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Description
概説
本技術のいくつかの実施形態は、天然僧帽弁を経皮的に交換する独自の難題に対処し、かつ生体構造に治療剤を送達するのに適切である僧帽弁置換デバイスを対象とする。大動脈弁を置換することと比較して、経皮的僧帽弁置換は、経皮的僧帽弁置換を大動脈弁置換よりも有意に困難にする独特の解剖学的障害物に直面する。第1に、比較的対称かつ均一な大動脈弁と異なり、僧帽弁輪は、しばしば対称性が欠けている非平面的な鞍のような幾何学形状を伴う、非円形のD字形または腎臓のような形状を有する。僧帽弁の複雑かつ高度に可変の生体構造は、特定の患者の天然僧帽弁輪にうまく適合する僧帽弁補綴を設計することを困難にする。結果として、補綴は、血液の逆流が起こることを可能にする隙間を残すことができる、天然弁尖および/または弁輪とうまく嵌合しなくてもよい。例えば、天然僧帽弁内への円筒形弁補綴の配置は、弁周囲漏出が起こってもよい天然弁の交連領域中に間隙を残してもよい。
本発明は、例えば、以下を提供する。
(項目1)
人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固定フレームの前記下流部に連結した第1の部分と、前記固定フレームの前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)前記人工心臓弁デバイスが、天然弁輪に位置付けられるとき、生体構造への送達のための前記凹部内にある治療剤、拡張部材と、を備える、人工心臓弁デバイス。
(項目2)
前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、項目1に記載のデバイス。
(項目3)
前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、項目1に記載のデバイス。
(項目4)
前記ワイヤが、前記固定フレームの前記上流部と一体である、項目1に記載のデバイス。
(項目5)
前記ワイヤが、前記固定フレームから機械的に絶縁される、項目1に記載のデバイス。
(項目6)
前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、項目1に記載のデバイス。
(項目7)
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目1に記載のデバイス。
(項目8)
前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目1に記載のデバイス。
(項目9)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目1に記載のデバイス。
(項目10)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、項目1に記載のデバイス。
(項目11)
前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、項目1に記載のデバイス。
(項目12)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、項目11に記載のデバイス。
(項目13)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目11に記載のデバイス。
(項目14)
人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固着部材の前記下流部に連結した第1の部分と、前記固着部材の前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)X線不透過性材料が、凹部内にある、拡張部材と、を備える、人工心臓弁デバイス。
(項目15)
前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、項目14に記載のデバイス。
(項目16)
前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、項目14に記載のデバイス。
(項目17)
前記ワイヤが、前記固定フレームの前記上流部と一体である、項目14に記載のデバイス。
(項目18)
前記ワイヤが、前記固定フレームから機械的に絶縁される、項目14に記載のデバイス。
(項目19)
前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、項目14に記載のデバイス。
(項目20)
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目14に記載のデバイス。
(項目21)
前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目14に記載のデバイス。
(項目22)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目14に記載のデバイス。
(項目23)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、項目14に記載のデバイス。
(項目24)
前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、項目14に記載のデバイス。
(項目25)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、項目24に記載のデバイス。
(項目26)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目24に記載のデバイス。
(項目27)
人工心臓弁デバイスであって、
内部を伴い、上流部および下流部を有する半径方向に拡大可能なフレームを有する固着部材であって、前記上流部が、対象中の心臓弁の天然弁輪に、および/またはその下流に位置する組織に対して外向きに押し付けるように構成され、かつ前記組織の形状に一致するように少なくとも部分的に変形可能であるように構成される組織固定部分を含む、固着部材と、
前記固着部材に対して位置付けられ、かつ前記内部を通る血流が遮断される閉鎖位置と、前記上流部から前記下流部へ向かう流れの方向で前記内部を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁であって、前記弁が、前記組織固定部分が前記組織の前記形状に一致するように変形されるとき、前記弁が有能なままであるように、前記固着部材の前記組織固定部分から内向きに離間される、弁と、
展開構成の前記固着部材の前記上流部から離れて横方向に延在する拡張アセンブリであって、前記拡張部材が、前記固着部材における第1の端部と、前記固着部材から離間される第2の端部と、を有する複数の個別織物セグメントを備え、前記織物セグメントが、前記拡張部材の周りに並んで配列されており、隣接した織物セグメントが、可撓性連結手段によって一緒にゆるく連結し、これによって、隣接した織物セグメントの前記第2の端部が、前記展開状態において互いに独立して構成され得る、拡張アセンブリと、を備える、人工心臓弁デバイス。
(項目28)
前記セグメントが、構造部材を含まない、項目27に記載の人工心臓弁デバイス。
(項目29)
前記拡張部材が、前記展開構成の前記拡大可能なフレームに対して変形するように構成されている、項目27に記載の人工心臓弁デバイス。
(項目30)
前記連結手段が、弾性である、項目27に記載の人工心臓弁デバイス。
(項目31)
前記連結手段が、縫合糸である、項目27に記載の人工心臓弁デバイス。
(項目32)
前記セグメントの前記遠位終端が、前記拡張部材の前記第2の端部と一致する、項目27に記載の人工心臓弁デバイス。
(項目33)
前記セグメントが前記固着部材に間接的にのみ連結されるように、前記セグメントが前記拡大可能なフレームから離間される、項目27に記載の人工心臓弁デバイス。
(項目34)
前記セグメントが、前記拡大可能なフレームに直接的に接続される、項目27に記載の人工心臓弁デバイス。
本技術のいくつかの実施形態は、天然僧帽弁を経皮的に交換する独自の難題に対処し、かつ生体構造に治療剤を送達するのに適切である僧帽弁置換デバイスを対象とする。大動脈弁を置換することと比較して、経皮的僧帽弁置換は、経皮的僧帽弁置換を大動脈弁置換よりも有意に困難にする独特の解剖学的障害物に直面する。第1に、比較的対称かつ均一な大動脈弁と異なり、僧帽弁輪は、しばしば対称性が欠けている非平面的な鞍のような幾何学形状を伴う、非円形のD字形または腎臓のような形状を有する。僧帽弁の複雑かつ高度に可変の生体構造は、特定の患者の天然僧帽弁輪にうまく適合する僧帽弁補綴を設計することを困難にする。結果として、補綴は、血液の逆流が起こることを可能にする隙間を残すことができる、天然弁尖および/または弁輪とうまく嵌合しなくてもよい。例えば、天然僧帽弁内への円筒形弁補綴の配置は、弁周囲漏出が起こってもよい天然弁の交連領域中に間隙を残してもよい。
本発明は、例えば、以下を提供する。
(項目1)
人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固定フレームの前記下流部に連結した第1の部分と、前記固定フレームの前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)前記人工心臓弁デバイスが、天然弁輪に位置付けられるとき、生体構造への送達のための前記凹部内にある治療剤、拡張部材と、を備える、人工心臓弁デバイス。
(項目2)
前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、項目1に記載のデバイス。
(項目3)
前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、項目1に記載のデバイス。
(項目4)
前記ワイヤが、前記固定フレームの前記上流部と一体である、項目1に記載のデバイス。
(項目5)
前記ワイヤが、前記固定フレームから機械的に絶縁される、項目1に記載のデバイス。
(項目6)
前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、項目1に記載のデバイス。
(項目7)
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目1に記載のデバイス。
(項目8)
前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目1に記載のデバイス。
(項目9)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目1に記載のデバイス。
(項目10)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、項目1に記載のデバイス。
(項目11)
前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、項目1に記載のデバイス。
(項目12)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、項目11に記載のデバイス。
(項目13)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目11に記載のデバイス。
(項目14)
人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固着部材の前記下流部に連結した第1の部分と、前記固着部材の前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)X線不透過性材料が、凹部内にある、拡張部材と、を備える、人工心臓弁デバイス。
(項目15)
前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、項目14に記載のデバイス。
(項目16)
前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、項目14に記載のデバイス。
(項目17)
前記ワイヤが、前記固定フレームの前記上流部と一体である、項目14に記載のデバイス。
(項目18)
前記ワイヤが、前記固定フレームから機械的に絶縁される、項目14に記載のデバイス。
(項目19)
前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、項目14に記載のデバイス。
(項目20)
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目14に記載のデバイス。
(項目21)
前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、項目14に記載のデバイス。
(項目22)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目14に記載のデバイス。
(項目23)
前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、項目14に記載のデバイス。
(項目24)
前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、項目14に記載のデバイス。
(項目25)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、項目24に記載のデバイス。
(項目26)
前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、項目24に記載のデバイス。
(項目27)
人工心臓弁デバイスであって、
内部を伴い、上流部および下流部を有する半径方向に拡大可能なフレームを有する固着部材であって、前記上流部が、対象中の心臓弁の天然弁輪に、および/またはその下流に位置する組織に対して外向きに押し付けるように構成され、かつ前記組織の形状に一致するように少なくとも部分的に変形可能であるように構成される組織固定部分を含む、固着部材と、
前記固着部材に対して位置付けられ、かつ前記内部を通る血流が遮断される閉鎖位置と、前記上流部から前記下流部へ向かう流れの方向で前記内部を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁であって、前記弁が、前記組織固定部分が前記組織の前記形状に一致するように変形されるとき、前記弁が有能なままであるように、前記固着部材の前記組織固定部分から内向きに離間される、弁と、
展開構成の前記固着部材の前記上流部から離れて横方向に延在する拡張アセンブリであって、前記拡張部材が、前記固着部材における第1の端部と、前記固着部材から離間される第2の端部と、を有する複数の個別織物セグメントを備え、前記織物セグメントが、前記拡張部材の周りに並んで配列されており、隣接した織物セグメントが、可撓性連結手段によって一緒にゆるく連結し、これによって、隣接した織物セグメントの前記第2の端部が、前記展開状態において互いに独立して構成され得る、拡張アセンブリと、を備える、人工心臓弁デバイス。
(項目28)
前記セグメントが、構造部材を含まない、項目27に記載の人工心臓弁デバイス。
(項目29)
前記拡張部材が、前記展開構成の前記拡大可能なフレームに対して変形するように構成されている、項目27に記載の人工心臓弁デバイス。
(項目30)
前記連結手段が、弾性である、項目27に記載の人工心臓弁デバイス。
(項目31)
前記連結手段が、縫合糸である、項目27に記載の人工心臓弁デバイス。
(項目32)
前記セグメントの前記遠位終端が、前記拡張部材の前記第2の端部と一致する、項目27に記載の人工心臓弁デバイス。
(項目33)
前記セグメントが前記固着部材に間接的にのみ連結されるように、前記セグメントが前記拡大可能なフレームから離間される、項目27に記載の人工心臓弁デバイス。
(項目34)
前記セグメントが、前記拡大可能なフレームに直接的に接続される、項目27に記載の人工心臓弁デバイス。
Claims (26)
- 人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固定フレームの前記下流部に連結した第1の部分と、前記固定フレームの前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)前記人工心臓弁デバイスが、天然弁輪に位置付けられるとき、生体構造への送達のための前記凹部内にある治療剤、拡張部材と、を備える、人工心臓弁デバイス。 - 前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、請求項1に記載のデバイス。
- 前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、請求項1に記載のデバイス。
- 前記ワイヤが、前記固定フレームの前記上流部と一体である、請求項1に記載のデバイス。
- 前記ワイヤが、前記固定フレームから機械的に絶縁される、請求項1に記載のデバイス。
- 前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、請求項1に記載のデバイス。
- 前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、請求項1に記載のデバイス。
- 前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、請求項1に記載のデバイス。 - 前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、請求項1に記載のデバイス。
- 前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、請求項1に記載のデバイス。
- 前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、請求項1に記載のデバイス。
- 前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、請求項11に記載のデバイス。
- 前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、請求項11に記載のデバイス。
- 人工心臓弁デバイスであって、
上流部および下流部を有する環状固定フレームを有する固着部材と、
前記固着部材の前記下流部に連結した第1の部分と、前記固着部材の前記上流部から半径方向に内向きに離間した第2の部分と、を有する管状弁支持体と、
前記弁支持体に連結され、かつ前記弁支持体を通る血流が遮断される閉鎖位置と、下流方向への前記弁支持体を通る血流が許容される開放位置とから移動可能である少なくとも1つの弁尖を有する、弁アセンブリと、
前記固定フレームに連結され、かつそこから半径方向に外向きに延在する拡張部材であって、前記拡張部材が、複数のワイヤを含み、前記ワイヤの少なくとも一部分が、外側材料によって包囲された内核を含み、(a)前記内核が、第1の材料であり、(b)前記外側材料が、前記第1の材料とは異なる第2の材料であり、かつある厚さを有し、(c)前記ワイヤが、前記外側材料の前記厚さの少なくとも一部分を通して延在する複数の凹部を含み、(d)X線不透過性材料が、凹部内にある、拡張部材と、を備える、人工心臓弁デバイス。 - 前記固定フレームの前記上流部が、前記管状弁支持体の前記第2の部分を実質的に変形させることなく、半径方向に変形可能である、請求項14に記載のデバイス。
- 前記拡張部材が、その長さの少なくとも一部分に沿って延在する封止部材をさらに含み、前記ワイヤが、前記封止部材に連結されている、請求項14に記載のデバイス。
- 前記ワイヤが、前記固定フレームの前記上流部と一体である、請求項14に記載のデバイス。
- 前記ワイヤが、前記固定フレームから機械的に絶縁される、請求項14に記載のデバイス。
- 前記第1の材料が、X線不透過性であり、前記第2の材料が、超弾性合金である、請求項14に記載のデバイス。
- 前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、請求項14に記載のデバイス。
- 前記第1の材料が、X線不透過性であり、
前記第2の材料が、超弾性合金であり、
前記治療剤が、抗炎症薬および生物活性剤のうちの少なくとも1つを含む、請求項14に記載のデバイス。 - 前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、請求項14に記載のデバイス。
- 前記複数の凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記内核の厚さの少なくとも一部分を通して延在し、これによって、前記複数の凹部のうちの前記少なくともいくつかが、前記内核内の中間の深さで終端する、請求項14に記載のデバイス。
- 前記拡張部材が、前記内核と前記外側材料との間に位置付けられた中間材料をさらに含む、請求項14に記載のデバイス。
- 前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さを通して延在し、それによって、前記中間材料の少なくとも一部分を露出する、請求項24に記載のデバイス。
- 前記凹部のうちの少なくともいくつかが、前記外側材料の全体厚さ、および前記中間材料の全体厚さを通して延在し、それによって、前記内核の少なくとも一部分を露出する、請求項24に記載のデバイス。
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2017
- 2017-07-06 US US15/642,834 patent/US10729541B2/en active Active
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2018
- 2018-06-21 CN CN202210554877.XA patent/CN115444619A/zh active Pending
- 2018-06-21 EP EP20192122.8A patent/EP3763332A1/en active Pending
- 2018-06-21 AU AU2018297210A patent/AU2018297210A1/en not_active Abandoned
- 2018-06-21 WO PCT/US2018/038841 patent/WO2019010010A1/en unknown
- 2018-06-21 JP JP2019572460A patent/JP2020525215A/ja active Pending
- 2018-06-21 CN CN201880045252.2A patent/CN110891525B/zh active Active
- 2018-06-21 EP EP18743631.6A patent/EP3648707B1/en active Active
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2020
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