JP2019530434A - アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 - Google Patents

アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 Download PDF

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JP2019530434A
JP2019530434A JP2019506082A JP2019506082A JP2019530434A JP 2019530434 A JP2019530434 A JP 2019530434A JP 2019506082 A JP2019506082 A JP 2019506082A JP 2019506082 A JP2019506082 A JP 2019506082A JP 2019530434 A JP2019530434 A JP 2019530434A
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seq
amino acid
acid sequence
hvr
antibody
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JP2019530434A5 (https=
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セス ハリス，
セス ハリス，
グレッグ ラザール，
グレッグ ラザール，
イェンリー ヤン，
イェンリー ヤン，
エリン エイチ． クリステンセン，
エリン エイチ． クリステンセン，
ジュリー ハン，
ジュリー ハン，
ジョン キム，
ジョン キム，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/526—CH3 domain
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019506082A 2016-08-05 2017-08-04 アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 Pending JP2019530434A (ja)

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US201662371671P 2016-08-05 2016-08-05
US62/371,671 2016-08-05
PCT/US2017/045642 WO2018027204A1 (en) 2016-08-05 2017-08-04 Multivalent and multiepitopic anitibodies having agonistic activity and methods of use

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JP2019530434A true JP2019530434A (ja) 2019-10-24
JP2019530434A5 JP2019530434A5 (https=) 2020-09-17

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US (2) US11046776B2 (https=)
EP (1) EP3494139B1 (https=)
JP (1) JP2019530434A (https=)
CN (1) CN109963871A (https=)
AR (1) AR109298A1 (https=)
TW (1) TW201808991A (https=)
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KR20210148943A (ko) * 2020-06-01 2021-12-08 머스트바이오 주식회사 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법
JP2023511652A (ja) * 2019-12-17 2023-03-22 フェインズ セラピューティクス，インコーポレーテッド 鎖間システインが選択的にマッチングされた二重特異性抗体及びその使用

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CN109563166B (zh) * 2016-04-28 2022-12-20 拜奥穆尼克斯制药 靶向egfr和her2的双特异性抗体
JP7337698B2 (ja) 2017-02-28 2023-09-04 シージェン インコーポレイテッド コンジュゲート化のためのシステイン突然変異抗体
CN120842423A (zh) 2017-03-27 2025-10-28 拜奥穆尼克斯制药 稳定的多特异性抗体
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US20210139985A1 (en) * 2018-04-10 2021-05-13 Board Of Regents, The University Of Texas System Dna-barcoded antigen multimers and methods of use thereof
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CN109627339B (zh) * 2019-01-25 2022-03-15 北京智仁美博生物科技有限公司 抗人pdl1抗体及其用途
CN110172090B (zh) * 2019-06-03 2020-04-03 中山标佳生物科技有限公司 Cd134单克隆抗体及其制备方法和癌症治疗中的应用
CN112210005B (zh) * 2019-07-11 2024-03-26 京天成生物技术(北京)有限公司 低免疫原性低adcc/cdc功能的抗c5人源化单抗及其应用
RU2731516C1 (ru) * 2019-08-01 2020-09-03 Федеральное государственное унитарное предприятие «Государственный научно-исследовательский институт особо чистых биопрепаратов» Федерального медико-биологического агентства Антитела против анафилатоксина C5a человека
CN115175930A (zh) 2020-02-05 2022-10-11 中外制药株式会社 用于产生和/或富集重组抗原结合分子的方法
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TWI909146B (zh) 2020-03-31 2025-12-21 日商中外製藥股份有限公司 Dll3靶向之多特異性抗原結合分子及其用途
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JP2023511652A (ja) * 2019-12-17 2023-03-22 フェインズ セラピューティクス，インコーポレーテッド 鎖間システインが選択的にマッチングされた二重特異性抗体及びその使用
KR20210148943A (ko) * 2020-06-01 2021-12-08 머스트바이오 주식회사 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법
KR102365669B1 (ko) 2020-06-01 2022-02-23 머스트바이오 주식회사 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법
KR20220030224A (ko) * 2020-06-01 2022-03-10 머스트바이오 주식회사 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법
KR102405816B1 (ko) 2020-06-01 2022-06-08 머스트바이오 주식회사 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법

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EP3494139A1 (en) 2019-06-12
EP3494139B1 (en) 2022-01-12
US11046776B2 (en) 2021-06-29
US20220064315A1 (en) 2022-03-03
CN109963871A (zh) 2019-07-02
AR109298A1 (es) 2018-11-14

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