06-17 | 1995-06-03 | N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria- mittel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5736557A (de) |
| EP (1) | EP0765313B1 (de) |
| JP (1) | JPH10501540A (de) |
| CN (1) | CN1120156C (de) |
| AT (1) | ATE247642T1 (de) |
| AU (1) | AU691306B2 (de) |
| CA (1) | CA2192203A1 (de) |
| DE (1) | DE69531543T2 (de) |
| DK (1) | DK0765313T3 (de) |
| ES (1) | ES2204956T3 (de) |
| IL (1) | IL114099A (de) |
| MX (1) | MX9606382A (de) |
| MY (1) | MY115176A (de) |
| NZ (1) | NZ288223A (de) |
| PT (1) | PT765313E (de) |
| WO (1) | WO1995035287A1 (de) |
| ZA (1) | ZA954796B (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0876346B1 (de) * | 1995-11-16 | 2001-07-25 | F. Hoffmann-La Roche Ag | Chinolinderivate als antimalariamittel |
| US5866562A (en) * | 1996-10-25 | 1999-02-02 | Bayer Aktiengesellschaft | Ring-bridged bis-quinolines |
| US6174897B1 (en) | 1996-10-25 | 2001-01-16 | Bayer Aktiengesellschaft | Bis-(quinolyl)-diamines |
| US5882996A (en) * | 1997-10-14 | 1999-03-16 | Industrial Technology Research Institute | Method of self-aligned dual damascene patterning using developer soluble arc interstitial layer |
| EP1377554A1 (de) * | 1999-06-16 | 2004-01-07 | University Of Iowa Research Foundation | Antagonismus der immunostimulatorischen cpg-oligonukleotiden durch 4-aminochinolinen und sonstigen schwachen basen |
| KR100520168B1 (ko) * | 1999-06-21 | 2005-10-10 | 주식회사 하이닉스반도체 | 화학증폭형 레지스트에 첨가되는 새로운 페닐렌디아민계 유도체 |
| DE10008522A1 (de) * | 2000-02-24 | 2001-09-06 | Hassan Jomaa | Verwendung von 2-PHenylendiaminderivaten zur Behandlung von Infektionen |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| US6818772B2 (en) | 2002-02-22 | 2004-11-16 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| WO2003070244A1 (en) * | 2002-02-22 | 2003-08-28 | Abbott Laboratories | Antagonist of melanin concentrating hormone and their uses |
| WO2007056580A2 (en) * | 2005-11-08 | 2007-05-18 | Pharmadyn, Inc. | Methods and compositions for treating diseases associated with pathogenic proteins |
| WO2007059372A2 (en) * | 2005-11-09 | 2007-05-24 | St. Jude Children's Research Hospital | Use of chloroquine to treat metabolic syndrome |
| US20110045100A1 (en) * | 2008-03-05 | 2011-02-24 | Georgetown University | Antimalarial Quinolines and Methods of Use Thereof |
| WO2010059633A2 (en) * | 2008-11-18 | 2010-05-27 | Oregon Health & Science University | Compounds for treating parasitic disease |
| IN2012DN01684A (de) | 2009-08-27 | 2015-06-05 | U S A Represented By The Secretary Dept Of Health And Human Services | |
| EP2394982A1 (de) | 2010-06-08 | 2011-12-14 | Lonza Ltd. | Verfahren zur Herstellung von cis-Diaminocycloalkanen |
| EP2394981A1 (de) | 2010-06-08 | 2011-12-14 | Lonza Ltd. | Verfahren zur Herstellung von cis-Diaminocycloalkanen |
| CN104788523B (zh) | 2010-06-22 | 2017-09-08 | 欧恩科斯欧公司 | 用于核酸结合物的具有内涵体溶解剂的优化的体内递送系统 |
| EP2527440A1 (de) | 2011-05-27 | 2012-11-28 | Institut Curie | Krebsbehandlung durch Kombination von Doppelstrangbruch nachahmenden DNA-Molekülen mit Hyperthermie |
| JPWO2015133280A1 (ja) * | 2014-03-03 | 2017-04-06 | 公立大学法人名古屋市立大学 | 抗マラリア活性化合物及び抗マラリア薬 |
| KR20170086518A (ko) * | 2014-11-25 | 2017-07-26 | 바스프 에스이 | 시스-풍부 mdach 및 트랜스-풍부 mdach의 제조 방법 |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| US10640456B2 (en) | 2016-06-28 | 2020-05-05 | Dai Nippon Printing Co., Ltd. | Compound and intermediate thereof |
| SG10202107429WA (en) | 2017-01-06 | 2021-08-30 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| CN111655268B (zh) | 2017-10-04 | 2024-03-26 | 艾维迪提生物科学公司 | 核酸-多肽组合物及其用途 |
| CN118638787A (zh) | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| IL319265A (en) | 2018-12-21 | 2025-04-01 | Avidity Biosciences Inc | Anti-transferrin receptor antibodies and their uses |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| EP3911640A4 (de) | 2019-01-18 | 2022-10-26 | Astrazeneca AB | Pcsk9-inhibitoren und verfahren zur verwendung davon |
| EP3959319A4 (de) | 2019-04-25 | 2023-06-07 | Avidity Biosciences, Inc. | Nukleinsäurezusammensetzungen und verfahren für multi-exon-skipping |
| US11578090B2 (en) | 2019-06-06 | 2023-02-14 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| JP7581252B2 (ja) | 2019-06-06 | 2024-11-12 | アビディティー バイオサイエンシーズ，インク． | Ｕｎａアミダイトおよびその使用 |
| AU2021237465A1 (en) | 2020-03-19 | 2022-10-13 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
| IL296393B1 (en) | 2020-03-27 | 2025-12-01 | Avidity Biosciences Inc | Compositions and methods of treating muscle dystrophy |
| US20230416786A1 (en) | 2020-11-30 | 2023-12-28 | Cellectis Sa | Use of aminoquinoline compounds for higher gene integration |
| CN118265544A (zh) | 2021-09-16 | 2024-06-28 | 艾维迪提生物科学公司 | 治疗面肩肱型肌营养不良的组合物和方法 |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| WO2025006639A2 (en) | 2023-06-27 | 2025-01-02 | Avidity Biosciences, Inc. | Compositions and methods of using prkag2-targeting antibody-oligonucleotide conjugates abstract |
| US12409230B2 (en) | 2023-06-30 | 2025-09-09 | Avidity Biosciences, Inc. | Compositions comprising PLN-targeting anti-transferrin receptor antibody-polynucleotides and methods of use thereof to treat cardiomyopathy |
| WO2025044946A1 (zh) * | 2023-08-25 | 2025-03-06 | 武汉人福创新药物研发中心有限公司 | 作为mrgprx2拮抗剂的化合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2816893A (en) * | 1957-12-17 | Improvements in or relating to | ||
| US2901484A (en) * | 1957-03-04 | 1959-08-25 | Abbott Lab | Bis-quinoliniums |
| US5510356A (en) * | 1991-10-03 | 1996-04-23 | University Of Nebraska Board Of Regents | Bisquinolines and processes for their production and use to treat malaria |
-
1995
- 1995-06-03 NZ NZ288223A patent/NZ288223A/en unknown
- 1995-06-03 WO PCT/EP1995/002123 patent/WO1995035287A1/en not_active Ceased
- 1995-06-03 AU AU27369/95A patent/AU691306B2/en not_active Ceased
- 1995-06-03 JP JP8501566A patent/JPH10501540A/ja not_active Withdrawn
- 1995-06-03 CA CA002192203A patent/CA2192203A1/en not_active Abandoned
- 1995-06-03 US US08/765,751 patent/US5736557A/en not_active Expired - Fee Related
- 1995-06-03 EP EP95922495A patent/EP0765313B1/de not_active Expired - Lifetime
- 1995-06-03 ES ES95922495T patent/ES2204956T3/es not_active Expired - Lifetime
- 1995-06-03 PT PT95922495T patent/PT765313E/pt unknown
- 1995-06-03 DK DK95922495T patent/DK0765313T3/da active
- 1995-06-03 MX MX9606382A patent/MX9606382A/es not_active IP Right Cessation
- 1995-06-03 DE DE69531543T patent/DE69531543T2/de not_active Expired - Fee Related
- 1995-06-03 CN CN95193643A patent/CN1120156C/zh not_active Expired - Fee Related
- 1995-06-03 AT AT95922495T patent/ATE247642T1/de not_active IP Right Cessation
- 1995-06-09 ZA ZA954796A patent/ZA954796B/xx unknown
- 1995-06-12 IL IL11409995A patent/IL114099A/xx not_active IP Right Cessation
- 1995-06-15 MY MYPI95001626A patent/MY115176A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA954796B (en) | 1996-01-03 |
| IL114099A0 (en) | 1995-10-31 |
| US5736557A (en) | 1998-04-07 |
| MY115176A (en) | 2003-04-30 |
| DE69531543D1 (de) | 2003-09-25 |
| CA2192203A1 (en) | 1995-12-28 |
| EP0765313A1 (de) | 1997-04-02 |
| ES2204956T3 (es) | 2004-05-01 |
| AU2736995A (en) | 1996-01-15 |
| PT765313E (pt) | 2003-11-28 |
| CN1153513A (zh) | 1997-07-02 |
| WO1995035287A1 (en) | 1995-12-28 |
| DK0765313T3 (da) | 2003-12-08 |
| CN1120156C (zh) | 2003-09-03 |
| AU691306B2 (en) | 1998-05-14 |
| EP0765313B1 (de) | 2003-08-20 |
| NZ288223A (en) | 1997-11-24 |
| JPH10501540A (ja) | 1998-02-10 |
| DE69531543T2 (de) | 2004-06-24 |
| MX9606382A (es) | 1997-03-29 |
| IL114099A (en) | 2000-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0765313 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |