MX351754B - Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas. - Google Patents

Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas.

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Publication number
MX351754B
MX351754B MX2013010946A MX2013010946A MX351754B MX 351754 B MX351754 B MX 351754B MX 2013010946 A MX2013010946 A MX 2013010946A MX 2013010946 A MX2013010946 A MX 2013010946A MX 351754 B MX351754 B MX 351754B
Authority
MX
Mexico
Prior art keywords
compositions
methods
treatment therewith
diaminocarboxamide
substituted
Prior art date
Application number
MX2013010946A
Other languages
English (en)
Other versions
MX2013010946A (es
Inventor
L Bennett Brydon
Elsner Jan
Erdman Paul
Hilgraf Robert
Ann Lebrun Laurie
Mccarrick Meg
F Moghaddam Mehran
a nagy Mark
Norris Stephen
A Paisner David
Sloss Marianne
J Romanow William
Satoh Yoshitaka
Tikhe Jayashree
Hyung Yoon Won
Delgado Mercedes
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of MX2013010946A publication Critical patent/MX2013010946A/es
Publication of MX351754B publication Critical patent/MX351754B/es

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

En la presente se proveen Compuestos de Diaminopirimidina teniendo las siguientes estructuras: (ver Fórmulas) en donde R1, R2, R3 y R4 son como se define en la presente, composiciones que comprenden una cantidad efectiva de un Compuesto de Diaminopirimidina, y métodos para tratar o prevenir trastornos fibróticos del hígado o una condición tratable o prevenible por inhibición de una vía de JNK.
MX2013010946A 2011-04-22 2012-04-20 Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas. MX351754B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161478076P 2011-04-22 2011-04-22
US201161555339P 2011-11-03 2011-11-03
PCT/US2012/034349 WO2012145569A1 (en) 2011-04-22 2012-04-20 Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith

Publications (2)

Publication Number Publication Date
MX2013010946A MX2013010946A (es) 2013-12-16
MX351754B true MX351754B (es) 2017-10-27

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US (7) US9139534B2 (es)
EP (2) EP4328223A2 (es)
JP (5) JP6027095B2 (es)
KR (2) KR102055532B1 (es)
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AR (1) AR087151A1 (es)
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