DE69531543D1 - N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel - Google Patents

N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel

Info

Publication number
DE69531543D1
DE69531543D1 DE69531543T DE69531543T DE69531543D1 DE 69531543 D1 DE69531543 D1 DE 69531543D1 DE 69531543 T DE69531543 T DE 69531543T DE 69531543 T DE69531543 T DE 69531543T DE 69531543 D1 DE69531543 D1 DE 69531543D1
Authority
DE
Germany
Prior art keywords
diyl
pct
bis
phenylene
cyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69531543T
Other languages
English (en)
Other versions
DE69531543T2 (de
Inventor
Werner Hofheinz
Werner Leupin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69531543D1 publication Critical patent/DE69531543D1/de
Application granted granted Critical
Publication of DE69531543T2 publication Critical patent/DE69531543T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69531543T 1994-06-17 1995-06-03 N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel Expired - Fee Related DE69531543T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH192894 1994-06-17
CH192894 1994-06-17
PCT/EP1995/002123 WO1995035287A1 (en) 1994-06-17 1995-06-03 N,n'-bis(quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials

Publications (2)

Publication Number Publication Date
DE69531543D1 true DE69531543D1 (de) 2003-09-25
DE69531543T2 DE69531543T2 (de) 2004-06-24

Family

ID=4221871

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69531543T Expired - Fee Related DE69531543T2 (de) 1994-06-17 1995-06-03 N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel

Country Status (17)

Country Link
US (1) US5736557A (de)
EP (1) EP0765313B1 (de)
JP (1) JPH10501540A (de)
CN (1) CN1120156C (de)
AT (1) ATE247642T1 (de)
AU (1) AU691306B2 (de)
CA (1) CA2192203A1 (de)
DE (1) DE69531543T2 (de)
DK (1) DK0765313T3 (de)
ES (1) ES2204956T3 (de)
IL (1) IL114099A (de)
MX (1) MX9606382A (de)
MY (1) MY115176A (de)
NZ (1) NZ288223A (de)
PT (1) PT765313E (de)
WO (1) WO1995035287A1 (de)
ZA (1) ZA954796B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2162110T3 (es) * 1995-11-16 2001-12-16 Hoffmann La Roche Derivados de la quinolina antimalaria.
US6174897B1 (en) 1996-10-25 2001-01-16 Bayer Aktiengesellschaft Bis-(quinolyl)-diamines
US5866562A (en) * 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
US5882996A (en) * 1997-10-14 1999-03-16 Industrial Technology Research Institute Method of self-aligned dual damascene patterning using developer soluble arc interstitial layer
WO2000076982A1 (en) * 1999-06-16 2000-12-21 University Of Iowa Research Foundation Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
KR100520168B1 (ko) * 1999-06-21 2005-10-10 주식회사 하이닉스반도체 화학증폭형 레지스트에 첨가되는 새로운 페닐렌디아민계 유도체
DE10008522A1 (de) * 2000-02-24 2001-09-06 Hassan Jomaa Verwendung von 2-PHenylendiaminderivaten zur Behandlung von Infektionen
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US6818772B2 (en) * 2002-02-22 2004-11-16 Abbott Laboratories Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
WO2003070244A1 (en) * 2002-02-22 2003-08-28 Abbott Laboratories Antagonist of melanin concentrating hormone and their uses
WO2007056580A2 (en) * 2005-11-08 2007-05-18 Pharmadyn, Inc. Methods and compositions for treating diseases associated with pathogenic proteins
WO2007059372A2 (en) * 2005-11-09 2007-05-24 St. Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
WO2009148659A2 (en) * 2008-03-05 2009-12-10 Georgetown University Antimalarial quinolines and methods of use thereof
WO2010059633A2 (en) * 2008-11-18 2010-05-27 Oregon Health & Science University Compounds for treating parasitic disease
US9375424B2 (en) 2009-08-27 2016-06-28 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Compounds that treat malaria and prevent malaria transmission
EP2394982A1 (de) 2010-06-08 2011-12-14 Lonza Ltd. Verfahren zur Herstellung von cis-Diaminocycloalkanen
EP2394981A1 (de) 2010-06-08 2011-12-14 Lonza Ltd. Verfahren zur Herstellung von cis-Diaminocycloalkanen
HUE037926T2 (hu) 2010-06-22 2018-09-28 Onxeo Nukleinsav konjugátumok számára endoszomolitikus szereket tartalmazó, optimalizált in vivo szállítórendszer
EP2527440A1 (de) 2011-05-27 2012-11-28 Institut Curie Krebsbehandlung durch Kombination von Doppelstrangbruch nachahmenden DNA-Molekülen mit Hyperthermie
JPWO2015133280A1 (ja) * 2014-03-03 2017-04-06 公立大学法人名古屋市立大学 抗マラリア活性化合物及び抗マラリア薬
WO2016083210A1 (de) * 2014-11-25 2016-06-02 Basf Se Verfahren zur herstellung von cis- und trans-angereichertem mdach
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
CN109415298B (zh) * 2016-06-28 2022-03-29 大日本印刷株式会社 化合物及其中间体
SG10202107429WA (en) 2017-01-06 2021-08-30 Avidity Biosciences Inc Nucleic acid-polypeptide compositions and methods of inducing exon skipping
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
MX2020003596A (es) 2017-10-04 2020-07-22 Avidity Biosciences Inc Composiciones de acido nucleico-polipeptido y usos de las mismos.
KR102443358B1 (ko) 2017-12-06 2022-09-14 어비디티 바이오사이언시스 인크. 근위축증 및 근긴장성 이영양증을 치료하는 조성물 및 방법
AU2019406199A1 (en) 2018-12-21 2021-07-29 Avidity Biosciences, Inc. Anti-transferrin receptor antibodies and uses thereof
CN113412258A (zh) 2019-01-18 2021-09-17 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
JP2022535588A (ja) 2019-06-06 2022-08-09 アビディティー バイオサイエンシーズ，インク． 核酸ポリペプチド組成物およびその使用
JP2023537798A (ja) 2020-03-19 2023-09-06 アビディティー バイオサイエンシーズ，インク． 顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法
EP4126066A4 (de) 2020-03-27 2024-04-24 Avidity Biosciences Inc Zusammensetzungen und verfahren zur behandlung von muskeldystrophie
EP4251746A1 (de) 2020-11-30 2023-10-04 Cellectis SA Verwendung von aminochinolinverbindungen zur höheren genintegration
WO2023043953A1 (en) 2021-09-16 2023-03-23 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816893A (en) * 1957-12-17 Improvements in or relating to
US2901484A (en) * 1957-03-04 1959-08-25 Abbott Lab Bis-quinoliniums
US5510356A (en) * 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria

Also Published As

Publication number Publication date
CN1120156C (zh) 2003-09-03
AU2736995A (en) 1996-01-15
DK0765313T3 (da) 2003-12-08
ES2204956T3 (es) 2004-05-01
IL114099A0 (en) 1995-10-31
EP0765313B1 (de) 2003-08-20
AU691306B2 (en) 1998-05-14
PT765313E (pt) 2003-11-28
EP0765313A1 (de) 1997-04-02
MY115176A (en) 2003-04-30
DE69531543T2 (de) 2004-06-24
ZA954796B (en) 1996-01-03
IL114099A (en) 2000-02-29
JPH10501540A (ja) 1998-02-10
MX9606382A (es) 1997-03-29
CA2192203A1 (en) 1995-12-28
CN1153513A (zh) 1997-07-02
US5736557A (en) 1998-04-07
WO1995035287A1 (en) 1995-12-28
ATE247642T1 (de) 2003-09-15
NZ288223A (en) 1997-11-24

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8339 Ceased/non-payment of the annual fee