MX9606382A - Derivados de n,n'-bis(quinolin-4-il)diamina, su preparacion y su uso como compuestos antimalaria. - Google Patents

Derivados de n,n'-bis(quinolin-4-il)diamina, su preparacion y su uso como compuestos antimalaria.

Info

Publication number
MX9606382A
MX9606382A MX9606382A MX9606382A MX9606382A MX 9606382 A MX9606382 A MX 9606382A MX 9606382 A MX9606382 A MX 9606382A MX 9606382 A MX9606382 A MX 9606382A MX 9606382 A MX9606382 A MX 9606382A
Authority
MX
Mexico
Prior art keywords
diyl
quinolin
bis
phenylene
cyclohexane
Prior art date
Application number
MX9606382A
Other languages
English (en)
Inventor
Werner Wofheinz
Werner Leupin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9606382A publication Critical patent/MX9606382A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a los derivados de N,N'-bis(quinolin-4-il)-diamina de la formula general (I), en donde R1 significa halogeno o trifluorometilo, R2 significa hidrogeno o halogeno, A significa ciclohexan-1,3-diilo, 2-metilo-ciclohexan-1,3-diilo, ciclohexan-1,4-diilo, diciclohexil-metan-4,4'-diilo, ciclopentan-1,3-diilo, fenilen-1,4, fenilen-1,3, fenilen-1,2, eten-1,2-diilo o etin-1,2-diilo y n y m pueden ser el mismo o diferentes y significan 0, 1 o 2, así como sus sales farmacéuticamente aceptables. Estos productos se usan como agentes para prevenir la malaria y para tratarla, especialmente en donde los patogenos son resistentes a la cloroquina.
MX9606382A 1994-06-17 1995-06-03 Derivados de n,n'-bis(quinolin-4-il)diamina, su preparacion y su uso como compuestos antimalaria. MX9606382A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH192894 1994-06-17
PCT/EP1995/002123 WO1995035287A1 (en) 1994-06-17 1995-06-03 N,n'-bis(quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials

Publications (1)

Publication Number Publication Date
MX9606382A true MX9606382A (es) 1997-03-29

Family

ID=4221871

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606382A MX9606382A (es) 1994-06-17 1995-06-03 Derivados de n,n'-bis(quinolin-4-il)diamina, su preparacion y su uso como compuestos antimalaria.

Country Status (17)

Country Link
US (1) US5736557A (es)
EP (1) EP0765313B1 (es)
JP (1) JPH10501540A (es)
CN (1) CN1120156C (es)
AT (1) ATE247642T1 (es)
AU (1) AU691306B2 (es)
CA (1) CA2192203A1 (es)
DE (1) DE69531543T2 (es)
DK (1) DK0765313T3 (es)
ES (1) ES2204956T3 (es)
IL (1) IL114099A (es)
MX (1) MX9606382A (es)
MY (1) MY115176A (es)
NZ (1) NZ288223A (es)
PT (1) PT765313E (es)
WO (1) WO1995035287A1 (es)
ZA (1) ZA954796B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199800854T2 (xx) * 1995-11-16 1998-08-21 F.Hoffmann-La Roche Ag Antis�tma kinolin t�revleri.
US6174897B1 (en) 1996-10-25 2001-01-16 Bayer Aktiengesellschaft Bis-(quinolyl)-diamines
US5866562A (en) * 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
US5882996A (en) * 1997-10-14 1999-03-16 Industrial Technology Research Institute Method of self-aligned dual damascene patterning using developer soluble arc interstitial layer
WO2000076982A1 (en) * 1999-06-16 2000-12-21 University Of Iowa Research Foundation Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
KR100520168B1 (ko) * 1999-06-21 2005-10-10 주식회사 하이닉스반도체 화학증폭형 레지스트에 첨가되는 새로운 페닐렌디아민계 유도체
DE10008522A1 (de) * 2000-02-24 2001-09-06 Hassan Jomaa Verwendung von 2-PHenylendiaminderivaten zur Behandlung von Infektionen
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US6818772B2 (en) * 2002-02-22 2004-11-16 Abbott Laboratories Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
WO2003070244A1 (en) * 2002-02-22 2003-08-28 Abbott Laboratories Antagonist of melanin concentrating hormone and their uses
WO2007056580A2 (en) * 2005-11-08 2007-05-18 Pharmadyn, Inc. Methods and compositions for treating diseases associated with pathogenic proteins
WO2007059372A2 (en) * 2005-11-09 2007-05-24 St. Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
US20110045100A1 (en) * 2008-03-05 2011-02-24 Georgetown University Antimalarial Quinolines and Methods of Use Thereof
US8481543B2 (en) 2008-11-18 2013-07-09 Oregon Health & Science University Compounds for treating parasitic disease
EP2470013A4 (en) * 2009-08-27 2013-05-01 Us Health COMPOUNDS FOR THE TREATMENT OF MALARIA AND FOR PREVENTING MALARIA TRANSMISSIONS
EP2394982A1 (en) 2010-06-08 2011-12-14 Lonza Ltd. Process for the preparation of cis-diaminocycloalkanes
EP2394981A1 (en) 2010-06-08 2011-12-14 Lonza Ltd. Process for the preparation of cis-diaminocycloalkanes
EA023927B1 (ru) 2010-06-22 2016-07-29 Дна Терапьютикс ОПТИМИЗИРОВАННАЯ С ПОМОЩЬЮ ЭНДОСОМОЛИТИЧЕСКИХ СРЕДСТВ СИСТЕМА ДОСТАВКИ in vivo КОНЪЮГАТОВ НУКЛЕИНОВОЙ КИСЛОТЫ
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
WO2015133280A1 (ja) * 2014-03-03 2015-09-11 公立大学法人名古屋市立大学 抗マラリア活性化合物及び抗マラリア薬
EP3224235B1 (de) 2014-11-25 2018-11-14 Basf Se Verfahren zur herstellung von cis- und trans-angereichertem mdach
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
WO2018003708A1 (ja) * 2016-06-28 2018-01-04 大日本印刷株式会社 化合物、及びその中間体
JP2020505330A (ja) 2017-01-06 2020-02-20 アビディティー バイオサイエンシーズ エルエルシー エクソンスキッピングを誘導する核酸ポリペプチド組成物および方法
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
MX2020003596A (es) 2017-10-04 2020-07-22 Avidity Biosciences Inc Composiciones de acido nucleico-polipeptido y usos de las mismos.
AU2018378812A1 (en) 2017-12-06 2020-07-09 Avidity Biosciences, Inc. Compositions and methods of treating muscle atrophy and myotonic dystrophy
SG11202106593UA (en) 2018-12-21 2021-07-29 Avidity Biosciences Inc Anti-transferrin receptor antibodies and uses thereof
CN113412258A (zh) 2019-01-18 2021-09-17 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
WO2020247782A1 (en) 2019-06-06 2020-12-10 Avidity Biosciences, Inc. Nucleic acid-polypeptide compositions and uses thereof
IL296387B1 (en) 2020-03-19 2024-04-01 Avidity Biosciences Inc Preparations and methods for the treatment of facial, back and arm muscle atrophy
WO2021195469A1 (en) 2020-03-27 2021-09-30 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
EP4251746A1 (en) 2020-11-30 2023-10-04 Cellectis SA Use of aminoquinoline compounds for higher gene integration
KR20240055874A (ko) 2021-09-16 2024-04-29 어비디티 바이오사이언시스 인크. 안면견갑상완 근이영양증을 치료하는 조성물 및 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816893A (en) * 1957-12-17 Improvements in or relating to
US2901484A (en) * 1957-03-04 1959-08-25 Abbott Lab Bis-quinoliniums
US5510356A (en) * 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria

Also Published As

Publication number Publication date
DK0765313T3 (da) 2003-12-08
DE69531543D1 (de) 2003-09-25
AU2736995A (en) 1996-01-15
AU691306B2 (en) 1998-05-14
WO1995035287A1 (en) 1995-12-28
ZA954796B (en) 1996-01-03
IL114099A0 (en) 1995-10-31
US5736557A (en) 1998-04-07
NZ288223A (en) 1997-11-24
CA2192203A1 (en) 1995-12-28
CN1153513A (zh) 1997-07-02
EP0765313B1 (en) 2003-08-20
PT765313E (pt) 2003-11-28
MY115176A (en) 2003-04-30
ATE247642T1 (de) 2003-09-15
JPH10501540A (ja) 1998-02-10
DE69531543T2 (de) 2004-06-24
CN1120156C (zh) 2003-09-03
IL114099A (en) 2000-02-29
ES2204956T3 (es) 2004-05-01
EP0765313A1 (en) 1997-04-02

Similar Documents

Publication Publication Date Title
MX9606382A (es) Derivados de n,n'-bis(quinolin-4-il)diamina, su preparacion y su uso como compuestos antimalaria.
YU19002A (sh) Derivati hinolil-propil-piperidina, njihovo dobivanje i smeše koje ih sadrže
TW325458B (en) Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
CA2100258A1 (en) Acridine Derivatives
ES8704929A1 (es) Procedimiento para preparar derivados de acido quinoloncar- boxilico
PH30732A (en) Dideoxydide-hydrocarbocyclic nucleosides.
HK1031867A1 (en) 2-phenoxyaniline derivatives
EP0411912A3 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
TW337985B (en) "N-(B-branched alkyl)-1, 2-benzisothiolin, 3ones, their preparation and their use as industrial biocides"
ZA94748B (en) Cytotoxic and antiviral compound.
DE69814667D1 (en) Camptothecin-derivate
EP0470686A3 (en) (benzhydryloxyethylpiperidyl)aliphatic acid derivatives and their use in the treatment of allergies and asthma
ATE63921T1 (de) 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
AU631209B2 (en) Carboxamide derivatives
EP0470832A3 (en) Biphenyl 5, 5'-bis-alkanoic acid derivatives, their production and use thereof
HK1067948A1 (en) Antitumor indolopyprolocarbazole derivative
GB9918079D0 (en) New cytotoxic pyrido (2,3,4-kl) acridine derivatives
EP0242230A3 (en) Pyrido û1,2-a¨ pyrimidine derivatives
ZA908309B (en) Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives
ES8504715A1 (es) Derivados de benzo (f) quinolina
IL109255A (en) Process for the preparation of 6-fluoro-2-haloquinolines and their use in the preparation of antimicrobial 1,8-benzo(b) naphthyridine derivatives

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees