JP2020532304A5 - - Google Patents
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- JP2020532304A5 JP2020532304A5 JP2020512821A JP2020512821A JP2020532304A5 JP 2020532304 A5 JP2020532304 A5 JP 2020532304A5 JP 2020512821 A JP2020512821 A JP 2020512821A JP 2020512821 A JP2020512821 A JP 2020512821A JP 2020532304 A5 JP2020532304 A5 JP 2020532304A5
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- JP
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- Prior art keywords
- amino acid
- acid sequence
- tcr
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 42
- 108091008874 T cell receptors Proteins 0.000 claims 37
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 37
- 210000004027 cell Anatomy 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 102000006390 HLA-B Antigens Human genes 0.000 claims 1
- 108010058607 HLA-B Antigens Proteins 0.000 claims 1
- 102000012215 HSC70 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010036652 HSC70 Heat-Shock Proteins Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000003439 radiotherapeutic effect Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553957P | 2017-09-04 | 2017-09-04 | |
| US62/553,957 | 2017-09-04 | ||
| PCT/US2018/049397 WO2019046856A1 (en) | 2017-09-04 | 2018-09-04 | T-CELL RECEPTORS THAT BIND TO SPECIFIC PHOSPHOPEPTIDES OF MIXED LINEAR LEUKEMIA (MLL) AND METHODS OF USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532304A JP2020532304A (ja) | 2020-11-12 |
| JP2020532304A5 true JP2020532304A5 (enExample) | 2021-10-21 |
| JP7387585B2 JP7387585B2 (ja) | 2023-11-28 |
Family
ID=63722758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512821A Active JP7387585B2 (ja) | 2017-09-04 | 2018-09-04 | 混合系統白血病（ｍｌｌ）特異的ホスホペプチドに結合するｔ細胞受容体およびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11718658B2 (enExample) |
| EP (1) | EP3679062B1 (enExample) |
| JP (1) | JP7387585B2 (enExample) |
| KR (1) | KR20200052327A (enExample) |
| CN (1) | CN111278854A (enExample) |
| AU (1) | AU2018326875A1 (enExample) |
| CA (1) | CA3073055A1 (enExample) |
| MA (1) | MA50084A (enExample) |
| SG (1) | SG11202001319QA (enExample) |
| WO (1) | WO2019046856A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046856A1 (en) | 2017-09-04 | 2019-03-07 | Agenus Inc. | T-CELL RECEPTORS THAT BIND TO SPECIFIC PHOSPHOPEPTIDES OF MIXED LINEAR LEUKEMIA (MLL) AND METHODS OF USE THEREOF |
| AU2020253491A1 (en) | 2019-04-05 | 2021-10-28 | Rootpath Genomics, Inc. | Compositions and methods for T-cell receptor gene assembly |
| WO2021216738A2 (en) * | 2020-04-21 | 2021-10-28 | Intima Bioscience, Inc. | Compositions and methods of generating an immune response |
| KR102827472B1 (ko) | 2020-04-29 | 2025-07-02 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 화합물 |
| WO2023148494A1 (en) * | 2022-02-03 | 2023-08-10 | University College Cardiff Consultants Limited | Novel t-cell receptor |
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| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
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| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
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| US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
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| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
| US6194137B1 (en) | 1999-04-13 | 2001-02-27 | Organ Recovery Systems, Inc. | Method of cryopreservation of blood vessels by vitrification |
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| CA2957258C (en) | 2014-08-05 | 2023-11-07 | MabQuest SA | Immunological reagents |
| AU2015308527C1 (en) | 2014-08-29 | 2021-07-15 | F. Hoffmann-La Roche Ag | Combination therapy of tumor-targeted IL-2 variant immunocytokines and antibodies against human PD-L1 |
| MA44907A (fr) * | 2015-09-11 | 2018-07-18 | Agenus Inc | Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation |
| WO2019046856A1 (en) | 2017-09-04 | 2019-03-07 | Agenus Inc. | T-CELL RECEPTORS THAT BIND TO SPECIFIC PHOSPHOPEPTIDES OF MIXED LINEAR LEUKEMIA (MLL) AND METHODS OF USE THEREOF |
-
2018
- 2018-09-04 WO PCT/US2018/049397 patent/WO2019046856A1/en not_active Ceased
- 2018-09-04 EP EP18782236.6A patent/EP3679062B1/en active Active
- 2018-09-04 AU AU2018326875A patent/AU2018326875A1/en not_active Abandoned
- 2018-09-04 KR KR1020207009786A patent/KR20200052327A/ko not_active Ceased
- 2018-09-04 SG SG11202001319QA patent/SG11202001319QA/en unknown
- 2018-09-04 MA MA050084A patent/MA50084A/fr unknown
- 2018-09-04 CA CA3073055A patent/CA3073055A1/en active Pending
- 2018-09-04 JP JP2020512821A patent/JP7387585B2/ja active Active
- 2018-09-04 CN CN201880069966.7A patent/CN111278854A/zh active Pending
-
2020
- 2020-03-03 US US16/807,742 patent/US11718658B2/en active Active
-
2023
- 2023-06-23 US US18/340,600 patent/US12391741B2/en active Active
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