ATE172454T1 - Pyridazinon derivate mit pharmazeutischer wirkung - Google Patents
Pyridazinon derivate mit pharmazeutischer wirkungInfo
- Publication number
- ATE172454T1 ATE172454T1 AT94918564T AT94918564T ATE172454T1 AT E172454 T1 ATE172454 T1 AT E172454T1 AT 94918564 T AT94918564 T AT 94918564T AT 94918564 T AT94918564 T AT 94918564T AT E172454 T1 ATE172454 T1 AT E172454T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- atom
- alkyl group
- pct
- hydrogen atom
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- -1 4-substituted piperazine ring Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15919493 | 1993-06-29 | ||
| JP11272194 | 1994-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE172454T1 true ATE172454T1 (de) | 1998-11-15 |
Family
ID=26451823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94918564T ATE172454T1 (de) | 1993-06-29 | 1994-06-24 | Pyridazinon derivate mit pharmazeutischer wirkung |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5728702A (de) |
| EP (1) | EP0706517B1 (de) |
| KR (1) | KR100255416B1 (de) |
| CN (1) | CN1044906C (de) |
| AT (1) | ATE172454T1 (de) |
| AU (1) | AU676341B2 (de) |
| CA (1) | CA2166326C (de) |
| CZ (1) | CZ289231B6 (de) |
| DE (1) | DE69414112T2 (de) |
| DK (1) | DK0706517T3 (de) |
| ES (1) | ES2124413T3 (de) |
| FI (1) | FI113963B (de) |
| HU (1) | HU221009B1 (de) |
| IL (1) | IL110040A (de) |
| NO (1) | NO306675B1 (de) |
| NZ (1) | NZ267510A (de) |
| RO (1) | RO114791B1 (de) |
| RU (1) | RU2138486C1 (de) |
| SK (1) | SK280786B6 (de) |
| TW (1) | TW408114B (de) |
| UA (1) | UA34481C2 (de) |
| WO (1) | WO1995001343A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2147841T3 (es) * | 1994-01-25 | 2000-10-01 | Nissan Chemical Ind Ltd | Derivados de piridazinona. |
| DE4430755A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| WO1999050248A1 (en) * | 1998-03-31 | 1999-10-07 | Nissan Chemical Industries, Ltd. | Pyridazinone hydrochloride compound and method for producing the same |
| DE60028998T8 (de) * | 1999-11-11 | 2007-02-22 | Nissan Chemical Industries, Ltd. | Verfahren zur herstellung einer benzylamin-verbindung |
| SE9904377D0 (sv) * | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| RU2179848C1 (ru) * | 2001-03-30 | 2002-02-27 | Государственное учреждение Тверская государственная медицинская академия | Применение антидепрессанта амитриптилина у больных раком легкого |
| EP1438298B1 (de) | 2001-10-22 | 2010-01-27 | Pfizer Products Inc. | Piperazinderivate mit ccr1-rezeptor-antagonistischer wirkung |
| RU2220738C1 (ru) * | 2002-08-30 | 2004-01-10 | Гапонюк Петр Яковлевич | Средство для лечения ринита |
| US20060080140A1 (en) * | 2004-02-09 | 2006-04-13 | Epic Systems Corporation | System and method for providing a clinical summary of patient information in various health care settings |
| WO2010099388A1 (en) * | 2009-02-27 | 2010-09-02 | Indigo Pharmaceuticals | Combinational use of a pde3 inhibitor and other agents |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0641455B2 (ja) * | 1984-12-10 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| JPH0641454B2 (ja) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| EP0201765B1 (de) * | 1985-04-27 | 1991-09-18 | Nissan Chemical Industries Ltd. | 3(2H) Pyridazinone, Verfahren zu ihrer Herstellung und diese enthaltende anti-allergische Mittel |
| US4978665A (en) * | 1987-01-20 | 1990-12-18 | Nissan Chemical Industries Ltd. | 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it |
| JPH02256668A (ja) * | 1988-12-20 | 1990-10-17 | Nissan Chem Ind Ltd | ピリダジノン誘導体 |
| HU208124B (en) * | 1990-04-25 | 1993-08-30 | Nissan Chemical Ind Ltd | Process for producing pyridazinone derivatives and pharmaceutical compositions comprising such derivatives as active ingredient |
| ES2147841T3 (es) * | 1994-01-25 | 2000-10-01 | Nissan Chemical Ind Ltd | Derivados de piridazinona. |
-
1994
- 1994-06-17 IL IL11004094A patent/IL110040A/xx not_active IP Right Cessation
- 1994-06-24 CZ CZ19953299A patent/CZ289231B6/cs not_active IP Right Cessation
- 1994-06-24 AT AT94918564T patent/ATE172454T1/de not_active IP Right Cessation
- 1994-06-24 DK DK94918564T patent/DK0706517T3/da active
- 1994-06-24 CN CN94192618A patent/CN1044906C/zh not_active Expired - Fee Related
- 1994-06-24 SK SK1624-95A patent/SK280786B6/sk unknown
- 1994-06-24 US US08/564,277 patent/US5728702A/en not_active Expired - Lifetime
- 1994-06-24 DE DE69414112T patent/DE69414112T2/de not_active Expired - Fee Related
- 1994-06-24 WO PCT/JP1994/001015 patent/WO1995001343A1/en not_active Ceased
- 1994-06-24 KR KR1019950705969A patent/KR100255416B1/ko not_active Expired - Fee Related
- 1994-06-24 RO RO95-02293A patent/RO114791B1/ro unknown
- 1994-06-24 AU AU69833/94A patent/AU676341B2/en not_active Ceased
- 1994-06-24 UA UA95125405A patent/UA34481C2/uk unknown
- 1994-06-24 CA CA002166326A patent/CA2166326C/en not_active Expired - Fee Related
- 1994-06-24 NZ NZ267510A patent/NZ267510A/en not_active IP Right Cessation
- 1994-06-24 RU RU96101173A patent/RU2138486C1/ru not_active IP Right Cessation
- 1994-06-24 HU HU9503807A patent/HU221009B1/hu not_active IP Right Cessation
- 1994-06-24 EP EP94918564A patent/EP0706517B1/de not_active Expired - Lifetime
- 1994-06-24 ES ES94918564T patent/ES2124413T3/es not_active Expired - Lifetime
- 1994-06-25 TW TW083105779A patent/TW408114B/zh not_active IP Right Cessation
-
1995
- 1995-12-28 FI FI956300A patent/FI113963B/fi not_active IP Right Cessation
- 1995-12-28 NO NO955328A patent/NO306675B1/no unknown
-
1997
- 1997-12-08 US US08/986,420 patent/US5929074A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |