JP2021138755A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021138755A5 JP2021138755A5 JP2021098226A JP2021098226A JP2021138755A5 JP 2021138755 A5 JP2021138755 A5 JP 2021138755A5 JP 2021098226 A JP2021098226 A JP 2021098226A JP 2021098226 A JP2021098226 A JP 2021098226A JP 2021138755 A5 JP2021138755 A5 JP 2021138755A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- unsubstituted
- above formula
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- IDOWYTYJUQMYTE-UHFFFAOYSA-N 2-[3-(diethylamino)propylamino]-4-[(4-methylcyclohexyl)amino]pyrimidine-5-carbonitrile Chemical compound CCN(CC)CCCNC1=NC=C(C#N)C(NC2CCC(C)CC2)=N1 IDOWYTYJUQMYTE-UHFFFAOYSA-N 0.000 claims 1
- PRVXZIQLVKRULX-UHFFFAOYSA-N 4-(3-methylbutylamino)-2-[3-(2-methylpiperidin-1-yl)propylamino]pyrimidine-5-carbonitrile Chemical compound C1=C(C#N)C(NCCC(C)C)=NC(NCCCN2C(CCCC2)C)=N1 PRVXZIQLVKRULX-UHFFFAOYSA-N 0.000 claims 1
- GBKXVXDNYFHIKP-UHFFFAOYSA-N 4-(cycloheptylamino)-2-[3-(2-methylpiperidin-1-yl)propylamino]pyrimidine-5-carbonitrile Chemical compound CC1CCCCN1CCCNC1=NC=C(C#N)C(NC2CCCCCC2)=N1 GBKXVXDNYFHIKP-UHFFFAOYSA-N 0.000 claims 1
- OBRZLFUDLHNMRP-UHFFFAOYSA-N 4-[(4-methylcyclohexyl)amino]-2-[3-(2-methylpiperidin-1-yl)propylamino]pyrimidine-5-carbonitrile Chemical compound C1CC(C)CCC1NC1=NC(NCCCN2C(CCCC2)C)=NC=C1C#N OBRZLFUDLHNMRP-UHFFFAOYSA-N 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 0 CCC(C(C)*)*(C)*C(IC(CC1)CCC1OCC)=C Chemical compound CCC(C(C)*)*(C)*C(IC(CC1)CCC1OCC)=C 0.000 description 37
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- QRMPKOFEUHIBNM-UHFFFAOYSA-N CC1CCC(C)CC1 Chemical compound CC1CCC(C)CC1 QRMPKOFEUHIBNM-UHFFFAOYSA-N 0.000 description 2
- MQWCXKGKQLNYQG-UHFFFAOYSA-N CC(CC1)CCC1O Chemical compound CC(CC1)CCC1O MQWCXKGKQLNYQG-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023183330A JP2023179797A (ja) | 2011-04-22 | 2023-10-25 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478076P | 2011-04-22 | 2011-04-22 | |
| US61/478,076 | 2011-04-22 | ||
| US201161555339P | 2011-11-03 | 2011-11-03 | |
| US61/555,339 | 2011-11-03 | ||
| JP2019052826A JP6898961B2 (ja) | 2011-04-22 | 2019-03-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019052826A Division JP6898961B2 (ja) | 2011-04-22 | 2019-03-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183330A Division JP2023179797A (ja) | 2011-04-22 | 2023-10-25 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021138755A JP2021138755A (ja) | 2021-09-16 |
| JP2021138755A5 true JP2021138755A5 (enExample) | 2021-12-16 |
| JP7374955B2 JP7374955B2 (ja) | 2023-11-07 |
Family
ID=46025954
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506559A Active JP6027095B2 (ja) | 2011-04-22 | 2012-04-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2016202099A Active JP6502302B2 (ja) | 2011-04-22 | 2016-10-13 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2019052826A Active JP6898961B2 (ja) | 2011-04-22 | 2019-03-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2021098226A Active JP7374955B2 (ja) | 2011-04-22 | 2021-06-11 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2023183330A Pending JP2023179797A (ja) | 2011-04-22 | 2023-10-25 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506559A Active JP6027095B2 (ja) | 2011-04-22 | 2012-04-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2016202099A Active JP6502302B2 (ja) | 2011-04-22 | 2016-10-13 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
| JP2019052826A Active JP6898961B2 (ja) | 2011-04-22 | 2019-03-20 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183330A Pending JP2023179797A (ja) | 2011-04-22 | 2023-10-25 | 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法 |
Country Status (35)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012245387C1 (en) | 2011-04-22 | 2016-05-05 | Signal Pharmaceuticals, Llc | Substituted Diaminocarboxamide and Diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
| SG11201503395TA (en) * | 2012-11-08 | 2015-05-28 | Bristol Myers Squibb Co | ALKYL AMIDE-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL IN THE MODULATION OF IL-12, IL-23 AND/OR IFNα |
| KR102243637B1 (ko) | 2013-03-14 | 2021-04-26 | 리커리엄 아이피 홀딩스, 엘엘씨 | 바이사이클릭 진통 화합물 |
| WO2015039613A1 (zh) * | 2013-09-18 | 2015-03-26 | 北京韩美药品有限公司 | 抑制btk和/或jak3激酶活性的化合物 |
| JP6345786B2 (ja) | 2013-12-05 | 2018-06-20 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼの阻害剤 |
| EP3080072A4 (en) | 2013-12-12 | 2017-07-19 | Kalyra Pharmaceuticals, inc. | Bicyclic alkyl compounds and synthesis |
| RU2016129380A (ru) * | 2013-12-20 | 2018-01-25 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием |
| NZ715903A (en) * | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| WO2015134710A1 (en) | 2014-03-07 | 2015-09-11 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
| WO2016044331A1 (en) | 2014-09-17 | 2016-03-24 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| ES2877642T3 (es) * | 2014-12-16 | 2021-11-17 | Signal Pharm Llc | Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida |
| WO2016100308A1 (en) | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| US20180022710A1 (en) | 2015-01-29 | 2018-01-25 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| EP3795553B1 (en) | 2015-07-24 | 2024-05-15 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
| WO2018019244A1 (zh) * | 2016-07-27 | 2018-02-01 | 广东东阳光药业有限公司 | 2,6-二甲基嘧啶酮衍生物的盐及其用途 |
| WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
| EP3509586A4 (en) * | 2016-09-12 | 2020-05-06 | Imago Pharmaceuticals, Inc. | TREATMENT OF FIBROTIC DISORDERS WITH JUN N-TERMINAL KINASE INHIBITORS |
| WO2018104916A1 (en) | 2016-12-09 | 2018-06-14 | Cadila Healthcare Limited | Treatment for primary biliary cholangitis |
| MX389668B (es) | 2017-05-15 | 2025-03-20 | Recurium Ip Holdings Llc | Compuestos biciclo[1.1.1]pentilo sustituidos y uso de los mismos para el tratamiento del dolor y fiebre. |
| MA49858A (fr) * | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| DK3676297T3 (da) | 2017-09-01 | 2023-08-14 | Denali Therapeutics Inc | Forbindelser, sammensætninger og fremgangsmåder |
| CN107573249B (zh) * | 2017-09-25 | 2018-12-25 | 上海馨远医药科技有限公司 | 一种反式4-烷氧基环己胺的制备方法 |
| SG11202003827YA (en) | 2017-11-01 | 2020-05-28 | Bristol Myers Squibb Co | Bridged bicyclic compounds as farnesoid x receptor modulators |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| CN111718332B (zh) * | 2019-03-19 | 2021-08-17 | 北京赛特明强医药科技有限公司 | 2-取代吡唑氨基-4-取代氨基-5-嘧啶甲酰胺类化合物、组合物及其应用 |
| CN114302878A (zh) | 2019-07-03 | 2022-04-08 | 大日本住友制药肿瘤公司 | 酪氨酸激酶非受体1(tnk1)抑制剂及其用途 |
| MX2022001413A (es) * | 2019-08-06 | 2022-03-29 | Lilly Co Eli | Compuesto de pirimidina-5-carboxamida. |
| CN112574123B (zh) * | 2019-09-30 | 2024-06-11 | 武汉朗来科技发展有限公司 | Jnk抑制剂、其药物组合物和用途 |
| WO2021178485A1 (en) * | 2020-03-06 | 2021-09-10 | National Health Research Institutes | Pyrimidine compounds and their pharmaceutical uses |
| CN113698408B (zh) * | 2020-05-22 | 2025-07-25 | 武汉朗来科技发展有限公司 | Jnk抑制剂、其药物组合物和用途 |
| WO2022048684A1 (zh) * | 2020-09-07 | 2022-03-10 | 武汉朗来科技发展有限公司 | Jnk抑制剂、其药物组合物和用途 |
| WO2022098809A1 (en) * | 2020-11-09 | 2022-05-12 | Merck Sharp & Dohme Corp. | Diaminopyrimidine carboxamide inhibitors of hpk1 |
| CN117500778A (zh) * | 2021-02-22 | 2024-02-02 | 普林斯顿大学保管委员会 | 2-取代的双环[1.1.1]戊烷 |
| AU2022412835A1 (en) | 2021-12-16 | 2024-06-20 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
| WO2023108536A1 (en) * | 2021-12-16 | 2023-06-22 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
| CN114315738B (zh) * | 2022-01-15 | 2023-08-18 | 重庆东寰科技开发有限公司 | 一种2,4-二氨基嘧啶-3-氧化物的制备方法 |
| WO2024097940A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Therapy for the treatment of cancer |
| CN120457121A (zh) * | 2022-12-30 | 2025-08-08 | 杭州矩阵生物药业有限公司 | 具有jnk抑制活性的嘧啶类衍生物及其应用 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH549339A (de) | 1971-05-12 | 1974-05-31 | Ciba Geigy Ag | Herbizides mittel. |
| US4301281A (en) * | 1979-04-18 | 1981-11-17 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid amides |
| DE3338859A1 (de) * | 1983-10-26 | 1985-05-09 | Bayer Ag, 5090 Leverkusen | Substituierte pyrimidine |
| DE69839338T2 (de) * | 1997-02-05 | 2008-07-10 | Warner-Lambert Company Llc | Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation |
| DE69839735D1 (de) * | 1997-12-15 | 2008-08-28 | Astellas Pharma Inc | Pyrimidin-5-carboxamid-derivate |
| EE200000706A (et) | 1998-05-26 | 2002-06-17 | Warner-Lambert Company | Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid |
| DE69933680T2 (de) | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
| JP4622047B2 (ja) | 1999-06-09 | 2011-02-02 | アステラス製薬株式会社 | 新規なヘテロ環カルボキサミド誘導体 |
| US6797706B1 (en) * | 1999-06-09 | 2004-09-28 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclecarboxamide derivative |
| WO2000076980A1 (en) | 1999-06-10 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Novel nitrogen-contaiing heterocyclic derivatives or salts thereof |
| DE60006541D1 (de) | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| JP4329290B2 (ja) * | 2000-10-06 | 2009-09-09 | 田辺三菱製薬株式会社 | 脂肪族含窒素五員環化合物 |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AU2003220968A1 (en) * | 2002-03-28 | 2003-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Anti-inflammatory agent |
| KR20050008849A (ko) | 2002-06-25 | 2005-01-21 | 교와 핫꼬 고교 가부시끼가이샤 | 2 환성 복소환 화합물 |
| JP4529685B2 (ja) * | 2002-06-28 | 2010-08-25 | アステラス製薬株式会社 | ジアミノピリミジンカルボキサミド誘導体 |
| HRP20050089B1 (hr) * | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| PL376823A1 (pl) * | 2002-11-01 | 2006-01-09 | Abbott Laboratories | Środki przeciwzakaźne |
| US7902203B2 (en) | 2002-11-01 | 2011-03-08 | Abbott Laboratories, Inc. | Anti-infective agents |
| JPWO2004054617A1 (ja) | 2002-12-13 | 2006-04-20 | 協和醗酵工業株式会社 | 中枢疾患の予防および／または治療剤 |
| JP2006516561A (ja) | 2003-01-17 | 2006-07-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類 |
| DE602004022633D1 (de) * | 2003-01-30 | 2009-10-01 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
| CN100497339C (zh) * | 2003-04-10 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 嘧啶并化合物 |
| EP1518655A1 (en) * | 2003-07-24 | 2005-03-30 | John Palmer Corp. | Apparatus for and process of gas-assisted injection molding of plastics material |
| BR122019017579B8 (pt) | 2003-08-15 | 2021-07-27 | Novartis Ag | 2,4-pirimidinadiaminas, seus usos, combinação e composição farmacêutica |
| CN1871009A (zh) | 2003-09-24 | 2006-11-29 | 惠氏控股公司 | 作为抗癌剂的5－芳基嘧啶 |
| US7253204B2 (en) * | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| WO2005095382A1 (ja) | 2004-03-30 | 2005-10-13 | Kyowa Hakko Kogyo Co., Ltd. | 抗腫瘍剤 |
| CA2571937A1 (en) * | 2004-07-08 | 2006-02-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| AU2005281736A1 (en) | 2004-09-10 | 2006-03-16 | Altana Pharma Ag | Roflumilast and syk inhibitor combination and methods of use thereof |
| US20080027034A1 (en) | 2004-09-10 | 2008-01-31 | Shah Tushar P | Ciclesonide and Syk Inhibitor Combination and Method of Use Thereof |
| JP2006124387A (ja) | 2004-09-30 | 2006-05-18 | Taisho Pharmaceut Co Ltd | 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法 |
| ES2380631T3 (es) | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posición 5 inhibidoras de VIH |
| WO2006091737A1 (en) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| GT200600105A (es) | 2005-03-10 | 2007-02-14 | Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos. | |
| AU2006283940A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 MAP kinase inhibitors and methods for using the same |
| WO2007032445A1 (ja) | 2005-09-16 | 2007-03-22 | Kyowa Hakko Kogyo Co., Ltd. | タンパク質キナーゼ阻害剤 |
| WO2007036791A1 (en) * | 2005-09-28 | 2007-04-05 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| WO2007076247A1 (en) * | 2005-12-21 | 2007-07-05 | Boehringer Ingelheim International Gmbh | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US20080139531A1 (en) | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| DK2146779T3 (en) | 2007-04-18 | 2016-11-28 | Pfizer Prod Inc | Sulfonylamid derivatives to treat abnormal cell growth. |
| KR20100017441A (ko) | 2007-04-27 | 2010-02-16 | 아스트라제네카 아베 | 증식성 병태를 치료하기 위한 ＥｐｈＢ4 키나제 억제제로서의 Ｎ'-(페닐)-Ｎ-(모르폴린-4-일-피리딘-2-일)-피리미딘-2,4-디아민 유도체 |
| WO2009010789A2 (en) | 2007-07-16 | 2009-01-22 | Astrazeneca Ab | Pyrimidine derivatives 934 |
| AU2008275918B2 (en) | 2007-07-17 | 2014-01-30 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as PKC inhibitors |
| EP2321283B1 (en) * | 2008-04-16 | 2016-07-13 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors |
| MX2010011463A (es) * | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
| CA2728893C (en) * | 2008-04-16 | 2017-03-14 | Portola Pharmaceuticals, Inc. | Inhibitors of syk protein kinase |
| JP2011518219A (ja) | 2008-04-22 | 2011-06-23 | ポートラ ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼの阻害剤 |
| JP2011518216A (ja) | 2008-04-22 | 2011-06-23 | アストラゼネカ アクチボラグ | 置換ピリミジン−５−カルボキサミド |
| CN102015704A (zh) * | 2008-04-29 | 2011-04-13 | 霍夫曼-拉罗奇有限公司 | Jnk的嘧啶基吡啶酮抑制剂 |
| MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| PE20100087A1 (es) | 2008-06-25 | 2010-02-08 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| SG10201510696RA (en) | 2008-06-27 | 2016-01-28 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
| BRPI0918472A2 (pt) * | 2008-09-01 | 2015-12-01 | Astellas Pharma Inc | composto 2,4-diaminopirimidina |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| CN102159547A (zh) | 2008-09-18 | 2011-08-17 | 安斯泰来制药株式会社 | 杂环甲酰胺化合物 |
| UY32158A (es) | 2008-10-03 | 2010-04-30 | Astrazeneca Ab | Derivados heterociclicos y metodos de uso de los mismos |
| JP2012505927A (ja) * | 2008-10-22 | 2012-03-08 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋのピリミジニルピリドン阻害剤 |
| BRPI0919885A2 (pt) | 2008-10-31 | 2015-08-11 | Centocor Ortho Biotech Inc | Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática |
| WO2010067886A1 (en) * | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivative |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| ES2433109T3 (es) | 2009-01-13 | 2013-12-09 | Glaxo Group Limited | Derivados de pirimidin-carboxamida como inhibidores de la Syk cinasa |
| US8377924B2 (en) * | 2009-01-21 | 2013-02-19 | Rigel Pharmaceuticals Inc. | Protein kinase C inhibitors and uses thereof |
| AR076550A1 (es) * | 2009-05-06 | 2011-06-22 | Portola Pharm Inc | Inhibidores de la janus tirosina kinasa (jak) |
| JP2012148977A (ja) * | 2009-05-20 | 2012-08-09 | Astellas Pharma Inc | アミノシクロヘキシルアルキル基を有する２，４−ジアミノピリミジン化合物 |
| AU2010258937A1 (en) * | 2009-06-08 | 2012-01-19 | Reduction Technologies Inc. | Systems, methods and devices for correcting spinal deformities |
| CA2764983A1 (en) | 2009-06-10 | 2010-12-16 | Abbott Laboratories | 2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors |
| JP2012197231A (ja) | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体 |
| WO2011065800A2 (ko) | 2009-11-30 | 2011-06-03 | 주식회사 오스코텍 | 피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물 |
| US20110130415A1 (en) | 2009-12-01 | 2011-06-02 | Rajinder Singh | Protein kinase c inhibitors and uses thereof |
| JP2011173853A (ja) * | 2010-02-26 | 2011-09-08 | Astellas Pharma Inc | 置換アミノアダマンチルアルキル基を有する２，４−ジアミノピリミジン化合物 |
| JP6035238B2 (ja) | 2010-07-21 | 2016-11-30 | ライジェル ファーマシューティカルズ， インコーポレイテッド | プロテインキナーゼｃ阻害剤およびその使用 |
| WO2012044936A1 (en) | 2010-09-30 | 2012-04-05 | Portola Pharmaceuticals, Inc. | Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide |
| WO2012045020A1 (en) | 2010-09-30 | 2012-04-05 | Portola Pharmaceuticals, Inc. | Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine |
| AU2012245387C1 (en) * | 2011-04-22 | 2016-05-05 | Signal Pharmaceuticals, Llc | Substituted Diaminocarboxamide and Diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
| RU2016129380A (ru) * | 2013-12-20 | 2018-01-25 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием |
| NZ715903A (en) * | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| WO2016100308A1 (en) * | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| ES2877642T3 (es) * | 2014-12-16 | 2021-11-17 | Signal Pharm Llc | Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida |
-
2012
- 2012-04-20 AU AU2012245387A patent/AU2012245387C1/en active Active
- 2012-04-20 WO PCT/US2012/034349 patent/WO2012145569A1/en not_active Ceased
- 2012-04-20 BR BR112013022813A patent/BR112013022813B1/pt active IP Right Grant
- 2012-04-20 UA UAA201313555A patent/UA120740C2/uk unknown
- 2012-04-20 CN CN201280019861.3A patent/CN103492370B/zh active Active
- 2012-04-20 SG SG2013074273A patent/SG194086A1/en unknown
- 2012-04-20 SI SI201232053T patent/SI2699553T1/sl unknown
- 2012-04-20 DK DK12718524.7T patent/DK2699553T3/da active
- 2012-04-20 EP EP12718524.7A patent/EP2699553B1/en active Active
- 2012-04-20 KR KR1020197007112A patent/KR102055532B1/ko active Active
- 2012-04-20 HR HRP20240097TT patent/HRP20240097T1/hr unknown
- 2012-04-20 TW TW105112041A patent/TWI599563B/zh active
- 2012-04-20 SG SG10201702654VA patent/SG10201702654VA/en unknown
- 2012-04-20 HU HUE12718524A patent/HUE064883T2/hu unknown
- 2012-04-20 RS RS20240075A patent/RS65202B1/sr unknown
- 2012-04-20 MX MX2013010946A patent/MX351754B/es active IP Right Grant
- 2012-04-20 CA CA2829264A patent/CA2829264C/en active Active
- 2012-04-20 FI FIEP12718524.7T patent/FI2699553T3/fi active
- 2012-04-20 PH PH1/2013/501921A patent/PH12013501921A1/en unknown
- 2012-04-20 CN CN201610882236.1A patent/CN106946795B/zh active Active
- 2012-04-20 TW TW106120278A patent/TWI681952B/zh active
- 2012-04-20 PT PT127185247T patent/PT2699553T/pt unknown
- 2012-04-20 CN CN202010398710.XA patent/CN111471021B/zh active Active
- 2012-04-20 JP JP2014506559A patent/JP6027095B2/ja active Active
- 2012-04-20 SM SM20240031T patent/SMT202400031T1/it unknown
- 2012-04-20 TW TW101114317A patent/TWI548621B/zh active
- 2012-04-20 RU RU2013152021A patent/RU2625309C2/ru active
- 2012-04-20 PL PL12718524.7T patent/PL2699553T3/pl unknown
- 2012-04-20 LT LTEPPCT/US2012/034349T patent/LT2699553T/lt unknown
- 2012-04-20 RU RU2017121958A patent/RU2697712C2/ru active
- 2012-04-20 US US13/451,574 patent/US9139534B2/en active Active
- 2012-04-20 CN CN201510389071.XA patent/CN105001165B/zh active Active
- 2012-04-20 PE PE2013002388A patent/PE20140502A1/es active IP Right Grant
- 2012-04-20 KR KR1020137027371A patent/KR101962488B1/ko active Active
- 2012-04-20 ES ES12718524T patent/ES2968700T3/es active Active
- 2012-04-20 CN CN202010398589.0A patent/CN111499580A/zh active Pending
- 2012-04-20 EP EP23205984.0A patent/EP4328223A3/en not_active Withdrawn
- 2012-04-23 AR ARP120101402 patent/AR087151A1/es active IP Right Grant
-
2013
- 2013-08-28 ZA ZA2013/06471A patent/ZA201306471B/en unknown
- 2013-09-26 CR CR20130490A patent/CR20130490A/es unknown
- 2013-10-03 IL IL228721A patent/IL228721A/en active IP Right Grant
- 2013-10-08 CO CO13238970A patent/CO6821941A2/es active IP Right Grant
- 2013-10-18 CL CL2013003025A patent/CL2013003025A1/es unknown
- 2013-10-21 NI NI201300113A patent/NI201300113A/es unknown
- 2013-10-21 EC ECSP13012985 patent/ECSP13012985A/es unknown
-
2015
- 2015-07-29 PH PH12015501677A patent/PH12015501677B1/en unknown
- 2015-07-31 US US14/814,633 patent/US9701643B2/en active Active
-
2016
- 2016-05-23 IL IL245792A patent/IL245792B/en active IP Right Grant
- 2016-10-13 JP JP2016202099A patent/JP6502302B2/ja active Active
-
2017
- 2017-06-07 US US15/616,039 patent/US10040770B2/en active Active
- 2017-06-15 IL IL252952A patent/IL252952B/en active IP Right Grant
-
2018
- 2018-06-28 US US16/021,415 patent/US10266500B2/en active Active
-
2019
- 2019-03-04 US US16/291,193 patent/US10919865B2/en active Active
- 2019-03-20 JP JP2019052826A patent/JP6898961B2/ja active Active
-
2020
- 2020-12-29 US US17/136,276 patent/US11325890B2/en active Active
-
2021
- 2021-06-11 JP JP2021098226A patent/JP7374955B2/ja active Active
-
2022
- 2022-03-29 US US17/707,471 patent/US12129237B2/en active Active
-
2023
- 2023-10-25 JP JP2023183330A patent/JP2023179797A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021138755A5 (enExample) | ||
| RU2361860C2 (ru) | Новые замещенные 3-сера-индолы | |
| JP2015524443A5 (enExample) | ||
| JP2013523733A5 (enExample) | ||
| RU2455288C2 (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| JP2012502974A5 (enExample) | ||
| JP2013517283A5 (enExample) | ||
| JP2018535999A5 (enExample) | ||
| JP2013530240A5 (enExample) | ||
| JP2015531774A5 (enExample) | ||
| JP2008513516A5 (enExample) | ||
| JP2016516699A5 (enExample) | ||
| JP2014511869A5 (enExample) | ||
| JP2012507535A5 (enExample) | ||
| JP2011500550A5 (enExample) | ||
| JP2013544860A5 (enExample) | ||
| JP2020502047A5 (enExample) | ||
| JP2013505949A5 (enExample) | ||
| JP2009504792A5 (enExample) | ||
| JP2020503293A5 (enExample) | ||
| JP2012532125A5 (enExample) | ||
| JP2020503292A5 (enExample) | ||
| JP2009501745A5 (enExample) | ||
| JP2020530479A5 (enExample) | ||
| JP2018522024A5 (enExample) |