JP2021184721A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021184721A5 JP2021184721A5 JP2021126285A JP2021126285A JP2021184721A5 JP 2021184721 A5 JP2021184721 A5 JP 2021184721A5 JP 2021126285 A JP2021126285 A JP 2021126285A JP 2021126285 A JP2021126285 A JP 2021126285A JP 2021184721 A5 JP2021184721 A5 JP 2021184721A5
- Authority
- JP
- Japan
- Prior art keywords
- bispecific
- bcma
- binding fragment
- antibody
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 33
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 32
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 32
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 32
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960000684 cytarabine Drugs 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960004931 histamine dihydrochloride Drugs 0.000 claims 1
- PPZMYIBUHIPZOS-UHFFFAOYSA-N histamine dihydrochloride Chemical compound Cl.Cl.NCCC1=CN=CN1 PPZMYIBUHIPZOS-UHFFFAOYSA-N 0.000 claims 1
- 102000046935 human TNFRSF17 Human genes 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Claims (26)
- 組換えＢＣＭＡ×ＣＤ３二重特異性抗体又はそのＢＣＭＡ×ＣＤ３二重特異性結合フラグメントであって、
ａ）第１の重鎖（ＨＣ１）と、
ｂ）第２の重鎖（ＨＣ２）と、
ｃ）第１の軽鎖（ＬＣ１）と、
ｄ）第２の軽鎖（ＬＣ２）と、を含み、
ＨＣ１はＬＣ１と結合され、ＨＣ２はＬＣ２と結合され、ＣＤ３に免疫特異的に結合する第１の抗原結合部位を形成するために、ＨＣ１は配列番号５９、配列番号６０、及び配列番号６１を含み、ＬＣ１は配列番号６２、配列番号６３、及び配列番号６４を含み、またＢＣＭＡに免疫特異的に結合する第２の抗原結合部位を形成するために、ＨＣ２は配列番号４、配列番号５、及び配列番号６を含み、ＬＣ２は配列番号２４、配列番号２５、及び配列番号２６を含む、組換えＢＣＭＡ×ＣＤ３二重特異性抗体又はそのＢＣＭＡ×ＣＤ３二重特異性結合フラグメント。 - 配列番号５５を含むＨＣ１と、配列番号５６を含むＬＣ１と、配列番号６５を含むＨＣ２と、配列番号７６を含むＬＣ２と、を含む、請求項１に記載の組換えＢＣＭＡ×ＣＤ３二重特異性抗体又はそのフラグメント。
- 前記抗体又は二重特異性結合フラグメントはＩｇＧである、請求項２に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントはＩｇＧ４アイソタイプである、請求項１～３のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントは、表面プラズモン共鳴により測定するとき、少なくとも０．２２ｎＭの親和性でヒトＢＣＭＡに免疫特異的に結合する、請求項１～４のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又はその二重特異性結合フラグメントは、ヒト骨髄腫細胞の表面上のＢＣＭＡに結合する、請求項１～５のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又はその二重特異性結合フラグメントは、ヒト多発性骨髄腫細胞の表面上のＢＣＭＡに結合する、請求項１～６のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントは、約０．３７ｎＭ未満のＥＣ ５０ でインビトロでヒトＴ細胞活性化を誘発する、請求項１～７のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントは、約０．４５ｎＭ未満のＥＣ ５０ でインビトロでＢＣＭＡ発現細胞のＴ細胞依存性細胞傷害を誘発する、請求項１～８のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントは、ＢＣＭＡアゴニストではない、請求項１～９のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 前記抗体又は二重特異性結合フラグメントは、１０ｎＭ未満の濃度でＮＦ－κＢ活性化を変化させない、請求項１～１０のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント。
- 請求項１～１１のいずれか一項に記載の抗体又は二重特異性結合フラグメントを発現している、組換え細胞。
- 前記細胞はハイブリドーマである、請求項１２に記載の細胞。
- がんを有する対象を処置するための方法で用いるための医薬組成物であって、請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントを含み、前記方法は、前記ＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントの治療的に有効な量を、それを必要とする対象に、がんを処置するのに十分な時間投与することを含む、医薬組成物。
- がん細胞の成長又は増殖を阻害するための方法で用いるための医薬組成物であって、請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントを含み、前記方法は、前記ＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントの治療的に有効な量を投与し、がん細胞の成長又は増殖を阻害することを含む、医薬組成物。
- Ｔ細胞をＢＣＭＡ発現がん細胞にリダイレクトする方法で用いるための医薬組成物であって、請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントを含み、前記方法は、前記ＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントの治療的に有効な量を投与し、Ｔ細胞をがんにリダイレクトすることを含む、医薬組成物。
- 前記がんは血液がんである、請求項１４～１６のいずれか一項に記載の医薬組成物。
- 前記血液がんはＢＣＭＡ発現Ｂ細胞がんである、請求項１７に記載の医薬組成物。
- 前記ＢＣＭＡ発現Ｂ細胞がんは多発性骨髄腫である、請求項１８に記載の医薬組成物。
- 前記方法は第２の治療剤を投与することを更に含む、請求項１４に記載の医薬組成物。
- 前記第２の治療剤は、化学療法剤又は標的化抗がん治療剤である、請求項２０に記載の医薬組成物。
- 前記化学療法剤は、シタラビン、アントラサイクリン、ヒスタミン二塩酸塩、又はインターロイキン２である、請求項２１に記載の医薬組成物。
- 請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントと、医薬的に許容され得る担体と、を含む、医薬組成物。
- 請求項１２または１３に記載の細胞を培養することにより、請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントを生成するための方法。
- 請求項１～１１のいずれか一項に記載のＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメントのＨＣ１、ＨＣ２、ＬＣ１、およびＬＣ２をコードする、単離された合成ポリヌクレオチド。
- 請求項１～１１のいずれか一項に定義されるようなＢＣＭＡ×ＣＤ３二重特異性抗体又は二重特異性結合フラグメント、及び／又は請求項２５に定義されるようなポリヌクレオチド、及びこれらのための包装、を含む、キット。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022196582A JP2023027228A (ja) | 2015-08-17 | 2022-12-08 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562206246P | 2015-08-17 | 2015-08-17 | |
| US62/206,246 | 2015-08-17 | ||
| JP2018508695A JP2018525005A (ja) | 2015-08-17 | 2016-08-16 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508695A Division JP2018525005A (ja) | 2015-08-17 | 2016-08-16 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022196582A Division JP2023027228A (ja) | 2015-08-17 | 2022-12-08 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021184721A JP2021184721A (ja) | 2021-12-09 |
| JP2021184721A5 true JP2021184721A5 (ja) | 2022-07-12 |
| JP7194240B2 JP7194240B2 (ja) | 2022-12-21 |
Family
ID=56740579
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508695A Pending JP2018525005A (ja) | 2015-08-17 | 2016-08-16 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
| JP2021126285A Active JP7194240B2 (ja) | 2015-08-17 | 2021-07-30 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
| JP2022196582A Pending JP2023027228A (ja) | 2015-08-17 | 2022-12-08 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508695A Pending JP2018525005A (ja) | 2015-08-17 | 2016-08-16 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022196582A Pending JP2023027228A (ja) | 2015-08-17 | 2022-12-08 | 抗ｂｃｍａ抗体、ｂｃｍａ及びｃｄ３に結合する二重特異性抗原結合分子、並びにそれらの使用 |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US10072088B2 (ja) |
| EP (2) | EP3337824B1 (ja) |
| JP (3) | JP2018525005A (ja) |
| KR (1) | KR20180040671A (ja) |
| CN (1) | CN108350076B (ja) |
| AR (1) | AR105724A1 (ja) |
| AU (1) | AU2016308567B2 (ja) |
| BR (1) | BR112018003017A2 (ja) |
| CA (1) | CA2995754A1 (ja) |
| CL (1) | CL2018000431A1 (ja) |
| CO (1) | CO2018001524A2 (ja) |
| CY (1) | CY1123297T1 (ja) |
| DK (1) | DK3337824T3 (ja) |
| EA (1) | EA201890513A1 (ja) |
| EC (1) | ECSP18019568A (ja) |
| ES (1) | ES2814550T3 (ja) |
| FI (1) | FIC20230012I1 (ja) |
| FR (2) | FR23C1011I1 (ja) |
| HR (1) | HRP20201375T1 (ja) |
| HU (2) | HUE050556T2 (ja) |
| IL (2) | IL298041A (ja) |
| JO (1) | JO3799B1 (ja) |
| LT (2) | LT3337824T (ja) |
| MA (1) | MA53750A (ja) |
| MX (2) | MX2018002043A (ja) |
| MY (1) | MY191325A (ja) |
| NI (1) | NI201800027A (ja) |
| NL (1) | NL301219I2 (ja) |
| PE (1) | PE20180795A1 (ja) |
| PH (1) | PH12018500361A1 (ja) |
| PL (1) | PL3337824T3 (ja) |
| PT (1) | PT3337824T (ja) |
| RS (1) | RS60755B1 (ja) |
| SI (1) | SI3337824T1 (ja) |
| SV (1) | SV2018005634A (ja) |
| TW (3) | TWI811023B (ja) |
| UA (1) | UA127515C2 (ja) |
| UY (1) | UY36859A (ja) |
| WO (1) | WO2017031104A1 (ja) |
| ZA (1) | ZA201801789B (ja) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| ES2898329T3 (es) | 2016-01-12 | 2022-03-07 | Oncotracker Inc | Métodos mejorados para supervisar el estado inmunitario de un sujeto |
| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| EP3416687A4 (en) | 2016-02-17 | 2019-10-23 | Seattle Genetics, Inc. | BCMA ANTIBODIES AND USE THEREOF FOR THE TREATMENT OF CANCER AND IMMUNOLOGICAL ILLNESSES |
| CA3023678A1 (en) * | 2016-05-09 | 2017-11-16 | Bristol-Myers Squibb Company | Tl1a antibodies and uses thereof |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| CR20190198A (es) | 2016-09-14 | 2019-10-11 | Teneobio Inc | Anticuerpos de unión a cd3 |
| MX2019007379A (es) | 2016-12-21 | 2019-09-18 | Teneobio Inc | Anticuerpos anti-bcma unicamente de cadena pesada. |
| EP3577134A1 (en) | 2017-01-31 | 2019-12-11 | Novartis AG | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| EP3589662A4 (en) | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELINE BINDING PROTEINS |
| EP3639028A4 (en) * | 2017-06-13 | 2021-04-14 | Inc. Onco Tracker | DIAGNOSTIC, PROGNOSTIC AND MONITORING PROCEDURES FOR MALIGNE SOLID TUMORS |
| US11427642B2 (en) | 2017-06-20 | 2022-08-30 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
| CN110891971B (zh) | 2017-06-20 | 2024-01-12 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| WO2019000223A1 (en) * | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
| KR20200035066A (ko) * | 2017-08-01 | 2020-04-01 | 메디뮨 엘엘씨 | Bcma 단클론 항체-약물 접합체 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| KR20200047660A (ko) * | 2017-09-01 | 2020-05-07 | 다나-파버 캔서 인스티튜트 인크. | 암의 치료를 위한 bcma 및 taci 항원에 특이적인 면역원성 펩타이드 |
| BR112020007249B1 (pt) | 2017-10-13 | 2022-11-22 | Harpoon Therapeutics, Inc | Roteína de ligação a antígeno de maturação de célula b, proteína de ligação multiespecífica e uso das referidas proteínas |
| BR112020007196A2 (pt) * | 2017-10-13 | 2020-12-01 | Harpoon Therapeutics, Inc. | proteínas triespecíficas e métodos de uso |
| JP2021501570A (ja) | 2017-10-18 | 2021-01-21 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
| MX2020004243A (es) * | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Receptores de anticuerpos y de antigenos quimericos especificos para el antigeno de maduracion de celulas b. |
| WO2019099639A1 (en) | 2017-11-15 | 2019-05-23 | Navartis Ag | Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies |
| WO2019108900A1 (en) | 2017-11-30 | 2019-06-06 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| TW201930591A (zh) | 2018-01-08 | 2019-08-01 | 瑞士商諾華公司 | 用於與嵌合抗原受體療法併用之免疫增強rna |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| EP3752203A1 (en) | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| WO2019190969A1 (en) * | 2018-03-26 | 2019-10-03 | Sutro Biopharma, Inc. | Anti-bcma receptor antibodies, compositions comprising anti bcma receptor antibodies and methods of making and using anti-bcma antibodies |
| KR20200143436A (ko) * | 2018-04-13 | 2020-12-23 | 아피메트 게엠베하 | Nk 세포 결합 항체 융합 구조체 |
| KR20220080044A (ko) * | 2018-05-16 | 2022-06-14 | 얀센 바이오테크 인코포레이티드 | 암 요법에 사용하기 위한 bcma/cd3 및 gprdc5d/cd3 이중특이성 항체 |
| EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
| EP3806962A1 (en) | 2018-06-13 | 2021-04-21 | Novartis AG | Bcma chimeric antigen receptors and uses thereof |
| WO2019241686A1 (en) * | 2018-06-14 | 2019-12-19 | Bluebird Bio, Inc. | Anti-bcma car antibodies, conjugates, and methods of use |
| WO2020004934A1 (ko) * | 2018-06-26 | 2020-01-02 | 에이비엘바이오 주식회사 | 항-bcma 항체 및 그 용도 |
| US11845797B2 (en) | 2018-07-03 | 2023-12-19 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| MA53168A (fr) | 2018-07-19 | 2021-05-26 | Regeneron Pharma | Anticorps anti-bcma x anti-cd3 bispécifiques et leurs utilisations |
| US20210284732A1 (en) * | 2018-07-31 | 2021-09-16 | Amgen Research (Munich) Gmbh | Dosing regimen for bcma-cd3 bispecific antibodies |
| EP3844267A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
| AU2019346466A1 (en) | 2018-09-25 | 2021-05-20 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| PE20211867A1 (es) * | 2018-11-01 | 2021-09-21 | Shandong New Time Pharmaceutical Co Ltd | Anticuerpos biespecificos y su uso |
| CN113412124A (zh) * | 2018-12-19 | 2021-09-17 | 希望之城 | Baff-r双特异性t细胞衔接子抗体 |
| MX2021009189A (es) * | 2019-02-01 | 2021-11-12 | Glaxosmithkline Ip Dev Ltd | Belantamab mafodotin en combinación con pembrolizumab para el tratamiento del cáncer. |
| AU2020229806A1 (en) | 2019-02-25 | 2021-07-29 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
| SG11202109163YA (en) * | 2019-02-26 | 2021-09-29 | Sorrento Therapeutics Inc | Antigen binding proteins that bind bcma |
| WO2020191316A1 (en) | 2019-03-21 | 2020-09-24 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| AU2020240132A1 (en) | 2019-03-21 | 2021-09-16 | Regeneron Pharmaceuticals, Inc. | Combination of IL-4/IL-13 pathway inhibitors and plasma cell ablation for treating allergy |
| EP3953455A1 (en) | 2019-04-12 | 2022-02-16 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| EP3733707A1 (en) | 2019-04-30 | 2020-11-04 | Celyad S.A. | Car t-cells targeting bcma and uses thereof |
| CA3134918A1 (en) * | 2019-05-03 | 2020-11-12 | John Lee | Anti-bcma antibody conjugate, compositions comprising the same, and methods of making and using the same |
| PE20220575A1 (es) | 2019-06-14 | 2022-04-20 | Teneobio Inc | Anticuerpos multiespecificos de cadena pesada que se unen a cd22 y cd3 |
| CN111269315B (zh) * | 2019-06-19 | 2022-04-08 | 北京智仁美博生物科技有限公司 | 针对bcma的单克隆抗体 |
| CN112585168B (zh) * | 2019-07-30 | 2022-04-15 | 上海翰森生物医药科技有限公司 | 抗bcma抗体、其抗原结合片段及其医药用途 |
| WO2021092060A1 (en) * | 2019-11-05 | 2021-05-14 | Engmab Sarl | Methods of treatment |
| JP2023503163A (ja) | 2019-11-26 | 2023-01-26 | ノバルティス アーゲー | キメラ抗原受容体及びその使用 |
| EP4069373A1 (en) | 2019-12-06 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Methods of treating multiple myeloma with bispecific anti-bcma x anti-cd3 antibodies |
| WO2021118246A1 (en) * | 2019-12-10 | 2021-06-17 | Abl Bio, Inc. | Anti-bcma/anti-4-1bb bispecific antibodies and uses thereof |
| WO2021132746A1 (en) * | 2019-12-24 | 2021-07-01 | Abl Bio, Inc. | Anti-bcma/anti-4-1bb bispecific antibodies and uses thereof |
| JP2023506262A (ja) * | 2019-12-16 | 2023-02-15 | ２セブンティ バイオ インコーポレイテッド | 抗ｂｃｍａ ｃａｒ抗体、コンジュゲートおよび使用方法 |
| WO2021173985A2 (en) | 2020-02-27 | 2021-09-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| KR20220147109A (ko) | 2020-02-27 | 2022-11-02 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| IL296358A (en) * | 2020-03-13 | 2022-11-01 | Janssen Biotech Inc | Materials and methods for modulating delta chain-mediated immunity |
| TW202144425A (zh) * | 2020-04-17 | 2021-12-01 | 大陸商上海翰森生物醫藥科技有限公司 | 特異性抗原結合分子，其製備方法及醫藥用途 |
| CN115894703A (zh) | 2020-04-29 | 2023-04-04 | 特尼奥生物股份有限公司 | 具有经修饰重链恒定区的多特异性重链抗体 |
| UY39191A (es) * | 2020-04-29 | 2021-11-30 | Teneobio Inc | Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas |
| CA3182697A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Biotech, Inc. | Methods for treating multiple myeloma |
| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| AU2021274151A1 (en) | 2020-05-19 | 2023-02-02 | Janssen Biotech, Inc. | Compositions comprising a T cell redirection therapeutic and a VLA-4 adhesion pathway inhibitor |
| IL298473A (en) | 2020-06-11 | 2023-01-01 | Novartis Ag | zbtb32 inhibitors and uses thereof |
| EP4171750A1 (en) | 2020-06-30 | 2023-05-03 | Teneobio, Inc. | Multi-specific antibodies binding to bcma |
| CN114075287B (zh) * | 2020-08-18 | 2023-07-21 | 湖南远泰生物技术有限公司 | 人源化bcma抗体和bcma-car-t细胞 |
| KR20230058427A (ko) | 2020-08-21 | 2023-05-03 | 노파르티스 아게 | Car 발현 세포의 생체내 생성을 위한 조성물 및 방법 |
| US20230398147A1 (en) | 2020-09-16 | 2023-12-14 | Amgen Inc. | Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer |
| WO2022098771A1 (en) * | 2020-11-03 | 2022-05-12 | Ab Studio Inc. | Multispecific antibodies and uses thereof |
| EP4240756A1 (en) | 2020-11-04 | 2023-09-13 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
| WO2022135468A1 (zh) * | 2020-12-23 | 2022-06-30 | 信达生物制药(苏州)有限公司 | 抗bcma×cd3双特异性抗体及其用途 |
| US20220233690A1 (en) | 2021-01-28 | 2022-07-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for treating cytokine release syndrome |
| CN117279953A (zh) | 2021-02-16 | 2023-12-22 | 詹森药业有限公司 | 靶向bcma、gprc5d和cd3的三特异性抗体 |
| EP4301785A1 (en) * | 2021-03-05 | 2024-01-10 | Atreca, Inc. | Epha2 antibodies |
| US20220315663A1 (en) | 2021-03-24 | 2022-10-06 | Janssen Pharmaceutica Nv | TRISPECIFIC ANTIBODY TARGETING CD79b, CD20, AND CD3 |
| GB2623199A (en) | 2021-04-08 | 2024-04-10 | Marengo Therapeutics Inc | Multifunctional molecules binding to TCR and uses thereof |
| EP4330381A1 (en) | 2021-04-27 | 2024-03-06 | Novartis AG | Viral vector production system |
| US11931420B2 (en) | 2021-04-30 | 2024-03-19 | Celgene Corporation | Combination therapies using an anti-BCMA antibody drug conjugate (ADC) in combination with a gamma secretase inhibitor (GSI) |
| TW202309522A (zh) | 2021-05-11 | 2023-03-01 | 美商健生生物科技公司 | 用於監測復發性及／或難治性多發性骨髓瘤之治療的方法及組成物 |
| AU2022281104A1 (en) | 2021-05-28 | 2024-01-18 | Janssen Biotech, Inc. | Bcma as a target for t cell redirecting antibodies in b cell lymphomas |
| CN115521381A (zh) * | 2021-06-24 | 2022-12-27 | 益科思特(北京)医药科技发展有限公司 | 结合bcma和cd3的双特异性抗体及其制备方法与应用 |
| CN115569191A (zh) * | 2021-07-05 | 2023-01-06 | 山东新时代药业有限公司 | 一种重组人源化抗bcma/cd3双特异性抗体冻干制剂 |
| WO2023020474A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Bcma targetting antibodies and uses thereof in cancer therapies |
| AR126838A1 (es) | 2021-08-20 | 2023-11-22 | Novartis Ag | Métodos para preparar células que expresan receptores de antígeno quiméricos |
| WO2023076921A1 (en) * | 2021-10-27 | 2023-05-04 | Janssen Biotech, Inc. | Methods for enhanced bcma immunohistochemistry detection in human and monkey tissue |
| CA3237175A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
| US20230279136A1 (en) * | 2021-11-10 | 2023-09-07 | Janssen Biotech, Inc. | Stable formulations comprising a bispecific bcma/cd3 antibody |
| WO2023098846A1 (zh) * | 2021-12-03 | 2023-06-08 | 江苏先声药业有限公司 | 抗bcma纳米抗体及其应用 |
| US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| CN117003871A (zh) * | 2022-04-28 | 2023-11-07 | 北京天广实生物技术股份有限公司 | 结合bcma和cd3的抗体及其用途 |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| WO2024095173A1 (en) | 2022-11-02 | 2024-05-10 | Janssen Biotech, Inc. | Methods of treating cancers |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| CN117186229B (zh) * | 2022-12-06 | 2024-03-29 | 成都赛恩吉诺生物科技有限公司 | 具有长cdr3序列的抗人bcma纳米抗体及car-t和应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521427B1 (en) | 1997-09-16 | 2003-02-18 | Egea Biosciences, Inc. | Method for the complete chemical synthesis and assembly of genes and genomes |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| WO2001024812A1 (en) | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| JP2004533997A (ja) | 2001-02-20 | 2004-11-11 | ザイモジェネティクス，インコーポレイティド | Ｂｃｍａ及びｔａｃｉの両者を結合する抗体 |
| CA2577082A1 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
| EP3178850B1 (en) | 2005-10-11 | 2021-01-13 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
| KR101866623B1 (ko) | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| WO2007117600A2 (en) | 2006-04-07 | 2007-10-18 | Macrogenics, Inc. | Combination therapy for treating autoimmune diseases |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| US20100183615A1 (en) | 2007-04-03 | 2010-07-22 | Micromet Ag | Cross-species-specific bispecific binders |
| TR201816277T4 (tr) | 2007-04-03 | 2018-11-21 | Amgen Res Munich Gmbh | Çapraz-tür-spesifik bağlama alanı. |
| SI2155783T1 (sl) | 2007-04-03 | 2013-10-30 | Amgen Research (Munich) Gmbh | Medvrstno specifiäśna cd3-epsilon vezavna domena |
| AU2009239437B2 (en) | 2008-04-25 | 2014-11-13 | University Of Washington | Levels of BCMA protein expression on B cells and use in diagnostic methods |
| HUE030090T2 (en) | 2008-10-01 | 2017-04-28 | Amgen Res (Munich) Gmbh | Species specific PSMAxCD3 bispecific single chain antibody |
| AU2009299793B2 (en) | 2008-10-01 | 2016-03-10 | Amgen Research (Munich) Gmbh | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| AU2009299794B2 (en) | 2008-10-01 | 2015-08-13 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
| WO2010051274A2 (en) | 2008-10-31 | 2010-05-06 | Centocor Ortho Biotech Inc. | Fibronectin type iii domain based scaffold compositions, methods and uses |
| MX2011008566A (es) | 2009-02-12 | 2011-11-29 | Janssen Biotech Inc | Composiciones supercontigo basadas en el dominio de fibronectina tipo iii, metodos y usos. |
| EP3141562A1 (en) | 2009-03-10 | 2017-03-15 | Biogen MA Inc. | Anti-bcma antibodies |
| EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| US9150663B2 (en) | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| EP3974453A3 (en) | 2010-11-16 | 2022-08-03 | Amgen Inc. | Agents and methods for treating diseases that correlate with bcma expression |
| US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| AU2012289926A1 (en) * | 2011-08-03 | 2014-03-13 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| KR102052774B1 (ko) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Ｆｃ 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계 |
| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| DK3653049T3 (da) | 2012-12-14 | 2023-11-13 | Omniab Inc | Polynukleotider, der koder for gnaverantistoffer med humane idiotyper, og dyr, der omfatter disse |
| EP3620468A1 (en) | 2013-02-05 | 2020-03-11 | EngMab Sàrl | Method for the selection of antibodies against bcma |
| EP2762497A1 (en) * | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
-
2016
- 2016-08-16 HU HUE16754148A patent/HUE050556T2/hu unknown
- 2016-08-16 KR KR1020187007297A patent/KR20180040671A/ko not_active Application Discontinuation
- 2016-08-16 EP EP16754148.1A patent/EP3337824B1/en active Active
- 2016-08-16 UA UAA201802674A patent/UA127515C2/uk unknown
- 2016-08-16 US US15/237,889 patent/US10072088B2/en active Active
- 2016-08-16 EA EA201890513A patent/EA201890513A1/ru unknown
- 2016-08-16 CN CN201680060812.2A patent/CN108350076B/zh active Active
- 2016-08-16 MA MA053750A patent/MA53750A/fr unknown
- 2016-08-16 MX MX2018002043A patent/MX2018002043A/es unknown
- 2016-08-16 EP EP20177664.8A patent/EP3757131A1/en active Pending
- 2016-08-16 RS RS20201050A patent/RS60755B1/sr unknown
- 2016-08-16 LT LTEP16754148.1T patent/LT3337824T/lt unknown
- 2016-08-16 TW TW111126438A patent/TWI811023B/zh active
- 2016-08-16 MY MYPI2018700579A patent/MY191325A/en unknown
- 2016-08-16 IL IL298041A patent/IL298041A/en unknown
- 2016-08-16 CA CA2995754A patent/CA2995754A1/en active Pending
- 2016-08-16 TW TW105126031A patent/TWI777924B/zh active
- 2016-08-16 DK DK16754148.1T patent/DK3337824T3/da active
- 2016-08-16 WO PCT/US2016/047146 patent/WO2017031104A1/en active Application Filing
- 2016-08-16 PT PT167541481T patent/PT3337824T/pt unknown
- 2016-08-16 JO JOP/2016/0184A patent/JO3799B1/ar active
- 2016-08-16 PE PE2018000262A patent/PE20180795A1/es unknown
- 2016-08-16 ES ES16754148T patent/ES2814550T3/es active Active
- 2016-08-16 SI SI201630895T patent/SI3337824T1/sl unknown
- 2016-08-16 JP JP2018508695A patent/JP2018525005A/ja active Pending
- 2016-08-16 AU AU2016308567A patent/AU2016308567B2/en active Active
- 2016-08-16 PL PL16754148T patent/PL3337824T3/pl unknown
- 2016-08-16 TW TW112124028A patent/TW202406935A/zh unknown
- 2016-08-16 BR BR112018003017-1A patent/BR112018003017A2/pt active Search and Examination
- 2016-08-17 AR ARP160102519A patent/AR105724A1/es unknown
- 2016-08-17 UY UY0001036859A patent/UY36859A/es active IP Right Grant
-
2018
- 2018-02-11 IL IL257468A patent/IL257468B2/en unknown
- 2018-02-15 PH PH12018500361A patent/PH12018500361A1/en unknown
- 2018-02-16 CL CL2018000431A patent/CL2018000431A1/es unknown
- 2018-02-16 CO CONC2018/0001524A patent/CO2018001524A2/es unknown
- 2018-02-16 NI NI201800027A patent/NI201800027A/es unknown
- 2018-02-16 SV SV2018005634A patent/SV2018005634A/es unknown
- 2018-02-16 MX MX2022006650A patent/MX2022006650A/es unknown
- 2018-03-14 EC ECIEPI201819568A patent/ECSP18019568A/es unknown
- 2018-03-16 ZA ZA201801789A patent/ZA201801789B/en unknown
-
2020
- 2020-08-28 HR HRP20201375TT patent/HRP20201375T1/hr unknown
- 2020-08-28 CY CY20201100810T patent/CY1123297T1/el unknown
-
2021
- 2021-07-30 JP JP2021126285A patent/JP7194240B2/ja active Active
-
2022
- 2022-12-08 JP JP2022196582A patent/JP2023027228A/ja active Pending
-
2023
- 2023-02-22 FR FR23C1011C patent/FR23C1011I1/fr active Active
- 2023-02-22 FI FIC20230012C patent/FIC20230012I1/fi unknown
- 2023-02-22 FR FR23C1012C patent/FR23C1012I1/fr active Active
- 2023-02-22 NL NL301219C patent/NL301219I2/nl unknown
- 2023-02-22 HU HUS2300011C patent/HUS2300011I1/hu unknown
- 2023-02-23 LT LTPA2023509C patent/LTPA2023509I1/lt unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021184721A5 (ja) | ||
| JP2019107018A5 (ja) | ||
| JP2018534933A5 (ja) | ||
| JP2017529838A5 (ja) | ||
| JP2008529497A5 (ja) | ||
| JP2022050618A5 (ja) | ||
| JP2004510752A5 (ja) | ||
| RU2007133108A (ru) | АНТИТЕЛА, СВЯЗЫВАЮЩИЕСЯ С EphA2, И МЕТОДЫ ИХ ИСПОЛЬЗОВАНИЯ | |
| RU2019111722A (ru) | Антитела против siglec-15 и способы их применения | |
| FI3394103T3 (fi) | Anti-PD-1-vasta-aineiden ja bispesifisten anti-CD20-/anti-CD3-vasta-aineiden yhdistelmä syövän hoitoon | |
| JP2020522513A5 (ja) | ||
| JP2011507932A5 (ja) | ||
| JP2017534253A5 (ja) | ||
| JP2007532139A5 (ja) | ||
| JP2006514024A5 (ja) | ||
| JP2017510559A5 (ja) | ||
| JP2010500371A5 (ja) | ||
| CA2798390A1 (en) | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies | |
| RU2013102225A (ru) | АНТИТЕЛА ПРОТИВ Axl И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| JP2009541492A5 (ja) | ||
| JP2013527761A5 (ja) | ||
| JP2014503189A5 (ja) | ||
| JP2010526028A5 (ja) | ||
| JP2020527332A5 (ja) | ||
| JP2014502955A5 (ja) |