AU2017252294B2 - Bioresorbable ocular drug delivery device - Google Patents

Bioresorbable ocular drug delivery device Download PDF

Info

Publication number
AU2017252294B2
AU2017252294B2 AU2017252294A AU2017252294A AU2017252294B2 AU 2017252294 B2 AU2017252294 B2 AU 2017252294B2 AU 2017252294 A AU2017252294 A AU 2017252294A AU 2017252294 A AU2017252294 A AU 2017252294A AU 2017252294 B2 AU2017252294 B2 AU 2017252294B2
Authority
AU
Australia
Prior art keywords
implant
drug
outer shell
eye
ocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017252294A
Other languages
English (en)
Other versions
AU2017252294A1 (en
Inventor
Thomas W. Burns
Kenneth Martin Curry
David Steven HAFFNER
Harold Alexander Heitzmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaukos Corp
Original Assignee
Glaukos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaukos Corp filed Critical Glaukos Corp
Publication of AU2017252294A1 publication Critical patent/AU2017252294A1/en
Assigned to DOSE MEDICAL CORPORATION reassignment DOSE MEDICAL CORPORATION Request for Assignment Assignors: BURNS, THOMAS, CURRY, KENNETH, HAFFNER, DAVID, HEITZMANN, HAROLD
Application granted granted Critical
Publication of AU2017252294B2 publication Critical patent/AU2017252294B2/en
Priority to AU2022201392A priority Critical patent/AU2022201392B2/en
Assigned to GLAUKOS CORPORATION reassignment GLAUKOS CORPORATION Request for Assignment Assignors: DOSE MEDICAL CORPORATION
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
AU2017252294A 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device Active AU2017252294B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022201392A AU2022201392B2 (en) 2016-04-20 2022-03-01 Bioresorbable ocular drug delivery device

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325378P 2016-04-20 2016-04-20
US62/325,378 2016-04-20
PCT/US2017/028665 WO2017184881A1 (en) 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022201392A Division AU2022201392B2 (en) 2016-04-20 2022-03-01 Bioresorbable ocular drug delivery device

Publications (2)

Publication Number Publication Date
AU2017252294A1 AU2017252294A1 (en) 2018-12-06
AU2017252294B2 true AU2017252294B2 (en) 2021-12-02

Family

ID=58672714

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017252294A Active AU2017252294B2 (en) 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device
AU2022201392A Active AU2022201392B2 (en) 2016-04-20 2022-03-01 Bioresorbable ocular drug delivery device

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022201392A Active AU2022201392B2 (en) 2016-04-20 2022-03-01 Bioresorbable ocular drug delivery device

Country Status (7)

Country Link
US (3) US11318043B2 (enExample)
EP (1) EP3442479A1 (enExample)
JP (3) JP7003110B2 (enExample)
CN (2) CN115120405A (enExample)
AU (2) AU2017252294B2 (enExample)
CA (1) CA3022830A1 (enExample)
WO (1) WO2017184881A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
WO2008061043A2 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
WO2009035571A2 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Lacrimal implant detection
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4289416A3 (en) 2009-05-18 2024-01-03 Dose Medical Corporation Drug eluting ocular implant
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
WO2013148275A2 (en) 2012-03-26 2013-10-03 Glaukos Corporation System and method for delivering multiple ocular implants
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
KR101841545B1 (ko) 2013-11-14 2018-03-23 아큐시스, 인코포레이티드 안구내 션트 삽입기
EP3677229A1 (en) 2014-05-29 2020-07-08 Glaukos Corporation Implants with controlled drug delivery features
EP3698703A1 (en) 2015-03-20 2020-08-26 Glaukos Corporation Gonioscopic devices
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN115120405A (zh) 2016-04-20 2022-09-30 多斯医学公司 生物可吸收眼部药物的递送装置
EP3458030B1 (en) 2016-05-20 2021-05-12 The Regents of The University of Colorado, A Body Corporate Lacrimal drug delivery device
KR102637575B1 (ko) * 2016-10-05 2024-02-20 타이탄 파머슈티컬즈 인코퍼레이티드 버스트 방출이 감소된 약물 전달용 이식 가능한 장치
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
EP3691586A2 (en) 2017-10-06 2020-08-12 Glaukos Corporation Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
WO2019094004A1 (en) * 2017-11-08 2019-05-16 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
JP7470046B2 (ja) * 2018-03-30 2024-04-17 アエリエ ファーマシューティカルズ インコーポレイテッド ６－アミノイソキノリンのモノ酸塩及びその使用
EP3976124A4 (en) * 2019-05-31 2023-02-08 DOSE Medical Corporation CROSS-LINKED HYDROGEL BIOERODABLE IMPLANTS AND ASSOCIATED METHODS OF USE
EP3990042A4 (en) 2019-06-27 2023-07-19 Layerbio, Inc. METHODS AND SYSTEMS FOR RELEASING EYE DEVICES
CN111150545A (zh) * 2020-01-02 2020-05-15 首都医科大学附属北京同仁医院 一种相变降温支架及其制备方法和相变降温组合支架
KR102154490B1 (ko) * 2020-01-03 2020-09-10 최만규 모델 하우스의 전시용 실내벽체 및 그 설치방법
CN111228034A (zh) * 2020-01-16 2020-06-05 贵州省人民医院 一种载药控释型泪道栓子及其制备方法
WO2021158013A1 (en) * 2020-02-04 2021-08-12 Korea Atomic Energy Research Institute Hydrogel and method for preparing the same
US12064376B2 (en) * 2020-06-03 2024-08-20 Glaukos Corporation Rho kinase inhibitor releasing implants and related methods of use
EP4161410A4 (en) * 2020-06-03 2024-07-17 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN111772920B (zh) * 2020-07-22 2025-01-07 苏州朗目医疗科技有限公司 青光眼引流装置及其引流植入物
WO2022251603A1 (en) * 2021-05-27 2022-12-01 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods
EP4346720A4 (en) * 2021-05-28 2025-01-01 Sight Sciences, Inc. INTRAOCULAR DEVICES, SYSTEMS AND METHODS
WO2023059933A1 (en) * 2021-10-08 2023-04-13 Purdue Research Foundation Ocular drug delivery device and related methods
EP4558093A2 (en) * 2022-07-22 2025-05-28 Spyglass Pharma, Inc. Intraocular drug delivery systems and methods of use
CN115969612A (zh) * 2022-12-20 2023-04-18 重庆医科大学附属第三医院(捷尔医院） 可生物降解的用于治疗青光眼的房水引流装置及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255061A1 (en) * 2009-01-29 2010-10-07 Forsight Labs, Llc Posterior Segment Drug Delivery
US20160045363A1 (en) * 2013-03-15 2016-02-18 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same

Family Cites Families (613)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663670A (en) 1900-07-30 1900-12-11 Marion W Wiswall Apparel dusting-cap.
US2031754A (en) 1932-11-04 1936-02-25 Ernest J Sweetland Extensible coupling
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
JPS5323011B2 (enExample) 1973-09-12 1978-07-12
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4207890A (en) 1977-01-04 1980-06-17 Mcneilab, Inc. Drug-dispensing device and method
US4113088A (en) 1977-06-06 1978-09-12 Binkhorst Richard D Sterile package
US4328803B1 (en) 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
DK90883A (da) 1982-03-18 1983-09-19 Merck & Co Inc Beholder til osmotisk afgivelse af et stof eller en stofblanding
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4955881A (en) 1985-08-16 1990-09-11 Alza Corporation Ruminant dispensing device
US4883864A (en) 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
GB8603099D0 (en) 1986-02-07 1986-03-12 Blass K G Gastrointestinal module
US4743248A (en) 1986-08-11 1988-05-10 Alza Corporation Dosage form for delivering acid sensitive beneficial agent
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4736836A (en) 1987-02-02 1988-04-12 Alongi Salvatore A Intraocular lens package
US4846793A (en) 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4828439A (en) 1987-05-15 1989-05-09 Giannuzzi Louis Screw anchor
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
CA1334168C (en) 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
FR2644058B1 (fr) 1989-03-10 1994-06-03 France Chirurgie Instr Bouchon meatique pour pathologie lacrymale
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5725529A (en) 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
CA2071137A1 (en) 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
WO1993003776A1 (en) 1991-08-16 1993-03-04 Galin Miles A Medicament coated refractive anterior chamber ocular implant
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
GB2260585A (en) 1991-10-09 1993-04-21 Avdel Systems Ltd Self-plugging blind rivet
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IL100112A (en) 1991-11-21 1996-01-31 Yeda Res & Dev Microdelivery device for enhanced drug administration to the eye
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
WO1993020784A1 (en) 1992-04-10 1993-10-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5380290A (en) 1992-04-16 1995-01-10 Pfizer Hospital Products Group, Inc. Body access device
WO1993024121A1 (fr) 1992-05-22 1993-12-09 Senju Pharmaceutical Co., Ltd. Medicament pour le glaucome
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
WO1994002081A1 (en) 1992-07-16 1994-02-03 Wong Vernon G Eye implant suitable for relief of glaucoma
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
ES2106553T5 (es) 1993-07-19 2008-02-16 Angiotech Pharmaceuticals, Inc. Composiciones anti-angiogenicas y metodos de uso.
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5731294A (en) 1993-07-27 1998-03-24 Hybridon, Inc. Inhibition of neovasularization using VEGF-specific oligonucleotides
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5500465A (en) 1994-03-10 1996-03-19 Board Of Trustees Operating Michigan State University Biodegradable multi-component polymeric materials based on unmodified starch-like polysaccharides
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
JPH09511507A (ja) 1994-04-04 1997-11-18 フリーマン，ウイリアム・アール 上昇した眼圧を治療するためのホスホニルメトキシアルキルヌクレオシドの使用
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
WO1995030429A1 (en) 1994-05-04 1995-11-16 Board Of Trustees Of The University Of Arkansas Novel ophthalmologic uses of protein c
US5599534A (en) 1994-08-09 1997-02-04 University Of Nebraska Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
US5665114A (en) 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
GB9417399D0 (en) 1994-08-30 1994-10-19 Scherer Corp R P Ocular treatment device
WO1996011720A1 (fr) 1994-10-17 1996-04-25 Kabushikikaisha Igaki Iryo Sekkei Extenseur endovasculaire liberant un medicament
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US5643321A (en) 1994-11-10 1997-07-01 Innovasive Devices Suture anchor assembly and methods
US5602143A (en) 1994-12-08 1997-02-11 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
US6228873B1 (en) 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5891084A (en) 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
WO1996020742A1 (en) 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
JPH10513455A (ja) 1995-02-10 1998-12-22 ザ ユニバーシティ オブ トロント イノベーションズ ファウンデーション 緑内障治療用のデプレニル化合物
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5547993A (en) 1995-10-24 1996-08-20 Mitsubishi Chemical Corporation Therapeutic agent for glaucoma
AU1201297A (en) 1995-12-21 1997-07-17 Pharmacia & Upjohn Ab Ophthalmic treatment
US5798380A (en) 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
GB9700390D0 (en) 1997-01-10 1997-02-26 Biocompatibles Ltd Device for use in the eye
FR2759577B1 (fr) 1997-02-17 1999-08-06 Corneal Ind Implant de sclerectomie profonde
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US6059812A (en) 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
DE19728069C1 (de) 1997-07-01 1999-02-11 Acritec Gmbh Vorrichtung zur Messung des Augeninnendrucks
US5980928A (en) 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6274138B1 (en) 1997-09-03 2001-08-14 Incyte Genomics, Inc. Human mitochondrial malate dehydrogenase
US7985415B2 (en) 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US20020164374A1 (en) 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6159458A (en) 1997-11-04 2000-12-12 Insite Vision Sustained release ophthalmic compositions containing water soluble medicaments
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6589198B1 (en) 1998-01-29 2003-07-08 David Soltanpour Implantable micro-pump assembly
US6682500B2 (en) 1998-01-29 2004-01-27 David Soltanpour Synthetic muscle based diaphragm pump apparatuses
US7780623B2 (en) 1998-01-29 2010-08-24 Soltanpour David P Implantable pump apparatuses
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
FR2777442B1 (fr) 1998-04-21 2000-07-28 Tornier Sa Ancre de suture a expansion reversible
JP2002512954A (ja) 1998-04-24 2002-05-08 マイトコー ミトコンドリア関連疾患を処置するための化合物および方法
US5997498A (en) 1998-05-07 1999-12-07 Johns Hopkins University Inline air humidifier, a system for humidifying air and methods related thereto
TW586944B (en) 1998-05-29 2004-05-11 Sumitomo Pharma Controlled release agent having a multi-layer structure
US6231853B1 (en) 1998-06-01 2001-05-15 Incyte Pharmaceuticals, Inc. Human glutathione peroxidase-6
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
KR100300527B1 (ko) 1998-09-03 2001-10-27 윤덕용 밀봉형무선압력측정소자및그제조방법
KR100274842B1 (ko) 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6348042B1 (en) 1999-02-02 2002-02-19 W. Lee Warren, Jr. Bioactive shunt
US6193656B1 (en) 1999-02-08 2001-02-27 Robert E. Jeffries Intraocular pressure monitoring/measuring apparatus and method
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
WO2000064393A1 (en) 1999-04-26 2000-11-02 Lynch Mary G Shunt device and method for treating glaucoma
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6306120B1 (en) 1999-06-07 2001-10-23 Ben Gee Tan Applicator and method for delivery of mitomycin to eye tissues during glaucoma filtering surgery
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US8550119B2 (en) 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20080277007A1 (en) 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
CA2380111A1 (en) 1999-08-03 2001-02-08 Smith & Nephew, Inc. Controlled release implantable devices
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
CA2379909C (en) 1999-08-06 2011-01-04 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
CA2383572C (en) 1999-10-21 2007-12-11 Alcon Universal Ltd. Sub-tenon drug delivery
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
EP1473003B1 (en) 1999-10-21 2008-11-19 Alcon, Inc. Drug delivery device
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
JP2003530144A (ja) 1999-12-10 2003-10-14 アイサイエンス コーポレイション 眼の病気の治療
US6939299B1 (en) 1999-12-13 2005-09-06 Kurt Petersen Implantable continuous intraocular pressure sensor
JP2003516809A (ja) 1999-12-16 2003-05-20 アルザ・コーポレーション レーザー切除に対するバリヤー層を有する剤型
KR100778908B1 (ko) 2000-01-12 2007-11-27 벡톤 디킨슨 앤드 컴퍼니 안내압을 감소시키기 위한 시스템 및 방법
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
WO2001070705A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US20070031473A1 (en) 2005-08-05 2007-02-08 Peyman Gholam A Drug delivery system and method
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US20040111050A1 (en) 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US20030060752A1 (en) 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
AU2001258095A1 (en) 2000-05-08 2001-11-20 The University Of British Columbia Drug delivery systems for photodynamic therapy
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
DE60131273T2 (de) 2000-05-19 2008-08-28 Michael S. Beverly Hills Berlin Laserapplikationssystem und methode zur verwendung im auge
WO2001097727A1 (en) 2000-06-19 2001-12-27 Glaukos Corporation Stented trabecular shunt and methods thereof
KR100355563B1 (ko) 2000-06-23 2002-10-11 주식회사 바이오메드랩 비등성 혼합물을 이용한 조직공학용 생분해성의 다공성고분자 지지체 및 그의 제조방법
US6692759B1 (en) 2000-06-28 2004-02-17 The Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
EP1637126B1 (en) 2000-07-05 2016-12-14 Allergan, Inc. Methods for treating inflammation of the eye
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US6629992B2 (en) 2000-08-04 2003-10-07 Advanced Cardiovascular Systems, Inc. Sheath for self-expanding stent
US7056533B2 (en) 2000-08-15 2006-06-06 Surmodics, Inc. Medicament incorporation matrix
US6749568B2 (en) 2000-08-21 2004-06-15 Cleveland Clinic Foundation Intraocular pressure measurement system including a sensor mounted in a contact lens
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
AU2001261262A1 (en) 2000-11-01 2002-05-15 Glaukos Corporation Glaucoma treatment device
ATE306951T1 (de) 2000-11-29 2005-11-15 Allergan Inc Verhinderung von transplantatabstossung im auge
EP1550471A1 (en) 2000-11-29 2005-07-06 Allergan Inc. Intraocular implants for preventing transplant rejection in the eye
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
EP1345588A2 (en) 2000-12-29 2003-09-24 Bausch & Lomb Incorporated Sustained release drug delivery devices
WO2002053128A2 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with multiple agents
US20020086051A1 (en) 2001-01-03 2002-07-04 Santos Viscasillas Sustained release drug delivery devices with coated drug cores
WO2002053129A1 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with prefabricated permeable plugs
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
WO2002058551A2 (en) 2001-01-22 2002-08-01 Integrated Sensing Systems, Inc. Wireless mems capacitive sensor for physiologic parameter measurement
WO2002058667A2 (en) 2001-01-26 2002-08-01 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US8060211B2 (en) 2001-02-13 2011-11-15 Second Sight Medical Products, Inc. Method of reducing retinal stress caused by an implantable retinal electrode array
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6989007B2 (en) 2001-02-21 2006-01-24 Solx, Inc. Devices and techniques for treating glaucoma
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
US20050278014A9 (en) 2001-03-07 2005-12-15 Wolfgang Daum Stent and method for drug delivery from stents
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
WO2002074052A2 (en) 2001-03-16 2002-09-26 Glaukos Corporation Applicator and methods for placing a trabecular shunt for glaucoma treatment
CA2683224C (en) 2001-04-07 2014-12-02 Glaukos Corporation System and methods thereof for treatment of ocular disorders
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US6533769B2 (en) 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
JP2004536631A (ja) 2001-05-03 2004-12-09 マサチューセッツ・アイ・アンド・イア・インファーマリー 移植可能な薬物送達デバイスおよびその使用
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
EP2316394B1 (en) 2001-06-12 2016-11-23 The Johns Hopkins University Reservoir device for intraocular drug delivery
WO2002103210A1 (en) 2001-06-15 2002-12-27 Hansford Derek J Nanopump devices and methods
US7592016B2 (en) 2001-06-28 2009-09-22 Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
DK1409065T3 (da) 2001-07-23 2007-05-21 Alcon Inc Oftalmisk medikamentafgivelsesanordning
DE60214697T2 (de) 2001-07-23 2007-09-13 Alcon Inc. Vorrichtung zur freisetzung eines ophthalmischen arzneimittels
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
AU2002324811B2 (en) 2001-08-29 2008-07-24 De Carvalho, Ricardo A P An implantable and sealable system for unidirectional delivery of therapeutic agents to targeted tissues
IN2014DN10834A (enExample) 2001-09-17 2015-09-04 Psivida Inc
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
US20030135201A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
FR2830766B1 (fr) 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese transpalpebrale
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030119000A1 (en) 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
US20080039769A1 (en) 2001-11-07 2008-02-14 Minu Llc Method of medical treatment using controlled heat delivery
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US6802829B2 (en) 2001-11-16 2004-10-12 Infinite Vision, Llc Spray device
WO2003043549A1 (de) 2001-11-22 2003-05-30 Eduard Anton Haefliger Vorrichtung und verfahren zur durchführung ophtalmologischer eingriffe
US7348055B2 (en) 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US20060034929A1 (en) 2001-12-27 2006-02-16 Brubaker Michael J Sustained release drug delivery devices with prefabricated permeable plugs
WO2003061625A2 (en) 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
JP2003210513A (ja) 2002-01-23 2003-07-29 Nidek Co Ltd 眼科用治療装置
AU2003219932A1 (en) 2002-02-28 2003-09-16 Gmp Vision Solutions, Inc. Device and method for monitoring aqueous flow within the eye
US20050069893A1 (en) 2002-03-01 2005-03-31 Josef Flammer Diagnostic method for glaucoma
US20060200113A1 (en) 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
WO2003077972A2 (en) 2002-03-11 2003-09-25 Alcon, Inc. Implantable drug delivery system
US20060100408A1 (en) 2002-03-11 2006-05-11 Powell P M Method for forming contact lenses comprising therapeutic agents
AR038926A1 (es) 2002-03-13 2005-02-02 Novartis Ag Materiales con contenido de multiples capas de vesiculas
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
JP4026745B2 (ja) 2002-03-26 2007-12-26 財団法人大阪産業振興機構 医療用システムおよびその製造方法
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20030195438A1 (en) 2002-04-12 2003-10-16 Petillo Phillip J. Method and apparatus to treat glaucoma
US20040024345A1 (en) 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
AU2003217531A1 (en) 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20070123767A1 (en) 2002-05-31 2007-05-31 Valentino Montegrande Intraocular pressure sensor and method of use
US20050159660A1 (en) 2002-05-31 2005-07-21 Valentino Montegrande Intraocular pressure sensor
US8273366B2 (en) 2002-06-05 2012-09-25 University Of Florida Research Foundation, Incorporated Ophthalmic drug delivery system
WO2003103549A1 (en) 2002-06-05 2003-12-18 University Of Florida Ophthalmic drug delivery system
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
JP4463681B2 (ja) 2002-07-15 2010-05-19 アルコン，インコーポレイテッド 眼内使用のための非ポリマー親油性薬学的インプラント組成物
US20040013702A1 (en) 2002-07-16 2004-01-22 Glover Eugene G. Implantable devices for the controlled release of cytotoxic agents
EP1534363B1 (en) 2002-07-19 2008-12-31 Yale University Uveoscleral drainage device
WO2004014218A2 (en) 2002-08-08 2004-02-19 Glaukos Corporation Implantable ocular pump to reduce intraocular pressure
US6890300B2 (en) 2002-08-27 2005-05-10 Board Of Trustees Of Michigan State University Implantable microscale pressure sensor system for pressure monitoring and management
JP4353510B2 (ja) 2002-09-09 2009-10-28 株式会社カネカ 組織再生用支持体及びその製造方法
US7192412B1 (en) 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
WO2004026347A2 (en) 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
US20050261641A1 (en) 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
USRE40722E1 (en) 2002-09-27 2009-06-09 Surmodics, Inc. Method and apparatus for coating of substrates
US7615010B1 (en) 2002-10-03 2009-11-10 Integrated Sensing Systems, Inc. System for monitoring the physiologic parameters of patients with congestive heart failure
US7131945B2 (en) 2002-10-16 2006-11-07 California Institute Of Technology Optically powered and optically data-transmitting wireless intraocular pressure sensor device
WO2004043231A2 (en) 2002-11-06 2004-05-27 Gmp Vision Solutions, Inc. Storage apparatus for surgical implant device
WO2004043435A2 (en) 2002-11-13 2004-05-27 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
EP1568359A4 (en) 2002-12-04 2011-05-18 Santen Pharmaceutical Co Ltd DRUG DELIVERY SYSTEM HAVING SUB-CONJUNCTIVAL DEPOSIT
WO2004056311A2 (en) 2002-12-17 2004-07-08 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20040137059A1 (en) 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
US20040216749A1 (en) 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
CA2515568A1 (en) 2003-02-18 2004-09-02 Hampar Karageozian Methods and devices for draining fluids and lowering intraocular pressure
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US20040163652A1 (en) 2003-02-25 2004-08-26 Colin Watson Condom with restriction band
USD490152S1 (en) 2003-02-28 2004-05-18 Glaukos Corporation Surgical handpiece
WO2005105197A2 (en) 2003-02-28 2005-11-10 Gmp Vision Solutions, Inc. Indwelling shunt device and methods for treating glaucoma
US7483750B2 (en) 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
US20050208102A1 (en) 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
EP1633320A2 (en) 2003-05-02 2006-03-15 SurModics, Inc. Implantable controlled release bioactive agent delivery device
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
AU2004247272A1 (en) 2003-06-16 2004-12-23 Solx, Inc. Shunt for the treatment of glaucoma
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
WO2005009297A1 (en) 2003-07-10 2005-02-03 Alcon, Inc. Ophthalmic drug delivery device
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
JP4869930B2 (ja) 2003-08-26 2012-02-08 ヴィスタ サイエンティフィック エルエルシー 眼科薬物供給装置
NZ617083A (en) 2003-08-27 2015-04-24 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
US20050055075A1 (en) 2003-09-08 2005-03-10 Leonard Pinchuk Methods for the manufacture of porous prostheses
CN1882338A (zh) 2003-09-18 2006-12-20 马库赛特公司 经巩膜递送
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US20050196455A1 (en) 2003-10-27 2005-09-08 Jianbing Chen Suspension delivery system for the sustained and controlled local release of pharmaceuticals
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
WO2005048875A2 (en) 2003-11-14 2005-06-02 Medical Instill Technologies, Inc. Delivery device and method of delivery
EP1687041A2 (en) 2003-11-20 2006-08-09 Angiotech International AG Soft tissue implants and anti-scarring agents
US20080058793A1 (en) 2006-06-12 2008-03-06 Pilla Arthur A Electromagnetic apparatus for prophylaxis and repair of ophthalmic tissue and method for using same
US20110112352A1 (en) 2003-12-05 2011-05-12 Pilla Arthur A Apparatus and method for electromagnetic treatment
US20050137538A1 (en) 2003-12-22 2005-06-23 Bausch & Lomb Incorporated Drug delivery device
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US20050250788A1 (en) 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20060004422A1 (en) 2004-03-11 2006-01-05 Dirk De Ridder Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
US7513893B2 (en) 2004-03-12 2009-04-07 Abraham Ebbie Soroudi Device and method for treatment of eyelid diseases
ES2638137T3 (es) 2004-03-26 2017-10-18 Molteno Ophtalmic Ltd. Implante oftálmico para tratar el glaucoma
US7654985B2 (en) 2004-03-30 2010-02-02 Given Imaging Ltd. Controlled detachment of intra-luminal medical device
US20060083772A1 (en) 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
KR20070033974A (ko) 2004-04-29 2007-03-27 아이싸이언스 인터벤셔날 코포레이션 방수 배출의 외과적 강화를 위한 장치와 방법
US20070212395A1 (en) 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
US20050244461A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
AU2005240078A1 (en) 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244465A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20050244500A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
CA2591267C (fr) 2004-04-30 2012-04-10 Eyegate Pharma S.A. Dispositif de iontophorese oculaire diminuant les irritations
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
BRPI0510485A (pt) 2004-04-30 2007-11-13 Allergan Inc implantes inibidores de tirosina cinase intravìtreos biodegradáveis
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
EP1761283A2 (en) 2004-06-07 2007-03-14 California Institute Of Technology Biodegradable drug-polymer delivery system
US7252006B2 (en) 2004-06-07 2007-08-07 California Institute Of Technology Implantable mechanical pressure sensor and method of manufacturing the same
EP1604697A1 (en) 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
US20060024350A1 (en) 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
CN101052435B (zh) 2004-07-02 2010-12-08 Qlt塞子传递公司 治疗介质递送装置
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
EP1773350B1 (en) 2004-07-12 2013-05-29 Allergan, Inc. Opthalmic compositions for treating ophthalmic conditions
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060021623A1 (en) 2004-07-30 2006-02-02 Miller Joan W Methods and compositions for treating ocular glaucoma
US20060032507A1 (en) 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
US7402156B2 (en) 2004-09-01 2008-07-22 Alcon, Inc. Counter pressure device for ophthalmic drug delivery
US20060084952A1 (en) 2004-09-03 2006-04-20 Pallikaris Ioannis G Device for the irradiation of the ciliary body of the eye
US7709049B2 (en) 2004-09-10 2010-05-04 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
WO2006035417A2 (en) 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
MX2007003789A (es) 2004-10-04 2007-07-20 Qlt Usa Inc Suministro ocular de formulaciones polimericas para suministro.
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US7226435B2 (en) 2004-10-14 2007-06-05 Alcon, Inc. Drug delivery device
US20060089590A1 (en) 2004-10-27 2006-04-27 John Higuchi Methods and devices for sustained in-vivo release of an active agent
US7958840B2 (en) 2004-10-27 2011-06-14 Surmodics, Inc. Method and apparatus for coating of substrates
WO2006053836A1 (en) 2004-11-16 2006-05-26 Universite De Liege Active substance delivery system comprising a hydrogel atrix and microcarriers
CN100553588C (zh) 2004-11-23 2009-10-28 小爱德华·K·王 控制眼和眼周围组织温度以及治疗眼疾病的医疗装置
US20060173397A1 (en) 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
CA2588449A1 (en) 2004-11-24 2006-06-01 Therakine Corporation An implant for intraocular drug delivery
US20070118065A1 (en) 2004-12-03 2007-05-24 Leonard Pinchuk Glaucoma Implant Device
US7837644B2 (en) 2004-12-03 2010-11-23 Innfocus, Llc Glaucoma implant device
KR20070101865A (ko) 2004-12-22 2007-10-17 알콘, 인코퍼레이티드 안과용 약물 전달 장치
EP1848749B1 (en) 2005-02-04 2018-10-31 Auburn University Contact drug delivery system
JP4974903B2 (ja) 2005-02-09 2012-07-11 参天製薬株式会社 疾患または状態を処置するための液体処方物
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
WO2006102378A2 (en) 2005-03-21 2006-09-28 Macusight, Inc. Drug delivery systems for treatment of diseases or conditions
EP1868661A1 (en) 2005-04-08 2007-12-26 SurModics, Inc. Sustained release implants for subretinal delivery
WO2006123248A2 (en) 2005-04-18 2006-11-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Improved methods and devices for delivering a therapeutic product to the ocular sphere of a subject
US7931909B2 (en) 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
US20060292222A1 (en) 2005-06-21 2006-12-28 Matthew Jonasse Drug delivery device having zero or near zero-order release kinetics
US20070021653A1 (en) 2005-06-27 2007-01-25 Lars-Olof Hattenbach Device for the injection of drugs into microvessels
EP1909973B1 (en) 2005-07-15 2018-08-22 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
KR20080031474A (ko) 2005-07-27 2008-04-08 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. 안구 질환의 치료를 위한 열충격의 사용
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070038174A1 (en) 2005-08-09 2007-02-15 Hopkins Mark A Ophthalmic injector system
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
WO2007034140A1 (en) 2005-09-21 2007-03-29 Aston University Chronotherapeutic ocular delivery system comprising a combination of prostaglandin and a beta-blocker for treating primary glaucoma
US20070065483A1 (en) 2005-09-21 2007-03-22 Chudzik Stephen J In vivo formed matrices including natural biodegradable polysaccharides and uses thereof
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
WO2007041584A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Implantable sensors, implantable pumps, and anti-scarring drug combinations
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
US20090082321A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
CA2602577C (en) 2005-10-18 2015-03-31 Allergan, Inc. Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues
TW200733993A (en) 2005-11-03 2007-09-16 Reseal Internat Ltd Partnership Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein
US8099162B2 (en) 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
US20080177220A1 (en) 2006-01-06 2008-07-24 The Curators Of The University Of Missouri Ultrasound-Mediated Transcleral Drug Delivery
WO2007082304A2 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
JP2009523540A (ja) 2006-01-17 2009-06-25 トランセンド メディカル インコーポレイテッド 緑内障処置装置
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US7887508B2 (en) 2006-03-14 2011-02-15 The University Of Southern California MEMS device and method for delivery of therapeutic agents
US8795711B2 (en) 2006-03-31 2014-08-05 Mati Therapeutics Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
EP2012654A2 (en) 2006-04-18 2009-01-14 Cascade Ophthalmics Intraocular pressure attenuation device
CA2650570C (en) 2006-04-26 2017-06-06 Eastern Virginia Medical School Systems and methods for monitoring and controlling internal pressure of an eye or body part
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
CN101484088A (zh) 2006-05-04 2009-07-15 赫伯特·考夫曼 眼治疗剂的给药方法、装置和系统
US20070260203A1 (en) 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
US7862540B2 (en) 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US7871399B2 (en) 2006-05-17 2011-01-18 Alcon Research, Ltd. Disposable ophthalmic injection device
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US20070268340A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
US7674243B2 (en) 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US20070270768A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Mechanical Linkage Mechanism For Ophthalmic Injection Device
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US20070293873A1 (en) 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US7458953B2 (en) 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070298073A1 (en) 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
WO2008005873A2 (en) 2006-06-30 2008-01-10 Aquesys Inc. Methods, systems and apparatus for relieving pressure in an organ
WO2008011125A2 (en) 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
US20080057102A1 (en) 2006-08-21 2008-03-06 Wouter Roorda Methods of manufacturing medical devices for controlled drug release
US20080086101A1 (en) 2006-08-25 2008-04-10 David Freilich Ophthalmic insert
MX2009002235A (es) 2006-08-30 2009-03-13 Jagotec Ag Formulaciones de dosis oral, solidas, de liberacion controlada que comprenden nisoldipina.
EP2059282A4 (en) 2006-09-06 2014-04-09 Innfocus Inc APPARATUS, METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISORDERS
WO2008039749A2 (en) 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
US20080097379A1 (en) 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080125712A1 (en) 2006-09-26 2008-05-29 Alcon Manufacturing, Ltd. Ophthalmic injection system
US20080097390A1 (en) 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
WO2008060360A2 (en) 2006-09-28 2008-05-22 Surmodics, Inc. Implantable medical device with apertures for delivery of bioactive agents
CA2664879C (en) 2006-09-29 2015-03-24 Surmodics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
MX2009003735A (es) 2006-10-05 2009-04-22 Panacea Biotec Ltd Composicion en deposito inyectable y su procedimiento de preparacion.
WO2008105958A2 (en) 2006-10-16 2008-09-04 Alcon Research, Ltd. Ceramic chamber with integrated temperature control device for ophthalmic medical device
US7535991B2 (en) 2006-10-16 2009-05-19 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US7620147B2 (en) 2006-12-13 2009-11-17 Oraya Therapeutics, Inc. Orthovoltage radiotherapy
US20080281292A1 (en) 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US8039010B2 (en) 2006-11-03 2011-10-18 Allergan, Inc. Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
US7494487B2 (en) 2006-11-03 2009-02-24 Mobius Therapeutics, Llc Apparatus and method for application of a pharmaceutical to the tympanic membrane for photodynamic laser myringotomy
US20080114076A1 (en) 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
WO2008061043A2 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
WO2008060575A2 (en) 2006-11-13 2008-05-22 Auburn University Drug delivery system and method
US8143410B2 (en) 2006-11-16 2012-03-27 Allergan, Inc. Kinase inhibitors
WO2008064111A2 (en) 2006-11-17 2008-05-29 Boston Scientific Limited Radiopaque medical devices
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
EP2091482A2 (en) 2006-12-01 2009-08-26 Allergan, Inc. Method for determining optimum intraocular locations for drug delivery systems
US8617143B2 (en) 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
US20080140024A1 (en) 2006-12-08 2008-06-12 Yoseph Yaacobi Drug delivery device
US20080145405A1 (en) 2006-12-15 2008-06-19 Kunzler Jay F Drug delivery devices
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
AR063619A1 (es) 2006-12-18 2009-02-04 Alcon Res Ltd Dispositivos y metodos para la administraicion de un farmaco oftalmico
US20080181928A1 (en) 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
KR20090102810A (ko) 2006-12-26 2009-09-30 큐엘티 플러그 딜리버리, 인코포레이티드 시력 결함을 억제하기 위한 약물 전달 임플란트
DE102007004906A1 (de) 2007-01-25 2008-07-31 Universität Rostock Augenimplantat
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US9144516B2 (en) 2007-02-08 2015-09-29 Sharpsight B.V. Device for intraocular administration of a substance, for example a medication, into a human or animal eye by means of a hypodermic needle
JP4799444B2 (ja) 2007-02-26 2011-10-26 パナソニック株式会社 シミュレーションシステム
TW200840554A (en) 2007-02-28 2008-10-16 Alcon Inc Coated medical implants and lenses
US7561085B2 (en) 2007-03-21 2009-07-14 Honeywell International Inc. Systems and methods for improving data converters
WO2008124009A2 (en) 2007-04-02 2008-10-16 The Cleveland Clinic Foundation Treating glaucoma
US8071119B2 (en) 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20090148498A1 (en) 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US20080306429A1 (en) 2007-06-07 2008-12-11 Shields Milton B Uveoscleral drainage device
EP2178502A2 (en) 2007-06-21 2010-04-28 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
WO2009012406A1 (en) 2007-07-17 2009-01-22 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities reference to priority document
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
CA2695454C (en) 2007-08-23 2016-09-20 Purdue Research Foundation Intra-ocular pressure sensor
US8303536B2 (en) 2007-08-30 2012-11-06 Sunstorm Research Corp. Implantable delivery device
US8075909B2 (en) 2007-09-04 2011-12-13 University Of Florida Research Foundation, Incorporated Contact lens based bioactive agent delivery system
KR101996336B1 (ko) 2007-09-07 2019-07-04 마티 테라퓨틱스 인코포레이티드 치료 약제의 서방성 약물 코어
WO2009035571A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Lacrimal implant detection
ES2732555T3 (es) 2007-09-07 2019-11-25 Mati Therapeutics Inc Implantes lagrimales y métodos relacionados
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8480638B2 (en) 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8109920B2 (en) 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
GB0722484D0 (en) 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
US20090130017A1 (en) 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US20090143752A1 (en) 2007-12-03 2009-06-04 Higuchi John W Passive intraocular drug delivery devices and associated methods
WO2009086112A2 (en) 2007-12-20 2009-07-09 University Of Southern California Apparatus and methods for delivering therapeutic agents
US20090162417A1 (en) 2007-12-21 2009-06-25 Cook Incorporated Drug eluting ocular conformer
US20110207987A1 (en) 2009-11-02 2011-08-25 Salutaris Medical Devices, Inc. Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
WO2009089288A1 (en) 2008-01-07 2009-07-16 Salutaris Md Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US20090177182A1 (en) 2008-01-09 2009-07-09 Hickingbotham Dyson W Glass Drug Chamber For Automated Ophthalmic Injection Device
US20090209945A1 (en) 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
JP2011510750A (ja) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ 薬物送達デバイス、キット及びそれらの方法
CN104825270B (zh) 2008-02-18 2017-10-24 马缇医疗股份有限公司 泪管植入物及相关方法
US20090274877A1 (en) 2008-03-11 2009-11-05 Edwin Chan Stimuli-responsive surfaces
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
EP2689789B1 (en) 2008-03-28 2019-03-13 SurModics, Inc. Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
WO2009128944A2 (en) 2008-04-18 2009-10-22 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
TWI542338B (zh) 2008-05-07 2016-07-21 壯生和壯生視覺關懷公司 用於活性劑之控制釋放的眼用裝置
WO2009137785A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Drug-delivery pumps and methods of manufacture
EP2320972B1 (en) 2008-05-08 2020-07-01 MiniPumps, LLC Implantable drug-delivery devices
CN104353150A (zh) 2008-05-08 2015-02-18 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
CN105251007A (zh) 2008-05-09 2016-01-20 马缇医疗股份有限公司 治疗青光眼和眼高血压的活性剂的持续释放递送
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8702995B2 (en) 2008-05-27 2014-04-22 Dober Chemical Corp. Controlled release of microbiocides
TW201006453A (en) * 2008-07-08 2010-02-16 Qlt Plug Delivery Inc Lacrimal implant body including comforting agent
EP2344095A1 (en) 2008-09-26 2011-07-20 The Cleveland Clinic Foundation Apparatus and method for delivering a therapeutic agent to ocular tissue
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US20100119519A1 (en) 2008-11-13 2010-05-13 Peyman Gholam A Ophthalmic drug delivery system and method
US20110125090A1 (en) 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
CN102271732B (zh) 2008-11-14 2014-12-31 得克萨斯大学体系董事会 纳米通道装置和相关方法
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
JP2012509737A (ja) 2008-11-26 2012-04-26 サーモディクス，インコーポレイティド 埋め込み式の眼薬送達器具および眼薬送達方法
CA2745884C (en) 2008-12-05 2017-08-01 Ivantis, Inc. Cannula for ocular implant delivery system
EP2962682B1 (en) 2008-12-11 2018-03-28 Massachusetts Institute Of Technology Method of making a contact lens drug delivery device
US20100152676A1 (en) 2008-12-16 2010-06-17 Alcon Research, Ltd. Drug Loading Through Plunger
US8070290B2 (en) 2008-12-17 2011-12-06 Glaukos Corporation Gonioscope for improved viewing
US20120257167A1 (en) 2008-12-17 2012-10-11 Glaukos Corporation Gonioscope for improved viewing
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
US20100160870A1 (en) 2008-12-18 2010-06-24 Alcon Research, Ltd. Two Piece Housing For Drug Loading
WO2010078428A1 (en) 2008-12-30 2010-07-08 Optimyst Systems, Inc. Ophthalmic fluid delivery system
US20100174272A1 (en) 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
EP2395951B1 (en) 2009-01-28 2020-07-29 Alcon Inc. Ocular implant with stiffness qualities
US9282891B2 (en) 2009-01-30 2016-03-15 Sundaraja Sitaram Iyengar Monitoring intra ocular pressure using pattern and color changes
WO2010093662A2 (en) 2009-02-10 2010-08-19 Psivida Us, Inc. Ocular trocar assembly
US20100204325A1 (en) 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
WO2010096449A2 (en) 2009-02-17 2010-08-26 Pharmanova, Inc. Implantable drug delivery devices
US20100225061A1 (en) 2009-03-09 2010-09-09 Bath David L System and method for gaming with an engagable projectile
CA2792484C (en) 2009-03-12 2017-10-31 Delpor, Inc. Implantable device for long-term delivery of drugs
US20100233241A1 (en) 2009-03-13 2010-09-16 Vista Scientific Llc Ophthalmic drug delivery system and applications
US20100239635A1 (en) 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
US20100247606A1 (en) 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
TWI495459B (zh) 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
US8337393B2 (en) 2009-04-03 2012-12-25 Transcend Medical, Inc. Ocular implant delivery systems and methods
EP4289416A3 (en) 2009-05-18 2024-01-03 Dose Medical Corporation Drug eluting ocular implant
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
CN102596097B (zh) 2009-06-03 2015-05-20 弗赛特实验室有限责任公司 一种眼插入件
US20120179122A1 (en) 2009-07-22 2012-07-12 Advanced Ophthalmic Pharma Ltd Device for applying an ophthalmic medicament mist
JP5641483B2 (ja) 2009-08-18 2014-12-17 国立大学法人東北大学 持続性ドラッグデリバリーシステム
US8808257B2 (en) 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
EP2473513B1 (en) 2009-09-03 2019-06-05 Allergan, Inc. Compounds as tyrosine kinase modulators
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
JP2013508092A (ja) 2009-10-22 2013-03-07 オン デマンド セラピューティクス，インコーポレイテッド 薬物リザーバーの破裂の視覚表示
CA2779104C (en) 2009-10-30 2018-07-17 Aton Pharma, Inc. Ocular drug delivery devices
DE102009052552A1 (de) 2009-11-10 2011-05-26 Fluoron Gmbh Spritze
USD645490S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
WO2011075481A1 (en) 2009-12-16 2011-06-23 Allergan, Inc. Intracameral devices for sustained delivery
USD645489S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
JP2013515741A (ja) 2009-12-23 2013-05-09 サイヴィーダ ユーエス，インコーポレイテッド 持続放出性送達デバイス
KR101911960B1 (ko) 2010-01-22 2018-10-25 알러간, 인코포레이티드 전방내 서방성 치료제 이식물
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US20130071349A1 (en) 2010-03-02 2013-03-21 Allergan, Inc. Biodegradable polymers for lowering intraocular pressure
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
US9320647B2 (en) 2010-03-31 2016-04-26 Ocuject, Llc Device and method for intraocular drug delivery
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
ES2634551T3 (es) 2010-04-03 2017-09-28 Praful Doshi Métodos para revestir una lente de contacto
US20130017243A1 (en) 2010-04-06 2013-01-17 Allergan, Inc. Sustained-release reservoir implants for intracameral drug delivery
US20110251568A1 (en) 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
US20130142858A1 (en) 2010-05-17 2013-06-06 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
US8444589B2 (en) 2010-06-09 2013-05-21 Transcend Medical, Inc. Ocular implant with fluid outflow pathways having microporous membranes
KR101180032B1 (ko) 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
WO2012012017A1 (en) 2010-07-20 2012-01-26 Alcon Research, Ltd. Closed loop glaucoma drug delivery system
EP2600812B1 (en) * 2010-08-05 2021-09-22 ForSight Vision4, Inc. Apparatus to treat an eye
HUE054113T2 (hu) 2010-08-05 2021-08-30 Forsight Vision4 Inc Injekciós készülék gyógyszerbejuttatáshoz
US8235053B2 (en) 2010-09-08 2012-08-07 Alcon Research, Ltd. Implantable punctal plug
US8864703B2 (en) 2010-10-05 2014-10-21 Alcon Research, Ltd. Drug introduction and placement system
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
US8915877B2 (en) 2010-10-12 2014-12-23 Emmett T. Cunningham, JR. Glaucoma drainage device and uses thereof
US9370444B2 (en) 2010-10-12 2016-06-21 Emmett T. Cunningham, JR. Subconjunctival conformer device and uses thereof
US20120100187A1 (en) 2010-10-26 2012-04-26 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
US8450367B2 (en) 2010-12-16 2013-05-28 Allergan, Inc. Sulfur derivatives as chemokine receptor modulators
US20120238994A1 (en) 2010-12-22 2012-09-20 Martin Nazzaro Two-piece injectable drug delivery device with heat-cured seal
JP5680766B2 (ja) 2011-01-24 2015-03-04 イー・エム・デイー・ミリポア・コーポレイシヨン 多孔質材料の加速混合ガス完全性試験
JP2012198134A (ja) 2011-03-22 2012-10-18 Chugoku Electric Power Co Inc:The 事故点標定装置、プログラム
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US20130004651A1 (en) 2011-07-01 2013-01-03 Patty Fu-Giles Sustained drug release from body implants using nanoparticle-embedded polymeric coating materials
US20130018360A1 (en) 2011-07-13 2013-01-17 Marissa Dockendorf Method for delivering ophthalmic drugs
US8486031B2 (en) 2011-07-29 2013-07-16 Allan J. Bogdan Eye treatment apparatus
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE
JP6100782B2 (ja) 2011-08-29 2017-03-22 キューエルティー インコーポレイテッド 緑内障および高眼圧症を治療するための活性剤の徐放送達
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
EP3659495B1 (en) 2011-09-13 2022-12-14 Dose Medical Corporation Intraocular physiological sensor
EP4094734A1 (en) 2011-09-14 2022-11-30 Forsight Vision5, Inc. Ocular insert apparatus
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8771220B2 (en) 2011-12-07 2014-07-08 Alcon Research, Ltd. Glaucoma active pressure regulation shunt
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8945214B2 (en) 2011-12-19 2015-02-03 Allergan, Inc. Intravitreal applicator
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
WO2013119843A1 (en) 2012-02-07 2013-08-15 On Demand Therapeutics, Inc. Drug delivery devices and methods of use thereof
WO2013148275A2 (en) 2012-03-26 2013-10-03 Glaukos Corporation System and method for delivering multiple ocular implants
US9504603B2 (en) 2012-04-02 2016-11-29 Ocuject, Llc Intraocular delivery devices and methods therefor
JP6511401B2 (ja) 2013-02-15 2019-05-15 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 持続型薬物送達インプラント
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
EP2981248B1 (en) 2013-04-01 2020-09-02 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
CA2830555A1 (en) 2013-10-18 2015-04-18 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
MX2016005508A (es) 2013-10-31 2016-08-03 Allergan Inc Implantes intraoculares que contienen prostamida y metodos para su uso.
EP3068371A1 (en) 2013-11-15 2016-09-21 Glaukos Corporation Ocular implants configured to store and release stable drug formulations
EP3677229A1 (en) 2014-05-29 2020-07-08 Glaukos Corporation Implants with controlled drug delivery features
JP6819908B2 (ja) 2014-09-19 2021-01-27 オクラー リミテッド 眼科用医薬組成物
EP3698703A1 (en) 2015-03-20 2020-08-26 Glaukos Corporation Gonioscopic devices
WO2016187355A1 (en) 2015-05-20 2016-11-24 Glaukos Corporation Therapeutic drug compositions and implants for delivery of same
RU2687764C1 (ru) 2015-06-03 2019-05-16 Эквисис, Инк. Размещение ав externo внутриглазного шунта
US20190000673A1 (en) 2015-07-22 2019-01-03 Glaukos Corporation Ocular implants for reduction of intraocular pressure and methods for implanting same
US20180333296A1 (en) 2015-09-02 2018-11-22 Dose Medical Corporation Drug delivery implants as intraocular drug depots and methods of using same
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20170058811A (ko) 2015-11-19 2017-05-29 글라우코스 코포레이션 전달 장치 시스템 및 녹내장 치료용 임플란트
CN115120405A (zh) 2016-04-20 2022-09-30 多斯医学公司 生物可吸收眼部药物的递送装置
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
USD833008S1 (en) 2017-02-27 2018-11-06 Glaukos Corporation Gonioscope
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
AU2018338994B2 (en) 2017-09-29 2024-03-28 Glaukos Corporation Intraocular physiological sensor
EP3691586A2 (en) 2017-10-06 2020-08-12 Glaukos Corporation Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
US20220119350A1 (en) 2019-02-22 2022-04-21 Glaukos Corporation Compounds for the treatment of ocular disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255061A1 (en) * 2009-01-29 2010-10-07 Forsight Labs, Llc Posterior Segment Drug Delivery
US20160045363A1 (en) * 2013-03-15 2016-02-18 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same

Also Published As

Publication number Publication date
WO2017184881A1 (en) 2017-10-26
AU2022201392A1 (en) 2022-03-24
JP7624376B2 (ja) 2025-01-30
US20220313486A1 (en) 2022-10-06
CN109937025A (zh) 2019-06-25
JP2019514640A (ja) 2019-06-06
CA3022830A1 (en) 2017-10-26
AU2017252294A1 (en) 2018-12-06
US11318043B2 (en) 2022-05-03
CN115120405A (zh) 2022-09-30
US20190125581A1 (en) 2019-05-02
CN109937025B (zh) 2022-07-29
AU2022201392B2 (en) 2024-02-29
EP3442479A1 (en) 2019-02-20
JP2022024060A (ja) 2022-02-08
JP2024161525A (ja) 2024-11-19
JP7003110B2 (ja) 2022-01-20
US20250161110A1 (en) 2025-05-22

Similar Documents

Publication Publication Date Title
AU2022201392B2 (en) Bioresorbable ocular drug delivery device
US12478504B2 (en) Drug eluting ocular implants
US20240065887A1 (en) Drug delivery implants as intraocular drug depots and methods of using same
EP2654715B1 (en) Drug eluting ocular implant
HK40103267A (en) Drug eluting ocular implant
HK40047493A (en) Drug eluting ocular implant
HK40047493B (en) Drug eluting ocular implant
HK40001057A (en) Drug eluting ocular implant
HK40001057B (en) Drug eluting ocular implant

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: DOSE MEDICAL CORPORATION

Free format text: FORMER APPLICANT(S): BURNS, THOMAS; HAFFNER, DAVID; CURRY, KENNETH; HEITZMANN, HAROLD

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: GLAUKOS CORPORATION

Free format text: FORMER OWNER(S): DOSE MEDICAL CORPORATION