JP2019516718A5 - - Google Patents
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- JP2019516718A5 JP2019516718A5 JP2018560589A JP2018560589A JP2019516718A5 JP 2019516718 A5 JP2019516718 A5 JP 2019516718A5 JP 2018560589 A JP2018560589 A JP 2018560589A JP 2018560589 A JP2018560589 A JP 2018560589A JP 2019516718 A5 JP2019516718 A5 JP 2019516718A5
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- compound according
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- tumor
- carcinoma
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- 150000001875 compounds Chemical class 0.000 claims 36
- -1 C 1 -C 3 alkyl Chemical group 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 10
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 208000009956 adenocarcinoma Diseases 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 206010025323 Lymphomas Diseases 0.000 claims 7
- 206010039491 Sarcoma Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 201000009030 Carcinoma Diseases 0.000 claims 5
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 5
- 206010024612 Lipoma Diseases 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 206010016629 fibroma Diseases 0.000 claims 4
- 201000011066 hemangioma Diseases 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 102200006538 rs121913530 Human genes 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 3
- 201000008808 Fibrosarcoma Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 3
- 206010043276 Teratoma Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
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- 125000005962 1,4-oxazepanyl group Chemical group 0.000 claims 2
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- 201000004404 Neurofibroma Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 208000002458 carcinoid tumor Diseases 0.000 claims 2
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- 230000000694 effects Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 206010027191 meningioma Diseases 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010073106 Bone giant cell tumour malignant Diseases 0.000 claims 1
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
- 201000005262 Chondroma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010061619 Deformity Diseases 0.000 claims 1
- 208000000471 Dysplastic Nevus Syndrome Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
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- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
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- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 206010031299 Osteosis Diseases 0.000 claims 1
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- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000000097 Sertoli-Leydig cell tumor Diseases 0.000 claims 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 206010048214 Xanthoma Diseases 0.000 claims 1
- 206010048215 Xanthomatosis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000005873 benzo[d]thiazolyl group Chemical group 0.000 claims 1
- 210000003445 biliary tract Anatomy 0.000 claims 1
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- 201000004262 breast ductal adenoma Diseases 0.000 claims 1
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- 229910052799 carbon Inorganic materials 0.000 claims 1
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- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000005217 chondroblastoma Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000009060 clear cell adenocarcinoma Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
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- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 201000007487 gallbladder carcinoma Diseases 0.000 claims 1
- 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000006359 hepatoblastoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000000284 histiocytoma Diseases 0.000 claims 1
- 201000004933 in situ carcinoma Diseases 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 206010022498 insulinoma Diseases 0.000 claims 1
- 210000002570 interstitial cell Anatomy 0.000 claims 1
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 201000004593 malignant giant cell tumor Diseases 0.000 claims 1
- 201000000289 malignant teratoma Diseases 0.000 claims 1
- 210000002418 meninge Anatomy 0.000 claims 1
- 208000010943 meningeal sarcoma Diseases 0.000 claims 1
- 201000003776 meninges sarcoma Diseases 0.000 claims 1
- 208000010492 mucinous cystadenocarcinoma Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 208000009091 myxoma Diseases 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
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- 208000004649 neutrophil actin dysfunction Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
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- 201000010198 papillary carcinoma Diseases 0.000 claims 1
- 208000024724 pineal body neoplasm Diseases 0.000 claims 1
- 201000004123 pineal gland cancer Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 208000004548 serous cystadenocarcinoma Diseases 0.000 claims 1
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- 210000001550 testis Anatomy 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 208000009540 villous adenoma Diseases 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662338116P | 2016-05-18 | 2016-05-18 | |
| US62/338,116 | 2016-05-18 | ||
| US201762444614P | 2017-01-10 | 2017-01-10 | |
| US62/444,614 | 2017-01-10 | ||
| PCT/US2017/033099 WO2017201161A1 (en) | 2016-05-18 | 2017-05-17 | Kras g12c inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516718A JP2019516718A (ja) | 2019-06-20 |
| JP2019516718A5 true JP2019516718A5 (OSRAM) | 2019-07-25 |
| JP7039489B2 JP7039489B2 (ja) | 2022-03-22 |
Family
ID=60326411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560589A Active JP7039489B2 (ja) | 2016-05-18 | 2017-05-17 | Ｋｒａｓ ｇ１２ｃ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11267812B2 (OSRAM) |
| EP (1) | EP3458445B1 (OSRAM) |
| JP (1) | JP7039489B2 (OSRAM) |
| KR (1) | KR102444509B1 (OSRAM) |
| CN (1) | CN109843856B (OSRAM) |
| AU (1) | AU2017266911B2 (OSRAM) |
| CA (1) | CA3024523A1 (OSRAM) |
| ES (1) | ES2863873T3 (OSRAM) |
| IL (1) | IL262867B (OSRAM) |
| MX (1) | MX382339B (OSRAM) |
| SG (1) | SG11201810171SA (OSRAM) |
| WO (1) | WO2017201161A1 (OSRAM) |
Families Citing this family (201)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX382339B (es) | 2016-05-18 | 2025-03-13 | Mirati Therapeutics Inc | Inhibidores g12c de kras. |
| PL3558955T3 (pl) | 2016-12-22 | 2021-12-27 | Amgen Inc. | Pochodne benzoizotiazolu, izotiazolo[3,4-b]pirydyny, chinazoliny, ftalazyny, pirydo[2,3-d]pirydazyny i pirydo[2,3-d]pirymidyny jako inhibitory kras g12c do leczenia raka płuc, trzustki lub jelita grubego |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| ES2928576T3 (es) | 2017-09-08 | 2022-11-21 | Amgen Inc | Inhibidores de KRAS G12C y métodos de uso de los mismos |
| EP3710439B1 (en) * | 2017-11-15 | 2023-02-15 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| TW201938561A (zh) * | 2017-12-08 | 2019-10-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| SG11202012697QA (en) | 2018-01-19 | 2021-02-25 | Medshine Discovery Inc | Pyridone-pyrimidine derivative acting as krasg12c mutein inhibitor |
| TW201942115A (zh) * | 2018-02-01 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物 |
| TW201942116A (zh) * | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
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| MA52564A (fr) | 2018-05-10 | 2021-03-17 | Amgen Inc | Inhibiteurs de kras g12c pour le traitement du cancer |
| WO2019232419A1 (en) * | 2018-06-01 | 2019-12-05 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| MA51848A (fr) * | 2018-06-12 | 2021-04-21 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| MX2021001706A (es) | 2018-08-16 | 2021-04-19 | Hoffmann La Roche | Compuestos de anillo fusionado. |
| ES2961253T3 (es) | 2018-08-31 | 2024-03-11 | Mirati Therapeutics Inc | Inhibidores de KRas G12C |
| LT3849537T (lt) * | 2018-09-10 | 2025-02-10 | Mirati Therapeutics, Inc. | Kompleksinės terapijos |
| WO2020055760A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
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| CN112955137B (zh) * | 2018-09-10 | 2025-05-13 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| US20220040181A1 (en) * | 2018-09-10 | 2022-02-10 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3853234B1 (en) | 2018-09-18 | 2025-04-23 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| WO2020062251A1 (en) | 2018-09-30 | 2020-04-02 | Xw Laboratories, Inc. | Compounds as neuronal histamine receptor-3 antagonists and uses thereof |
| EP3871673B1 (en) | 2018-10-26 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | Novel indazole compound or salt thereof |
| MA51530B1 (fr) | 2018-11-09 | 2024-12-31 | F. Hoffmann-La Roche Ag | Composés cycliques fondus |
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| KR20220027879A (ko) * | 2019-05-29 | 2022-03-08 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 질소 함유 헤테로사이클릭 유도체의 조절제, 이의 제조방법 및 용도 |
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| TW202115089A (zh) * | 2019-07-01 | 2021-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 喹唑啉酮類衍生物、其製備方法及其在醫藥上的應用 |
| CN112300153B (zh) * | 2019-07-26 | 2023-06-13 | 博瑞生物医药（苏州）股份有限公司 | 一种杂环化合物、药物组合物和用途 |
| CN112390788A (zh) * | 2019-08-13 | 2021-02-23 | 苏州闻天医药科技有限公司 | 一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途 |
| CN112390797A (zh) * | 2019-08-15 | 2021-02-23 | 微境生物医药科技(上海)有限公司 | 新型螺环类K-Ras G12C抑制剂 |
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| CN112430234B (zh) * | 2019-08-26 | 2023-04-28 | 信达生物制药(苏州)有限公司 | 一种新型kras g12c蛋白抑制剂及其制备方法和用途 |
| WO2021041671A1 (en) | 2019-08-29 | 2021-03-04 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| CN114616232A (zh) * | 2019-09-06 | 2022-06-10 | 正大天晴药业集团南京顺欣制药有限公司 | 氮杂环庚烷并嘧啶类衍生物及其医药用途 |
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| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| CN112538084B (zh) * | 2019-09-23 | 2023-06-20 | 信达生物制药(苏州)有限公司 | 新颖的kras g12c蛋白抑制剂及其制备方法和用途 |
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- 2017-05-17 KR KR1020187036747A patent/KR102444509B1/ko active Active
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