JP2020528937A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020528937A5 JP2020528937A5 JP2020527851A JP2020527851A JP2020528937A5 JP 2020528937 A5 JP2020528937 A5 JP 2020528937A5 JP 2020527851 A JP2020527851 A JP 2020527851A JP 2020527851 A JP2020527851 A JP 2020527851A JP 2020528937 A5 JP2020528937 A5 JP 2020528937A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- xaa
- heteroatoms
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCC[C@@]([C@]1N2)SC[C@@]1NC2=*C Chemical compound CCCCC[C@@]([C@]1N2)SC[C@@]1NC2=*C 0.000 description 5
- XWXHLUBRCRYQSB-UHFFFAOYSA-N CC(CCOCCNC(C)=O)NC Chemical compound CC(CCOCCNC(C)=O)NC XWXHLUBRCRYQSB-UHFFFAOYSA-N 0.000 description 1
- KXDILFLCDRATRI-UHFFFAOYSA-N CCCCOCc1c[n](CC)nn1 Chemical compound CCCCOCc1c[n](CC)nn1 KXDILFLCDRATRI-UHFFFAOYSA-N 0.000 description 1
- VTWBTZUWYSQJLE-YUMQZZPRSA-N CCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O Chemical compound CCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O VTWBTZUWYSQJLE-YUMQZZPRSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023064212A JP2023103222A (ja) | 2017-07-26 | 2023-04-11 | 普遍的なａｂｔ化合物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537034P | 2017-07-26 | 2017-07-26 | |
| US62/537,034 | 2017-07-26 | ||
| PCT/US2018/043964 WO2019023501A1 (en) | 2017-07-26 | 2018-07-26 | UNIVERSAL ABT COMPOUNDS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023064212A Division JP2023103222A (ja) | 2017-07-26 | 2023-04-11 | 普遍的なａｂｔ化合物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528937A JP2020528937A (ja) | 2020-10-01 |
| JP2020528937A5 true JP2020528937A5 (enExample) | 2021-08-12 |
| JP7824730B2 JP7824730B2 (ja) | 2026-03-05 |
Family
ID=65040850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527851A Active JP7824730B2 (ja) | 2017-07-26 | 2018-07-26 | 普遍的なａｂｔ化合物及びその使用 |
| JP2023064212A Withdrawn JP2023103222A (ja) | 2017-07-26 | 2023-04-11 | 普遍的なａｂｔ化合物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023064212A Withdrawn JP2023103222A (ja) | 2017-07-26 | 2023-04-11 | 普遍的なａｂｔ化合物及びその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20200390895A1 (enExample) |
| EP (1) | EP3658170A4 (enExample) |
| JP (2) | JP7824730B2 (enExample) |
| KR (1) | KR102772176B1 (enExample) |
| CN (2) | CN119684469A (enExample) |
| AU (1) | AU2018307794B2 (enExample) |
| BR (1) | BR112020001583A2 (enExample) |
| CA (1) | CA3069986A1 (enExample) |
| EA (1) | EA202090372A1 (enExample) |
| IL (1) | IL272192B1 (enExample) |
| MX (1) | MX421628B (enExample) |
| PH (1) | PH12020550035A1 (enExample) |
| SG (1) | SG11202000628XA (enExample) |
| WO (1) | WO2019023501A1 (enExample) |
| ZA (1) | ZA202405748B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12491246B2 (en) | 2018-12-20 | 2025-12-09 | Biohaven Therapeutics Ltd. | Combination therapy of arms and natural killer cells |
| CA3143513A1 (en) * | 2019-07-03 | 2021-01-07 | Kleo Pharmaceuticals, Inc. | Cd38-binding agents and uses thereof |
| KR20220103986A (ko) * | 2019-11-18 | 2022-07-25 | 클레오 파마슈티컬스 인코포레이티드 | 지정 접합 기술 |
| EP4069311A1 (en) * | 2019-12-03 | 2022-10-12 | Debiopharm Research & Manufacturing SA | Reactive conjugates |
| WO2021195401A1 (en) * | 2020-03-25 | 2021-09-30 | Biohaven Therapeutics Ltd. | Technologies for preventing or treating infections |
| WO2022078566A1 (en) * | 2020-10-12 | 2022-04-21 | Debiopharm Research & Manufacturing S.A. | Reactive conjugates |
| US20240335555A1 (en) * | 2021-02-06 | 2024-10-10 | Biohaven Therapeutics Ltd. | Technologies for preventing or treating infections |
| IL307799A (en) * | 2021-05-17 | 2023-12-01 | Biohaven Therapeutics Ltd | Agents for targeted coupling techniques and conjugated products |
| PH12023553152A1 (en) * | 2021-05-17 | 2024-03-11 | Biohaven Therapeutics Ltd | Compositions including conjugated therapy enhancers |
| CN121127237A (zh) * | 2023-04-28 | 2025-12-12 | 拜奥海芬治疗学有限公司 | 用于靶向循环蛋白的选择性降解的双官能小分子 |
| CN121038815A (zh) | 2023-04-29 | 2025-11-28 | 拜奥海芬治疗学有限公司 | 半乳糖缺陷型免疫球蛋白的双功能降解剂 |
| WO2025158412A1 (en) | 2024-01-26 | 2025-07-31 | Biohaven Therapeutics Ltd. | BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS |
| WO2025181697A1 (en) | 2024-02-26 | 2025-09-04 | Biohaven Therapeutics Ltd. | Bifunctional degraders of anti-pla2r antibody |
| WO2025210538A1 (en) | 2024-04-02 | 2025-10-09 | Biohaven Therapeutics Ltd. | Bifunctional degraders |
| WO2026028159A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Bifunctional degraders for the treatment of graves' disease |
| WO2026028158A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Targeted degradation of anti-aav antibodies to enable aav-based gene therapy |
| WO2026150353A2 (en) | 2025-01-11 | 2026-07-16 | Biohaven Therapeutics Ltd. | Antibody-drug conjugates for delivering cytotoxic agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2444680A1 (en) | 2001-04-18 | 2002-10-31 | Dyax Corp. | Binding molecules for fc-region polypeptides |
| US8372950B2 (en) * | 2006-11-02 | 2013-02-12 | Kagoshima University | IgG binding peptide |
| WO2013162757A1 (en) * | 2012-04-26 | 2013-10-31 | Yale University | Cytotoxic-drug delivering molecules targeting hiv (cdm-hs), cytotoxic activity against the human immunodeficiency virus and methods of use |
| WO2014178878A1 (en) * | 2013-05-03 | 2014-11-06 | Yale University | Synthetic antibody mimetic compounds (syams) targeting cancer, especially prostate cancer |
| JP6172446B2 (ja) * | 2013-05-20 | 2017-08-02 | 大日本印刷株式会社 | 鏡餅セットおよびその包装体 |
| JP2016088906A (ja) * | 2014-11-07 | 2016-05-23 | 国立大学法人九州大学 | 架橋剤、Ｆｃγ受容体発現細胞集積剤、分子標的免疫治療薬、標識試薬、Ｆｃγ受容体発現細胞集積方法および分子標的免疫治療方法 |
-
2018
- 2018-07-26 SG SG11202000628XA patent/SG11202000628XA/en unknown
- 2018-07-26 BR BR112020001583-0A patent/BR112020001583A2/pt unknown
- 2018-07-26 US US16/634,032 patent/US20200390895A1/en active Pending
- 2018-07-26 MX MX2020000976A patent/MX421628B/es unknown
- 2018-07-26 CN CN202411680036.9A patent/CN119684469A/zh active Pending
- 2018-07-26 WO PCT/US2018/043964 patent/WO2019023501A1/en not_active Ceased
- 2018-07-26 KR KR1020207005231A patent/KR102772176B1/ko active Active
- 2018-07-26 CN CN201880062045.8A patent/CN111148527B/zh active Active
- 2018-07-26 IL IL272192A patent/IL272192B1/en unknown
- 2018-07-26 AU AU2018307794A patent/AU2018307794B2/en active Active
- 2018-07-26 JP JP2020527851A patent/JP7824730B2/ja active Active
- 2018-07-26 EA EA202090372A patent/EA202090372A1/ru unknown
- 2018-07-26 EP EP18838275.8A patent/EP3658170A4/en active Pending
- 2018-07-26 CA CA3069986A patent/CA3069986A1/en active Pending
-
2020
- 2020-01-22 PH PH12020550035A patent/PH12020550035A1/en unknown
-
2023
- 2023-04-11 JP JP2023064212A patent/JP2023103222A/ja not_active Withdrawn
-
2024
- 2024-07-25 ZA ZA2024/05748A patent/ZA202405748B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020263231B2 (en) | Camptothecin derivatives | |
| JP7337907B2 (ja) | トル様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物ならびにその方法および使用 | |
| JP2024038168A (ja) | 生物活性分子コンジュゲート、その調製法及び使用 | |
| CN105530942B (zh) | 一种包含大环内酯类非对映体的药物组合物、其制备方法和用途 | |
| JP5116686B2 (ja) | Ｃｃ−１０６５類似体の調製方法及び調製用化合物 | |
| KR20250004686A (ko) | 항체-약물 접합체, 및 이의 제조 방법 및 용도 | |
| JP6903635B2 (ja) | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 | |
| TW202122115A (zh) | 包含抗人類ｒｏｒ１抗體之抗體—藥物結合物及其用途 | |
| US20260022127A1 (en) | Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells | |
| CN105849092A (zh) | 作为免疫调节剂的1，3，4-*二唑和1，3，4-噻二唑衍生物 | |
| WO2023198195A1 (en) | Conjugate comprising toll-like receptor agonist | |
| KR102591073B1 (ko) | 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도 | |
| IL293095B1 (en) | Directed conjugation technologies | |
| WO2023155808A1 (zh) | 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途 | |
| TW202241897A (zh) | 抗體藥物結合物、醫藥組合物及治療應用 | |
| AU2022234694A1 (en) | Compound or salt thereof, and antibody obtained using same | |
| CN116997339A (zh) | 作为治疗剂的cGAS活性抑制剂 | |
| WO2021195401A1 (en) | Technologies for preventing or treating infections | |
| CN120957758A (zh) | 大环化合物及其制备方法和用途 | |
| JP2024508426A (ja) | 免疫調節物質及び免疫調節物質コンジュゲート | |
| TW202608866A (zh) | 包含ｓｔｉｎｇ促效劑之抗體藥物結合物及其用途 | |
| CN119053607B (zh) | 喜树碱类化合物及其偶联物、其制备方法和用途 | |
| TW202535884A (zh) | 從生物活性化合物的偶聯物的選擇性藥物釋放 | |
| CN121971644A (zh) | 一类配体药物偶联物及其制备方法和用途 | |
| TW202334176A (zh) | 新穎的澳瑞他汀(auristatin)類似物及其免疫綴合物 |