CN115667316A - Fab-HCAb结构的结合蛋白 - Google Patents
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Abstract
提供一种结合蛋白，其包括蛋白功能区A和蛋白功能区B，两者靶向不同的抗原或抗原的不同表位；所述蛋白功能区A为Fab；所述蛋白功能区B为VH，所述结合蛋白还包括Fc同源二聚体；所述蛋白功能区A和蛋白功能区B的数量均为二个；所述结合蛋白为左右对称的结构；所述结合蛋白从N末端至C末端依次为蛋白功能区A、蛋白功能区B和Fc，其中所述蛋白功能区A与所述蛋白功能区B通过L1连接，所述蛋白功能区B与所述Fc通过L2连接。所述结合蛋白具有较小的分子量、较少的多肽链、更简单的结构；其具有通用性的结构，可适用于多种不同的靶点组合；相较于其他结构的双特异性结合蛋白能够更强的激活效应细胞的能力。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010618158 | 2020-06-30 | ||
| CN2020106304716 | 2020-06-30 | ||
| CN202010630471 | 2020-06-30 | ||
| CN2020106181580 | 2020-06-30 | ||
| CN2020114238326 | 2020-12-08 | ||
| CN202011423832 | 2020-12-08 | ||
| PCT/CN2021/102935 WO2022002006A1 (zh) | 2020-06-30 | 2021-06-29 | Fab-HCAb结构的结合蛋白 |
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| Publication Number | Publication Date |
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| CN115667316A true CN115667316A (zh) | 2023-01-31 |
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| CN202180040307.2A Pending CN115667316A (zh) | 2020-06-30 | 2021-06-29 | Fab-HCAb结构的结合蛋白 |
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| US (1) | US20230287143A1 (zh) |
| CN (1) | CN115667316A (zh) |
| TW (1) | TWI818276B (zh) |
| WO (1) | WO2022002006A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024131731A1 (zh) * | 2022-12-19 | 2024-06-27 | 和铂医药(上海)有限责任公司 | "κ/λ"Fab-Fab串联多特异性结合蛋白及其制备和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200944231A (en) * | 2007-11-30 | 2009-11-01 | Glaxo Group Ltd | Antigen-binding constructs |
| GB201005063D0 (en) * | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| US20180346571A1 (en) * | 2015-11-17 | 2018-12-06 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| WO2018014260A1 (en) * | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| JP2019530434A (ja) * | 2016-08-05 | 2019-10-24 | ジェネンテック， インコーポレイテッド | アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 |
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2021
- 2021-06-29 WO PCT/CN2021/102935 patent/WO2022002006A1/zh active Application Filing
- 2021-06-29 CN CN202180040307.2A patent/CN115667316A/zh active Pending
- 2021-06-29 US US18/013,530 patent/US20230287143A1/en active Pending
- 2021-06-29 TW TW110123881A patent/TWI818276B/zh active
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| Publication number | Publication date |
|---|---|
| WO2022002006A1 (zh) | 2022-01-06 |
| US20230287143A1 (en) | 2023-09-14 |
| TWI818276B (zh) | 2023-10-11 |
| TW202202526A (zh) | 2022-01-16 |
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