US20220104936A1 - IOL with Drug Delivery Devices and Uninterrupted PCO Barrier Edge - Google Patents
IOL with Drug Delivery Devices and Uninterrupted PCO Barrier Edge Download PDFInfo
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- US20220104936A1 US20220104936A1 US17/062,909 US202017062909A US2022104936A1 US 20220104936 A1 US20220104936 A1 US 20220104936A1 US 202017062909 A US202017062909 A US 202017062909A US 2022104936 A1 US2022104936 A1 US 2022104936A1
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- drug delivery
- delivery device
- haptic
- ophthalmic implant
- posterior
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/169—Surrounding optic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Definitions
- the inventions described below relate to the field of ophthalmic implants such as intraocular lenses.
- Intraocular lenses are artificial lenses for the eye that can be implanted to replace the natural lens of a patient's eye after the natural lens is removed.
- the natural lens might be removed because it is affected by cataracts, and the IOL can be implanted to provide clear vision and some degree of focusing to the patient.
- An intraocular lens may also be implanted in a patient without removing the natural lens (a phakic intraocular lens or PIOL), to correct extreme near-sightedness or far-sightedness. It is advantageous to administer some therapeutic agents to the eye, coincident with implantation of the IOL, to alleviate various side effects of the IOL or treat other conditions of the eye that might coexist with the conditions that lead to cataracts.
- Posterior capsular opacification is a condition that affects some IOL implantations, and occurs due to migration of lens epithelial cells into the region between the IOL and the posterior portion of the lens capsule. As these lens epithelial cells proliferate and differentiate in this region, the posterior portion of the lens capsule becomes opaque. This can cause visual impairment, sometimes referred to as a secondary cataract. This effect may be limited by the structure of the IOL itself, such as forming the IOL with a posterior surface and circumferential side wall surface joined with a sharply angular edge (typically referred to as a square edge). The posterior portion of the lens capsule collapses onto the IOL, and fuses to the IOL, and the fused join between the posterior portion of the lens capsule and the sharply angular edge of the IOL serves as a barrier to lens epithelial cells.
- PCO Posterior capsular opacification
- the devices and methods described below provide for placement of drug delivery devices on IOL haptics while preserving a PCO barrier edge around the entire periphery of the back side of the IOL.
- the configuration may be employed with IOL's and other ophthalmic implants.
- the configuration allows implantation of an IOL along with implantation of drug delivery devices to treat various conditions affecting implant patients while maintaining a PCO barrier which is effective around the entire periphery of the IOL.
- the device includes an IOL assembly comprising a lens, and a haptic.
- the IOL assembly is characterized by an anterior surface and a posterior surface, and a circumferential side wall, wherein the posterior surface joins the circumferential side wall in a sharply angular edge, where the sharply angular edge defines a plane of the sharply angular edge, and the sharply angular edge is functional as a PCO barrier edge.
- the drug delivery devices are disposed on the haptics, and are configured and disposed on the haptic such that a posterior-most surface of each drug delivery device is anteriorly displaced from the plane. With this construction, the presence of the drug delivery devices on the haptics do not disrupt formation of a PCO barrier between the sharp edge and the posterior portion of the lens capsule.
- the posterior-most extent of the drug delivery device may extend posteriorly beyond the plane of the PCO barrier edge of the lens.
- the drug delivery device is configured with a posterior surface and a circumferential side wall adjacent the posterior side wall, and, like the PCO barrier edge of the IOL described above, the posterior surface of the drug delivery device joins the circumferential side wall of the drug delivery device in a sharply angular edge (also a posterior-lateral edge).
- the anterior surface of the drug delivery device is configured such that forces exerted on the drug delivery device by the capsular bag do not promote tilting of the IOL relative to the equatorial plane of the capsular bag, so that the optical axis of the IOL lens is not angled relative to the optical axis of the eye.
- the posterior surface may be a flat surface parallel to the plane of the IOL, or a curved surface bounded by an edge which lies in a plane parallel to the plane of the IOL.
- FIGS. 1 and 2 illustrate the environment of use of an ophthalmic implant system for drug delivery.
- FIG. 3 is a view of the IOL and drug delivery devices, showing the posterior aspect of the device.
- FIG. 4 is a view of the IOL and drug delivery devices, showing the anterior aspect of the device.
- FIG. 5 illustrates the intraocular lens and drug delivery devices, illustrating the anterior offset of the haptics and drug delivery devices.
- FIG. 6 illustrates the sharply angular edge of the IOL.
- FIGS. 7 and 8 illustrate an IOL and drug delivery device combination in which the drug delivery device posterior is provided with a PCO barrier edge distinct from the PCO barrier edge of the IOL.
- FIG. 9 shows the drug delivery device similar to that of FIG. 8 with the addition of additional panels or blocks depending from an anterior panel of the drug delivery device.
- FIG. 10 illustrates a configuration in which the plane (D) is posteriorly displaced from the plane (P) defined by the PCO barrier edge 24 E of the IOL.
- FIG. 11 illustrates a configuration of the drug delivery device and the haptic configured to avoid twisting of the drug delivery device about the haptic.
- FIGS. 12 and 13 illustrate a means of preventing outward movement of the drug delivery device on the haptic, and features of the drug delivery device which prevent or limit twisting of the drug delivery device within the capsular bag.
- FIGS. 1 and 2 illustrate placement and use of an IOL (or other ophthalmic implant system) in the eye of a patient.
- the eye 1 includes a lens 2 (the natural lens of the eye) and lens capsular bag 3 , and the anterior chamber 4 which includes the cornea 5 and iris 6 and aqueous humour filling the space between the cornea and the iris, and a posterior chamber 7 between the iris and the capsular bag.
- the posterior cavity/vitreous body 8 is the large space between the lens and the retina 9 .
- the natural lens 2 of the eye is characterized by an optical axis 10 .
- the capsular bag is characterized by an equatorial plane 13 , which is generally perpendicular to the optical axis. (In the following description of the ophthalmic implant and/or intraocular lens system, the terms posterior and anterior will be used in relation to the anatomy of the eye, in which the cornea is anterior and the retina is posterior.)
- FIG. 2 illustrates a placement of the IOL system (or other ophthalmic implant system) 11 in the eye including the intraocular lens assembly 12 and drug delivery device 30 which is implanted in the capsular bag in conjunction with the intraocular lens assembly 12 .
- the drug delivery device 30 is disposed on the haptics 28 .
- the intraocular lens assembly 12 includes a lens 24 and one or more haptics 28 , and one or more drug delivery devices 30 .
- the intraocular lens assembly 12 is characterized by an anterior surface 24 A and a posterior surface 24 P and a circumferential side wall surface 24 C.
- ophthalmic implants such as a capsular tension ring, or a capsular scaffold for holding the drug delivery devices in place may take the place of the IOL.
- the haptics may be any form of haptic, such as C-loops or J-loops.
- FIG. 3 is a view of the IOL 12 and drug delivery devices 30 , showing the posterior aspect of the device, including the posterior surface 24 P of the lens 24 , and the sharply angular posterior-lateral edge 24 E of the IOL, which may be the edge of the lens proper, or the edge of a frame surrounding the lens.
- the joint 31 between the haptic and the lens is preferably displaced/offset anteriorly from the sharp edge, to retain the PCO edge entirely around the periphery of the posterior side of the lens.
- a drug delivery device 30 is disposed on one or both haptics 28 (preferably both), secured in any suitable manner, such as a friction fit of the tubular (rectangular or cylindrical) drug delivery device slipped over the haptic.
- the drug delivery device is characterized by a posterior surface 30 P, facing posteriorly just as the posterior surface 24 P of the lens does.
- the posterior surface 30 P is also displaced/offset anteriorly from the posterior-lateral edge 24 E, to avoid disruption of the fusion of the posterior capsule 3 to the posterior-lateral edge 24 E.
- the front edge of the IOL at which point the anterior surface 24 A meets the circumferential side wall surface of the IOL, may be a sharply angular edge comparable to the edge 24 E on the posterior side of the IOL, or may be rounded or configured to obtain desired optical characteristics.
- FIG. 5 illustrates the intraocular lens assembly 12 , including the lens 24 , one or more haptics 28 , and one or more drug delivery devices 30 .
- the sharp edge 24 E between the posterior surface 24 P of the IOL and circumferential side wall surface 24 C is an edge that circumscribes the lens 24 (preferably entirely circumscribes the lens), and establishes a plane (P) in which the sharp edge lies.
- the posterior-most extent of the drug delivery devices and optionally, the joint between the haptic and the lens is displaced anteriorly from this plane, not extending posteriorly to the plane (P) established by the sharp posterior edge of the IOL.
- the plane of the sharp posterior edge is marked as plane (P).
- the posterior extent of the drug delivery devices attached to the haptics is limited (and, optionally, the haptic joint), for example, by an offset represented by plane D.
- the offset is sufficient to avoid disruption of the fusion of the posterior portion of the capsule with the sharp angular edge 24 E, and may be 0.1 to 1.0 mm.
- the sharply angular edge 24 E may be any edge configured to function as a PCO barrier edge, and may be characterized by, for example, and inside angle ⁇ of 80-100°, and a corner radius 32 of less than 500 um, and preferably less than 60 um. This is illustrated in FIG. 6 .
- the natural lens capsule 3 (shown in phantom) has collapsed onto the IOL, and, along the line at which the capsule meets the sharp edge 24 E, and this forms an effective barrier against migration of the lens endothelial cells from the anterior chamber into the space posterior to the IOL, between the IOL posterior surface and the capsule posterior surface.
- the drug delivery devices may be provided in many configurations. As illustrated in the figures, the drug delivery devices may be configured as a collar or sleeve with a through-hole, which can be slipped over the haptic and retained with a friction fit or detent arrangement.
- the drug delivery devices may comprise a polymer matrix with therapeutic agents embedded in the matrix, or it may be comprised of a therapeutic agent in an erodible form.
- the matrix preferably comprises silicone, though other suitable matrix material may be used.
- the entirety of the drug delivery device may comprise the matrix material loaded with therapeutic agent, or an erodible therapeutic agent, or the matrix material loaded with therapeutic agent, or an erodible therapeutic agent may be limited to portions of the drug delivery device, while the remaining portions are provided for structure.
- the IOL assembly of FIGS. 3 through 6 with the drug delivery device configured and disposed on the haptic such that a posterior-most surface of the drug delivery device will be anteriorly displaced from the plane (P) once installed so that the presence of the drug delivery device on the haptic does not disrupt formation of a PCO barrier with the PCO barrier edge of the IOL lens when implanted within a capsular bag of an eye of the patient; and thereafter the capsular bag will approximate the IOL, and form a PCO barrier between the posterior portion of the capsular bag and the sharply angular edge uninterrupted by the posterior of the drug delivery device.
- FIGS. 7 and 8 illustrate an IOL 12 and drug delivery device 30 assembled, in which the drug delivery device posterior is provided with a PCO barrier edge distinct from the PCO barrier edge of the IOL.
- the IOL system 11 includes the IOL 12 with haptics 28 extending from the lens 24 .
- the drug delivery device 30 is disposed on the haptic, and, in this configuration, includes a posterior panel 33 with a posterior surface 33 P which may or may not extend posteriorly beyond the plane (P) of the PCO barrier edge (shown in FIGS. 5 and 6 ), and an oblong aperture 34 which accommodates a portion of the haptic nearest the rim of the IOL lens which is oblong and mated to the oblong aperture.
- Two posts 35 extend anteriorly from the posterior panel 33 to join with an anterior panel 36 which is disposed on the anterior side of the haptic 28 , forming the aperture 34 which is bounded by the posterior panel 33 , anterior panel 36 and posts 35 .
- the posterior surface 33 P of posterior panel 33 of the drug delivery device is joined to the side wall 33 C of the posterior panel with a sharply angular edge 33 E.
- This sharply angular edge may be similar to that of the sharply angular edge of the IOL, formed at the junction of the posterior surface 33 P and the circumferential side wall 33 C of the posterior side wall.
- the sharply angular edge 33 E of the posterior panel may define a plane (D) which may be posterior to, or anterior to, or co-planar with, the plane (P) defined by the PCO barrier edge 24 E of the IOL.
- the drug delivery device 30 is configured and disposed on the haptic 28 such that the sharply angular edge 33 E of the drug delivery device 30 is anteriorly displaced from the plane (P), posteriorly displaced from the plane (P), or co-planar with the plane (P).
- FIG. 10 illustrates a configuration in which the plane (D) is posteriorly displaced from the plane (P) defined by the PCO barrier edge 24 E of the IOL.
- the sharply angular edge 33 E of the posterior panel 33 preferably extends entirely around the posterior panel and side wall of the posterior panel.
- the sharply angular edge 33 E of the posterior panel 33 , and the circumferential side wall 33 C may immediately abut the circumferential side wall 24 C of the IOL, or the sharply angular edge 33 E of the posterior panel 33 , and the circumferential side wall 33 C may be spaced from the circumferential side wall 24 C, leaving a small radial gap between the PCO barrier edge of the IOL and the PCO barrier edge of the posterior panel 33 , such that the circumferential side wall 33 C of the posterior panel 33 is radially, outwardly displaced from the side wall 24 C of the IOL 24 .
- the area of the posterior panel directly abutting the IOL side wall may be provided with an edge that is not sharply angular, and the PCO barrier edge and remaining edge of the posterior panel will provide a sharply angular edge around entire periphery of the combined IOL and drug delivery device.
- FIG. 8 shows the drug delivery device 30 of FIG. 7 in isolation, showing the aperture 34 , posts 35 and posterior panel 33 and the anterior panel 36 .
- FIG. 9 shows the drug delivery device 30 similar to that of FIG. 8 showing the apertures 34 , posts 35 and posterior panel 33 and the anterior panel 36 , with the addition of additional side panels or blocks 37 .
- the side panels may extend posteriorly from the anterior panel, or they may be fixed to the posts.
- the portion of this drug delivery device which comprises a matrix material loaded with therapeutic agent, or an erodible therapeutic agent may include one or more, or all, of the anterior panel, posts, posterior panel or side panel(s).
- the IOL assembly and drug delivery device configurations of FIGS. 7, 8 and 9 may be implanted within the capsular bag of an eye of the patient, and the capsular bag may then approximate the IOL, and form a PCO barrier between the posterior portion of the capsular bag and the sharply angular edge of the IOL and form a PCO barrier between the capsular bag and the sharply angular edge of the posterior panel.
- the drug delivery device 30 will be secured on the haptic 28 such that a portion of the circumferential side wall 33 C of the posterior panel 33 immediately abuts a portion of the side wall 24 C of the IOL 24 , or such that the circumferential side wall 33 C of the posterior panel 33 is radially, outwardly displaced from the side wall 24 C of the IOL 24 , leaving a radial gap between the PCO barrier edge of the IOL and the PCO barrier edge of the posterior panel 33 .
- FIG. 11 illustrates a configuration of the drug delivery device 30 and the haptic 28 .
- the aperture through the drug delivery device is keyed to the shape of the base of the haptic, in any suitable manner and any suitable means, to inhibit or prevent rotation of the drug delivery device about the base of the haptic.
- this is accomplished with a haptic base 28 B having a square or rectangular cross section, and a drug delivery device having a matching square or rectangular aperture sized to accommodate the haptic base.
- the drug delivery device is configured for disposition on the haptic, and the aperture is configured to accept the haptic base, and the aperture is correspondingly keyed to the shape and size of the haptic base in a configuration which inhibits rotation of the drug delivery device about the haptic base.
- the drug delivery device In the assembled configuration, the drug delivery device is disposed on the haptic base, with the haptic base occupying the aperture.
- Any other configuration, in which the aperture is keyed to the haptic base may be employed, such as an elliptical haptic base paired with an elliptical aperture, or a hexagonal haptic base paired with a hexagonal aperture in the drug delivery device.
- various means for preventing twisting of the drug delivery device about the haptic or haptic base may be employed.
- the haptic may include a detent ridge 38 protruding from the haptic, with an optional corresponding detent accepting groove on the interior of the drug delivery device aperture.
- the drug delivery device may, once in place over the haptic base, impinge or abut the detent, thus preventing movement of the drug delivery device over the haptic.
- FIGS. 12 and 13 illustrate an embodiment of the haptic and drug delivery device, in which the haptic has a notch 39 disposed on the side of the haptic base 28 B.
- the notch combined with a configuration of the post of the drug delivery device which fits within the notch provides an interference fit between the drug delivery device and the haptic. Once the drug delivery device is stretched over the haptic base, a post of the drug delivery device will fit within the notch, and the interference fit between the notch and the post will prevent outward migration of the drug delivery device.
- FIGS. 12 and 13 illustrate another means of preventing outward movement, which includes a shoulder 40 rising anteriorly from the haptic, combined with a shoulder on the anterior panel or plate of the drug delivery device.
- FIG. 13 also illustrates features of the drug delivery device which prevent or limit twisting of the drug delivery device with the capsular bag.
- the anterior panels are configured to limit the potential for twisting of the IOL relative the equator, or the plane established by the equator, of the capsular bag.
- the anterior panel 36 has planar anterior surface 36 A in which the entire edge 36 E lies in a plane A, or a curved anterior surface in which the entire edge 36 E lies in a plane A, and this planar surface or edge plane is disposed in a plane A which is parallel to the major plane of the IOL lens B, and, when properly implanted, the equatorial plane of the capsular bag (item 13 in FIG. 1 ).
- the anterior panel may have a large lateral or circumferential dimension 41 compared to the radial dimension 42 ( FIG. 11 ) and the anterior surface of the anterior panel is preferably flat, and aligned in a plane parallel to the plane of the IOL.
- the IOL may be implanted by folding or rolling it into a small diameter configuration in an injector, inserting the injector through a small slit between the cornea and sclera, and pushing the IOL from the injector.
- the IOL unfurls within the capsular bag and the haptics open and expand to the extent permitted by the confines of the capsular bag.
- the capsular bag will eventually collapse upon the IOL, and the posterior portion of the capsule will approximate the surfaces of the IOL, and in particular the sharp edge 24 E.
- the tight join between the capsule and the sharp edge inhibits migration of lens epithelial cells to the region between the posterior portion of the capsule and the posterior surface of the IOL.
- the drug delivery device may be secured to the haptic upon manufacture, or it may be secured by the surgeon immediately before implantation, immediately after implantation, or long after implantation (for example as a replacement for an original drug delivery device which has been depleted).
- the drug delivery device can be configured to deliver various therapeutic agents to treat various conditions.
- Brimonidine, latanoprost, timolol, pilocarpine, brinzolamide and other drugs in the general categories of beta blockers, alpha agonists, ROCK Inhibitors, adenosine receptor agonists, carbonic anhydrase inhibitors, adrenergic and cholinergic receptor activating agents, and prostaglandin analogues may be incorporated into the drug delivery devices to treat glaucoma.
- Aflibercept, bevacizumab, pegaptanib, ranibizumab, steroids, and aptamers may be incorporated into the drug delivery devices to treat wet macular degeneration.
- Complement factors, anti-oxidants and anti-inflammatory agents may be incorporated into the drug delivery devices to treat dry macular degeneration.
- Methotrexate, antibodies, dexamethasone, triamcinolone, and other steroid agents may be incorporated into the drug delivery devices to treat uveitis.
- Anti-proliferative agents, anti-mitotic agents, anti-inflammatory agents, and other medications that would inhibit the spread of lens epithelial cells may be incorporated into the drug delivery devices to treat posterior capsular opacification.
- Antibiotics such as fluoroquinolones, non-steroidal agents such as ketorolacs, and steroids such as prednisolones may be incorporated into the drug delivery devices for post-op management after cataract surgery to treat infection and inflammation.
- each configuration may be employed with various other forms of ocular implants intended for implantation in the capsular bag, including capsular tension rings and capsular scaffolds.
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Abstract
Description
- The inventions described below relate to the field of ophthalmic implants such as intraocular lenses.
- Intraocular lenses (IOL's) are artificial lenses for the eye that can be implanted to replace the natural lens of a patient's eye after the natural lens is removed. The natural lens might be removed because it is affected by cataracts, and the IOL can be implanted to provide clear vision and some degree of focusing to the patient. An intraocular lens may also be implanted in a patient without removing the natural lens (a phakic intraocular lens or PIOL), to correct extreme near-sightedness or far-sightedness. It is advantageous to administer some therapeutic agents to the eye, coincident with implantation of the IOL, to alleviate various side effects of the IOL or treat other conditions of the eye that might coexist with the conditions that lead to cataracts. Side-effects such as infection and inflammation, and conditions such as glaucoma, can be treated with therapeutic agents that may be incorporated into additional devices that may be secured to the IOL. In addition to IOL's, ocular implants not including lenses may be implanted to address various other conditions.
- Posterior capsular opacification (PCO) is a condition that affects some IOL implantations, and occurs due to migration of lens epithelial cells into the region between the IOL and the posterior portion of the lens capsule. As these lens epithelial cells proliferate and differentiate in this region, the posterior portion of the lens capsule becomes opaque. This can cause visual impairment, sometimes referred to as a secondary cataract. This effect may be limited by the structure of the IOL itself, such as forming the IOL with a posterior surface and circumferential side wall surface joined with a sharply angular edge (typically referred to as a square edge). The posterior portion of the lens capsule collapses onto the IOL, and fuses to the IOL, and the fused join between the posterior portion of the lens capsule and the sharply angular edge of the IOL serves as a barrier to lens epithelial cells.
- Previous patent applications, such as Kahook, et al., Ophthalmic Device For Drug Delivery, U.S. Pub. 2020/0022840 (Jan. 23, 2020) disclose various configurations of drug delivery devices to be used in conjunction with IOL's. Others have proposed placement of drug delivery devices on haptics. For those situations in which placement of the drug delivery devices on the haptics is preferred, we propose configurations that do not disrupt the square edge needed to block migration of lens endothelial cells to the back side of the IOL.
- The devices and methods described below provide for placement of drug delivery devices on IOL haptics while preserving a PCO barrier edge around the entire periphery of the back side of the IOL. The configuration may be employed with IOL's and other ophthalmic implants. The configuration allows implantation of an IOL along with implantation of drug delivery devices to treat various conditions affecting implant patients while maintaining a PCO barrier which is effective around the entire periphery of the IOL. The device includes an IOL assembly comprising a lens, and a haptic. The IOL assembly is characterized by an anterior surface and a posterior surface, and a circumferential side wall, wherein the posterior surface joins the circumferential side wall in a sharply angular edge, where the sharply angular edge defines a plane of the sharply angular edge, and the sharply angular edge is functional as a PCO barrier edge. The drug delivery devices are disposed on the haptics, and are configured and disposed on the haptic such that a posterior-most surface of each drug delivery device is anteriorly displaced from the plane. With this construction, the presence of the drug delivery devices on the haptics do not disrupt formation of a PCO barrier between the sharp edge and the posterior portion of the lens capsule.
- In another configuration which preserves a PCO barrier edge, the posterior-most extent of the drug delivery device may extend posteriorly beyond the plane of the PCO barrier edge of the lens. In this configuration, the drug delivery device is configured with a posterior surface and a circumferential side wall adjacent the posterior side wall, and, like the PCO barrier edge of the IOL described above, the posterior surface of the drug delivery device joins the circumferential side wall of the drug delivery device in a sharply angular edge (also a posterior-lateral edge).
- Additionally, other configurations of the drug delivery device described below provide for stable positioning of the IOL and drug delivery device within the capsular bag. The anterior surface of the drug delivery device is configured such that forces exerted on the drug delivery device by the capsular bag do not promote tilting of the IOL relative to the equatorial plane of the capsular bag, so that the optical axis of the IOL lens is not angled relative to the optical axis of the eye. The posterior surface may be a flat surface parallel to the plane of the IOL, or a curved surface bounded by an edge which lies in a plane parallel to the plane of the IOL.
-
FIGS. 1 and 2 illustrate the environment of use of an ophthalmic implant system for drug delivery. -
FIG. 3 is a view of the IOL and drug delivery devices, showing the posterior aspect of the device. -
FIG. 4 is a view of the IOL and drug delivery devices, showing the anterior aspect of the device. -
FIG. 5 illustrates the intraocular lens and drug delivery devices, illustrating the anterior offset of the haptics and drug delivery devices. -
FIG. 6 illustrates the sharply angular edge of the IOL. -
FIGS. 7 and 8 illustrate an IOL and drug delivery device combination in which the drug delivery device posterior is provided with a PCO barrier edge distinct from the PCO barrier edge of the IOL. -
FIG. 9 shows the drug delivery device similar to that ofFIG. 8 with the addition of additional panels or blocks depending from an anterior panel of the drug delivery device. -
FIG. 10 illustrates a configuration in which the plane (D) is posteriorly displaced from the plane (P) defined by thePCO barrier edge 24E of the IOL. -
FIG. 11 illustrates a configuration of the drug delivery device and the haptic configured to avoid twisting of the drug delivery device about the haptic. -
FIGS. 12 and 13 illustrate a means of preventing outward movement of the drug delivery device on the haptic, and features of the drug delivery device which prevent or limit twisting of the drug delivery device within the capsular bag. -
FIGS. 1 and 2 illustrate placement and use of an IOL (or other ophthalmic implant system) in the eye of a patient. The eye 1 includes a lens 2 (the natural lens of the eye) and lenscapsular bag 3, and theanterior chamber 4 which includes thecornea 5 andiris 6 and aqueous humour filling the space between the cornea and the iris, and aposterior chamber 7 between the iris and the capsular bag. The posterior cavity/vitreous body 8 is the large space between the lens and theretina 9. Thenatural lens 2 of the eye is characterized by anoptical axis 10. The capsular bag is characterized by anequatorial plane 13, which is generally perpendicular to the optical axis. (In the following description of the ophthalmic implant and/or intraocular lens system, the terms posterior and anterior will be used in relation to the anatomy of the eye, in which the cornea is anterior and the retina is posterior.) -
FIG. 2 illustrates a placement of the IOL system (or other ophthalmic implant system) 11 in the eye including theintraocular lens assembly 12 anddrug delivery device 30 which is implanted in the capsular bag in conjunction with theintraocular lens assembly 12. As shown inFIG. 2 , and in more detail inFIGS. 3 through 5 , thedrug delivery device 30 is disposed on thehaptics 28. Theintraocular lens assembly 12 includes alens 24 and one ormore haptics 28, and one or moredrug delivery devices 30. Theintraocular lens assembly 12 is characterized by ananterior surface 24A and aposterior surface 24P and a circumferentialside wall surface 24C. Other ophthalmic implants such as a capsular tension ring, or a capsular scaffold for holding the drug delivery devices in place may take the place of the IOL. The haptics may be any form of haptic, such as C-loops or J-loops. -
FIG. 3 is a view of theIOL 12 anddrug delivery devices 30, showing the posterior aspect of the device, including theposterior surface 24P of thelens 24, and the sharply angular posterior-lateral edge 24E of the IOL, which may be the edge of the lens proper, or the edge of a frame surrounding the lens. The joint 31 between the haptic and the lens is preferably displaced/offset anteriorly from the sharp edge, to retain the PCO edge entirely around the periphery of the posterior side of the lens. (Typically, the lens and haptics will be integrally formed, and this “joint” refers to the transition between the lens and the haptic.) Adrug delivery device 30 is disposed on one or both haptics 28 (preferably both), secured in any suitable manner, such as a friction fit of the tubular (rectangular or cylindrical) drug delivery device slipped over the haptic. The drug delivery device is characterized by aposterior surface 30P, facing posteriorly just as theposterior surface 24P of the lens does. Theposterior surface 30P is also displaced/offset anteriorly from the posterior-lateral edge 24E, to avoid disruption of the fusion of theposterior capsule 3 to the posterior-lateral edge 24E. For completeness,FIG. 4 is a view of the IOL and drug delivery devices, showing the anterior aspect of the device, including theanterior surface 24A of thelens 24, each haptic 28, and thedrug delivery devices 30 secured to the haptics. The front edge of the IOL, at which point theanterior surface 24A meets the circumferential side wall surface of the IOL, may be a sharply angular edge comparable to theedge 24E on the posterior side of the IOL, or may be rounded or configured to obtain desired optical characteristics. -
FIG. 5 illustrates theintraocular lens assembly 12, including thelens 24, one or morehaptics 28, and one or moredrug delivery devices 30. As shown inFIG. 5 , thesharp edge 24E between theposterior surface 24P of the IOL and circumferentialside wall surface 24C is an edge that circumscribes the lens 24 (preferably entirely circumscribes the lens), and establishes a plane (P) in which the sharp edge lies. The posterior-most extent of the drug delivery devices and optionally, the joint between the haptic and the lens is displaced anteriorly from this plane, not extending posteriorly to the plane (P) established by the sharp posterior edge of the IOL. InFIG. 6 , the plane of the sharp posterior edge is marked as plane (P). The posterior extent of the drug delivery devices attached to the haptics is limited (and, optionally, the haptic joint), for example, by an offset represented by plane D. The offset is sufficient to avoid disruption of the fusion of the posterior portion of the capsule with the sharpangular edge 24E, and may be 0.1 to 1.0 mm. The sharplyangular edge 24E may be any edge configured to function as a PCO barrier edge, and may be characterized by, for example, and inside angle α of 80-100°, and acorner radius 32 of less than 500 um, and preferably less than 60 um. This is illustrated inFIG. 6 . - As shown in
FIG. 5 , the natural lens capsule 3 (shown in phantom) has collapsed onto the IOL, and, along the line at which the capsule meets thesharp edge 24E, and this forms an effective barrier against migration of the lens endothelial cells from the anterior chamber into the space posterior to the IOL, between the IOL posterior surface and the capsule posterior surface. - The drug delivery devices may be provided in many configurations. As illustrated in the figures, the drug delivery devices may be configured as a collar or sleeve with a through-hole, which can be slipped over the haptic and retained with a friction fit or detent arrangement. The drug delivery devices may comprise a polymer matrix with therapeutic agents embedded in the matrix, or it may be comprised of a therapeutic agent in an erodible form. The matrix preferably comprises silicone, though other suitable matrix material may be used. The entirety of the drug delivery device may comprise the matrix material loaded with therapeutic agent, or an erodible therapeutic agent, or the matrix material loaded with therapeutic agent, or an erodible therapeutic agent may be limited to portions of the drug delivery device, while the remaining portions are provided for structure.
- In use, the IOL assembly of
FIGS. 3 through 6 with the drug delivery device configured and disposed on the haptic such that a posterior-most surface of the drug delivery device will be anteriorly displaced from the plane (P) once installed so that the presence of the drug delivery device on the haptic does not disrupt formation of a PCO barrier with the PCO barrier edge of the IOL lens when implanted within a capsular bag of an eye of the patient; and thereafter the capsular bag will approximate the IOL, and form a PCO barrier between the posterior portion of the capsular bag and the sharply angular edge uninterrupted by the posterior of the drug delivery device. -
FIGS. 7 and 8 illustrate anIOL 12 anddrug delivery device 30 assembled, in which the drug delivery device posterior is provided with a PCO barrier edge distinct from the PCO barrier edge of the IOL. As shown inFIG. 7 , theIOL system 11 includes theIOL 12 withhaptics 28 extending from thelens 24. Thedrug delivery device 30 is disposed on the haptic, and, in this configuration, includes aposterior panel 33 with aposterior surface 33P which may or may not extend posteriorly beyond the plane (P) of the PCO barrier edge (shown inFIGS. 5 and 6 ), and anoblong aperture 34 which accommodates a portion of the haptic nearest the rim of the IOL lens which is oblong and mated to the oblong aperture. Twoposts 35 extend anteriorly from theposterior panel 33 to join with ananterior panel 36 which is disposed on the anterior side of the haptic 28, forming theaperture 34 which is bounded by theposterior panel 33,anterior panel 36 and posts 35. As appears fromFIG. 8 , theposterior surface 33P ofposterior panel 33 of the drug delivery device is joined to the side wall 33C of the posterior panel with a sharplyangular edge 33E. This sharply angular edge may be similar to that of the sharply angular edge of the IOL, formed at the junction of theposterior surface 33P and the circumferential side wall 33C of the posterior side wall. The sharplyangular edge 33E of the posterior panel may define a plane (D) which may be posterior to, or anterior to, or co-planar with, the plane (P) defined by thePCO barrier edge 24E of the IOL. Thus, thedrug delivery device 30 is configured and disposed on the haptic 28 such that the sharplyangular edge 33E of thedrug delivery device 30 is anteriorly displaced from the plane (P), posteriorly displaced from the plane (P), or co-planar with the plane (P).FIG. 10 illustrates a configuration in which the plane (D) is posteriorly displaced from the plane (P) defined by thePCO barrier edge 24E of the IOL. - The sharply
angular edge 33E of theposterior panel 33 preferably extends entirely around the posterior panel and side wall of the posterior panel. The sharplyangular edge 33E of theposterior panel 33, and the circumferential side wall 33C may immediately abut thecircumferential side wall 24C of the IOL, or the sharplyangular edge 33E of theposterior panel 33, and the circumferential side wall 33C may be spaced from thecircumferential side wall 24C, leaving a small radial gap between the PCO barrier edge of the IOL and the PCO barrier edge of theposterior panel 33, such that the circumferential side wall 33C of theposterior panel 33 is radially, outwardly displaced from theside wall 24C of theIOL 24. - If the plane (D) is coplanar with the plane (P), and the posterior panel directly abuts the IOL side wall, the area of the posterior panel directly abutting the IOL side wall may be provided with an edge that is not sharply angular, and the PCO barrier edge and remaining edge of the posterior panel will provide a sharply angular edge around entire periphery of the combined IOL and drug delivery device.
-
FIG. 8 shows thedrug delivery device 30 ofFIG. 7 in isolation, showing theaperture 34, posts 35 andposterior panel 33 and theanterior panel 36.FIG. 9 shows thedrug delivery device 30 similar to that ofFIG. 8 showing theapertures 34, posts 35 andposterior panel 33 and theanterior panel 36, with the addition of additional side panels or blocks 37. The side panels may extend posteriorly from the anterior panel, or they may be fixed to the posts. The portion of this drug delivery device which comprises a matrix material loaded with therapeutic agent, or an erodible therapeutic agent may include one or more, or all, of the anterior panel, posts, posterior panel or side panel(s). - In use, the IOL assembly and drug delivery device configurations of
FIGS. 7, 8 and 9 may be implanted within the capsular bag of an eye of the patient, and the capsular bag may then approximate the IOL, and form a PCO barrier between the posterior portion of the capsular bag and the sharply angular edge of the IOL and form a PCO barrier between the capsular bag and the sharply angular edge of the posterior panel. Thedrug delivery device 30 will be secured on the haptic 28 such that a portion of the circumferential side wall 33C of theposterior panel 33 immediately abuts a portion of theside wall 24C of theIOL 24, or such that the circumferential side wall 33C of theposterior panel 33 is radially, outwardly displaced from theside wall 24C of theIOL 24, leaving a radial gap between the PCO barrier edge of the IOL and the PCO barrier edge of theposterior panel 33. - This may be accomplished by securing the
drug delivery device 30 on the haptic 28 such that the sharplyangular edge 33E of thedrug delivery device 30 is anteriorly displaced from the plane (P), such that the sharplyangular edge 33E of thedrug delivery device 30 is posteriorly displaced from the plane (P), or such that the sharplyangular edge 33E of thedrug delivery device 30 is co-planar with the plane (P). - Various configurations of the drug delivery device may be employed to ensure that the
IOL assembly 11, once implanted, remains in the preferred anterior/posterior position within the capsular bag, and remains in the desired orientation with the plane of thelens 24 perpendicular to theoptical axis 10 of the eye, and, correspondingly, coplanar with the equatorial plane of the capsular bag, or in a plane parallel to the equatorial plane of the capsular bag.FIG. 11 illustrates a configuration of thedrug delivery device 30 and the haptic 28. To avoid twisting of the drug delivery device about the haptic, the aperture through the drug delivery device (between the posterior panel and the anterior panel and connecting posts) is keyed to the shape of the base of the haptic, in any suitable manner and any suitable means, to inhibit or prevent rotation of the drug delivery device about the base of the haptic. InFIG. 11 , this is accomplished with ahaptic base 28B having a square or rectangular cross section, and a drug delivery device having a matching square or rectangular aperture sized to accommodate the haptic base. Thus, the drug delivery device is configured for disposition on the haptic, and the aperture is configured to accept the haptic base, and the aperture is correspondingly keyed to the shape and size of the haptic base in a configuration which inhibits rotation of the drug delivery device about the haptic base. In the assembled configuration, the drug delivery device is disposed on the haptic base, with the haptic base occupying the aperture. Any other configuration, in which the aperture is keyed to the haptic base, may be employed, such as an elliptical haptic base paired with an elliptical aperture, or a hexagonal haptic base paired with a hexagonal aperture in the drug delivery device. Thus, various means for preventing twisting of the drug delivery device about the haptic or haptic base may be employed. - Means for preventing radially outward movement of the drug delivery device on the haptic may also be employed. As shown in
FIG. 11 for example, the haptic may include adetent ridge 38 protruding from the haptic, with an optional corresponding detent accepting groove on the interior of the drug delivery device aperture. The drug delivery device may, once in place over the haptic base, impinge or abut the detent, thus preventing movement of the drug delivery device over the haptic.FIGS. 12 and 13 illustrate an embodiment of the haptic and drug delivery device, in which the haptic has anotch 39 disposed on the side of thehaptic base 28B. The notch combined with a configuration of the post of the drug delivery device which fits within the notch provides an interference fit between the drug delivery device and the haptic. Once the drug delivery device is stretched over the haptic base, a post of the drug delivery device will fit within the notch, and the interference fit between the notch and the post will prevent outward migration of the drug delivery device. -
FIGS. 12 and 13 illustrate another means of preventing outward movement, which includes ashoulder 40 rising anteriorly from the haptic, combined with a shoulder on the anterior panel or plate of the drug delivery device. Once the drug delivery device is stretched over the haptic base, the drug delivery device will impinge on the shoulder and interfere with the shoulder and will prevent outward migration of the drug delivery device. -
FIG. 13 also illustrates features of the drug delivery device which prevent or limit twisting of the drug delivery device with the capsular bag. The anterior panels are configured to limit the potential for twisting of the IOL relative the equator, or the plane established by the equator, of the capsular bag. Referring toFIG. 13 , theanterior panel 36 has planar anterior surface 36A in which theentire edge 36E lies in a plane A, or a curved anterior surface in which theentire edge 36E lies in a plane A, and this planar surface or edge plane is disposed in a plane A which is parallel to the major plane of the IOL lens B, and, when properly implanted, the equatorial plane of the capsular bag (item 13 inFIG. 1 ). The anterior panel may have a large lateral orcircumferential dimension 41 compared to the radial dimension 42 (FIG. 11 ) and the anterior surface of the anterior panel is preferably flat, and aligned in a plane parallel to the plane of the IOL. With this configuration, collapse of the capsular bag upon the IOL and the drug delivery device will be unlikely to exert forces on the IOL and drug delivery device which may twist or tilt the IOL within the capsular bag. - The IOL may be implanted by folding or rolling it into a small diameter configuration in an injector, inserting the injector through a small slit between the cornea and sclera, and pushing the IOL from the injector. Upon ejection from the injector, the IOL unfurls within the capsular bag and the haptics open and expand to the extent permitted by the confines of the capsular bag. The capsular bag will eventually collapse upon the IOL, and the posterior portion of the capsule will approximate the surfaces of the IOL, and in particular the
sharp edge 24E. The tight join between the capsule and the sharp edge inhibits migration of lens epithelial cells to the region between the posterior portion of the capsule and the posterior surface of the IOL. The drug delivery device may be secured to the haptic upon manufacture, or it may be secured by the surgeon immediately before implantation, immediately after implantation, or long after implantation (for example as a replacement for an original drug delivery device which has been depleted). - In each embodiment described, the drug delivery device can be configured to deliver various therapeutic agents to treat various conditions. Brimonidine, latanoprost, timolol, pilocarpine, brinzolamide and other drugs in the general categories of beta blockers, alpha agonists, ROCK Inhibitors, adenosine receptor agonists, carbonic anhydrase inhibitors, adrenergic and cholinergic receptor activating agents, and prostaglandin analogues may be incorporated into the drug delivery devices to treat glaucoma. Aflibercept, bevacizumab, pegaptanib, ranibizumab, steroids, and aptamers may be incorporated into the drug delivery devices to treat wet macular degeneration. Complement factors, anti-oxidants and anti-inflammatory agents may be incorporated into the drug delivery devices to treat dry macular degeneration. Methotrexate, antibodies, dexamethasone, triamcinolone, and other steroid agents may be incorporated into the drug delivery devices to treat uveitis. Anti-proliferative agents, anti-mitotic agents, anti-inflammatory agents, and other medications that would inhibit the spread of lens epithelial cells may be incorporated into the drug delivery devices to treat posterior capsular opacification. Antibiotics such as fluoroquinolones, non-steroidal agents such as ketorolacs, and steroids such as prednisolones may be incorporated into the drug delivery devices for post-op management after cataract surgery to treat infection and inflammation.
- While the configurations described above are described in the context of intraocular lens, each configuration may be employed with various other forms of ocular implants intended for implantation in the capsular bag, including capsular tension rings and capsular scaffolds.
- While the preferred embodiments of the devices and methods have been described in reference to the environment in which they were developed, they are merely illustrative of the principles of the inventions. The elements of the various embodiments may be incorporated into each of the other species to obtain the benefits of those elements in combination with such other species, and the various beneficial features may be employed in embodiments alone or in combination with each other. Other embodiments and configurations may be devised without departing from the spirit of the inventions and the scope of the appended claims.
Claims (46)
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GB2113232.9A GB2601599A (en) | 2020-10-05 | 2020-11-10 | IOL with drug delivery devices and uninterrupted PCO barrier edge |
CA3193357A CA3193357A1 (en) | 2020-10-05 | 2021-10-05 | Iol with drug delivery devices and uninterrupted pco barrier edge |
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EP21878391.8A EP4225210A1 (en) | 2020-10-05 | 2021-10-05 | Iol with drug delivery devices and uninterrupted pco barrier edge |
JP2023520466A JP2023544411A (en) | 2020-10-05 | 2021-10-05 | IOL with drug delivery device and continuous PCO barrier edge |
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US17/947,001 US11883277B2 (en) | 2020-10-05 | 2022-09-16 | IOL with drug delivery devices and uninterrupted PCO barrier edge |
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Cited By (1)
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DE102022112803A1 (en) | 2022-05-20 | 2023-11-23 | Carl Zeiss Meditec Ag | Intraocular lens with a medication reservoir, arranged on a haptic arm in a radial recess |
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US20220104936A1 (en) * | 2020-10-05 | 2022-04-07 | SpyGlass Pharma, Inc. | IOL with Drug Delivery Devices and Uninterrupted PCO Barrier Edge |
WO2023009654A2 (en) * | 2021-07-28 | 2023-02-02 | SpyGlass Pharma, Inc. | Stabilized intraocular drug delivery systems and methods of use |
EP4376768A1 (en) | 2021-07-30 | 2024-06-05 | Spyglass Pharma, Inc. | Systems to affix devices to intraocular lens assemblies and related methods |
DE102022112804B4 (en) * | 2022-05-20 | 2023-12-21 | Carl Zeiss Meditec Ag | Drug storage for an intraocular lens and intraocular lens with such a drug storage |
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US20100074942A1 (en) * | 2007-03-14 | 2010-03-25 | Washington, University Of | Device and method for intraocular drug delivery |
US20180368974A1 (en) * | 2015-11-04 | 2018-12-27 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
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DE102022112803A1 (en) | 2022-05-20 | 2023-11-23 | Carl Zeiss Meditec Ag | Intraocular lens with a medication reservoir, arranged on a haptic arm in a radial recess |
WO2023222551A1 (en) | 2022-05-20 | 2023-11-23 | Carl Zeiss Meditec Ag | Intraocular lens comprising a medicament reservoir |
DE102022112803B4 (en) | 2022-05-20 | 2023-12-14 | Carl Zeiss Meditec Ag | Intraocular lens with a medication reservoir, arranged on a haptic arm in a radial recess |
Also Published As
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WO2022076456A1 (en) | 2022-04-14 |
GB2586420B (en) | 2021-11-03 |
US11654014B2 (en) | 2023-05-23 |
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JP2023544411A (en) | 2023-10-23 |
AU2021357703A1 (en) | 2023-04-27 |
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GB2586420A (en) | 2021-02-17 |
US11883277B2 (en) | 2024-01-30 |
EP4225210A1 (en) | 2023-08-16 |
GB2586420B8 (en) | 2022-04-20 |
GB2586420A8 (en) | 2022-04-20 |
CA3193357A1 (en) | 2022-04-14 |
GB2601599A (en) | 2022-06-08 |
GB2586420C2 (en) | 2022-07-06 |
AU2021357703A9 (en) | 2024-02-08 |
GB202017747D0 (en) | 2020-12-23 |
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