JP2012502974A5 - - Google Patents
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- Publication number
- JP2012502974A5 JP2012502974A5 JP2011527431A JP2011527431A JP2012502974A5 JP 2012502974 A5 JP2012502974 A5 JP 2012502974A5 JP 2011527431 A JP2011527431 A JP 2011527431A JP 2011527431 A JP2011527431 A JP 2011527431A JP 2012502974 A5 JP2012502974 A5 JP 2012502974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ylmethoxy
- dihydroxy
- biphenyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002947 alkylene group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000001475 halogen functional group Chemical group 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- -1 -OH Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- HKHLJBBDUOPRQN-ACJLOTCBSA-N (2s,3r)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]butanamide Chemical compound C1=CC(CO[C@@](C)([C@H](O)C)C(=O)NO)=CC=C1C1=CC=CC=C1 HKHLJBBDUOPRQN-ACJLOTCBSA-N 0.000 claims 1
- SIXFEBVKDCSUST-ICSRJNTNSA-N (2s,3r)-n,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1ON=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 SIXFEBVKDCSUST-ICSRJNTNSA-N 0.000 claims 1
- SYCHQJMHORHPDP-FPOVZHCZSA-N (2s,3s)-3-(furan-2-yl)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1OC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 SYCHQJMHORHPDP-FPOVZHCZSA-N 0.000 claims 1
- GSUWLVYTJTWUHP-ICSRJNTNSA-N (2s,3s)-3-cyclopropyl-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C1CC1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 GSUWLVYTJTWUHP-ICSRJNTNSA-N 0.000 claims 1
- JCZKNQBVKSRKGG-WMZOPIPTSA-N (2s,3s)-5,5,5-trifluoro-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CC(F)(F)F)C(=O)NO)=CC=C1C1=CC=CC=C1 JCZKNQBVKSRKGG-WMZOPIPTSA-N 0.000 claims 1
- KXQHQOVKEMSLRA-FPOVZHCZSA-N (2s,3s)-5-ethoxy-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCOCC)C(=O)NO)=CC=C1C1=CC=CC=C1 KXQHQOVKEMSLRA-FPOVZHCZSA-N 0.000 claims 1
- OEIHVBMZXNURRL-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-2,4-dimethyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)C(C)C)C(=O)NO)=CC=C1C1=CC=CC=C1 OEIHVBMZXNURRL-ICSRJNTNSA-N 0.000 claims 1
- JGQMWGGZNFCDEO-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyridin-2-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1N=CC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 JGQMWGGZNFCDEO-UNMCSNQZSA-N 0.000 claims 1
- XDHPXTDIDHKVFF-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyridin-3-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=NC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 XDHPXTDIDHKVFF-UNMCSNQZSA-N 0.000 claims 1
- RKDZGGUXXBBZTR-FPOVZHCZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyrimidin-5-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=NC=NC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 RKDZGGUXXBBZTR-FPOVZHCZSA-N 0.000 claims 1
- HKHLJBBDUOPRQN-UGSOOPFHSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]butanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)C)C(=O)NO)=CC=C1C1=CC=CC=C1 HKHLJBBDUOPRQN-UGSOOPFHSA-N 0.000 claims 1
- LPHYIYSLVMHHIT-FPOVZHCZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]heptanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCCC)C(=O)NO)=CC=C1C1=CC=CC=C1 LPHYIYSLVMHHIT-FPOVZHCZSA-N 0.000 claims 1
- UZEYYYATUXVBCZ-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]hexanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCC)C(=O)NO)=CC=C1C1=CC=CC=C1 UZEYYYATUXVBCZ-ICSRJNTNSA-N 0.000 claims 1
- VKJROWRLVCWQPU-HKUYNNGSSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CC)C(=O)NO)=CC=C1C1=CC=CC=C1 VKJROWRLVCWQPU-HKUYNNGSSA-N 0.000 claims 1
- WFVASGYQNPHMCF-GMAHTHKFSA-N (2s,3s)-n,3-dihydroxy-2-methyl-3-phenyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=CC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 WFVASGYQNPHMCF-GMAHTHKFSA-N 0.000 claims 1
- IYOHQOLEWXCJEG-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-3-(1h-imidazol-5-yl)-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1N=CNC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 IYOHQOLEWXCJEG-ICSRJNTNSA-N 0.000 claims 1
- MRYZMLDBJLIIPW-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-3-[5-(hydroxymethyl)furan-2-yl]-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1OC(CO)=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 MRYZMLDBJLIIPW-UNMCSNQZSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- KIXXNPCYAPCLLP-UHFFFAOYSA-N CCC(C)C(C1)N1NN Chemical compound CCC(C)C(C1)N1NN KIXXNPCYAPCLLP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9824908P | 2008-09-19 | 2008-09-19 | |
| US61/098,249 | 2008-09-19 | ||
| PCT/IB2009/053809 WO2010032147A2 (en) | 2008-09-19 | 2009-09-01 | Hydroxamic acid derivatives useful as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502974A JP2012502974A (ja) | 2012-02-02 |
| JP2012502974A5 true JP2012502974A5 (enExample) | 2012-10-04 |
| JP5524215B2 JP5524215B2 (ja) | 2014-06-18 |
Family
ID=41664561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527431A Expired - Fee Related JP5524215B2 (ja) | 2008-09-19 | 2009-09-01 | 抗菌剤として有用なヒドロキサム酸誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8722686B2 (enExample) |
| EP (1) | EP2334636A2 (enExample) |
| JP (1) | JP5524215B2 (enExample) |
| CA (1) | CA2735929C (enExample) |
| WO (1) | WO2010032147A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI519508B (zh) | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
| WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2011132712A1 (ja) | 2010-04-20 | 2011-10-27 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| ES2626457T3 (es) | 2011-03-07 | 2017-07-25 | Pfizer Inc. | Derivados de fluoro-piridinona útiles como agentes antibacterianos |
| CA2830866A1 (en) * | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| ES2526687T3 (es) * | 2011-04-08 | 2015-01-14 | Pfizer Inc. | Derivados de isoxazol útiles como agentes antibacterianos |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| CN103012207B (zh) * | 2012-12-29 | 2015-05-27 | 吉首大学 | 二芳基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途 |
| CN102993052B (zh) * | 2012-12-29 | 2014-07-09 | 吉首大学 | 芳基丙酰氧肟酸类尿素酶抑制剂及其合成和用途 |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| DK2975022T3 (da) | 2013-03-15 | 2019-07-15 | Fujifilm Toyama Chemical Co Ltd | Hidtil ukendt hydroxaminsyrederivat eller salt deraf |
| HK1221912A1 (zh) | 2013-10-04 | 2017-06-16 | Novartis Ag | 用於治疗乙肝病毒的有机化合物 |
| EP3052464B1 (en) * | 2013-10-04 | 2020-04-15 | Novartis AG | 3'end caps for rna-interferring agents for use in rna interference |
| EP3134401B1 (en) | 2014-04-22 | 2018-06-13 | Novartis AG | Isoxazoline hydroxamic acid derivatives as lpxc inhibitors |
| BR112017004798A2 (pt) | 2014-09-12 | 2017-12-12 | Toyama Chemical Co Ltd | composição farmacêutica que contém um derivado de ácido hidroxâmico ou um seu sal |
| JPWO2016039432A1 (ja) | 2014-09-12 | 2017-06-22 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体および抗菌性物質を組み合わせて使用する方法 |
| DK3233843T3 (da) * | 2014-12-16 | 2019-11-18 | Novartis Ag | Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| JP6941630B2 (ja) | 2016-06-14 | 2021-09-29 | ノバルティス アーゲー | 抗菌剤としての（ｒ）−４（５−（シクロプロピルエチニル）イソオキサゾール−３−イル）−ｎ−ヒドロキシ−２−メチル−２−（メチルスルホニル）ブタンアミドの結晶形 |
| AR108864A1 (es) | 2016-06-23 | 2018-10-03 | Achaogen Inc | Agentes antibacterianos |
| HUE057849T2 (hu) | 2017-01-11 | 2022-06-28 | Alkermes Inc | Hiszton deacetiláz biciklusos gátlói |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| CN107226845B (zh) * | 2017-05-31 | 2020-10-09 | 成都雅途生物技术有限公司 | 一种抗多重耐药菌的化合物yt-011及其制备方法 |
| LT3664802T (lt) | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| KR102455390B1 (ko) | 2017-10-02 | 2022-10-17 | 아릭사 파마슈티컬스 인코포레이티드 | 아즈트레오남 유도체 및 이의 용도 |
| ES2991492T3 (es) | 2018-10-01 | 2024-12-03 | Arixa Pharmaceuticals Inc | Derivados de relebactam y usos de los mismos |
| AU2020237440B2 (en) | 2019-03-12 | 2022-10-20 | Arixa Pharmaceuticals, Inc. | Crystalline form of an avibactam derivative |
| US11565999B2 (en) | 2019-04-25 | 2023-01-31 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
| CN116348448A (zh) * | 2020-07-24 | 2023-06-27 | 明德赛特制药公司 | 赛洛辛和赛洛西宾的可扩展合成路线 |
| CN116730870B (zh) * | 2023-08-08 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | 异羟肟酸类化合物或其可药用盐、及其用途和制备方法 |
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| JPS50121218A (enExample) * | 1974-03-01 | 1975-09-23 | ||
| US4769461A (en) * | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| DK1052984T3 (da) * | 1998-02-07 | 2004-09-20 | Vernalis Oxford Ltd | Antibakterielle midler |
| GB9925470D0 (en) * | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| ES2180456B1 (es) | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| KR101076018B1 (ko) * | 2003-01-08 | 2011-10-21 | 유니버시티 오브 워싱톤 | 항균제 |
| GB0302431D0 (en) | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| MX2007006961A (es) | 2004-12-10 | 2007-10-04 | Univ Emory | Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal. |
| WO2006118155A1 (ja) * | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| US20060258691A1 (en) | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Methods and compositions for improving cognition |
| JP2009520695A (ja) | 2005-12-15 | 2009-05-28 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| WO2007093904A1 (en) | 2006-02-14 | 2007-08-23 | Pfizer Products Inc. | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
| WO2008045671A1 (en) * | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| CN101016270B (zh) | 2006-12-30 | 2012-05-09 | 天津药物研究院 | 取代的哌嗪基苯基异噁唑啉衍生物及其用途 |
| US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| WO2008115262A2 (en) | 2007-03-20 | 2008-09-25 | Curis, Inc. | Hsp90 inhibitors containing a zinc binding moiety |
| WO2010017060A1 (en) | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| ES2626457T3 (es) | 2011-03-07 | 2017-07-25 | Pfizer Inc. | Derivados de fluoro-piridinona útiles como agentes antibacterianos |
| CA2830866A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| ES2526687T3 (es) | 2011-04-08 | 2015-01-14 | Pfizer Inc. | Derivados de isoxazol útiles como agentes antibacterianos |
-
2009
- 2009-09-01 JP JP2011527431A patent/JP5524215B2/ja not_active Expired - Fee Related
- 2009-09-01 US US13/119,484 patent/US8722686B2/en not_active Expired - Fee Related
- 2009-09-01 CA CA2735929A patent/CA2735929C/en not_active Expired - Fee Related
- 2009-09-01 EP EP09787063A patent/EP2334636A2/en not_active Withdrawn
- 2009-09-01 WO PCT/IB2009/053809 patent/WO2010032147A2/en not_active Ceased
-
2014
- 2014-03-24 US US14/223,061 patent/US9340493B2/en not_active Expired - Fee Related