|
WO2009088990A1
(en)
|
2008-01-04 |
2009-07-16 |
Intellikine, Inc. |
Certain chemical entities, compositions and methods
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
CA2738429C
(en)
|
2008-09-26 |
2016-10-25 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
|
EP2427195B1
(en)
|
2009-05-07 |
2019-05-01 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
KR101758046B1
(ko)
|
2009-12-22 |
2017-07-14 |
버텍스 파마슈티칼스 인코포레이티드 |
포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제
|
|
US8604032B2
(en)
|
2010-05-21 |
2013-12-10 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
EP2637669A4
(en)
|
2010-11-10 |
2014-04-02 |
Infinity Pharmaceuticals Inc |
Heterocyclic compounds and their use
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
NZ612909A
(en)
|
2011-01-10 |
2015-09-25 |
Infinity Pharmaceuticals Inc |
Processes for preparing isoquinolinones and solid forms of isoquinolinones
|
|
EP2734520B1
(en)
|
2011-07-19 |
2016-09-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
TWI565709B
(zh)
|
2011-07-19 |
2017-01-11 |
英菲尼提製藥股份有限公司 |
雜環化合物及其用途
|
|
RU2014111823A
(ru)
|
2011-08-29 |
2015-10-10 |
Инфинити Фармасьютикалз, Инк. |
Гетероциклические соединения и их применения
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
ES2645984T3
(es)
*
|
2012-04-25 |
2017-12-11 |
Raqualia Pharma Inc |
Derivados de pirrolopiridinona como bloqueadores de TTX-S
|
|
SI2861595T1
(sl)
|
2012-06-13 |
2017-04-26 |
Incyte Holdings Corporation |
Substituirane triciklične spojine kot inhibitorji fgfr
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
UA110688C2
(uk)
*
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
CA2890105C
(en)
|
2012-11-01 |
2023-03-21 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
LT2986610T
(lt)
|
2013-04-19 |
2018-04-10 |
Incyte Holdings Corporation |
Bicikliniai heterociklai, kaip fgfr inhibitoriai
|
|
SG10201802061TA
(en)
*
|
2013-09-25 |
2018-05-30 |
Vertex Pharma |
A selective inhibitor of phosphatidylinositol 3-kinase-gamma
|
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
SG10201902074UA
(en)
|
2013-10-04 |
2019-04-29 |
Infinity Pharmaceuticals Inc |
Heterocyclic compounds and uses thereof
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
CN113616656B
(zh)
|
2014-03-19 |
2023-02-17 |
无限药品股份有限公司 |
用于治疗PI3K-γ介导的障碍的杂环化合物
|
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
US10294205B2
(en)
|
2014-04-16 |
2019-05-21 |
Nanyang Technological University |
Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
|
|
CN106536508B
(zh)
|
2014-04-23 |
2019-08-09 |
武田药品工业株式会社 |
用于治疗阿尔茨海默病的具有胆碱能毒蕈碱m1受体正变构调节剂活性的化合物
|
|
EA201692265A1
(ru)
*
|
2014-06-13 |
2017-05-31 |
Джилид Сайэнс, Инк. |
Ингибиторы фосфатидилинозитол-3-киназы
|
|
ES2763103T3
(es)
|
2014-06-13 |
2020-05-27 |
Gilead Sciences Inc |
Inhibidor de la fosfatidilinositol 3-quinasa
|
|
NZ726360A
(en)
|
2014-06-13 |
2018-04-27 |
Gilead Sciences Inc |
Phosphatidylinositol 3-kinase inhibitors
|
|
EA201692266A1
(ru)
|
2014-06-13 |
2017-06-30 |
Джилид Сайэнс, Инк. |
Ингибиторы фосфатидилинозитол-3-киназы
|
|
CN106458932A
(zh)
|
2014-06-13 |
2017-02-22 |
吉利德科学公司 |
磷脂酰肌醇3‑激酶抑制剂
|
|
WO2016054491A1
(en)
|
2014-10-03 |
2016-04-07 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
|
SG10201913036RA
(en)
|
2015-02-20 |
2020-02-27 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
EP3280708B1
(en)
|
2015-04-10 |
2021-09-01 |
Araxes Pharma LLC |
Substituted quinazoline compounds and methods of use thereof
|
|
EP3283462B1
(en)
|
2015-04-15 |
2020-12-02 |
Araxes Pharma LLC |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
WO2017045955A1
(en)
*
|
2015-09-14 |
2017-03-23 |
Basf Se |
Heterobicyclic compounds
|
|
AU2016322552B2
(en)
|
2015-09-14 |
2021-03-25 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356359B1
(en)
|
2015-09-28 |
2021-10-20 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
US10875842B2
(en)
|
2015-09-28 |
2020-12-29 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356349A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
US10459801B2
(en)
|
2015-09-30 |
2019-10-29 |
Commvault Systems, Inc. |
Dynamic triggering of block-level backups based on block change thresholds and corresponding file identities using indexing in a data storage management system
|
|
WO2017068412A1
(en)
|
2015-10-21 |
2017-04-27 |
Otsuka Pharmaceutical Co., Ltd. |
Benzolactam compounds as protein kinase inhibitors
|
|
CA3002875A1
(en)
*
|
2015-10-22 |
2017-04-27 |
Selvita S.A. |
Pyridone derivatives and their use as kinase inhibitors
|
|
EA038635B9
(ru)
|
2015-11-16 |
2021-10-26 |
Араксис Фарма Ллк |
2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения
|
|
WO2017107087A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
WO2017107089A1
(en)
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
US10329289B2
(en)
|
2015-12-23 |
2019-06-25 |
Merck Sharp & Dohme Corp. |
6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
|
|
US10858355B2
(en)
|
2016-03-10 |
2020-12-08 |
Astrazeneca Ab |
Inhibitors of phosphatidylinositol 3-kinase gamma
|
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
|
CN108713019B
(zh)
|
2016-03-17 |
2021-06-15 |
豪夫迈·罗氏有限公司 |
具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
|
|
GB201604970D0
(en)
|
2016-03-23 |
2016-05-04 |
Syngenta Participations Ag |
Improvements in or relating to organic compounds
|
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
WO2017223422A1
(en)
|
2016-06-24 |
2017-12-28 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
WO2018064510A1
(en)
|
2016-09-29 |
2018-04-05 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2018068017A1
(en)
*
|
2016-10-07 |
2018-04-12 |
Araxes Pharma Llc |
Heterocyclic compounds as inhibitors of ras and methods of use thereof
|
|
WO2018112843A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
WO2018112842A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
|
|
US11274093B2
(en)
|
2017-01-26 |
2022-03-15 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
US11059819B2
(en)
|
2017-01-26 |
2021-07-13 |
Janssen Biotech, Inc. |
Fused hetero-hetero bicyclic compounds and methods of use thereof
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
EP3573964A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
WO2018140514A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
GB201706327D0
(en)
|
2017-04-20 |
2017-06-07 |
Otsuka Pharma Co Ltd |
A pharmaceutical compound
|
|
EP3630745A2
(en)
|
2017-05-25 |
2020-04-08 |
Araxes Pharma LLC |
Covalent inhibitors of kras
|
|
JP2020521741A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
がんの処置のための化合物およびその使用の方法
|
|
CN110831933A
(zh)
|
2017-05-25 |
2020-02-21 |
亚瑞克西斯制药公司 |
喹唑啉衍生物作为突变kras、hras或nras的调节剂
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
WO2018226545A1
(en)
*
|
2017-06-09 |
2018-12-13 |
Merck Sharp & Dohme Corp. |
Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
JP6647738B2
(ja)
|
2017-06-12 |
2020-02-14 |
矢崎総業株式会社 |
電池パック
|
|
WO2019000237A1
(en)
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000236A1
(en)
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000238A1
(en)
*
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
IL277794B2
(en)
*
|
2018-04-06 |
2024-02-01 |
Black Belt Tx Ltd |
ATF6 inhibitors and uses thereof
|
|
KR20210018264A
(ko)
|
2018-05-04 |
2021-02-17 |
인사이트 코포레이션 |
Fgfr 억제제의 염
|
|
PL3788047T3
(pl)
|
2018-05-04 |
2025-04-14 |
Incyte Corporation |
Stałe postacie inhibitora fgfr i sposoby ich otrzymywania
|
|
BR112021001709A2
(pt)
|
2018-08-01 |
2021-05-04 |
Araxes Pharma Llc |
compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
|
|
US11078204B2
(en)
|
2018-11-13 |
2021-08-03 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
WO2020102150A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Heterocyclic derivatives as pi3k inhibitors
|
|
WO2020102216A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Substituted heterocyclic derivatives as pi3k inhibitors
|
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
|
WO2020210379A1
(en)
|
2019-04-10 |
2020-10-15 |
Hangzhou Zhengxiang Pharmaceuticals Co., Ltd. |
Phosphatidylinositol 3-kinase inhibitors
|
|
EP3980010A4
(en)
|
2019-06-04 |
2023-06-07 |
Arcus Biosciences, Inc. |
2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
WO2021067374A1
(en)
|
2019-10-01 |
2021-04-08 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
CR20220169A
(es)
|
2019-10-14 |
2022-10-27 |
Incyte Corp |
Heterociclos bicíclicos como inhibidores de fgfr
|
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
JP7720840B2
(ja)
|
2019-12-04 |
2025-08-08 |
インサイト・コーポレイション |
Ｆｇｆｒ阻害剤としての三環式複素環
|
|
AU2020395185A1
(en)
|
2019-12-04 |
2022-06-02 |
Incyte Corporation |
Derivatives of an FGFR inhibitor
|
|
WO2021146424A1
(en)
|
2020-01-15 |
2021-07-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
CA3174675A1
(en)
*
|
2020-04-29 |
2021-11-04 |
Relay Therapeutics, Inc. |
Pi3k.alpha. inhibitors and methods of use thereof
|
|
CN114516856B
(zh)
*
|
2020-11-20 |
2025-05-23 |
安徽中科拓苒药物科学研究有限公司 |
二氢异喹啉酮和异吲哚啉酮衍生物及其用途
|
|
WO2022197577A1
(en)
*
|
2021-03-17 |
2022-09-22 |
Merck Sharp & Dohme Llc |
Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
|
|
TW202304459A
(zh)
|
2021-04-12 |
2023-02-01 |
美商英塞特公司 |
包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
|
|
EP4352060A1
(en)
|
2021-06-09 |
2024-04-17 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
US11939331B2
(en)
|
2021-06-09 |
2024-03-26 |
Incyte Corporation |
Tricyclic heterocycles as FGFR inhibitors
|
|
WO2023081759A1
(en)
*
|
2021-11-03 |
2023-05-11 |
Relay Therapeutics, Inc. |
Bifunctional pi3k-alpha inhibitors and uses thereof
|
|
CN118302427A
(zh)
*
|
2021-12-02 |
2024-07-05 |
上海翰森生物医药科技有限公司 |
稠环类衍生物调节剂、其制备方法和应用
|
|
KR102670554B1
(ko)
*
|
2022-01-04 |
2024-05-30 |
주식회사 이노보테라퓨틱스 |
캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
|
|
WO2023168378A1
(en)
*
|
2022-03-04 |
2023-09-07 |
Synnovation Therapeutics, Inc. |
Pi3ka inhibitors
|
|
JP2025531798A
(ja)
*
|
2022-09-09 |
2025-09-25 |
上海▲瑛▼黎薬業有限公司 |
含窒素複素環化合物、その医薬組成物および使用
|
|
WO2024153238A1
(zh)
*
|
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