WO2015051430A1 - Disposição introduzida em suporte para plastia ou troca de válvula cardíaca - Google Patents

Disposição introduzida em suporte para plastia ou troca de válvula cardíaca Download PDF

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Publication number
WO2015051430A1
WO2015051430A1 PCT/BR2014/000168 BR2014000168W WO2015051430A1 WO 2015051430 A1 WO2015051430 A1 WO 2015051430A1 BR 2014000168 W BR2014000168 W BR 2014000168W WO 2015051430 A1 WO2015051430 A1 WO 2015051430A1
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WO
WIPO (PCT)
Prior art keywords
ring
heart
ovoid
adjusting
tension
Prior art date
Application number
PCT/BR2014/000168
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English (en)
French (fr)
Inventor
Antonio Francisco NEVES FILHO
Original Assignee
Neves Filho Antonio Francisco
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Publication date
Application filed by Neves Filho Antonio Francisco filed Critical Neves Filho Antonio Francisco
Publication of WO2015051430A1 publication Critical patent/WO2015051430A1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A61F2/2448—D-shaped rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility

Definitions

  • the present utility model discloses an arrangement inserted in a heart valve replacement or replacement holder comprising a holder positioned over the mitral valve, whose atrial face is provided with an ovoid ring (9) consisting of metal parts ( 20) and plastic parts (10).
  • the anchorage can be adapted by adjusting the tension exerted on the papillary muscles and the spring effect promoted by the helical filaments (13) on the PTFE cords (7), according to the pathology or physiological characteristics of the patient.
  • the adjusting elements (11) are protected by silicon cocoons (12) with fragile part (14) for access to the screws without removing the cocoon (12).
  • a traditional method comprises the use of mechanical side flow valves such as that of Starr-Edwards (first disclosed in US3099016).
  • This device consists of an occluder element - usually of spherical profile - interposed in the blood flow path, diverting it.
  • the initial project addressed several disadvantages such as the structural fragility of the cage rods, the low ball resistance (resulting in septic injuries) and the need for permanent anticoagulant drug therapy to the patient. Also highlighted is the positioning of the valves as another impacting factor on the patient's health.
  • PI0711664-0 was developed to replace injured tendon cords in cases of mitral prolapse. There is no mention or any information in the report that supports its application in valve repair or replacement. This document contemplates a rudimentary rope and hook connection. Similarly, international application WO2012106602 discloses an apparatus and a method of positioning thereof incorporating some common elements into PI0711664-0.
  • US2013079873 describes in turn an assembly comprising a prosthetic valve, provided with a valve portion and a holder containing securing means for supporting it to the mitral annulus, providing a locking mechanism to prevent slippage of the chains. and mentioning the possibility that the clamping mechanism may be a screw.
  • the clamping mechanism may be a screw.
  • One of the limitations of this device is that it is impossible to adjust the dimensions of the chains quickly. If adjustments are required, the device should be removed, adjusted and repositioned over the valve. Still, the exposure of Supportive fixation elements facilitates contamination or even injury to the cardiac muscles.
  • the present utility model discloses an arrangement introduced in a support for cardiac valve replacement or replacement comprising an ovoid ring (10) complementary to the atrial face of the mitral valve.
  • an ovoid ring (10) complementary to the atrial face of the mitral valve.
  • the ovoid ring (10) are a plurality of fasteners (6), each protected by silicone cocoons (12).
  • Adjusting elements (11) position PTFE cords (7) over which inert and helical filaments are disposed
  • a hook (8) is provided for attachment to the papillary muscles (5).
  • Figure 1 shows a detailed view of the support, positioned over the mitral valve.
  • Figure 2 illustrates a sagittal sectional view of the heart, in which the support is positioned over the mitral valve and tensioned by the cords (7).
  • Figure 3 illustrates a perspective view of the ovoid shaped support device. with cords (7), hooks (8) and adjusting device (11).
  • Figure 4 illustrates a top view of the support device positioned on the mitral valve.
  • Figure 5 illustrates a detailed view of one of the fasteners (11).
  • Figure 6 illustrates a top perspective view of one of the fasteners (11).
  • the device disclosed herein comprises a support positioned over the mitral valve, in whose atrial face, an ovoid ring (10) is provided.
  • Figure 1 shows a detailed top view of the ovoid ring (9) composed of a plastic part (11) and a metal part (20), on which is placed an adjusting element (11) covered by a cocoon of silicone (12) comprising a weakened region
  • Figure 2 illustrates an application of the ovoid ring (9) to the heart valve, consisting of rigid metal parts (20) and flexible plastic parts (10), tensioned by cords (7) anchored to the papillary muscles (5) by hooks. (8), allowing the remodeling of the heart valve. More specifically, the anchorage can be adapted by adjusting the tension exerted on the papillary muscles (5) on the PTFE cords (7), according to the pathology or physiological characteristics of the patient.
  • Figure 3 illustrates a perspective view of the ovoid ring (9), composed of metal parts (20) and flexible plastic parts (10) with a plurality of fasteners (6) at the bottom which is placed in the fabric. of the diseased heart valve.
  • the adjusting elements (11) are intended for the PTFE cords (7), which have an inert helical filament (13) and are spring loaded.
  • Figure 4 illustrates a top view of the holder, comprising a pair of adjusting elements (11), the latter comprising a tensioning screw (15), positioned complementary to the weakened region (14) of the cocoon (14). 12).
  • This construction makes it possible to adjust the tension of the strands (7) by means of a tensioning screw (15) without the need to remove the ring.
  • the weakened region (14) is positioned over the second diameter adjusting screw (17), which in turn communicates to an axis (16) that regulates the perimeter of the ring by a striated region, communicating with the tensioning screw (15).
  • Figures 5 and 6 show, respectively, the lower and upper view of the adjusting element (11) having a diameter adjusting screw (17) which regulates the perimeter of the ovoid ring (9) by means of a region.
  • plastic rings One way to improve the mechanical strength of plastic rings is to make them rigid and resistant material such as metals or rigid plastics.
  • this construction prevents adjustment of the ring perimeter, which is necessary according to the pathology and anatomy of the patient.
  • the ring size decision is made prior to the surgical procedure, but fine adjustment is always required during the procedure.
  • the invention brings an ovoid ring (9) with metal parts (20) interspersed with flexible parts (10) and two adjusting elements (11).
  • the metallic part (20) provides mechanical resistance to the device, while the flexible part (10) allows the accommodation of the ring (09) in the patient's heart valve.
  • a plurality of hooks (6) are constructed on the underside of the ovoid ring (10) throughout its perimeter. When the hooks (6) penetrate the heart tissue, the ring (9) is positioned and fixed.
  • the ring (9) is tensioned by strings (7) of inert material such as PFTE, with helical filaments
  • the ovoid ring (9) offers:

Abstract

O presente modelo de utilidade revela uma disposição introduzida em um suporte para plastia ou troca de válvula cardíaca, compreendendo um anel ovóide (9), para posicionamento na válvula mitral, constituído de partes metálicas (20) e partes plásticas (10). Na parte superior do anel (9) encontram-se dois elementos de ajuste (11), os quais possuem: um primeiro parafuso de regulagem de tensão (15) para ajuste da tensão dos cordões (7) de PTFE com filamentos helicoidais e inertes (13) com efeito mola que são ancorados por anzóis (8) nos músculos papilares (5), e um segundo parafuso de ajuste de diâmetro (17) que regula o diâmetro do anel ovóide (9), regulados conforme a patologia ou características fisiológicas do paciente. Os elementos de ajuste (11) são protegidos por casulos de silicone (12) com parte fragilizada (14) para acesso aos parafusos sem a retirada do casulo (12).

Description

"DISPOSIÇÃO INTRODUZIDA EM SUPORTE PARA PLASTIA OU TROCA DE VÁLVULA CARDÍACA"
Campo de Aplicação
[001] O presente modelo de utilidade revela uma disposição introduzida em um suporte para plastia ou troca de válvula cardíaca, compreendendo um suporte posicionado sobre a válvula mitral, cuja face atrial, dispõe-se um anel ovóide (9) constituído de partes metálicas (20) e partes plásticas (10). Na parte superior do anel (9) encontram-se dois elementos de ajuste (11). Os citados elementos de ajuste (11) possuem um parafuso de regulagem de tensão (15) para tensionar os cordões (7) de PTFE com filamentos helicoidais e inertes (13) com efeito mola que, sendo os cordões (7) ancorados por anzóis (8) nos músculos papilares (5) e um segundo parafuso de ajuste de diâmetro (17) que regula o diâmetro do anel ovóide (9) . A ancoragem pode ser adaptada ajustando a tensão exercida nos músculos papilares e o efeito mola promovido pelos filamentos helicoidais (13), sobre os cordões de PTFE (7), conforme a patologia ou características fisiológicas do paciente. Os elementos de ajuste (11) são protegidos por casulos de silicone (12) com parte fragilizada (14) para acesso aos parafusos sem a retirada do casulo (12).
Descrição do estado da técnica
[002] No estado da técnica observa-se uma série de abordagens distintas para o tratamento de disfunções associadas às válvulas cardíacas. Um método tradicional compreende o uso de válvulas mecânicas de fluxo lateral, como a de Starr-Edwards (revelado inicialmente na patente US3099016) . Este dispositivo consiste em um elemento oclusor - usualmente de perfil esférico - interposto no trajeto do fluxo sanguíneo, desviando-o. O projeto inicial contemplava diversas desvantagens como, por exemplo, a fragilidade estrutural das hastes da gaiola, a baixa resistência da esfera (acarretando em lesões aos septos) e a necessidade de uma terapia medicamentosa permanente de anticoagulantes ao paciente. Destaca-se ainda o posicionamento das válvulas como outro fator impactante na saúde do paciente.
[003] A evolução dos dispositivos de oclusão ocorreu por meio do desenvolvimento de. válvulas mecânicas de fluxo frontal, dotadas de estruturas pivotantes que permitiam um fluxo sanguíneo unidirecional . Entretanto, aspectos negativos como a fadiga 'mecânica, o uso de anticoagulantes e a calcificação da válvula cardíaca ainda persistiram. Algumas formas para se contornar parcialmente os problemas do estado da técnica foram descritas nos documentos PI9700076-0 e US6113631.
[004] Uma proposta alternativa abrange o uso de biopróteses ou válvulas bioprostéticas , construídas predominantemente a partir de tecido biológico (pericárdio bovino ou suíno) mimetizando os folhetos constituintes das válvulas do coração humano. Os documentos PI9202905-1 e US6358277 são ilustrativos desta concepção . [005] A abordagem cirúrgica da maioria dos quadros de regurgitação mitral (valvuloplastias ) demanda a aplicação de anéis de anuloplastia para fixação da base sendo um procedimento relativamente demorado, uma vez que as variações anatómicas de cada individuo exigem um cuidado maior para sua fixação.
[006] Por sua vez, o dispositivo revelado em
PI0711664-0 foi desenvolvido para substituir cordas tendineas lesadas nos casos de prolapso mitral. Não há menção ou qualquer informação no relatório que suporte sua aplicação em plastias ou substituição de válvulas. Neste documento contempla-se uma conexão rudimentar por cordas e gancho. Da mesma forma, o pedido internacional WO2012106602 revela um aparato e um método de posicionamento do mesmo, incorporando alguns elementos comuns ao PI0711664-0.
[007] O pedido US2013079873 descreve por sua vez um conjunto compreendendo uma válvula prostética, dotada de uma porção valvar e um suporte contendo meios de fixação para suporte do mesmo ao annulus mitral, prevendo um mecanismo de fechadura de modo a evitar o deslizamento das correntes e mencionando a possibilidade do mecanismo de fixação poder ser um parafuso. Uma das limitações pertinentes a este dispositivo reside na impossibilidade de se ajustar as dimensões das correntes de forma ágil. Caso sejam necessários ajustes, o dispositivo deve ser retirado, regulado e posicionado novamente sobre a válvula. Ainda, a exposição dos elementos de fixação de suporte facilita a contaminação ou mesmo lesão da musculatura cardíaca.
[008] Diante do estado da técnica, percebe-se que existe a demanda por meios ou sistemas que aumentem a confiabilidade dos procedimentos cirúrgicos e reduzam o tempo de duração dos mesmos .
Objetivos do Modelo
[009] Neste sentido, visando contornar as desvantagens existentes no estado da técnica, o presente modelo de utilidade revela uma disposição introduzida em um suporte para plastia ou troca de válvula cardíaca, compreendendo um anel ovóide (10) de perfil complementar à face atrial da válvula mitral. No anel ovóide (10) encontra-se uma pluralidade de elementos de fixação (6), cada qual protegida por casulos de silicone (12). Elementos de ajuste (11) posicionam cordões (7) de PTFE, sobre a qual se dispõe filamentos helicoidais e inertes
(13), com efeito mola. Na porção terminal de cada cordão
(7), prevê-se um anzol (8) para fixação aos músculos papilares ( 5 ) .
Breve descrição das Figuras
[0010] A Figura 1 revela uma vista detalhada do suporte, posicionado sobre a válvula mitral.
[0011] A Figura 2 ilustra uma vista em corte sagital do coração, na qual é posicionado o suporte sobre a válvula mitral e tensionado pelos cordões (7) .
[0012] A Figura 3 ilustra uma vista em perspectiva do dispositivo de suporte de formato ovóide com os cordões (7), anzóis (8) e dispositivo de ajuste (11).
[0013] A Figura 4 ilustra uma vista superior do dispositivo de suporte posicionado na válvula mitral.
[0014] A Figura 5 ilustra uma vista detalhada de um dos elemento de fixação (11) .
[0015] A Figura 6 ilustra uma vista em perspectiva superior de um dos elementos de fixação (11) .
Descrição Detalhada das Figuras
[0016] O dispositivo ora revelado compreende um suporte posicionado sobre a válvula mitral, em cuja face atrial, dispõe-se um anel ovóide (10).
[0017] A Figura 1 ilustra uma vista detalhada superior do anel ovóide (9) composto de uma parte plástica (11) e uma parte metálica (20), sobre a qual é colocado um elemento de ajuste (11) coberto por um casulo de silicone (12), compreendendo uma região enfraquecida
(14) por onde se podem acessar os parafusos de ajustes vistos nas outras figuras. Do elemento de ajuste (11) sai um cordão de PTFE (7) que é tensionado ao apertar um dos parafusos de ajuste e ancorado por um anzol (8). Tal configuração permite evitar a exposição dos componentes dos elementos de ajuste (11) ao meio fisiológico.
[0018] A Figura 2 ilustra uma aplicação do anel ovóide (9) na válvula cardíaca, constituído de partes metálicas rígidas (20) e partes plásticas flexíveis (10), tensionado por cordões (7) ancorados nos músculos papilares (5) por anzóis (8), permitindo o remodelamento da válvula cardíaca. Mais especificamente, a ancoragem pode ser adaptada ajustando a tensão exercida nos músculos papilares (5) sobre os cordões de PTFE (7), conforme a patologia ou características fisiológicas do paciente .
[0019] A Figura 3 ilustra uma vista em perspectiva o anel ovóide (9), composto de partes metálicas (20) e partes plásticas flexíveis (10) com uma pluralidade de elementos de fixação (6) na parte inferior que é colocada no tecido da válvula cardíaca doente. Os elementos de ajuste (11) tencionam os cordões (7) de PTFE, que possuem filamentos helicoidais (13) de caráter inerte e são dotados de efeito mola. A porção terminal de
(7) fixa um anzol (8) para fixação aos músculos papilares
(5) .
[0020] A Figura 4 ilustra uma vista superior do suporte, compreendendo um par de elementos de ajuste (11), estes últimos compreendem um parafuso de regulagem de tensão (15), posicionado de forma complementar à região enfraquecida (14) do casulo (12). Esta construção permite ajustar a tensão dos cordões (7) por meio de um parafuso de regulagem de tensão (15) sem a necessidade de retirar o anel. Neste caso, a região enfraquecida (14) é posicionada sobre o segundo parafuso de regulagem de diâmetro (17), que por sua vez, se comunica a um eixo (16) que regula o perímetro do anel por uma região estriada, comunicante com o parafuso de regulagem de tensão ( 15 ) . [0021] As figuras 5 e 6 mostram, respectivamente, a vista inferior e superior do elemento de ajuste (11) que possui um parafuso de regulagem de diâmetro (17) que regula o perímetro do anel ovóide (9) por meio de uma região estriada do eixo (16) e um parafuso de regulagem de tensão (15) que ajusta a tensão dos cordões (7) que está acoplado a um eixo reforçado
(16) ·
DESCRIÇÃO DA INVENÇÃO
[0022] Atualmente, os anéis utilizados em procedimentos de plastia são flexíveis, o que prejudica a ancoragem e tensionamento de stents e válvulas cardíacas posicionadas sobre eles.
[0023] Uma forma de melhorar a resistência mecânica dos anéis de plastia é a construção em material rígido e resistente como metais ou plásticos rígidos. Entretanto, essa construção impede a regulagem o perímetro do anel, o que é necessário de acordo com a patologia e anatomia do paciente. A decisão do tamanho do anel é feita previamente ao procedimento cirúrgico, mas é sempre necessária a regulagem fina durante o procedimento .
[0024] Para resolver esse problema, o invento trás um anel ovóide (9) com partes metálicas (20) intercalada com partes flexíveis (10) e dois elementos de ajuste (11). Assim, a parte metálica (20) oferece resistência mecânica ao dispositivo, enquanto a parte flexível (10) permite a acomodação do anel (09) na válvula cardíaca do paciente.
[0025] A fim de fixar o anel, uma pluralidade de ganchos (6) é construída na parte inferior do anel ovóide (10), em todo o seu perímetro. Quando os ganchos (6) penetram o tecido do coração, o anel (9) é posicionado e fixado .
[0026] Porém, a pressão sanguínea e o batimento cardíaco prejudicam a fixação das válvulas artificiais. Sendo assim o anel (9) é tensionado por cordões (7) de material inerte como o PFTE, com filamentos helicoidais
(13) e efeito de mola, sendo na extremidade fixado um anzol (8) que é ancorado nos músculos papilares. A tensão dos cordões (7) é ajustada por parafusos de ajusta de tensão (15) .
[0027] Em suma, o anel ovóide (9) oferece:
[0028] - resistência mecânica em razão das partes metálicas (20);
[0029] - flexibilidade por causa das partes plásticas flexíveis (21);
[0030] - possibilidade de ajuste por meio dos elementos de ajuste (11);
[0031] - boa fixação no músculo cardíaco em razão dos ganchos (6);
[0032] - possibilidade de tensionamento com cordões (7) de ancoragem, o que aumenta a resistência à pressão sanguínea e movimento cardíaco.

Claims

REIVINDICAÇÃO
"DISPOSIÇÃO INTRODUZIDA EM SUPORTE PARA PLASTIA OU TROCA DE VÁLVULA CARDÍACA" caracterizada por compreender um anel de perfil ovóide (9) composto de partes metálicas rígidas (20) e partes plásticas flexíveis (10), sendo que na parte inferior do perfil ovóide (9) encontram-se uma pluralidade de elementos de fixação (6), enquanto na parte superior são fixados dois elementos de ajuste (11), diametralmente opostos, que possuem um parafuso de ajuste de diâmetro (17) que regula o perímetro do perfil ovóide (9) por meio de uma região estriada do eixo (16) e um segundo parafuso de regulagem de tensão (15) que tensiona os cordões (7) de PTFE, os quais são dotados de filamentos helicoidais (13) de caráter inerte e efeito mola com uma porção terminal presa a um anzol (8), sendo o anzol (8) ancorado nos músculos papilares (5); o parafuso de regulagem de tensão
(15) aciona um eixo (16) onde os cordões (7) são enrolados, tensionando os cordões depois de ancorados pelos anzóis (8); sobre os elementos de ajuste (11) são colocados casulos (12) com uma parte fragilizada (14) por onde se tem acesso aos parafusos de ajuste de diâmetro
(17) e parafuso de regulagem de tensão (15) sem a retirada do casulo.
PCT/BR2014/000168 2013-10-10 2014-05-20 Disposição introduzida em suporte para plastia ou troca de válvula cardíaca WO2015051430A1 (pt)

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BR202013026161 2013-10-10
BRBR202013026161-6 2013-10-10

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WO2015051430A1 true WO2015051430A1 (pt) 2015-04-16

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US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US9572662B2 (en) 2011-06-21 2017-02-21 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
RU169013U1 (ru) * 2016-03-28 2017-03-01 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Плоское жесткое опорное кольцо митрального клапана
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9730792B2 (en) 2007-09-13 2017-08-15 Georg Lutter Truncated cone heart valve stent
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9833315B2 (en) 2011-08-11 2017-12-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9895221B2 (en) 2012-07-28 2018-02-20 Tendyne Holdings, Inc. Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10201419B2 (en) 2014-02-05 2019-02-12 Tendyne Holdings, Inc. Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US10219900B2 (en) 2012-07-30 2019-03-05 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10363135B2 (en) 2013-10-29 2019-07-30 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US10405976B2 (en) 2013-05-30 2019-09-10 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10463494B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US10517728B2 (en) 2014-03-10 2019-12-31 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US10555718B2 (en) 2013-10-17 2020-02-11 Tendyne Holdings, Inc. Apparatus and methods for alignment and deployment of intracardiac devices
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10595996B2 (en) 2013-06-25 2020-03-24 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US10610354B2 (en) 2013-08-01 2020-04-07 Tendyne Holdings, Inc. Epicardial anchor devices and methods
US10610358B2 (en) 2015-12-28 2020-04-07 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
US10610356B2 (en) 2015-02-05 2020-04-07 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10667905B2 (en) 2015-04-16 2020-06-02 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786351B2 (en) 2015-01-07 2020-09-29 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US11039921B2 (en) 2016-06-13 2021-06-22 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
US11065116B2 (en) 2016-07-12 2021-07-20 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
US11090157B2 (en) 2016-06-30 2021-08-17 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
US11096782B2 (en) 2015-12-03 2021-08-24 Tendyne Holdings, Inc. Frame features for prosthetic mitral valves
US11154399B2 (en) 2017-07-13 2021-10-26 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
US11179236B2 (en) 2009-12-08 2021-11-23 Colorado State University Research Foundation Device and system for transcatheter mitral valve replacement
US11191639B2 (en) 2017-08-28 2021-12-07 Tendyne Holdings, Inc. Prosthetic heart valves with tether coupling features
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US11648110B2 (en) 2019-12-05 2023-05-16 Tendyne Holdings, Inc. Braided anchor for mitral valve
US11678980B2 (en) 2020-08-19 2023-06-20 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning
US11951002B2 (en) 2021-03-23 2024-04-09 Tendyne Holdings, Inc. Apparatus and methods for valve and tether fixation

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US9730792B2 (en) 2007-09-13 2017-08-15 Georg Lutter Truncated cone heart valve stent
US11179236B2 (en) 2009-12-08 2021-11-23 Colorado State University Research Foundation Device and system for transcatheter mitral valve replacement
US10517725B2 (en) 2010-12-23 2019-12-31 Twelve, Inc. System for mitral valve repair and replacement
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US11571303B2 (en) 2010-12-23 2023-02-07 Twelve, Inc. System for mitral valve repair and replacement
US9579196B2 (en) 2011-06-21 2017-02-28 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9585751B2 (en) 2011-06-21 2017-03-07 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10028827B2 (en) 2011-06-21 2018-07-24 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11523900B2 (en) 2011-06-21 2022-12-13 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9572662B2 (en) 2011-06-21 2017-02-21 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10751173B2 (en) 2011-06-21 2020-08-25 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11712334B2 (en) 2011-06-21 2023-08-01 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10034750B2 (en) 2011-06-21 2018-07-31 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11123180B2 (en) 2011-08-11 2021-09-21 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11484404B2 (en) 2011-08-11 2022-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US10639145B2 (en) 2011-08-11 2020-05-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US10617519B2 (en) 2011-08-11 2020-04-14 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11311374B2 (en) 2011-08-11 2022-04-26 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11364116B2 (en) 2011-08-11 2022-06-21 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11123181B2 (en) 2011-08-11 2021-09-21 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11135055B2 (en) 2011-08-11 2021-10-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US11382737B2 (en) 2011-08-11 2022-07-12 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9833315B2 (en) 2011-08-11 2017-12-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11826249B2 (en) 2011-10-19 2023-11-28 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10052204B2 (en) 2011-10-19 2018-08-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10335278B2 (en) 2011-10-19 2019-07-02 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11497603B2 (en) 2011-10-19 2022-11-15 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299917B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11197758B2 (en) 2011-10-19 2021-12-14 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US11617648B2 (en) 2011-10-19 2023-04-04 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10945835B2 (en) 2011-10-19 2021-03-16 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9295552B2 (en) 2011-10-19 2016-03-29 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11628063B2 (en) 2011-10-19 2023-04-18 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10016271B2 (en) 2011-10-19 2018-07-10 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299927B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US10952844B2 (en) 2011-12-16 2021-03-23 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US11129714B2 (en) 2012-03-01 2021-09-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US10258468B2 (en) 2012-03-01 2019-04-16 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9895221B2 (en) 2012-07-28 2018-02-20 Tendyne Holdings, Inc. Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US11759318B2 (en) 2012-07-28 2023-09-19 Tendyne Holdings, Inc. Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US11090155B2 (en) 2012-07-30 2021-08-17 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US10219900B2 (en) 2012-07-30 2019-03-05 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US11311379B2 (en) 2013-04-02 2022-04-26 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10463494B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US11364119B2 (en) 2013-04-04 2022-06-21 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US11234821B2 (en) 2013-05-20 2022-02-01 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US11617645B2 (en) 2013-05-30 2023-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US10405976B2 (en) 2013-05-30 2019-09-10 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US11471281B2 (en) 2013-06-25 2022-10-18 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US10595996B2 (en) 2013-06-25 2020-03-24 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US11612480B2 (en) 2013-08-01 2023-03-28 Tendyne Holdings, Inc. Epicardial anchor devices and methods
US10610354B2 (en) 2013-08-01 2020-04-07 Tendyne Holdings, Inc. Epicardial anchor devices and methods
US11246562B2 (en) 2013-10-17 2022-02-15 Tendyne Holdings, Inc. Apparatus and methods for alignment and deployment of intracardiac devices
US10555718B2 (en) 2013-10-17 2020-02-11 Tendyne Holdings, Inc. Apparatus and methods for alignment and deployment of intracardiac devices
US10363135B2 (en) 2013-10-29 2019-07-30 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US11096783B2 (en) 2013-10-29 2021-08-24 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US11464628B2 (en) 2014-02-05 2022-10-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US11589985B2 (en) 2014-02-05 2023-02-28 Tendyne Holdings, Inc. Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US10201419B2 (en) 2014-02-05 2019-02-12 Tendyne Holdings, Inc. Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US11045183B2 (en) 2014-02-11 2021-06-29 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US11382753B2 (en) 2014-03-10 2022-07-12 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US10517728B2 (en) 2014-03-10 2019-12-31 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US10786351B2 (en) 2015-01-07 2020-09-29 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US10610356B2 (en) 2015-02-05 2020-04-07 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US11523902B2 (en) 2015-04-16 2022-12-13 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10667905B2 (en) 2015-04-16 2020-06-02 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10820996B2 (en) 2015-08-21 2020-11-03 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US11576782B2 (en) 2015-08-21 2023-02-14 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US11318012B2 (en) 2015-09-18 2022-05-03 Tendyne Holdings, Inc. Apparatus and methods for delivery of prosthetic mitral valve
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US11096782B2 (en) 2015-12-03 2021-08-24 Tendyne Holdings, Inc. Frame features for prosthetic mitral valves
US11464629B2 (en) 2015-12-28 2022-10-11 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
US10610358B2 (en) 2015-12-28 2020-04-07 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
RU169013U1 (ru) * 2016-03-28 2017-03-01 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Плоское жесткое опорное кольцо митрального клапана
US11033390B2 (en) 2016-04-29 2021-06-15 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US11253354B2 (en) 2016-05-03 2022-02-22 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US11039921B2 (en) 2016-06-13 2021-06-22 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
US11701226B2 (en) 2016-06-30 2023-07-18 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
US11090157B2 (en) 2016-06-30 2021-08-17 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
US11065116B2 (en) 2016-07-12 2021-07-20 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US11654021B2 (en) 2017-04-18 2023-05-23 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US11737873B2 (en) 2017-04-18 2023-08-29 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US11389295B2 (en) 2017-04-18 2022-07-19 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US11786370B2 (en) 2017-05-11 2023-10-17 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US11559398B2 (en) 2017-06-02 2023-01-24 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US11464659B2 (en) 2017-06-06 2022-10-11 Twelve, Inc. Crimping device for loading stents and prosthetic heart valves
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11877926B2 (en) 2017-07-06 2024-01-23 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11154399B2 (en) 2017-07-13 2021-10-26 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
US11191639B2 (en) 2017-08-28 2021-12-07 Tendyne Holdings, Inc. Prosthetic heart valves with tether coupling features
US11648110B2 (en) 2019-12-05 2023-05-16 Tendyne Holdings, Inc. Braided anchor for mitral valve
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US11678980B2 (en) 2020-08-19 2023-06-20 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning
US11951002B2 (en) 2021-03-23 2024-04-09 Tendyne Holdings, Inc. Apparatus and methods for valve and tether fixation

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