JP2019519245A5 - - Google Patents
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- JP2019519245A5 JP2019519245A5 JP2018568903A JP2018568903A JP2019519245A5 JP 2019519245 A5 JP2019519245 A5 JP 2019519245A5 JP 2018568903 A JP2018568903 A JP 2018568903A JP 2018568903 A JP2018568903 A JP 2018568903A JP 2019519245 A5 JP2019519245 A5 JP 2019519245A5
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- 150000007523 nucleic acids Chemical class 0.000 claims description 74
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 60
- 229920001184 polypeptide Polymers 0.000 claims description 43
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 43
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 43
- 239000000427 antigen Substances 0.000 claims description 37
- 102000036639 antigens Human genes 0.000 claims description 37
- 108091007433 antigens Proteins 0.000 claims description 37
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 230000000174 oncolytic effect Effects 0.000 claims description 16
- 239000012636 effector Substances 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 6
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- 238000011282 treatment Methods 0.000 claims description 6
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- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims description 4
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- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 2
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- 101150013553 CD40 gene Proteins 0.000 description 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 description 1
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- 241000991587 Enterovirus C Species 0.000 description 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 1
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 description 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
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- 102000017578 LAG3 Human genes 0.000 description 1
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- 241000700562 Myxoma virus Species 0.000 description 1
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- 241000702263 Reovirus sp. Species 0.000 description 1
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- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022014714A JP2022048304A (ja) | 2016-06-30 | 2022-02-02 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
| JP2023181009A JP2023174945A (ja) | 2016-06-30 | 2023-10-20 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357195P | 2016-06-30 | 2016-06-30 | |
| US62/357,195 | 2016-06-30 | ||
| PCT/US2017/040354 WO2018006005A1 (en) | 2016-06-30 | 2017-06-30 | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014714A Division JP2022048304A (ja) | 2016-06-30 | 2022-02-02 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019519245A JP2019519245A (ja) | 2019-07-11 |
| JP2019519245A5 true JP2019519245A5 (enExample) | 2020-08-06 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568903A Withdrawn JP2019519245A (ja) | 2016-06-30 | 2017-06-30 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
| JP2022014714A Withdrawn JP2022048304A (ja) | 2016-06-30 | 2022-02-02 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
| JP2023181009A Pending JP2023174945A (ja) | 2016-06-30 | 2023-10-20 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014714A Withdrawn JP2022048304A (ja) | 2016-06-30 | 2022-02-02 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
| JP2023181009A Pending JP2023174945A (ja) | 2016-06-30 | 2023-10-20 | ポリペプチド製剤の偽型腫瘍溶解性ウィルス送達 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20180057594A1 (enExample) |
| EP (1) | EP3478321A4 (enExample) |
| JP (3) | JP2019519245A (enExample) |
| KR (1) | KR20190035714A (enExample) |
| CN (1) | CN109983121A (enExample) |
| AU (1) | AU2017290828A1 (enExample) |
| BR (1) | BR112019000015A2 (enExample) |
| CA (1) | CA3029426A1 (enExample) |
| IL (2) | IL263879B (enExample) |
| MX (1) | MX2019000252A (enExample) |
| RU (2) | RU2021127872A (enExample) |
| SG (1) | SG11201811600PA (enExample) |
| WO (1) | WO2018006005A1 (enExample) |
Families Citing this family (55)
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| US10888549B2 (en) | 2016-03-07 | 2021-01-12 | The Johns Hopkins University | Pharmaceutical agents targeting cancer stem cells |
| EP3478321A4 (en) | 2016-06-30 | 2020-04-22 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| US12121573B2 (en) | 2019-07-14 | 2024-10-22 | Tianxin Wang | Methods and agents including STING agonist to treat tumor |
| EP4063859A1 (en) | 2017-04-28 | 2022-09-28 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
| AU2018273958B2 (en) | 2017-05-25 | 2022-07-21 | Leidos, Inc. | PD-1 and CTLA-4 dual inhibitor peptides |
| KR20200042904A (ko) * | 2017-07-26 | 2020-04-24 | 온코루스, 인크. | 종양용해성 바이러스 벡터 및 그의 용도 |
| CA3071376A1 (en) | 2017-08-03 | 2019-02-07 | Amgen Inc. | Interleukin-21 muteins and methods of treatment |
| EP3833765A1 (en) * | 2017-08-09 | 2021-06-16 | The Ohio State Innovation Foundation | Oncolytic virus carrying e-cadherin and uses thereof |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| AU2019207895A1 (en) | 2018-01-12 | 2020-06-18 | Amgen Inc. | Anti-PD-1 antibodies and methods of treatment |
| IL321888A (en) * | 2018-04-15 | 2025-09-01 | Immvira Co Ltd | Antibodies that bind PD-1 and their uses |
| WO2019201169A1 (en) * | 2018-04-15 | 2019-10-24 | Salubris (Chengdu) Biotech Co., Ltd | Antibodies binding pd-1 and uses thereof |
| CN108727504B (zh) * | 2018-04-16 | 2021-08-27 | 泉州向日葵生物科技有限公司 | 一种ifn与抗pd-l1抗体的融合蛋白及其应用 |
| CN118147029A (zh) | 2018-07-11 | 2024-06-07 | 阿克蒂姆治疗有限公司 | 工程化的免疫刺激性细菌菌株及其用途 |
| CN110819657B (zh) * | 2018-08-10 | 2021-11-19 | 睿丰康生物医药科技(浙江)有限公司 | 一种减毒棒状病毒的制备方法及应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| SG11202103497WA (en) * | 2018-10-22 | 2021-05-28 | Univ Pittsburgh Commonwealth Sys Higher Education | Cleavable activators of cxcr3 and methods of use |
| MX2021005448A (es) * | 2018-11-13 | 2021-08-11 | Oncorus Inc | Polinucleotidos encapsulados y metodos de uso. |
| EP3906038A4 (en) | 2018-11-21 | 2022-06-01 | Mayo Foundation for Medical Education and Research | ADENOVIRUS AND METHODS OF USE OF ADENOVIRUS |
| MX2021007639A (es) | 2018-12-27 | 2021-08-11 | Amgen Inc | Formulaciones de virus liofilizadas. |
| JP2022516318A (ja) * | 2019-01-04 | 2022-02-25 | オンコラス， インコーポレイテッド | カプセル化ポリヌクレオチド及び使用方法 |
| US20220127319A1 (en) | 2019-01-15 | 2022-04-28 | Cornell University | Recombinant mucins, and compositions and methods for using the same |
| WO2020160047A2 (en) | 2019-01-28 | 2020-08-06 | Rhode Island Council On Postsecondary Education | Phlip® peptide-mediated epitope tethering at cell surfaces |
| CN113474458A (zh) * | 2019-01-30 | 2021-10-01 | 威斯塔解剖学和生物学研究所 | 靶向癌症抗原的dna编码的双特异性t细胞连接子以及在癌症治疗中的使用方法 |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| CA3176660A1 (en) | 2019-02-27 | 2020-09-03 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| KR20210135532A (ko) | 2019-03-05 | 2021-11-15 | 암젠 인크 | 암 치료를 위한 종양 용해 바이러스의 용도 |
| CN113811603B (zh) * | 2019-03-15 | 2024-08-16 | 河谷细胞有限公司 | 重组erIL-15 NK细胞 |
| TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
| EP3911671A1 (en) * | 2019-04-29 | 2021-11-24 | Mayo Foundation for Medical Education and Research | Multivalent pd-l1 binding compounds for treating cancer |
| CA3141162A1 (en) | 2019-05-22 | 2020-11-26 | Leidos, Inc. | Lag3 binding peptides |
| JP7457037B2 (ja) * | 2019-05-31 | 2024-03-27 | 広州威溶特医薬科技有限公司 | Ｍ１ウイルス変異体及びその使用 |
| WO2021011844A2 (en) * | 2019-07-17 | 2021-01-21 | The Regents Of The University Of California | Combination cancer therapy agents and methods |
| MX2022004323A (es) * | 2019-10-10 | 2022-08-02 | Univ Arizona State | Virus oncoliticos que expresan captadores multiespecificos de celulas inmunitarias. |
| EP4058578A2 (en) | 2019-11-12 | 2022-09-21 | Actym Therapeutics, Inc. | Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products |
| CN115916226A (zh) * | 2020-02-07 | 2023-04-04 | 希望之城 | 用于治疗癌症的溶瘤病毒组合物和方法 |
| CN111759841A (zh) * | 2020-06-03 | 2020-10-13 | 山西第三医学研究发展有限公司 | 一种用匹多莫德在抗新型冠状病毒感染中的应用 |
| US20210386804A1 (en) * | 2020-06-11 | 2021-12-16 | Tibor Bakács | Combination of viral superinfection therapy with subthreshold doses of nivolumab plus ipilimumab in chronic HBV patients |
| CN113832114A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用 |
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| CN113969266B (zh) * | 2021-10-26 | 2023-10-13 | 山东大学齐鲁医院 | 一种重组溶瘤腺病毒及其应用 |
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-
2017
- 2017-06-30 EP EP17821384.9A patent/EP3478321A4/en not_active Withdrawn
- 2017-06-30 WO PCT/US2017/040354 patent/WO2018006005A1/en not_active Ceased
- 2017-06-30 CA CA3029426A patent/CA3029426A1/en active Pending
- 2017-06-30 AU AU2017290828A patent/AU2017290828A1/en not_active Abandoned
- 2017-06-30 MX MX2019000252A patent/MX2019000252A/es unknown
- 2017-06-30 RU RU2021127872A patent/RU2021127872A/ru unknown
- 2017-06-30 JP JP2018568903A patent/JP2019519245A/ja not_active Withdrawn
- 2017-06-30 SG SG11201811600PA patent/SG11201811600PA/en unknown
- 2017-06-30 RU RU2019102391A patent/RU2758007C2/ru active
- 2017-06-30 CN CN201780051486.3A patent/CN109983121A/zh active Pending
- 2017-06-30 KR KR1020197002887A patent/KR20190035714A/ko not_active Ceased
- 2017-06-30 BR BR112019000015-1A patent/BR112019000015A2/pt not_active IP Right Cessation
- 2017-09-29 US US15/720,696 patent/US20180057594A1/en not_active Abandoned
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2018
- 2018-10-25 US US16/170,764 patent/US10604574B2/en active Active
- 2018-12-20 IL IL263879A patent/IL263879B/en active IP Right Grant
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2020
- 2020-01-28 US US16/775,164 patent/US11078280B2/en not_active Expired - Fee Related
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2021
- 2021-04-11 IL IL282216A patent/IL282216A/en unknown
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2022
- 2022-02-02 JP JP2022014714A patent/JP2022048304A/ja not_active Withdrawn
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2023
- 2023-10-20 JP JP2023181009A patent/JP2023174945A/ja active Pending
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