JPS57134467A - Pyridine derivative and its preparation - Google Patents
Pyridine derivative and its preparationInfo
- Publication number
- JPS57134467A JPS57134467A JP1990381A JP1990381A JPS57134467A JP S57134467 A JPS57134467 A JP S57134467A JP 1990381 A JP1990381 A JP 1990381A JP 1990381 A JP1990381 A JP 1990381A JP S57134467 A JPS57134467 A JP S57134467A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- preparation
- alkoxycarbonyl
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compounds including novel substances useful as intermediates for the preparation of vitamin B6, etc., easily, by using a specific 1,2,4-triazine derivative as a raw material, and reacting with an olefin.
CONSTITUTION: A 1,2,4-triazine derivative of formulaI(R1 is a group convertible to carboxylic acid group, e.g. H, alkyl, amino, alkoxy, alkylthio, aryl, carboxyl, alkoxycarbonyl, cyano, etc.; R2 and R3 are H, alkyl, amino, alkoxy, alkylthio, or aryl) is made to react with an olefin of formula II[A and B are cyano, carboxyl, alkoxycarbonyl, halogenocarbonyl, formyl, or carbamoyl, or A and B together form -COOCO-, -COSCO- or heterocyclic group of formula IV or formula V (R4 and R5 are alkyl)]to obtain a pyridine derivative of formula III (when R1 is as defined above excepting alkyl, and R2 and R3 are not H at the same time, the compound is novel substance).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1990381A JPS57134467A (en) | 1981-02-13 | 1981-02-13 | Pyridine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1990381A JPS57134467A (en) | 1981-02-13 | 1981-02-13 | Pyridine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57134467A true JPS57134467A (en) | 1982-08-19 |
JPS6326759B2 JPS6326759B2 (en) | 1988-05-31 |
Family
ID=12012160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1990381A Granted JPS57134467A (en) | 1981-02-13 | 1981-02-13 | Pyridine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57134467A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000076975A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
WO2011087776A1 (en) * | 2009-12-22 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
-
1981
- 1981-02-13 JP JP1990381A patent/JPS57134467A/en active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000076975A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
US6504032B1 (en) | 1999-06-14 | 2003-01-07 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
WO2011087776A1 (en) * | 2009-12-22 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
US8466288B2 (en) | 2009-12-22 | 2013-06-18 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
US9676759B2 (en) | 2009-12-22 | 2017-06-13 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
EP3309152A1 (en) * | 2009-12-22 | 2018-04-18 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
US10183933B2 (en) | 2009-12-22 | 2019-01-22 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
EP3808739A1 (en) * | 2009-12-22 | 2021-04-21 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
Also Published As
Publication number | Publication date |
---|---|
JPS6326759B2 (en) | 1988-05-31 |
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