JP2019501671A5 - - Google Patents
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- JP2019501671A5 JP2019501671A5 JP2018555311A JP2018555311A JP2019501671A5 JP 2019501671 A5 JP2019501671 A5 JP 2019501671A5 JP 2018555311 A JP2018555311 A JP 2018555311A JP 2018555311 A JP2018555311 A JP 2018555311A JP 2019501671 A5 JP2019501671 A5 JP 2019501671A5
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- virus
- inhibitor
- immune
- ligand
- promoter
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- 241000700605 Viruses Species 0.000 claims description 82
- 108090000623 proteins and genes Proteins 0.000 claims description 43
- 230000037361 pathway Effects 0.000 claims description 32
- 239000003112 inhibitor Substances 0.000 claims description 26
- 206010028980 Neoplasm Diseases 0.000 claims description 22
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- 239000002246 antineoplastic agent Substances 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 16
- 230000003213 activating effect Effects 0.000 claims description 15
- 241000700584 Simplexvirus Species 0.000 claims description 10
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
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- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 7
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- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims description 7
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- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 6
- 108010029697 CD40 Ligand Proteins 0.000 claims description 6
- 102100032937 CD40 ligand Human genes 0.000 claims description 6
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims description 6
- 241000712079 Measles morbillivirus Species 0.000 claims description 6
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- 108090000288 Glycoproteins Proteins 0.000 claims description 4
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- 241000713869 Moloney murine leukemia virus Species 0.000 claims description 4
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims description 4
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- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 3
- 102100031256 Cyclic GMP-AMP synthase Human genes 0.000 claims description 3
- 101710118064 Cyclic GMP-AMP synthase Proteins 0.000 claims description 3
- 102100025626 GTP-binding protein GEM Human genes 0.000 claims description 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 3
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 3
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 3
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims description 3
- 229940125563 LAG3 inhibitor Drugs 0.000 claims description 3
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 3
- 239000012270 PD-1 inhibitor Substances 0.000 claims description 3
- 239000012668 PD-1-inhibitor Substances 0.000 claims description 3
- 239000012271 PD-L1 inhibitor Substances 0.000 claims description 3
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 3
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 3
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- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 3
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims description 3
- 230000000799 fusogenic effect Effects 0.000 claims description 3
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- 230000005855 radiation Effects 0.000 claims description 3
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- 241001430294 unidentified retrovirus Species 0.000 claims description 3
- 108010046080 CD27 Ligand Proteins 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 108010017987 CD30 Ligand Proteins 0.000 claims description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 2
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- 108700002232 Immediate-Early Genes Proteins 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 101710169105 Minor spike protein Proteins 0.000 claims description 2
- 101710081079 Minor spike protein H Proteins 0.000 claims description 2
- 101800001693 R-peptide Proteins 0.000 claims description 2
- 241000702263 Reovirus sp. Species 0.000 claims description 2
- 102100021696 Syncytin-1 Human genes 0.000 claims description 2
- 102100021742 Syncytin-2 Human genes 0.000 claims description 2
- 101710091284 Syncytin-2 Proteins 0.000 claims description 2
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 2
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims description 2
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 claims description 2
- 101150085955 US11 gene Proteins 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
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- 108700014844 flt3 ligand Proteins 0.000 claims description 2
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- 241001529453 unidentified herpesvirus Species 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
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- 241000725643 Respiratory syncytial virus Species 0.000 description 5
- 238000002347 injection Methods 0.000 description 2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022034569A JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
| JP2024119344A JP2024153748A (ja) | 2016-01-08 | 2024-07-25 | 操作された腫瘍溶解性ウイルス |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1600382.4 | 2016-01-08 | ||
| GBGB1600380.8A GB201600380D0 (en) | 2016-01-08 | 2016-01-08 | Modified virus |
| GBGB1600381.6A GB201600381D0 (en) | 2016-01-08 | 2016-01-08 | Virus strain |
| GB1600381.6 | 2016-01-08 | ||
| GBGB1600382.4A GB201600382D0 (en) | 2016-01-08 | 2016-01-08 | Engineered virus |
| GB1600380.8 | 2016-01-08 | ||
| PCT/GB2017/050038 WO2017118866A1 (en) | 2016-01-08 | 2017-01-09 | Engineered virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022034569A Division JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501671A JP2019501671A (ja) | 2019-01-24 |
| JP2019501671A5 true JP2019501671A5 (enExample) | 2020-01-30 |
| JP7038664B2 JP7038664B2 (ja) | 2022-03-18 |
Family
ID=57796748
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555311A Active JP7038664B2 (ja) | 2016-01-08 | 2017-01-09 | 操作された腫瘍溶解性ウイルス |
| JP2018555310A Active JP7038065B2 (ja) | 2016-01-08 | 2017-01-09 | 腫瘍溶解性ウイルス株 |
| JP2018555309A Active JP6959258B2 (ja) | 2016-01-08 | 2017-01-09 | 改変された腫瘍溶解性ウイルス |
| JP2021163811A Active JP7295192B2 (ja) | 2016-01-08 | 2021-10-05 | 改変された腫瘍溶解性ウイルス |
| JP2022034569A Pending JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
| JP2023094818A Pending JP2023113885A (ja) | 2016-01-08 | 2023-06-08 | 改変された腫瘍溶解性ウイルス |
| JP2024119344A Pending JP2024153748A (ja) | 2016-01-08 | 2024-07-25 | 操作された腫瘍溶解性ウイルス |
| JP2025128636A Pending JP2025163138A (ja) | 2016-01-08 | 2025-07-31 | 改変された腫瘍溶解性ウイルス |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555310A Active JP7038065B2 (ja) | 2016-01-08 | 2017-01-09 | 腫瘍溶解性ウイルス株 |
| JP2018555309A Active JP6959258B2 (ja) | 2016-01-08 | 2017-01-09 | 改変された腫瘍溶解性ウイルス |
| JP2021163811A Active JP7295192B2 (ja) | 2016-01-08 | 2021-10-05 | 改変された腫瘍溶解性ウイルス |
| JP2022034569A Pending JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
| JP2023094818A Pending JP2023113885A (ja) | 2016-01-08 | 2023-06-08 | 改変された腫瘍溶解性ウイルス |
| JP2024119344A Pending JP2024153748A (ja) | 2016-01-08 | 2024-07-25 | 操作された腫瘍溶解性ウイルス |
| JP2025128636A Pending JP2025163138A (ja) | 2016-01-08 | 2025-07-31 | 改変された腫瘍溶解性ウイルス |
Country Status (13)
| Country | Link |
|---|---|
| US (13) | US10570377B2 (enExample) |
| EP (8) | EP3400290B1 (enExample) |
| JP (8) | JP7038664B2 (enExample) |
| KR (2) | KR20250026348A (enExample) |
| CN (3) | CN109153977B (enExample) |
| AU (2) | AU2017205216B2 (enExample) |
| CA (3) | CA3011009A1 (enExample) |
| DK (4) | DK3400291T4 (enExample) |
| ES (4) | ES2831080T5 (enExample) |
| IL (2) | IL260480B (enExample) |
| MX (1) | MX2018008413A (enExample) |
| SG (2) | SG10202108724YA (enExample) |
| WO (4) | WO2017118865A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60115600T2 (de) * | 2000-01-21 | 2006-07-20 | Biovex Ltd. | Virusstämme für die onkolytische behandlung von krebs |
| PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
| JP2010529820A (ja) | 2007-05-31 | 2010-08-26 | クリシュナン ラム | 最小限の固定子鉄心を備えたスイッチドリラクタンス機 |
| NZ711946A (en) | 2013-03-14 | 2020-05-29 | Icahn School Med Mount Sinai | Newcastle disease viruses and uses thereof |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| BR112018000917A2 (pt) | 2015-07-16 | 2018-09-11 | Bioxcel Therapeutics Inc | abordagem inovadora para o tratamento de câncer através da imunomodulação |
| EP3400290B1 (en) * | 2016-01-08 | 2023-04-05 | Replimune Limited | Oncolytic virus strain |
| AR107469A1 (es) | 2016-01-27 | 2018-05-02 | Oncorus Inc | Vectores virales oncolíticos y sus usos |
| RU2748378C2 (ru) | 2016-03-16 | 2021-05-25 | Амаль Терапьютикс Са | Комбинация модулятора иммунных контрольных точек и комплекса, содержащего проникающий в клетку пептид, карго-молекулу и пептидный агонист tlr, для применения в медицине |
| CN108350468B (zh) * | 2016-04-22 | 2020-10-30 | 深圳市亦诺微医药科技有限公司 | 用于癌症治疗的溶瘤性单纯疱疹病毒(oHSV)专性载体及其构建体的构建 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US20190336552A1 (en) | 2016-05-30 | 2019-11-07 | Astellas Pharma Inc. | Genetically engineered vaccinia viruses |
| US10888594B2 (en) | 2016-05-30 | 2021-01-12 | National University Corporation Tottori University | Genetically engineered vaccinia viruses |
| WO2018006005A1 (en) * | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| DK3515476T3 (da) | 2016-09-21 | 2024-09-02 | Amal Therapeutics Sa | Fusion der omfatter et cellepenetrerende peptid, en multiepitop og en trl-peptidagnost til behandlingen af cancer |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| GB201700350D0 (en) * | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| CN110678750A (zh) | 2017-04-28 | 2020-01-10 | 美国默沙东药厂 | 用于癌症治疗的生物标志物 |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| CA3070299A1 (en) | 2017-07-26 | 2019-01-31 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| JP7079171B2 (ja) | 2017-08-03 | 2022-06-01 | アムジエン・インコーポレーテツド | インターロイキン－２１ムテイン及び治療方法 |
| MX2020002502A (es) | 2017-09-08 | 2020-07-20 | Amgen Inc | Inhibidores de kras g12c y metodos para utilizarlos. |
| CN109554353B (zh) * | 2017-09-26 | 2021-08-06 | 杭州康万达医药科技有限公司 | 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途 |
| EP3708657A4 (en) * | 2017-11-08 | 2021-08-25 | Kagoshima University | ONCOLYTIC VIRUS (ONCOLYTIC IMMUNOTHERAPY) THAT IS CAPABLE OF TREATING METASTATIC CANCER ALSO WITH ENSURED SAFETY, WITH EXPRESSION CONTROL SYSTEM THAT BUILDS AN OPTIMAL EXPRESSION LEVEL |
| EP3710035A4 (en) * | 2017-11-13 | 2021-12-29 | Bioxcel Therapeutics, Inc. | Methods and compositions for treating cancer by modifying multiple arms of the immune system |
| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス， インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
| US11518808B2 (en) | 2018-01-12 | 2022-12-06 | Amgen Inc. | Anti-PD-1 antibodies and methods of treatment |
| WO2019147982A1 (en) * | 2018-01-26 | 2019-08-01 | Celldex Therapeutics, Inc. | Methods of treating cancer with dendritic cell mobilizing agents |
| GB201804473D0 (en) * | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | Modified oncolytic adenoviruses |
| CN108635380A (zh) * | 2018-04-13 | 2018-10-12 | 北京唯源立康生物科技有限公司 | 重组溶瘤病毒组合物及其在制备用于治疗肿瘤的药物中的应用 |
| CA3103371A1 (en) * | 2018-06-21 | 2019-12-26 | Replimune Limited | Treatment using oncolytic virus |
| WO2020006486A1 (en) * | 2018-06-29 | 2020-01-02 | Krystal Biotech, Inc. | Compositions and methods for antibody delivery |
| CN109161561A (zh) * | 2018-08-09 | 2019-01-08 | 湖北科技学院 | 一种选择性杀灭前列腺癌细胞的新型溶瘤病毒及其构建方法 |
| EP3837277A4 (en) | 2018-08-17 | 2022-05-11 | Icahn School of Medicine at Mount Sinai | RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION |
| WO2020052551A1 (en) * | 2018-09-10 | 2020-03-19 | Genesail Biotech (Shanghai) Co. Ltd. | A modified oncolytic virus, composition and use thereof |
| KR20210065976A (ko) * | 2018-09-26 | 2021-06-04 | 아스텔라스세이야쿠 가부시키가이샤 | 종양 용해성 백시니아 바이러스와 면역 체크포인트 저해제의 병용에 의한 암 요법 그리고 이것에 사용하기 위한 의약 조성물 및 조합 의약 |
| JP7566750B2 (ja) | 2018-12-27 | 2024-10-15 | アムジェン インコーポレイテッド | 凍結乾燥ウイルス製剤 |
| CN111606999B (zh) * | 2019-02-26 | 2022-09-06 | 南京惟亚德生物医药有限公司 | 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用 |
| EP3935182A1 (en) * | 2019-03-05 | 2022-01-12 | Amgen Inc. | Use of oncolytic viruses for the treatment of cancer |
| TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
| CN110054678B (zh) * | 2019-05-16 | 2023-04-18 | 中国医学科学院血液病医院（血液学研究所） | 一种膜结合型mFLT3LG蛋白及其应用 |
| CN110218707B (zh) * | 2019-05-29 | 2021-10-22 | 上海市公共卫生临床中心 | 一种新型溶瘤病毒及其制备方法和应用 |
| KR20220044310A (ko) * | 2019-08-05 | 2022-04-07 | 고쿠리츠 다이가쿠 호우징 도우카이 고쿠리츠 다이가쿠 기코우 | 악성 종양을 치료하기 위한 병용약, 악성 종양을 치료하기 위한 의약 조성물 및 악성 종양 치료용 의약 조성물 |
| CA3156880A1 (en) * | 2019-11-06 | 2021-05-14 | Memgen, Inc. | Replication-enhanced oncolytic adenoviruses |
| CN110982794B (zh) * | 2020-03-05 | 2020-06-16 | 北京唯源立康生物科技有限公司 | 一种修饰的单纯疱疹病毒 |
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