ES2863873T3 - Inhibidores de KRAS G12C - Google Patents
Inhibidores de KRAS G12C Download PDFInfo
- Publication number
- ES2863873T3 ES2863873T3 ES17800088T ES17800088T ES2863873T3 ES 2863873 T3 ES2863873 T3 ES 2863873T3 ES 17800088 T ES17800088 T ES 17800088T ES 17800088 T ES17800088 T ES 17800088T ES 2863873 T3 ES2863873 T3 ES 2863873T3
- Authority
- ES
- Spain
- Prior art keywords
- mmol
- alkyl
- optionally substituted
- carboxylate
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- UHNCQJLEINZUNT-UHFFFAOYSA-N tert-butyl 4-oxo-1,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate Chemical compound N1=CNC(=O)C2=C1CN(C(=O)OC(C)(C)C)CC2 UHNCQJLEINZUNT-UHFFFAOYSA-N 0.000 description 1
- SDLGKSBUCUJCRU-VIFPVBQESA-N tert-butyl-dimethyl-[(3s)-pyrrolidin-3-yl]oxysilane Chemical compound CC(C)(C)[Si](C)(C)O[C@H]1CCNC1 SDLGKSBUCUJCRU-VIFPVBQESA-N 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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| PCT/US2017/033099 WO2017201161A1 (en) | 2016-05-18 | 2017-05-17 | Kras g12c inhibitors |
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| US20190062330A1 (en) | 2019-02-28 |
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| SG11201810171SA (en) | 2018-12-28 |
| AU2017266911B2 (en) | 2021-09-02 |
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| CA3024523A1 (en) | 2017-11-23 |
| EP3458445B1 (en) | 2021-02-17 |
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| US10125134B2 (en) | 2018-11-13 |
| EP3458445A1 (en) | 2019-03-27 |
| IL262867B (en) | 2022-01-01 |
| US20210269432A1 (en) | 2021-09-02 |
| KR102444509B1 (ko) | 2022-09-19 |
| JP7039489B2 (ja) | 2022-03-22 |
| EP3458445A4 (en) | 2019-11-13 |
| US10633381B2 (en) | 2020-04-28 |
| IL262867A (en) | 2019-03-31 |
| CN109843856B (zh) | 2023-05-02 |
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