JP2019514640A5 - - Google Patents

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JP2019514640A5
JP2019514640A5 JP2019506601A JP2019506601A JP2019514640A5 JP 2019514640 A5 JP2019514640 A5 JP 2019514640A5 JP 2019506601 A JP2019506601 A JP 2019506601A JP 2019506601 A JP2019506601 A JP 2019506601A JP 2019514640 A5 JP2019514640 A5 JP 2019514640A5
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JP
Japan
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drug
implant
ocular implant
outer shell
inner lumen
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JP2019506601A
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Japanese (ja)
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JP2019514640A (ja
JP7003110B2 (ja
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Priority claimed from PCT/US2017/028665 external-priority patent/WO2017184881A1/en
Publication of JP2019514640A publication Critical patent/JP2019514640A/ja
Publication of JP2019514640A5 publication Critical patent/JP2019514640A5/ja
Priority to JP2021185479A priority Critical patent/JP7624376B2/ja
Application granted granted Critical
Publication of JP7003110B2 publication Critical patent/JP7003110B2/ja
Priority to JP2024137655A priority patent/JP2024161525A/ja
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JP2019506601A 2016-04-20 2017-04-20 生体吸収性眼球薬物送達デバイス Active JP7003110B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021185479A JP7624376B2 (ja) 2016-04-20 2021-11-15 生体吸収性眼球薬物送達デバイス
JP2024137655A JP2024161525A (ja) 2016-04-20 2024-08-19 生体吸収性眼球薬物送達デバイス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325378P 2016-04-20 2016-04-20
US62/325,378 2016-04-20
PCT/US2017/028665 WO2017184881A1 (en) 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021185479A Division JP7624376B2 (ja) 2016-04-20 2021-11-15 生体吸収性眼球薬物送達デバイス

Publications (3)

Publication Number Publication Date
JP2019514640A JP2019514640A (ja) 2019-06-06
JP2019514640A5 true JP2019514640A5 (enExample) 2020-05-28
JP7003110B2 JP7003110B2 (ja) 2022-01-20

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Application Number Title Priority Date Filing Date
JP2019506601A Active JP7003110B2 (ja) 2016-04-20 2017-04-20 生体吸収性眼球薬物送達デバイス
JP2021185479A Active JP7624376B2 (ja) 2016-04-20 2021-11-15 生体吸収性眼球薬物送達デバイス
JP2024137655A Pending JP2024161525A (ja) 2016-04-20 2024-08-19 生体吸収性眼球薬物送達デバイス

Family Applications After (2)

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JP2021185479A Active JP7624376B2 (ja) 2016-04-20 2021-11-15 生体吸収性眼球薬物送達デバイス
JP2024137655A Pending JP2024161525A (ja) 2016-04-20 2024-08-19 生体吸収性眼球薬物送達デバイス

Country Status (7)

Country Link
US (3) US11318043B2 (enExample)
EP (1) EP3442479A1 (enExample)
JP (3) JP7003110B2 (enExample)
CN (2) CN115120405A (enExample)
AU (2) AU2017252294B2 (enExample)
CA (1) CA3022830A1 (enExample)
WO (1) WO2017184881A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
JP5748407B2 (ja) 2006-11-10 2015-07-15 グローコス コーポレーション ブドウ膜強膜シャント
MX2010002619A (es) * 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Deteccion de implante lagrimal.
CA2762536C (en) 2009-05-18 2019-05-21 Dose Medical Corporation Drug eluting ocular implant
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
EP2654715B1 (en) 2010-11-24 2017-01-25 Dose Medical Corporation Drug eluting ocular implant
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
EP2830553B1 (en) 2012-03-26 2017-12-27 Glaukos Corporation Apparatus for delivering multiple ocular implants
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
CN108451712B (zh) 2013-11-14 2021-05-04 阿奎西斯公司 眼内分流器插入器
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
AU2016235432B2 (en) 2015-03-20 2020-02-27 Glaukos Corporation Gonioscopic devices
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
JP7054211B2 (ja) * 2016-05-20 2022-04-13 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト 涙腺ドラッグ送給デバイス
EP3522825B1 (en) * 2016-10-05 2023-06-07 Titan Pharmaceuticals, Inc. Implantable devices for drug delivery with reduced burst release
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
EP3691586A2 (en) 2017-10-06 2020-08-12 Glaukos Corporation Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
JP6909356B2 (ja) * 2017-11-08 2021-07-28 アクシス、インコーポレイテッド 手動で調整可能な眼内流動調節
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
AU2019245390B2 (en) * 2018-03-30 2022-02-17 Alcon Inc. Mono-(acid) salts of 6-aminoisoquinolines and uses thereof
EP3976124A4 (en) * 2019-05-31 2023-02-08 DOSE Medical Corporation CROSS-LINKED HYDROGEL BIOERODABLE IMPLANTS AND ASSOCIATED METHODS OF USE
KR20220036946A (ko) 2019-06-27 2022-03-23 레이어바이오 인크. 안구 장치 전달 방법 및 시스템
CN111150545A (zh) * 2020-01-02 2020-05-15 首都医科大学附属北京同仁医院 一种相变降温支架及其制备方法和相变降温组合支架
KR102154490B1 (ko) * 2020-01-03 2020-09-10 최만규 모델 하우스의 전시용 실내벽체 및 그 설치방법
CN111228034A (zh) * 2020-01-16 2020-06-05 贵州省人民医院 一种载药控释型泪道栓子及其制备方法
US12496273B2 (en) * 2020-02-04 2025-12-16 Korea Atomic Energy Research Institute Hydrogel and method for preparing the same
US12064376B2 (en) * 2020-06-03 2024-08-20 Glaukos Corporation Rho kinase inhibitor releasing implants and related methods of use
EP4161410A4 (en) * 2020-06-03 2024-07-17 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN111772920B (zh) * 2020-07-22 2025-01-07 苏州朗目医疗科技有限公司 青光眼引流装置及其引流植入物
US12268633B2 (en) * 2020-11-04 2025-04-08 Alcon Inc. Medical implant
KR20240013804A (ko) * 2021-05-27 2024-01-30 더블유. 엘. 고어 앤드 어소시에이트스, 인코포레이티드 약물 치료 전달 시스템 및 방법
US20220378612A1 (en) * 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
WO2023059933A1 (en) * 2021-10-08 2023-04-13 Purdue Research Foundation Ocular drug delivery device and related methods
US12193972B2 (en) 2022-07-22 2025-01-14 SpyGlass Pharma, Inc. Intraocular drug delivery systems and methods of use
CN115969612A (zh) * 2022-12-20 2023-04-18 重庆医科大学附属第三医院(捷尔医院) 可生物降解的用于治疗青光眼的房水引流装置及其制备方法

Family Cites Families (615)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663670A (en) 1900-07-30 1900-12-11 Marion W Wiswall Apparel dusting-cap.
US2031754A (en) 1932-11-04 1936-02-25 Ernest J Sweetland Extensible coupling
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
JPS5323011B2 (enExample) 1973-09-12 1978-07-12
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4207890A (en) 1977-01-04 1980-06-17 Mcneilab, Inc. Drug-dispensing device and method
US4113088A (en) 1977-06-06 1978-09-12 Binkhorst Richard D Sterile package
US4328803B1 (en) 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
DK90883A (da) 1982-03-18 1983-09-19 Merck & Co Inc Beholder til osmotisk afgivelse af et stof eller en stofblanding
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4955881A (en) 1985-08-16 1990-09-11 Alza Corporation Ruminant dispensing device
US4883864A (en) 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
GB8603099D0 (en) 1986-02-07 1986-03-12 Blass K G Gastrointestinal module
US4743248A (en) 1986-08-11 1988-05-10 Alza Corporation Dosage form for delivering acid sensitive beneficial agent
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4736836A (en) 1987-02-02 1988-04-12 Alongi Salvatore A Intraocular lens package
US4846793A (en) 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4828439A (en) 1987-05-15 1989-05-09 Giannuzzi Louis Screw anchor
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
CA1334168C (en) 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
FR2644058B1 (fr) 1989-03-10 1994-06-03 France Chirurgie Instr Bouchon meatique pour pathologie lacrymale
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5725529A (en) 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
CA2071137A1 (en) 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
DK0601055T3 (da) 1991-08-16 2000-10-02 Joseph C Salamone Medikamentovertrukket brydende okulært forkammerimplantat
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
GB2260585A (en) 1991-10-09 1993-04-21 Avdel Systems Ltd Self-plugging blind rivet
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IL100112A (en) 1991-11-21 1996-01-31 Yeda Res & Dev Microdelivery device for enhanced drug administration to the eye
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
WO1993020784A1 (en) 1992-04-10 1993-10-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5380290A (en) 1992-04-16 1995-01-10 Pfizer Hospital Products Group, Inc. Body access device
EP0642789B1 (en) 1992-05-22 1999-09-29 Senju Pharmaceutical Co., Ltd. Remedy for glaucoma
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
WO1994002081A1 (en) 1992-07-16 1994-02-03 Wong Vernon G Eye implant suitable for relief of glaucoma
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
EP1632259B1 (en) 1993-07-19 2011-12-21 Angiotech Pharmaceuticals, Inc. Anti-angiogene compositions and methods of use
US5731294A (en) 1993-07-27 1998-03-24 Hybridon, Inc. Inhibition of neovasularization using VEGF-specific oligonucleotides
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5500465A (en) 1994-03-10 1996-03-19 Board Of Trustees Operating Michigan State University Biodegradable multi-component polymeric materials based on unmodified starch-like polysaccharides
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
EP0754046A1 (en) 1994-04-04 1997-01-22 FREEMAN, William R. Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
WO1995030429A1 (en) 1994-05-04 1995-11-16 Board Of Trustees Of The University Of Arkansas Novel ophthalmologic uses of protein c
US5599534A (en) 1994-08-09 1997-02-04 University Of Nebraska Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
US5665114A (en) 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
GB9417399D0 (en) 1994-08-30 1994-10-19 Scherer Corp R P Ocular treatment device
EP1181904B1 (en) 1994-10-17 2009-06-24 Kabushikikaisha Igaki Iryo Sekkei Stent for liberating drug
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US5643321A (en) 1994-11-10 1997-07-01 Innovasive Devices Suture anchor assembly and methods
US5602143A (en) 1994-12-08 1997-02-11 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
US6228873B1 (en) 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5891084A (en) 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
WO1996020742A1 (en) 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
WO1996024346A1 (en) 1995-02-10 1996-08-15 The University Of Toronto Innovations Foundation Deprenyl compounds for treatment of glaucoma
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5547993A (en) 1995-10-24 1996-08-20 Mitsubishi Chemical Corporation Therapeutic agent for glaucoma
AU1201297A (en) 1995-12-21 1997-07-17 Pharmacia & Upjohn Ab Ophthalmic treatment
US5798380A (en) 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
GB9700390D0 (en) 1997-01-10 1997-02-26 Biocompatibles Ltd Device for use in the eye
FR2759577B1 (fr) 1997-02-17 1999-08-06 Corneal Ind Implant de sclerectomie profonde
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US6059812A (en) 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
DE19728069C1 (de) 1997-07-01 1999-02-11 Acritec Gmbh Vorrichtung zur Messung des Augeninnendrucks
US5980928A (en) 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6274138B1 (en) 1997-09-03 2001-08-14 Incyte Genomics, Inc. Human mitochondrial malate dehydrogenase
US7985415B2 (en) 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US20020164374A1 (en) 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6159458A (en) 1997-11-04 2000-12-12 Insite Vision Sustained release ophthalmic compositions containing water soluble medicaments
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6589198B1 (en) 1998-01-29 2003-07-08 David Soltanpour Implantable micro-pump assembly
US7780623B2 (en) 1998-01-29 2010-08-24 Soltanpour David P Implantable pump apparatuses
US6682500B2 (en) 1998-01-29 2004-01-27 David Soltanpour Synthetic muscle based diaphragm pump apparatuses
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
FR2777442B1 (fr) 1998-04-21 2000-07-28 Tornier Sa Ancre de suture a expansion reversible
EP1071414A1 (en) 1998-04-24 2001-01-31 Mitokor Compounds and methods for treating mitochondria-associated diseases
US5997498A (en) 1998-05-07 1999-12-07 Johns Hopkins University Inline air humidifier, a system for humidifying air and methods related thereto
TW586944B (en) 1998-05-29 2004-05-11 Sumitomo Pharma Controlled release agent having a multi-layer structure
US6231853B1 (en) 1998-06-01 2001-05-15 Incyte Pharmaceuticals, Inc. Human glutathione peroxidase-6
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
KR100300527B1 (ko) 1998-09-03 2001-10-27 윤덕용 밀봉형무선압력측정소자및그제조방법
KR100274842B1 (ko) 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6348042B1 (en) 1999-02-02 2002-02-19 W. Lee Warren, Jr. Bioactive shunt
US6193656B1 (en) 1999-02-08 2001-02-27 Robert E. Jeffries Intraocular pressure monitoring/measuring apparatus and method
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
HUP0200860A2 (en) 1999-04-26 2002-07-29 Gmp Vision Solutions Inc Stent device and method for treating glaucoma
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6306120B1 (en) 1999-06-07 2001-10-23 Ben Gee Tan Applicator and method for delivery of mitomycin to eye tissues during glaucoma filtering surgery
BR0011982B1 (pt) 1999-06-28 2009-05-05 estrutura elastomérica, método de atuação de uma estrutura elastomérica, método de controle de fluido ou gás através de uma estrutura elastomérica, método de micro-fabricação de uma estrutura elastomérica, uso de uma membrana flexìvel, uso de camadas elastoméricas unidas, uso de um material elastomérico e estrutura elastomérica micro-fabricada.
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8550119B2 (en) 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20080277007A1 (en) 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
WO2001008717A1 (en) 1999-08-03 2001-02-08 Smith & Nephew, Inc. Controlled release implantable devices
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
JP4859317B2 (ja) 1999-08-06 2012-01-25 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 薬剤放出生分解性繊維インプラント
KR100732262B1 (ko) 1999-10-21 2007-06-25 알콘, 인코퍼레이티드 약물 전달 장치
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
DE60018777T2 (de) 1999-10-21 2006-02-02 Alcon Inc. Medikamentenversorgung der sub-tenon
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
KR100771150B1 (ko) 1999-12-10 2007-10-29 아이싸이언스 인터벤셔날 코포레이션 안 질환의 치료방법
US6939299B1 (en) 1999-12-13 2005-09-06 Kurt Petersen Implantable continuous intraocular pressure sensor
DE60018606T2 (de) 1999-12-16 2005-07-28 Alza Corp., Mountain View Dosierungsformen mit einer Barriereschicht gegen Laserablation
NZ520099A (en) 2000-01-12 2005-03-24 Becton Dickinson Co Systems and methods for reducing intraocular pressure
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
AU2001219185A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US20070031473A1 (en) 2005-08-05 2007-02-08 Peyman Gholam A Drug delivery system and method
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20030060752A1 (en) 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20040111050A1 (en) 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US20040115268A1 (en) 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
WO2001085212A2 (en) 2000-05-08 2001-11-15 The University Of British Columbia Drug delivery systems for photodynamic therapy
ATE377404T1 (de) 2000-05-19 2007-11-15 Michael S Berlin Laserapplikationssystem und methode zur verwendung im auge
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
CA2407953A1 (en) 2000-06-19 2001-12-27 Glaukos Corporation Stented trabecular shunt and methods thereof
KR100355563B1 (ko) 2000-06-23 2002-10-11 주식회사 바이오메드랩 비등성 혼합물을 이용한 조직공학용 생분해성의 다공성고분자 지지체 및 그의 제조방법
US6692759B1 (en) 2000-06-28 2004-02-17 The Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
EP1637126B1 (en) 2000-07-05 2016-12-14 Allergan, Inc. Methods for treating inflammation of the eye
US6629992B2 (en) 2000-08-04 2003-10-07 Advanced Cardiovascular Systems, Inc. Sheath for self-expanding stent
US7056533B2 (en) 2000-08-15 2006-06-06 Surmodics, Inc. Medicament incorporation matrix
US6749568B2 (en) 2000-08-21 2004-06-15 Cleveland Clinic Foundation Intraocular pressure measurement system including a sensor mounted in a contact lens
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
AU2001261262A1 (en) 2000-11-01 2002-05-15 Glaukos Corporation Glaucoma treatment device
DE60114229T2 (de) 2000-11-29 2006-07-06 Allergan, Inc., Irvine Verhinderung von transplantatabstossung im auge
EP1550471A1 (en) 2000-11-29 2005-07-06 Allergan Inc. Intraocular implants for preventing transplant rejection in the eye
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
WO2002056863A2 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
US20020086051A1 (en) 2001-01-03 2002-07-04 Santos Viscasillas Sustained release drug delivery devices with coated drug cores
DE60137542D1 (de) 2001-01-03 2009-03-12 Bausch & Lomb Wirkstoffabgabevorrichtungen mit verzögerter freisetzung mehrere stoffe enthaltend
CA2432225C (en) 2001-01-03 2008-01-15 Michael J. Brubaker Sustained release drug delivery devices with prefabricated permeable plugs
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
WO2002056763A2 (en) 2001-01-22 2002-07-25 Integrated Sensing Systems, Inc. Mems capacitive sensor for physiologic parameter measurement
US6991808B2 (en) 2001-01-26 2006-01-31 Bausch & Lomb Inc. Process for the production of sustained release drug delivery devices
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US8060211B2 (en) 2001-02-13 2011-11-15 Second Sight Medical Products, Inc. Method of reducing retinal stress caused by an implantable retinal electrode array
US6989007B2 (en) 2001-02-21 2006-01-24 Solx, Inc. Devices and techniques for treating glaucoma
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
US20050278014A9 (en) 2001-03-07 2005-12-15 Wolfgang Daum Stent and method for drug delivery from stents
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
EP1367968A4 (en) 2001-03-16 2006-12-13 Glaukos Corp APPLICATOR AND METHOD FOR SETTING A TRABECULAR SHUNT FOR GLUCKOM TREATMENT
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
JP4264704B2 (ja) 2001-04-07 2009-05-20 グローコス コーポレーション 緑内障ステントおよび緑内障治療方法
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
WO2002089699A2 (en) 2001-05-03 2002-11-14 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US6533769B2 (en) 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
EP1387671A1 (en) 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantable drug delivery device and use thereof
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
CA2450771C (en) 2001-06-12 2010-09-07 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US20030010638A1 (en) 2001-06-15 2003-01-16 Hansford Derek J. Nanopump devices and methods
US7592016B2 (en) 2001-06-28 2009-09-22 Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
WO2003009784A1 (en) 2001-07-23 2003-02-06 Alcon, Inc. Ophthalmic drug delivery device
DE60217679T2 (de) 2001-07-23 2007-10-25 Alcon Inc. Vorrichtung zur freisetzung eines ophthalmischen arzneimittels
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
CA2456025C (en) 2001-08-29 2011-11-22 Ricardo A.P. De Carvalho An implantable and sealable system for unidirectional delivery of therapeutic agents to tissues
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
IN2014DN10834A (enExample) 2001-09-17 2015-09-04 Psivida Inc
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
AU2002337788A1 (en) 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
FR2830766B1 (fr) 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese transpalpebrale
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030119000A1 (en) 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
US20080039769A1 (en) 2001-11-07 2008-02-14 Minu Llc Method of medical treatment using controlled heat delivery
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US6802829B2 (en) 2001-11-16 2004-10-12 Infinite Vision, Llc Spray device
JP4217624B2 (ja) 2001-11-22 2009-02-04 アントン ヘフリガー,エーデュアルト 眼科手術を行う装置および方法
US7348055B2 (en) 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US20060034929A1 (en) 2001-12-27 2006-02-16 Brubaker Michael J Sustained release drug delivery devices with prefabricated permeable plugs
CA2473355C (en) 2002-01-18 2012-01-03 Michael E. Snyder Sustained release ophthalmological device and method of making and using the same
JP2003210513A (ja) 2002-01-23 2003-07-29 Nidek Co Ltd 眼科用治療装置
AU2003219932A1 (en) 2002-02-28 2003-09-16 Gmp Vision Solutions, Inc. Device and method for monitoring aqueous flow within the eye
WO2003074735A1 (en) 2002-03-01 2003-09-12 Flammer, Josef Diagnostic method for glaucoma
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US20060200113A1 (en) 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
KR101173497B1 (ko) 2002-03-11 2012-08-14 알콘, 인코퍼레이티드 이식 가능한 약물 전달 시스템
US20060100408A1 (en) 2002-03-11 2006-05-11 Powell P M Method for forming contact lenses comprising therapeutic agents
TW200304385A (en) 2002-03-13 2003-10-01 Novartis Ag Materials containing multiple layers of vesicles
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
JP4026745B2 (ja) 2002-03-26 2007-12-26 財団法人大阪産業振興機構 医療用システムおよびその製造方法
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20030195438A1 (en) 2002-04-12 2003-10-16 Petillo Phillip J. Method and apparatus to treat glaucoma
US20040024345A1 (en) 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
AU2003217531A1 (en) 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20070123767A1 (en) 2002-05-31 2007-05-31 Valentino Montegrande Intraocular pressure sensor and method of use
US20050159660A1 (en) 2002-05-31 2005-07-21 Valentino Montegrande Intraocular pressure sensor
ATE424795T1 (de) 2002-06-05 2009-03-15 Univ Florida Ophthalmisches arzneimittelabgabesystem
US8273366B2 (en) 2002-06-05 2012-09-25 University Of Florida Research Foundation, Incorporated Ophthalmic drug delivery system
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
JP4463681B2 (ja) 2002-07-15 2010-05-19 アルコン,インコーポレイテッド 眼内使用のための非ポリマー親油性薬学的インプラント組成物
US20040013702A1 (en) 2002-07-16 2004-01-22 Glover Eugene G. Implantable devices for the controlled release of cytotoxic agents
EP2286773B1 (en) 2002-07-19 2012-10-17 Yale University Uveoscleral drainage device
ES2318185T3 (es) 2002-08-08 2009-05-01 Glaukos Corporation Bomba ocular implantable para reducir la presion intraocular.
AU2003268169A1 (en) 2002-08-27 2004-03-19 Michigan State University Implantable microscale pressure sensor system
JP4353510B2 (ja) 2002-09-09 2009-10-28 株式会社カネカ 組織再生用支持体及びその製造方法
US7192412B1 (en) 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
WO2004026347A2 (en) 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
US20050261641A1 (en) 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
USRE40722E1 (en) 2002-09-27 2009-06-09 Surmodics, Inc. Method and apparatus for coating of substrates
US7615010B1 (en) 2002-10-03 2009-11-10 Integrated Sensing Systems, Inc. System for monitoring the physiologic parameters of patients with congestive heart failure
US7131945B2 (en) 2002-10-16 2006-11-07 California Institute Of Technology Optically powered and optically data-transmitting wireless intraocular pressure sensor device
US20040154946A1 (en) 2002-11-06 2004-08-12 Kenneth Solovay Storage apparatus for surgical implant device
WO2004043435A2 (en) 2002-11-13 2004-05-27 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
CA2508303C (en) 2002-12-04 2012-10-23 Santen Pharmaceutical Co., Ltd. Drug delivery system using subconjunctival depot
WO2004056311A2 (en) 2002-12-17 2004-07-08 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
US20040137059A1 (en) 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20040216749A1 (en) 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
WO2004066871A2 (en) 2003-01-24 2004-08-12 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
WO2004073552A2 (en) 2003-02-18 2004-09-02 Hampar Karageozian Methods and devices for draining fluids and lowering intraocular pressure
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US20040163652A1 (en) 2003-02-25 2004-08-26 Colin Watson Condom with restriction band
USD490152S1 (en) 2003-02-28 2004-05-18 Glaukos Corporation Surgical handpiece
US7483750B2 (en) 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
US20050208102A1 (en) 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
US8021680B2 (en) 2003-05-02 2011-09-20 Surmodics, Inc. Controlled release bioactive agent delivery device
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
US7207965B2 (en) 2003-06-16 2007-04-24 Solx, Inc. Shunt for the treatment of glaucoma
CN1805719A (zh) 2003-07-10 2006-07-19 爱尔康公司 眼药输送装置
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
WO2005020907A2 (en) 2003-08-26 2005-03-10 Vista Scientific Ocular drug delivery device
KR101471732B1 (ko) 2003-08-27 2014-12-16 옵쏘테크 코포레이션 안구의 혈관신생성 장애를 치료하기 위한 조합 치료법
US20050055075A1 (en) 2003-09-08 2005-03-10 Leonard Pinchuk Methods for the manufacture of porous prostheses
WO2005027906A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
EP1686963A1 (en) 2003-10-27 2006-08-09 PSivida Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
EP1708780A4 (en) 2003-11-14 2010-10-13 Medical Instill Tech Inc DISTRIBUTION DEVICE AND DISTRIBUTION METHOD
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
WO2005051232A2 (en) 2003-11-20 2005-06-09 Angiotech International Ag Soft tissue implants and anti-scarring agents
US20080058793A1 (en) 2006-06-12 2008-03-06 Pilla Arthur A Electromagnetic apparatus for prophylaxis and repair of ophthalmic tissue and method for using same
US20110112352A1 (en) 2003-12-05 2011-05-12 Pilla Arthur A Apparatus and method for electromagnetic treatment
US20050137538A1 (en) 2003-12-22 2005-06-23 Bausch & Lomb Incorporated Drug delivery device
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
BRPI0506837A (pt) 2004-01-12 2007-06-12 Iscience Surgical Corp injetor para materiais viscosos, e, dispositivos e kit para fornecer microquantidades de materiais viscosos
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US20050250788A1 (en) 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20060004422A1 (en) 2004-03-11 2006-01-05 Dirk De Ridder Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
US7513893B2 (en) 2004-03-12 2009-04-07 Abraham Ebbie Soroudi Device and method for treatment of eyelid diseases
PT1732484T (pt) 2004-03-26 2017-08-31 Molteno Ophthalmic Ltd Implante oftálmico para o tratamento de glaucoma
US7654985B2 (en) 2004-03-30 2010-02-02 Given Imaging Ltd. Controlled detachment of intra-luminal medical device
US20060083772A1 (en) 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2007534383A (ja) 2004-04-23 2007-11-29 ジーエムピー ヴィジョン ソルーションズ インコーポレイテッド 留置シャント装置及び緑内障のための装置及び方法
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
CN1976732A (zh) 2004-04-29 2007-06-06 i科学外科公司 用于外科手术式改善房水引流的装置和方法
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US20070212395A1 (en) 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
BRPI0510485A (pt) 2004-04-30 2007-11-13 Allergan Inc implantes inibidores de tirosina cinase intravìtreos biodegradáveis
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US20050244500A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
WO2005115281A2 (fr) 2004-04-30 2005-12-08 Optis France Dispositif de iontophorese oculaire diminuant les irritations
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244461A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
AU2005240078A1 (en) 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20050244465A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
WO2005120578A2 (en) 2004-06-07 2005-12-22 California Institute Of Technology Biodegradable drug-polymer delivery system
WO2005121735A2 (en) 2004-06-07 2005-12-22 California Institute Of Technology Implantable mechanical pressure sensor and method of manufacturing the same
EP1604697A1 (en) 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
WO2006002366A2 (en) 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable ocular devices, methods and systems
CN101052435B (zh) 2004-07-02 2010-12-08 Qlt塞子传递公司 治疗介质递送装置
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
JP2008505978A (ja) 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
WO2006015016A2 (en) 2004-07-30 2006-02-09 Massachusetts Eye And Ear Infirmary Photodynamic therapy and compositions for treating ocular glaucoma
US20060032507A1 (en) 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
US7402156B2 (en) 2004-09-01 2008-07-22 Alcon, Inc. Counter pressure device for ophthalmic drug delivery
US20060084952A1 (en) 2004-09-03 2006-04-20 Pallikaris Ioannis G Device for the irradiation of the ciliary body of the eye
WO2006031532A2 (en) 2004-09-10 2006-03-23 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
EP2153824A1 (en) 2004-09-27 2010-02-17 Sigmoid Pharma Limited Seamless multiparticulate formulations
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US20060210604A1 (en) 2004-10-04 2006-09-21 Eric Dadey Ocular delivery of polymeric delivery formulations
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US7226435B2 (en) 2004-10-14 2007-06-05 Alcon, Inc. Drug delivery device
US7958840B2 (en) 2004-10-27 2011-06-14 Surmodics, Inc. Method and apparatus for coating of substrates
US8246949B2 (en) 2004-10-27 2012-08-21 Aciont, Inc. Methods and devices for sustained in-vivo release of an active agent
WO2006053836A1 (en) 2004-11-16 2006-05-26 Universite De Liege Active substance delivery system comprising a hydrogel atrix and microcarriers
US20060173397A1 (en) 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
EP1816980B1 (en) 2004-11-23 2011-03-16 Edward Wong Medical device for temperature control and treatment of the eye and surrounding tissues
KR20080016780A (ko) 2004-11-24 2008-02-22 테라킨 리미티드 안내 약물 전달용 임플란트
US20070118065A1 (en) 2004-12-03 2007-05-24 Leonard Pinchuk Glaucoma Implant Device
US7837644B2 (en) 2004-12-03 2010-11-23 Innfocus, Llc Glaucoma implant device
CA2588692A1 (en) 2004-12-22 2006-06-29 Alcon, Inc. Device for ophthalmic drug delivery
MX2007009417A (es) 2005-02-04 2007-08-17 Univ Auburn Sistema de suministro de farmaco de contacto.
US8637070B2 (en) 2005-02-09 2014-01-28 Santen Pharmaceutical Co., Ltd. Rapamycin formulations and methods of their use
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
EP1871366A2 (en) 2005-03-21 2008-01-02 Macusight, Inc. Drug delivery systems for treatment of diseases or conditions
US8003124B2 (en) 2005-04-08 2011-08-23 Surmodics, Inc. Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease
EP1871890B1 (en) 2005-04-18 2011-06-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and devices for delivering a therapeutic product to the ocular sphere of a subject
US7931909B2 (en) 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
US20060292222A1 (en) 2005-06-21 2006-12-28 Matthew Jonasse Drug delivery device having zero or near zero-order release kinetics
US20070021653A1 (en) 2005-06-27 2007-01-25 Lars-Olof Hattenbach Device for the injection of drugs into microvessels
EP1909973B1 (en) 2005-07-15 2018-08-22 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
JP2009507770A (ja) 2005-07-27 2009-02-26 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド 眼性疾患の治療への、熱ショックの使用
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070038174A1 (en) 2005-08-09 2007-02-15 Hopkins Mark A Ophthalmic injector system
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
ATE540705T1 (de) 2005-09-21 2012-01-15 Surmodics Inc Überzüge und artikel mit natürlichen biologisch abbaubaren polysacchariden
ES2326282T3 (es) 2005-09-21 2009-10-06 Aston University Sistema de suministro ocular cronoterapeutico que comprende una combinacion de prostaglandina y de un betabloqueante para el tratamiento de un glaucoma primario.
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
WO2007041584A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Implantable sensors, implantable pumps, and anti-scarring drug combinations
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
US20090082321A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
KR101430760B1 (ko) 2005-10-18 2014-08-19 알러간, 인코포레이티드 후안부 조직으로 선택적으로 침투하는 글루코코르티코이드유도체를 사용한 안과 요법
TW200733993A (en) 2005-11-03 2007-09-16 Reseal Internat Ltd Partnership Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein
US8099162B2 (en) 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
US20080177220A1 (en) 2006-01-06 2008-07-24 The Curators Of The University Of Missouri Ultrasound-Mediated Transcleral Drug Delivery
WO2007082305A2 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
ES2653845T3 (es) 2006-01-17 2018-02-09 Novartis Ag Dispositivo de tratamiento de administración de fármaco
ES2551782T3 (es) 2006-01-17 2015-11-23 Transcend Medical, Inc. Dispositivo para el tratamiento de glaucoma
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
EP2316505B1 (en) 2006-03-14 2017-01-18 University Of Southern California Mems device for delivery of therapeutic agents
NZ571758A (en) 2006-03-31 2012-06-29 Quadra Logic Tech Inc A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
EP2012654A2 (en) 2006-04-18 2009-01-14 Cascade Ophthalmics Intraocular pressure attenuation device
JP5244092B2 (ja) 2006-04-26 2013-07-24 イースタン バージニア メディカル スクール 眼または身体部分の内部圧をモニターおよび制御するためのシステムおよび方法
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
CN101484088A (zh) 2006-05-04 2009-07-15 赫伯特·考夫曼 眼治疗剂的给药方法、装置和系统
US20070260203A1 (en) 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US7862540B2 (en) 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US20070270768A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Mechanical Linkage Mechanism For Ophthalmic Injection Device
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US7871399B2 (en) 2006-05-17 2011-01-18 Alcon Research, Ltd. Disposable ophthalmic injection device
US7674243B2 (en) 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US20070268340A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
US20070293873A1 (en) 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US7458953B2 (en) 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070298073A1 (en) 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
EP2043572B1 (en) 2006-06-30 2014-12-31 Aquesys Inc. Apparatus for relieving pressure in an organ
US20080152694A1 (en) 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US9248121B2 (en) 2006-08-21 2016-02-02 Abbott Laboratories Medical devices for controlled drug release
US20080086101A1 (en) 2006-08-25 2008-04-10 David Freilich Ophthalmic insert
US9101544B2 (en) 2006-08-30 2015-08-11 Jagotec Ag Controlled release nisoldipine compositions
WO2008030958A2 (en) 2006-09-06 2008-03-13 Innfocus, Llc Apparatus, methods and devices for treatment of ocular disorders
US20080075753A1 (en) 2006-09-25 2008-03-27 Chappa Ralph A Multi-layered coatings and methods for controlling elution of active agents
US20080097379A1 (en) 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080125712A1 (en) 2006-09-26 2008-05-29 Alcon Manufacturing, Ltd. Ophthalmic injection system
US20080097390A1 (en) 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
WO2008060360A2 (en) 2006-09-28 2008-05-22 Surmodics, Inc. Implantable medical device with apertures for delivery of bioactive agents
EP2068828A2 (en) 2006-09-29 2009-06-17 SurModics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
JP2010505819A (ja) 2006-10-05 2010-02-25 パナセア バイオテック リミテッド デポ型注射剤組成物とその調製方法
US7535991B2 (en) 2006-10-16 2009-05-19 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US20080281292A1 (en) 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US7620147B2 (en) 2006-12-13 2009-11-17 Oraya Therapeutics, Inc. Orthovoltage radiotherapy
WO2008105958A2 (en) 2006-10-16 2008-09-04 Alcon Research, Ltd. Ceramic chamber with integrated temperature control device for ophthalmic medical device
US7494487B2 (en) 2006-11-03 2009-02-24 Mobius Therapeutics, Llc Apparatus and method for application of a pharmaceutical to the tympanic membrane for photodynamic laser myringotomy
US8039010B2 (en) 2006-11-03 2011-10-18 Allergan, Inc. Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
US20080114076A1 (en) 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
JP5748407B2 (ja) 2006-11-10 2015-07-15 グローコス コーポレーション ブドウ膜強膜シャント
WO2008060575A2 (en) 2006-11-13 2008-05-22 Auburn University Drug delivery system and method
US8143410B2 (en) 2006-11-16 2012-03-27 Allergan, Inc. Kinase inhibitors
US20090036768A1 (en) 2006-11-17 2009-02-05 Boston Scientific Scimed, Inc. Medical devices
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
EP2091482A2 (en) 2006-12-01 2009-08-26 Allergan, Inc. Method for determining optimum intraocular locations for drug delivery systems
US8617143B2 (en) 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
WO2008073576A1 (en) 2006-12-08 2008-06-19 Alcon, Inc. Drug delivery device
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
US20080145405A1 (en) 2006-12-15 2008-06-19 Kunzler Jay F Drug delivery devices
CA2670944A1 (en) 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
US20080181928A1 (en) 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
JP2010514517A (ja) 2006-12-26 2010-05-06 キューエルティー プラグ デリバリー,インク. 視覚欠損の抑制のための薬物送達インプラント
DE102007004906A1 (de) 2007-01-25 2008-07-31 Universität Rostock Augenimplantat
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
ES2438041T3 (es) 2007-02-08 2014-01-15 Arnaldo Goncalves Dispositivo para administración intraocular de una substancia, por ejemplo un medicamento, en un ojo humano o animal mediante una aguja hipodérmica
JP4799444B2 (ja) 2007-02-26 2011-10-26 パナソニック株式会社 シミュレーションシステム
TW200840554A (en) 2007-02-28 2008-10-16 Alcon Inc Coated medical implants and lenses
US7561085B2 (en) 2007-03-21 2009-07-14 Honeywell International Inc. Systems and methods for improving data converters
WO2008124009A2 (en) 2007-04-02 2008-10-16 The Cleveland Clinic Foundation Treating glaucoma
US20090148498A1 (en) 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US8071119B2 (en) 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
WO2008154502A1 (en) 2007-06-07 2008-12-18 Yale University Uveoscleral drainage device
US8492334B2 (en) 2007-06-21 2013-07-23 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
EP2173289A4 (en) 2007-07-17 2010-11-24 Transcend Medical Inc EYE IMPLANT WITH HYDROGEL EXPANSION CAPABILITIES
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
EP2182841A4 (en) 2007-08-23 2013-04-03 Purdue Research Foundation INTRAOCULAR PRESSURE SENSOR
US8303536B2 (en) 2007-08-30 2012-11-06 Sunstorm Research Corp. Implantable delivery device
US8075909B2 (en) 2007-09-04 2011-12-13 University Of Florida Research Foundation, Incorporated Contact lens based bioactive agent delivery system
EP2205191B1 (en) 2007-09-07 2014-11-12 Mati Therapeutics Inc. Lacrimal implant
CN101984745B (zh) 2007-09-07 2013-08-14 Qlt股份有限公司 用于持续释放治疗药物的药物核心
MX2010002619A (es) 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Deteccion de implante lagrimal.
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8480638B2 (en) 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8109920B2 (en) 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
GB0722484D0 (en) 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
US20090130017A1 (en) 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US20090143752A1 (en) 2007-12-03 2009-06-04 Higuchi John W Passive intraocular drug delivery devices and associated methods
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US20090162417A1 (en) 2007-12-21 2009-06-25 Cook Incorporated Drug eluting ocular conformer
DK2227257T3 (da) 2008-01-07 2013-09-30 Salutaris Medical Devices Inc Anordninger til minimal-invasiv ekstraokular afgivelse af stråling til den posteriore del af øjet
US20090177182A1 (en) 2008-01-09 2009-07-09 Hickingbotham Dyson W Glass Drug Chamber For Automated Ophthalmic Injection Device
US20090209945A1 (en) 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
JP2011510750A (ja) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ 薬物送達デバイス、キット及びそれらの方法
CA2715489C (en) 2008-02-18 2017-09-19 Qlt Plug Delivery, Inc. Lacrimal implants and their use in the treatment of eye disorders
WO2009151678A1 (en) 2008-03-11 2009-12-17 Massachusetts Institute Of Technology Stimuli-responsive surfaces
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
WO2009120361A2 (en) 2008-03-28 2009-10-01 Surmodics, Inc. Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
EP2265293B1 (en) 2008-04-18 2015-11-04 SurModics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
TWI542338B (zh) 2008-05-07 2016-07-21 壯生和壯生視覺關懷公司 用於活性劑之控制釋放的眼用裝置
CN103394142B (zh) 2008-05-08 2015-08-19 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
ES2603027T3 (es) 2008-05-08 2017-02-23 Minipumps, Llc Métodos de fabricación de bombas de administración de fármacos
CN104353150A (zh) 2008-05-08 2015-02-18 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
CN105251007A (zh) 2008-05-09 2016-01-20 马缇医疗股份有限公司 治疗青光眼和眼高血压的活性剂的持续释放递送
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8702995B2 (en) 2008-05-27 2014-04-22 Dober Chemical Corp. Controlled release of microbiocides
WO2010006053A1 (en) 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
WO2010036966A1 (en) 2008-09-26 2010-04-01 The Cleveland Clinic Foundation Apparatus and method for delivering a therapeutic agent to ocular tissue
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US20100119519A1 (en) 2008-11-13 2010-05-13 Peyman Gholam A Ophthalmic drug delivery system and method
US20110125090A1 (en) 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
EP2355864B1 (en) 2008-11-14 2016-11-09 The Board of Regents of The University of Texas System Nanochanneled device and related methods
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
EP2367527A2 (en) 2008-11-26 2011-09-28 SurModics, Inc. Implantable ocular drug delivery device and methods
CN105056369B (zh) 2008-12-05 2019-02-22 伊万提斯公司 用于将眼部植入物输送到眼睛中的方法和装置
EP2370054B1 (en) 2008-12-11 2015-10-07 Massachusetts Institute of Technology Contact lens drug delivery device
US20100152676A1 (en) 2008-12-16 2010-06-17 Alcon Research, Ltd. Drug Loading Through Plunger
WO2010077987A1 (en) 2008-12-17 2010-07-08 Glaukos Corporation Gonioscope for improved viewing
US20120257167A1 (en) 2008-12-17 2012-10-11 Glaukos Corporation Gonioscope for improved viewing
US20100160870A1 (en) 2008-12-18 2010-06-24 Alcon Research, Ltd. Two Piece Housing For Drug Loading
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
WO2010078428A1 (en) 2008-12-30 2010-07-08 Optimyst Systems, Inc. Ophthalmic fluid delivery system
AU2009333100B2 (en) 2009-01-02 2014-08-14 Alcon Research, Ltd. In-situ refillable ophthalmic implant
ES2786101T3 (es) 2009-01-28 2020-10-08 Alcon Inc Implante ocular con cualidades de rigidez, métodos y sistema de implantación
AU2010208046B2 (en) 2009-01-29 2014-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
WO2010100654A2 (en) 2009-01-30 2010-09-10 Panduranga Revankar Krishna Prasad A device to directly monitor intra ocular pressure by a person based on pattern and colour changes
EP2395930A4 (en) 2009-02-10 2013-04-10 Psivida Inc EYE TROWART ASSEMBLY
US20100204325A1 (en) 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
WO2010096449A2 (en) 2009-02-17 2010-08-26 Pharmanova, Inc. Implantable drug delivery devices
US20100225061A1 (en) 2009-03-09 2010-09-09 Bath David L System and method for gaming with an engagable projectile
WO2010105093A2 (en) 2009-03-12 2010-09-16 Delpor, Inc. Implantable device for long-term delivery of drugs
US20100233241A1 (en) 2009-03-13 2010-09-16 Vista Scientific Llc Ophthalmic drug delivery system and applications
WO2010111232A2 (en) 2009-03-23 2010-09-30 Micell Technologies, Inc. Drug delivery medical device
US20100247606A1 (en) 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
TWI495459B (zh) 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞(二)
US8337393B2 (en) 2009-04-03 2012-12-25 Transcend Medical, Inc. Ocular implant delivery systems and methods
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2762536C (en) * 2009-05-18 2019-05-21 Dose Medical Corporation Drug eluting ocular implant
AU2010256558B2 (en) 2009-06-03 2013-10-03 Forsight Labs, Llc Anterior segment drug delivery
US20120179122A1 (en) 2009-07-22 2012-07-12 Advanced Ophthalmic Pharma Ltd Device for applying an ophthalmic medicament mist
EP2481399B1 (en) 2009-08-18 2015-11-25 Tohoku University Sustained drug delivery system
US8808257B2 (en) 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
MX2012002591A (es) 2009-09-03 2012-04-02 Allergan Inc Compuestos como moduladores de tirosina cinasas.
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
EP2490617A1 (en) 2009-10-22 2012-08-29 On Demand Therapeutics, Inc. Visual indication of rupture of drug reservoir
CA2779104C (en) 2009-10-30 2018-07-17 Aton Pharma, Inc. Ocular drug delivery devices
EP2496304A4 (en) 2009-11-02 2013-04-17 Salutaris Medical Devices Inc METHOD AND DEVICES FOR THE ADMINISTRATION OF MINIMALLY INVASIVE EXTRACOLAR RADIATION
DE102009052552A1 (de) 2009-11-10 2011-05-26 Fluoron Gmbh Spritze
USD645489S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
USD645490S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
WO2011075481A1 (en) 2009-12-16 2011-06-23 Allergan, Inc. Intracameral devices for sustained delivery
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
WO2011079232A1 (en) 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
CN102821753A (zh) 2010-01-22 2012-12-12 阿勒根公司 前房内持续释放治疗药植入物
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
EP2533737B1 (en) 2010-02-08 2014-01-08 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
EP2538929A4 (en) 2010-02-25 2014-07-09 Univ Johns Hopkins DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE
US20130071349A1 (en) 2010-03-02 2013-03-21 Allergan, Inc. Biodegradable polymers for lowering intraocular pressure
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
US9320647B2 (en) 2010-03-31 2016-04-26 Ocuject, Llc Device and method for intraocular drug delivery
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
NZ602673A (en) 2010-04-03 2014-09-26 Praful Doshi Medical devices including medicaments and methods of making and using same
CA2795706A1 (en) 2010-04-06 2011-10-13 Allergan, Inc. Sustained-release reservoir implants for intracameral drug delivery
US20110251568A1 (en) 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
US20130142858A1 (en) 2010-05-17 2013-06-06 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
US8444589B2 (en) 2010-06-09 2013-05-21 Transcend Medical, Inc. Ocular implant with fluid outflow pathways having microporous membranes
KR101180032B1 (ko) 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
US20120022505A1 (en) 2010-07-20 2012-01-26 Bruno Dacquay Closed loop glaucoma drug delivery system
WO2012019136A2 (en) 2010-08-05 2012-02-09 Forsight Vision 4, Inc. Injector apparatus and method for drug delivery
JP5907966B2 (ja) * 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
US8235053B2 (en) 2010-09-08 2012-08-07 Alcon Research, Ltd. Implantable punctal plug
US8864703B2 (en) 2010-10-05 2014-10-21 Alcon Research, Ltd. Drug introduction and placement system
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
US8915877B2 (en) 2010-10-12 2014-12-23 Emmett T. Cunningham, JR. Glaucoma drainage device and uses thereof
US9370444B2 (en) 2010-10-12 2016-06-21 Emmett T. Cunningham, JR. Subconjunctival conformer device and uses thereof
US20120100187A1 (en) 2010-10-26 2012-04-26 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
EP2654715B1 (en) 2010-11-24 2017-01-25 Dose Medical Corporation Drug eluting ocular implant
CN103380115B (zh) 2010-12-16 2016-08-24 阿勒根公司 作为趋化因子受体调节剂的硫衍生物
WO2012088306A2 (en) 2010-12-22 2012-06-28 Psivida Us, Inc. Two-piece injectable drug delivery device with heat-cured seal
US9108138B2 (en) 2011-01-24 2015-08-18 Emd Millipore Corporation Accelerated mixed gas integrity testing of porous materials
JP2012198134A (ja) 2011-03-22 2012-10-18 Chugoku Electric Power Co Inc:The 事故点標定装置、プログラム
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US20130004651A1 (en) 2011-07-01 2013-01-03 Patty Fu-Giles Sustained drug release from body implants using nanoparticle-embedded polymeric coating materials
US20130018360A1 (en) 2011-07-13 2013-01-17 Marissa Dockendorf Method for delivering ophthalmic drugs
US8486031B2 (en) 2011-07-29 2013-07-16 Allan J. Bogdan Eye treatment apparatus
WO2013030679A2 (en) 2011-08-29 2013-03-07 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
EP3659495B1 (en) 2011-09-13 2022-12-14 Dose Medical Corporation Intraocular physiological sensor
RU2740680C2 (ru) 2011-09-14 2021-01-19 Форсайт Вижн5, Инк. Глазное вкладочное устройство и способы
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8771220B2 (en) 2011-12-07 2014-07-08 Alcon Research, Ltd. Glaucoma active pressure regulation shunt
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8945214B2 (en) 2011-12-19 2015-02-03 Allergan, Inc. Intravitreal applicator
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
EP2811952A1 (en) 2012-02-07 2014-12-17 On Demand Therapeutics, Inc. Drug delivery devices and methods of use thereof
EP2830553B1 (en) 2012-03-26 2017-12-27 Glaukos Corporation Apparatus for delivering multiple ocular implants
US9504603B2 (en) 2012-04-02 2016-11-29 Ocuject, Llc Intraocular delivery devices and methods therefor
AU2014216112B2 (en) 2013-02-15 2019-02-21 Allergan, Inc. Sustained drug delivery implant
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
RU2015146211A (ru) 2013-04-01 2017-05-19 Аллерган, Инк. Микросферная система доставки лекарственного средства для замедленного внутриглазного высвобождения
CA2830555A1 (en) 2013-10-18 2015-04-18 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
HUE050902T2 (hu) 2013-10-31 2021-01-28 Allergan Inc Prosztamidot tartalmazó intraokuláris implantátumok és azok alkalmazási módszerei
AU2014348667A1 (en) 2013-11-15 2016-06-02 Glaukos Corporation Ocular implants configured to store and release stable drug formulations
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
CN117695204A (zh) 2014-09-19 2024-03-15 奥叙拉尔有限公司 眼部药物组合物
AU2016235432B2 (en) 2015-03-20 2020-02-27 Glaukos Corporation Gonioscopic devices
WO2016187355A1 (en) 2015-05-20 2016-11-24 Glaukos Corporation Therapeutic drug compositions and implants for delivery of same
US10470927B2 (en) 2015-06-03 2019-11-12 Aquesys, Inc. AB externo intraocular shunt placement
CA2993407A1 (en) 2015-07-22 2017-01-26 Glaukos Corporation Ocular implants for reduction of intraocular pressure
US20180333296A1 (en) 2015-09-02 2018-11-22 Dose Medical Corporation Drug delivery implants as intraocular drug depots and methods of using same
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20170058811A (ko) 2015-11-19 2017-05-29 글라우코스 코포레이션 전달 장치 시스템 및 녹내장 치료용 임플란트
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
USD833008S1 (en) 2017-02-27 2018-11-06 Glaukos Corporation Gonioscope
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
JP7457648B2 (ja) 2017-09-29 2024-03-28 グローコス コーポレーション 眼内生理学的センサ
EP3691586A2 (en) 2017-10-06 2020-08-12 Glaukos Corporation Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
WO2020172615A1 (en) 2019-02-22 2020-08-27 Glaukos Corporation Compounds for the treatment of ocular disease

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