JP2020534375A5 - - Google Patents
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- JP2020534375A5 JP2020534375A5 JP2020538753A JP2020538753A JP2020534375A5 JP 2020534375 A5 JP2020534375 A5 JP 2020534375A5 JP 2020538753 A JP2020538753 A JP 2020538753A JP 2020538753 A JP2020538753 A JP 2020538753A JP 2020534375 A5 JP2020534375 A5 JP 2020534375A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- membered
- saturated
- sulfur
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 144
- 229910052757 nitrogen Inorganic materials 0.000 claims description 82
- 125000005842 heteroatom Chemical group 0.000 claims description 79
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 70
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 70
- 229910052760 oxygen Inorganic materials 0.000 claims description 70
- 239000001301 oxygen Substances 0.000 claims description 70
- 229920006395 saturated elastomer Polymers 0.000 claims description 70
- 229910052717 sulfur Inorganic materials 0.000 claims description 70
- 239000011593 sulfur Substances 0.000 claims description 70
- 150000001875 compounds Chemical class 0.000 claims description 61
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 40
- 125000002619 bicyclic group Chemical group 0.000 claims description 38
- 229910052736 halogen Inorganic materials 0.000 claims description 28
- 150000002367 halogens Chemical class 0.000 claims description 28
- 150000002431 hydrogen Chemical class 0.000 claims description 26
- 125000001931 aliphatic group Chemical group 0.000 claims description 25
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 10
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 229910052712 strontium Inorganic materials 0.000 claims description 10
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 206010018338 Glioma Diseases 0.000 claims description 8
- 206010025323 Lymphomas Diseases 0.000 claims description 8
- 125000005605 benzo group Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 6
- 208000032612 Glial tumor Diseases 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
- 230000002062 proliferating effect Effects 0.000 claims description 6
- 208000003098 Ganglion Cysts Diseases 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 208000005400 Synovial Cyst Diseases 0.000 claims description 4
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims description 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 4
- 125000002950 monocyclic group Chemical group 0.000 claims description 4
- 210000003739 neck Anatomy 0.000 claims description 4
- 210000004214 philadelphia chromosome Anatomy 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 201000003076 Angiosarcoma Diseases 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 2
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 201000009030 Carcinoma Diseases 0.000 claims description 2
- 201000000274 Carcinosarcoma Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000017701 Endocrine disease Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims description 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims description 2
- 208000017604 Hodgkin disease Diseases 0.000 claims description 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims description 2
- 206010023256 Juvenile melanoma benign Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 208000015021 Meningeal Neoplasms Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000014767 Myeloproliferative disease Diseases 0.000 claims description 2
- 201000004458 Myoma Diseases 0.000 claims description 2
- 208000012902 Nervous system disease Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 201000004404 Neurofibroma Diseases 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 2
- 235000011613 Pinus brutia Nutrition 0.000 claims description 2
- 241000018646 Pinus brutia Species 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 206010037127 Pseudolymphoma Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims description 2
- 208000000389 T-cell leukemia Diseases 0.000 claims description 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 208000008383 Wilms tumor Diseases 0.000 claims description 2
- 208000009956 adenocarcinoma Diseases 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 201000000053 blastoma Diseases 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 210000001072 colon Anatomy 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims description 2
- 230000000593 degrading effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000008184 embryoma Diseases 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 210000003238 esophagus Anatomy 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000002518 glial effect Effects 0.000 claims description 2
- 210000003128 head Anatomy 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 201000002313 intestinal cancer Diseases 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 206010024627 liposarcoma Diseases 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims description 2
- 230000036244 malformation Effects 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 208000010943 meningeal sarcoma Diseases 0.000 claims description 2
- 201000003776 meninges sarcoma Diseases 0.000 claims description 2
- 201000008026 nephroblastoma Diseases 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 210000002784 stomach Anatomy 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 206010042863 synovial sarcoma Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 210000003932 urinary bladder Anatomy 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 230000002861 ventricular Effects 0.000 claims description 2
- 0 C*N(C)CC(*(C)C)=O Chemical compound C*N(C)CC(*(C)C)=O 0.000 description 4
- 102000015367 CRBN Human genes 0.000 description 4
- 101000941994 Homo sapiens Protein cereblon Proteins 0.000 description 4
- 238000010835 comparative analysis Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023175302A JP7818560B2 (ja) | 2017-09-22 | 2023-10-10 | タンパク質分解剤およびそれらの使用 |
| JP2025136973A JP2025170324A (ja) | 2017-09-22 | 2025-08-20 | タンパク質分解剤およびそれらの使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562206P | 2017-09-22 | 2017-09-22 | |
| US62/562,206 | 2017-09-22 | ||
| US201762610403P | 2017-12-26 | 2017-12-26 | |
| US62/610,403 | 2017-12-26 | ||
| US201862714527P | 2018-08-03 | 2018-08-03 | |
| US62/714,527 | 2018-08-03 | ||
| PCT/US2018/052242 WO2019060742A1 (en) | 2017-09-22 | 2018-09-21 | AGENTS FOR DEGRADING PROTEINS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023175302A Division JP7818560B2 (ja) | 2017-09-22 | 2023-10-10 | タンパク質分解剤およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534375A JP2020534375A (ja) | 2020-11-26 |
| JP2020534375A5 true JP2020534375A5 (https=) | 2021-10-21 |
| JP7366031B2 JP7366031B2 (ja) | 2023-10-20 |
Family
ID=65810510
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538753A Active JP7366031B2 (ja) | 2017-09-22 | 2018-09-21 | タンパク質分解剤およびそれらの使用 |
| JP2023175302A Active JP7818560B2 (ja) | 2017-09-22 | 2023-10-10 | タンパク質分解剤およびそれらの使用 |
| JP2025136973A Pending JP2025170324A (ja) | 2017-09-22 | 2025-08-20 | タンパク質分解剤およびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023175302A Active JP7818560B2 (ja) | 2017-09-22 | 2023-10-10 | タンパク質分解剤およびそれらの使用 |
| JP2025136973A Pending JP2025170324A (ja) | 2017-09-22 | 2025-08-20 | タンパク質分解剤およびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11623932B2 (https=) |
| EP (2) | EP3684365A4 (https=) |
| JP (3) | JP7366031B2 (https=) |
| AU (2) | AU2018338314B2 (https=) |
| CA (2) | CA3076613A1 (https=) |
| IL (4) | IL295603B2 (https=) |
| MX (3) | MX2020003190A (https=) |
| WO (1) | WO2019060742A1 (https=) |
Families Citing this family (106)
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|---|---|---|---|---|
| BR112019011200B1 (pt) | 2016-12-01 | 2021-12-28 | Arvinas Operations, Inc | Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio |
| BR112019015312A2 (pt) | 2017-01-26 | 2020-03-10 | Arvinas Operations, Inc. | Moduladores da proteólise pelo receptor de estrogênio e métodos de uso associados |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| CN111372585A (zh) | 2017-11-16 | 2020-07-03 | C4医药公司 | 用于靶蛋白降解的降解剂和降解决定子 |
| PT3728207T (pt) | 2017-12-21 | 2023-03-14 | Ribon Therapeutics Inc | Quinazolinonas como inibidores de parp14 |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| EP3773576A4 (en) | 2018-03-26 | 2021-12-29 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| WO2019195609A2 (en) | 2018-04-04 | 2019-10-10 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
| EP3781156A4 (en) | 2018-04-16 | 2022-05-18 | C4 Therapeutics, Inc. | SPIROCYCLIC COMPOUNDS |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
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| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| CN120574283A (zh) * | 2019-04-05 | 2025-09-02 | 凯麦拉医疗公司 | Stat降解剂和其用途 |
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| CN110058014B (zh) * | 2019-04-25 | 2021-06-04 | 中国科学院化学研究所 | 用于筛选lrpprc调控剂的产品及鉴定lrpprc调控剂的方法 |
| JP7289510B2 (ja) * | 2019-05-08 | 2023-06-12 | 国立大学法人高知大学 | 認知症治療薬のスクリーニング方法 |
| CA3135592A1 (en) | 2019-05-20 | 2020-11-26 | Xiaochao Ma | Therapeutic agents for erythropoietic protoporphyria (epp) and x-linked protoporphyria (xlp) |
| WO2020251972A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2020257278A2 (en) * | 2019-06-18 | 2020-12-24 | Dana-Farber Cancer Institute, Inc. | Small molecule target bromo/acetyl proteins and uses thereof |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
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| EP3999182A1 (en) | 2019-07-17 | 2022-05-25 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
| KR20220054347A (ko) | 2019-08-26 | 2022-05-02 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법 |
| WO2021041942A1 (en) | 2019-08-28 | 2021-03-04 | University Of Kentucky Research Foundation | Collagen p4h1 inhibitor and its use |
| CN110596403B (zh) * | 2019-09-17 | 2022-12-16 | 中山大学附属第一医院 | 用于卵巢癌诊断的特异性蛋白标记物及制备方法 |
| CA3154386A1 (en) | 2019-10-17 | 2021-04-22 | Michael Berlin | Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety |
| CN110749733B (zh) * | 2019-12-06 | 2021-08-27 | 四川大学华西医院 | Tgif2ly自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| JP2023507172A (ja) * | 2019-12-17 | 2023-02-21 | オリオニス バイオサイエンシズ，インコーポレイテッド | タンパク質分解の調節 |
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| EP4077319A1 (en) * | 2019-12-20 | 2022-10-26 | Calico Life Sciences LLC | Protein tyrosine phosphatase degraders and methods of use thereof |
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| WO2021162493A1 (ko) * | 2020-02-14 | 2021-08-19 | 보로노이 주식회사 | 단백질 키나아제 분해 유도 화합물 및 이의 용도 |
| CN111214664B (zh) * | 2020-02-24 | 2022-02-11 | 大连医科大学 | USP2和HSP90抑制剂联合使用抑制ErbB2阳性乳腺癌生长的应用 |
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| EP3878847A1 (en) * | 2020-03-13 | 2021-09-15 | Centre Régional de Lutte contre le Cancer - Centre François Baclesse | Bcl-2 family proteins modulating compounds for cancer treatment |
| EP4122925A4 (en) * | 2020-03-17 | 2024-04-17 | Medshine Discovery Inc. | Proteolysis regulator and method for using same |
| CA3170503A1 (en) * | 2020-03-17 | 2021-09-23 | Nan JI | Stat degraders and uses thereof |
| KR20230005160A (ko) | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
| JP7644139B2 (ja) | 2020-03-21 | 2025-03-11 | アルヴィナス・オペレーションズ・インコーポレイテッド | インダゾール系化合物及び関連使用方法 |
| CA3172589A1 (en) * | 2020-05-21 | 2021-11-25 | Dana-Farber Cancer Institute, Inc. | Piperidine-2,6-diones as small molecule degraders of helios and methods of use |
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| JP2023530030A (ja) | 2020-06-19 | 2023-07-12 | シーフォー セラピューティクス， インコーポレイテッド | Ｂｒａｆ分解剤 |
| KR102654220B1 (ko) * | 2020-07-07 | 2024-04-04 | 한국식품연구원 | Cmip 억제제를 포함하는 지방간 질환의 예방 또는 치료용 약학적 조성물 |
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| JP7692128B2 (ja) * | 2020-07-17 | 2025-06-13 | 国立医薬品食品衛生研究所長 | 新規化合物及び医薬組成物 |
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-
2018
- 2018-09-21 WO PCT/US2018/052242 patent/WO2019060742A1/en not_active Ceased
- 2018-09-21 MX MX2020003190A patent/MX2020003190A/es unknown
- 2018-09-21 IL IL295603A patent/IL295603B2/en unknown
- 2018-09-21 JP JP2020538753A patent/JP7366031B2/ja active Active
- 2018-09-21 US US16/649,732 patent/US11623932B2/en active Active
- 2018-09-21 EP EP18857581.5A patent/EP3684365A4/en active Pending
- 2018-09-21 AU AU2018338314A patent/AU2018338314B2/en active Active
- 2018-09-21 CA CA3076613A patent/CA3076613A1/en active Pending
- 2018-09-21 EP EP25195747.8A patent/EP4624467A3/en active Pending
- 2018-09-21 CA CA3283159A patent/CA3283159A1/en active Pending
- 2018-09-21 IL IL322809A patent/IL322809A/en unknown
- 2018-09-21 IL IL307995A patent/IL307995A/en unknown
- 2018-09-21 IL IL273432A patent/IL273432B/en unknown
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2020
- 2020-03-20 MX MX2022013526A patent/MX2022013526A/es unknown
- 2020-03-20 MX MX2023015185A patent/MX2023015185A/es unknown
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2022
- 2022-06-10 US US17/837,449 patent/US20230115184A1/en active Pending
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2023
- 2023-10-10 JP JP2023175302A patent/JP7818560B2/ja active Active
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2025
- 2025-03-12 AU AU2025201796A patent/AU2025201796A1/en not_active Abandoned
- 2025-08-19 US US19/304,052 patent/US20260085075A1/en active Pending
- 2025-08-20 JP JP2025136973A patent/JP2025170324A/ja active Pending
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