JP2019535831A5 - - Google Patents
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- JP2019535831A5 JP2019535831A5 JP2019547600A JP2019547600A JP2019535831A5 JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5 JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphorus
- nitrogen
- sulfur
- oxygen
- silicon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 COP(**)N(*)* Chemical compound COP(**)N(*)* 0.000 description 4
- USASGRZAGIBLKB-UHFFFAOYSA-N CC(C)(C)[n]1c(N=C(N)NC2=O)c2nc1 Chemical compound CC(C)(C)[n]1c(N=C(N)NC2=O)c2nc1 USASGRZAGIBLKB-UHFFFAOYSA-N 0.000 description 1
- OEHLXFHBMYNPOZ-IMSGDLLMSA-N C[C@@]1(c2ccccc2)OP(C)N2[C@@H]1CCC2 Chemical compound C[C@@]1(c2ccccc2)OP(C)N2[C@@H]1CCC2 OEHLXFHBMYNPOZ-IMSGDLLMSA-N 0.000 description 1
- REHLFRCNMJTHIZ-QXNREYOVSA-N C[C@]([C@H]1N2CCC1)(c1ccccc1)OP2I Chemical compound C[C@]([C@H]1N2CCC1)(c1ccccc1)OP2I REHLFRCNMJTHIZ-QXNREYOVSA-N 0.000 description 1
- KHZYHKBQROIRKP-BEWYTNLXSA-N C[Si+](C[C@@H]([C@@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 Chemical compound C[Si+](C[C@@H]([C@@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 KHZYHKBQROIRKP-BEWYTNLXSA-N 0.000 description 1
- KHZYHKBQROIRKP-HXIJRHRVSA-N C[Si+](C[C@H]([C@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 Chemical compound C[Si+](C[C@H]([C@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 KHZYHKBQROIRKP-HXIJRHRVSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023026999A JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426079P | 2016-11-23 | 2016-11-23 | |
| US62/426,079 | 2016-11-23 | ||
| PCT/US2017/062996 WO2018098264A1 (en) | 2016-11-23 | 2017-11-22 | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023026999A Division JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535831A JP2019535831A (ja) | 2019-12-12 |
| JP2019535831A5 true JP2019535831A5 (enExample) | 2021-01-07 |
| JP7296882B2 JP7296882B2 (ja) | 2023-06-23 |
Family
ID=62195630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547600A Active JP7296882B2 (ja) | 2016-11-23 | 2017-11-22 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
| JP2023026999A Pending JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023026999A Pending JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11873316B2 (enExample) |
| EP (1) | EP3544987A4 (enExample) |
| JP (2) | JP7296882B2 (enExample) |
| CN (1) | CN110088113A (enExample) |
| MA (1) | MA46905A (enExample) |
| WO (1) | WO2018098264A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| EP3094728B1 (en) | 2014-01-16 | 2022-03-09 | Wave Life Sciences Ltd. | Chiral design |
| AU2015367378A1 (en) | 2014-12-17 | 2017-06-15 | Proqr Therapeutics Ii B.V. | Targeted RNA editing |
| CN117965536A (zh) | 2015-07-22 | 2024-05-03 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| MA46427A (fr) | 2015-10-09 | 2018-08-15 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| MA43822A (fr) | 2016-03-13 | 2018-11-28 | Wave Life Sciences Ltd | Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides |
| EP3452596A4 (en) | 2016-05-04 | 2020-03-18 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS |
| US11013757B2 (en) | 2016-06-03 | 2021-05-25 | Wave Life Sciences Ltd. | Oligonucleotides, compositions and methods thereof |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| WO2018041973A1 (en) | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| WO2018098264A1 (en) | 2016-11-23 | 2018-05-31 | Wave Life Sciences Ltd. | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| CA3065523A1 (en) | 2017-06-02 | 2018-12-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| WO2018237194A1 (en) | 2017-06-21 | 2018-12-27 | Wave Life Sciences Ltd. | Compounds, compositions and methods for synthesis |
| AU2018316159A1 (en) | 2017-08-08 | 2020-02-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| CN111108096A (zh) | 2017-09-18 | 2020-05-05 | 波涛生命科学有限公司 | 寡核苷酸制备技术 |
| EP3694530A4 (en) | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
| JP2021521140A (ja) | 2018-04-12 | 2021-08-26 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| CA3098624A1 (en) | 2018-05-11 | 2019-11-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| AU2020241559A1 (en) | 2019-03-20 | 2021-11-11 | Wave Life Sciences Ltd. | Technologies useful for oligonucleotide preparation |
| MX2021012981A (es) | 2019-04-25 | 2022-01-18 | Wave Life Sciences Ltd | Composiciones de oligonucleotido y metodos de uso de las mismas. |
| MX2022014606A (es) | 2020-05-22 | 2023-03-08 | Wave Life Sciences Ltd | Composiciones de oligonucleótidos bicatenarios y métodos relacionados con las mismas. |
| EP4479535A1 (en) | 2022-02-14 | 2024-12-25 | ProQR Therapeutics II B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| EP4555086A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| EP4555085A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| KR20250113455A (ko) | 2022-11-24 | 2025-07-25 | 프로큐알 테라퓨틱스 Ⅱ 비.브이. | 유전성 hfe-혈색소침착증의 치료를 위한 안티센스 올리고뉴클레오티드 |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| WO2024121373A1 (en) | 2022-12-09 | 2024-06-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| WO2024175550A1 (en) | 2023-02-20 | 2024-08-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| JP2026510408A (ja) | 2023-03-24 | 2026-04-02 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | 神経障害の処置のためのアンチセンスオリゴヌクレオチド |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| EP4688143A1 (en) | 2023-03-27 | 2026-02-11 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2024256620A1 (en) | 2023-06-16 | 2024-12-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
| AU2024287308A1 (en) | 2023-07-13 | 2025-12-18 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| EP4774393A1 (en) | 2023-09-07 | 2026-07-15 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2025096809A1 (en) | 2023-10-31 | 2025-05-08 | Korro Bio, Inc. | Oligonucleotides comprising phosphoramidate internucleotide linkages |
| AU2024379264A1 (en) | 2023-11-16 | 2026-05-14 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025128799A1 (en) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| AU2024402199A1 (en) | 2023-12-20 | 2026-07-16 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026050243A1 (en) | 2024-08-26 | 2026-03-05 | Korro Bio, Inc. | Galnac conjugated oligonucleotides for rna editing |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2026093339A1 (en) | 2024-10-29 | 2026-05-07 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of peroxisome biogenesis disorders in the zellweger spectrum (pbd-zsd) |
| WO2026122478A1 (en) | 2024-12-02 | 2026-06-11 | Korro Bio, Inc. | Extrahepatic delivery formulations and methods |
| WO2026136663A1 (en) | 2024-12-18 | 2026-06-25 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
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| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| CN111164091B (zh) | 2017-06-02 | 2025-01-07 | 波涛生命科学有限公司 | 寡核苷酸组合物及其使用方法 |
| WO2018237194A1 (en) | 2017-06-21 | 2018-12-27 | Wave Life Sciences Ltd. | Compounds, compositions and methods for synthesis |
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| EP3965780A4 (en) | 2019-05-09 | 2023-10-25 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE |
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| JP2023548584A (ja) | 2020-11-08 | 2023-11-17 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物及びその方法 |
| CN116507724A (zh) | 2020-11-08 | 2023-07-28 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| CA3232070A1 (en) | 2021-09-26 | 2023-03-30 | Prashant MONIAN | Oligonucleotide compositions and methods thereof |
| EP4404942A4 (en) | 2021-09-26 | 2026-06-17 | Wave Life Sciences Ltd | Compositions for the Editing of Transcripts MECP2 and Related Processes |
| EP4422645A4 (en) | 2021-10-27 | 2025-12-03 | Wave Life Sciences Ltd | OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE |
| AU2021471586A1 (en) | 2021-10-27 | 2024-05-09 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| EP4476202A4 (en) | 2022-02-11 | 2026-06-10 | Wave Life Sciences Ltd | STEREOSELECTIVE TECHNOLOGIES FOR CHIRICAL COMPOUNDS |
| US20250197857A1 (en) | 2022-03-02 | 2025-06-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof for exon skipping |
| EP4507700A2 (en) | 2022-04-15 | 2025-02-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods relating thereto |
| CN119452084A (zh) | 2022-05-12 | 2025-02-14 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| EP4569115A4 (en) | 2022-08-11 | 2026-07-15 | Wave Life Sciences Ltd | OLIGONUCLEOTID COMPOSITIONS AND ASSOCIATED PROCESSES |
| EP4753719A1 (en) | 2023-08-03 | 2026-06-10 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
-
2017
- 2017-11-22 WO PCT/US2017/062996 patent/WO2018098264A1/en not_active Ceased
- 2017-11-22 MA MA046905A patent/MA46905A/fr unknown
- 2017-11-22 CN CN201780072663.6A patent/CN110088113A/zh active Pending
- 2017-11-22 US US16/463,328 patent/US11873316B2/en active Active
- 2017-11-22 EP EP17874211.0A patent/EP3544987A4/en active Pending
- 2017-11-22 JP JP2019547600A patent/JP7296882B2/ja active Active
-
2023
- 2023-02-24 JP JP2023026999A patent/JP2023062180A/ja active Pending
- 2023-11-28 US US18/522,146 patent/US12473321B2/en active Active
-
2025
- 2025-07-29 US US19/284,561 patent/US20260193286A1/en active Pending
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