CA3022830A1 - Bioresorbable ocular drug delivery device - Google Patents

Bioresorbable ocular drug delivery device Download PDF

Info

Publication number
CA3022830A1
CA3022830A1 CA3022830A CA3022830A CA3022830A1 CA 3022830 A1 CA3022830 A1 CA 3022830A1 CA 3022830 A CA3022830 A CA 3022830A CA 3022830 A CA3022830 A CA 3022830A CA 3022830 A1 CA3022830 A1 CA 3022830A1
Authority
CA
Canada
Prior art keywords
implant
drug
outer shell
eye
ocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3022830A
Other languages
English (en)
French (fr)
Inventor
Harold Alexander Heitzmann
Kenneth Martin Curry
David Steven HAFFNER
Thomas W. Burns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dose Medical Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3022830A1 publication Critical patent/CA3022830A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
CA3022830A 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device Pending CA3022830A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325378P 2016-04-20 2016-04-20
US62/325,378 2016-04-20
PCT/US2017/028665 WO2017184881A1 (en) 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device

Publications (1)

Publication Number Publication Date
CA3022830A1 true CA3022830A1 (en) 2017-10-26

Family

ID=58672714

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3022830A Pending CA3022830A1 (en) 2016-04-20 2017-04-20 Bioresorbable ocular drug delivery device

Country Status (7)

Country Link
US (3) US11318043B2 (enExample)
EP (1) EP3442479A1 (enExample)
JP (3) JP7003110B2 (enExample)
CN (2) CN115120405A (enExample)
AU (2) AU2017252294B2 (enExample)
CA (1) CA3022830A1 (enExample)
WO (1) WO2017184881A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
CA2668954C (en) 2006-11-10 2020-09-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
RU2010112417A (ru) * 2007-09-07 2011-10-10 Клт Плаг Диливери, Инк. (Us) Обнаружение лакримальных имплантатов
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
EP3412260B1 (en) 2009-05-18 2020-08-26 Dose Medical Corporation Drug eluting ocular implant
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
JP6465490B2 (ja) 2012-03-26 2019-02-06 グローコス コーポレーション インプラント送達装置
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
JP6574780B2 (ja) 2013-11-14 2019-09-11 アクエシス， インコーポレイテッド 眼内シャントインサーター
CA2950187A1 (en) 2014-05-29 2015-12-03 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
CA2980289C (en) 2015-03-20 2024-05-14 Glaukos Corporation Gonioscopic devices
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CA3022830A1 (en) * 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
JP7054211B2 (ja) 2016-05-20 2022-04-13 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト 涙腺ドラッグ送給デバイス
CN110022794A (zh) * 2016-10-05 2019-07-16 泰坦医药品公司 具有减少的突释的用于药物递送的可植入装置
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
CN110573117B (zh) 2017-10-06 2021-10-26 格劳科斯公司 用于递送多个眼部植入物的系统和方法
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
RU2740728C1 (ru) * 2017-11-08 2021-01-20 Эквисис, Инк. Ручная регулировка интраокулярного потока
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
MX2020010300A (es) * 2018-03-30 2020-10-20 Aerie Pharmaceuticals Inc Sales monoacidas de 6-aminoisoquinolinas y usos de las mismas.
WO2020243602A1 (en) * 2019-05-31 2020-12-03 Dose Medical Corporation Bioerodible cross-linked hydrogel implants and related methods of use
JP2022538347A (ja) 2019-06-27 2022-09-01 レイヤーバイオ，インコーポレーテッド 眼用デバイス送達方法およびシステム
CN111150545A (zh) * 2020-01-02 2020-05-15 首都医科大学附属北京同仁医院 一种相变降温支架及其制备方法和相变降温组合支架
KR102154490B1 (ko) * 2020-01-03 2020-09-10 최만규 모델 하우스의 전시용 실내벽체 및 그 설치방법
CN111228034A (zh) * 2020-01-16 2020-06-05 贵州省人民医院 一种载药控释型泪道栓子及其制备方法
WO2021247907A1 (en) * 2020-06-03 2021-12-09 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
WO2021247690A1 (en) * 2020-06-03 2021-12-09 Glaukos Corporation Rho kinase inhibitor releasing implants and related methods of use
CN111772920B (zh) * 2020-07-22 2025-01-07 苏州朗目医疗科技有限公司 青光眼引流装置及其引流植入物
US12268633B2 (en) * 2020-11-04 2025-04-08 Alcon Inc. Medical implant
KR20240013804A (ko) * 2021-05-27 2024-01-30 더블유. 엘. 고어 앤드 어소시에이트스, 인코포레이티드 약물 치료 전달 시스템 및 방법
US20220378612A1 (en) * 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
WO2023059933A1 (en) * 2021-10-08 2023-04-13 Purdue Research Foundation Ocular drug delivery device and related methods
JP2025523244A (ja) * 2022-07-22 2025-07-17 スパイグラス ファーマ インコーポレイテッド 眼内薬物送達システム及び使用方法
CN115969612A (zh) * 2022-12-20 2023-04-18 重庆医科大学附属第三医院(捷尔医院） 可生物降解的用于治疗青光眼的房水引流装置及其制备方法

Family Cites Families (615)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663670A (en) 1900-07-30 1900-12-11 Marion W Wiswall Apparel dusting-cap.
US2031754A (en) 1932-11-04 1936-02-25 Ernest J Sweetland Extensible coupling
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
JPS5323011B2 (enExample) 1973-09-12 1978-07-12
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4142526A (en) 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4207890A (en) 1977-01-04 1980-06-17 Mcneilab, Inc. Drug-dispensing device and method
US4113088A (en) 1977-06-06 1978-09-12 Binkhorst Richard D Sterile package
US4328803B1 (en) 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
DK90883A (da) 1982-03-18 1983-09-19 Merck & Co Inc Beholder til osmotisk afgivelse af et stof eller en stofblanding
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4955881A (en) 1985-08-16 1990-09-11 Alza Corporation Ruminant dispensing device
US4883864A (en) 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
GB8603099D0 (en) 1986-02-07 1986-03-12 Blass K G Gastrointestinal module
US4743248A (en) 1986-08-11 1988-05-10 Alza Corporation Dosage form for delivering acid sensitive beneficial agent
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4736836A (en) 1987-02-02 1988-04-12 Alongi Salvatore A Intraocular lens package
US4846793A (en) 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4828439A (en) 1987-05-15 1989-05-09 Giannuzzi Louis Screw anchor
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
CA1334168C (en) 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
FR2644058B1 (fr) 1989-03-10 1994-06-03 France Chirurgie Instr Bouchon meatique pour pathologie lacrymale
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5725529A (en) 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
CA2071137A1 (en) 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
SG81873A1 (en) 1991-08-16 2001-07-24 Miles A Galin Medicament coated refractive anterior chamber ocular implant
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
GB2260585A (en) 1991-10-09 1993-04-21 Avdel Systems Ltd Self-plugging blind rivet
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IL100112A (en) 1991-11-21 1996-01-31 Yeda Res & Dev Microdelivery device for enhanced drug administration to the eye
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
AU4282793A (en) 1992-04-10 1993-11-18 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5380290A (en) 1992-04-16 1995-01-10 Pfizer Hospital Products Group, Inc. Body access device
DE69326610T2 (de) 1992-05-22 2000-06-08 Senju Pharmaceutical Co., Ltd. Arzneimittel gegen glaukom
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
WO1994002081A1 (en) 1992-07-16 1994-02-03 Wong Vernon G Eye implant suitable for relief of glaucoma
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
DE69435341D1 (de) 1993-07-19 2011-05-05 Angiotech Pharm Inc Herstellungsmethode eines Stents mit anti-angiogener Zusammensetzung
US5731294A (en) 1993-07-27 1998-03-24 Hybridon, Inc. Inhibition of neovasularization using VEGF-specific oligonucleotides
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5500465A (en) 1994-03-10 1996-03-19 Board Of Trustees Operating Michigan State University Biodegradable multi-component polymeric materials based on unmodified starch-like polysaccharides
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
CA2185699A1 (en) 1994-04-04 1995-10-12 William R. Freeman Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AU2467395A (en) 1994-05-04 1995-11-29 Board Of Trustees Of The University Of Arkansas, The Novel ophthalmologic uses of protein c
US5599534A (en) 1994-08-09 1997-02-04 University Of Nebraska Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
US5665114A (en) 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
GB9417399D0 (en) 1994-08-30 1994-10-19 Scherer Corp R P Ocular treatment device
AU699821B2 (en) 1994-10-17 1998-12-17 Kabushikikaisha Igaki Iryo Sekkei Stent for liberating drug
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US5643321A (en) 1994-11-10 1997-07-01 Innovasive Devices Suture anchor assembly and methods
US5602143A (en) 1994-12-08 1997-02-11 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
US6228873B1 (en) 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5891084A (en) 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
WO1996020742A1 (en) 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
AU723047B2 (en) 1995-02-10 2000-08-17 University Of Toronto Innovations Foundation, The Deprenyl compounds for treatment of glaucoma
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5547993A (en) 1995-10-24 1996-08-20 Mitsubishi Chemical Corporation Therapeutic agent for glaucoma
AU1201297A (en) 1995-12-21 1997-07-17 Pharmacia & Upjohn Ab Ophthalmic treatment
US5798380A (en) 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
GB9700390D0 (en) 1997-01-10 1997-02-26 Biocompatibles Ltd Device for use in the eye
FR2759577B1 (fr) 1997-02-17 1999-08-06 Corneal Ind Implant de sclerectomie profonde
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US6059812A (en) 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
DE19728069C1 (de) 1997-07-01 1999-02-11 Acritec Gmbh Vorrichtung zur Messung des Augeninnendrucks
US5980928A (en) 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6274138B1 (en) 1997-09-03 2001-08-14 Incyte Genomics, Inc. Human mitochondrial malate dehydrogenase
US7985415B2 (en) 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US20020164374A1 (en) 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6159458A (en) 1997-11-04 2000-12-12 Insite Vision Sustained release ophthalmic compositions containing water soluble medicaments
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6589198B1 (en) 1998-01-29 2003-07-08 David Soltanpour Implantable micro-pump assembly
US7780623B2 (en) 1998-01-29 2010-08-24 Soltanpour David P Implantable pump apparatuses
US6682500B2 (en) 1998-01-29 2004-01-27 David Soltanpour Synthetic muscle based diaphragm pump apparatuses
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
FR2777442B1 (fr) 1998-04-21 2000-07-28 Tornier Sa Ancre de suture a expansion reversible
CA2329709A1 (en) 1998-04-24 1999-11-04 Mitokor Compounds and methods for treating mitochondria-associated diseases
US5997498A (en) 1998-05-07 1999-12-07 Johns Hopkins University Inline air humidifier, a system for humidifying air and methods related thereto
TW586944B (en) 1998-05-29 2004-05-11 Sumitomo Pharma Controlled release agent having a multi-layer structure
US6231853B1 (en) 1998-06-01 2001-05-15 Incyte Pharmaceuticals, Inc. Human glutathione peroxidase-6
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
KR100300527B1 (ko) 1998-09-03 2001-10-27 윤덕용 밀봉형무선압력측정소자및그제조방법
KR100274842B1 (ko) 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6348042B1 (en) 1999-02-02 2002-02-19 W. Lee Warren, Jr. Bioactive shunt
US6193656B1 (en) 1999-02-08 2001-02-27 Robert E. Jeffries Intraocular pressure monitoring/measuring apparatus and method
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
HK1041802A1 (zh) 1999-04-26 2002-07-26 Gmp Vision Solutions, Inc. 治疗青光眼的支架装置和方法
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6306120B1 (en) 1999-06-07 2001-10-23 Ben Gee Tan Applicator and method for delivery of mitomycin to eye tissues during glaucoma filtering surgery
GB2352283A (en) 1999-06-28 2001-01-24 California Inst Of Techn Microfabricated valves, pumps, mirror array and refracting structure
US8550119B2 (en) 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20080277007A1 (en) 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
JP2003508185A (ja) 1999-08-03 2003-03-04 スミス アンド ネフュー インコーポレーテッド 埋め込み型制御放出装置
CN1378445B (zh) 1999-08-06 2013-02-06 得克萨斯系统大学评议会 药物释放生物可降解纤维植入物
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
TR200201047T2 (tr) 1999-10-21 2002-07-22 Alcon, Inc. İlaç verme vasıtası.
US6413245B1 (en) 1999-10-21 2002-07-02 Alcon Universal Ltd. Sub-tenon drug delivery
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
JP2003530144A (ja) 1999-12-10 2003-10-14 アイサイエンス コーポレイション 眼の病気の治療
US6939299B1 (en) 1999-12-13 2005-09-06 Kurt Petersen Implantable continuous intraocular pressure sensor
CN1198584C (zh) 1999-12-16 2005-04-27 阿尔萨公司 具有激光烧蚀的阻隔层的剂型
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
RU2262331C2 (ru) 2000-01-12 2005-10-20 Бектон, Дикинсон Энд Компани Шунт, имплантат, система и способ снижения внутриглазного давления, способ изготовления имплантата для роговицы (варианты)
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
US6660870B1 (en) 2000-03-17 2003-12-09 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US20070031473A1 (en) 2005-08-05 2007-02-08 Peyman Gholam A Drug delivery system and method
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20040111050A1 (en) 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20030060752A1 (en) 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US20040115268A1 (en) 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
AU2001258095A1 (en) 2000-05-08 2001-11-20 The University Of British Columbia Drug delivery systems for photodynamic therapy
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
ATE377404T1 (de) 2000-05-19 2007-11-15 Michael S Berlin Laserapplikationssystem und methode zur verwendung im auge
EP1292256A1 (en) 2000-06-19 2003-03-19 Glaukos Corporation Stented trabecular shunt and methods thereof
KR100355563B1 (ko) 2000-06-23 2002-10-11 주식회사 바이오메드랩 비등성 혼합물을 이용한 조직공학용 생분해성의 다공성고분자 지지체 및 그의 제조방법
US6692759B1 (en) 2000-06-28 2004-02-17 The Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
EP1637126B1 (en) 2000-07-05 2016-12-14 Allergan, Inc. Methods for treating inflammation of the eye
US6629992B2 (en) 2000-08-04 2003-10-07 Advanced Cardiovascular Systems, Inc. Sheath for self-expanding stent
AU2001281304B2 (en) 2000-08-15 2006-05-25 Surmodics, Inc. Medicament incorporation matrix
US6749568B2 (en) 2000-08-21 2004-06-15 Cleveland Clinic Foundation Intraocular pressure measurement system including a sensor mounted in a contact lens
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
AU2001261262A1 (en) 2000-11-01 2002-05-15 Glaukos Corporation Glaucoma treatment device
EP1621219A3 (en) 2000-11-29 2006-03-22 Allergan, Inc. Intraocular implants for preventing transplant rejection in the eye
AU3649502A (en) 2000-11-29 2002-06-11 Oculex Pharm Inc Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
CA2434156A1 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
ES2320533T3 (es) 2001-01-03 2009-05-25 BAUSCH & LOMB INCORPORATED Dispositivos de administracion de farmacos de liberacion sostenida con multiples agentes.
JP2004521882A (ja) 2001-01-03 2004-07-22 ボシュ・アンド・ロム・インコーポレイテッド 組立式透過性プラグを備えた徐放薬剤送達装置
WO2002053130A2 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
DE60219607T2 (de) 2001-01-09 2007-12-27 Microchips, Inc., Bedford Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
WO2002058551A2 (en) 2001-01-22 2002-08-01 Integrated Sensing Systems, Inc. Wireless mems capacitive sensor for physiologic parameter measurement
EP1365738A2 (en) 2001-01-26 2003-12-03 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US8060211B2 (en) 2001-02-13 2011-11-15 Second Sight Medical Products, Inc. Method of reducing retinal stress caused by an implantable retinal electrode array
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6989007B2 (en) 2001-02-21 2006-01-24 Solx, Inc. Devices and techniques for treating glaucoma
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
US20050278014A9 (en) 2001-03-07 2005-12-15 Wolfgang Daum Stent and method for drug delivery from stents
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
CA2540761A1 (en) 2001-03-16 2002-09-26 Glaukos Corporation Applicator and methods for placing a trabecular shunt for glaucoma treatment
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
AU2002258754B2 (en) 2001-04-07 2006-08-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US6533769B2 (en) 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
EP1387671A1 (en) 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantable drug delivery device and use thereof
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
JP4677538B2 (ja) 2001-06-12 2011-04-27 ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン 眼内薬物送達のためのリザーバデバイス
WO2002103210A1 (en) 2001-06-15 2002-12-27 Hansford Derek J Nanopump devices and methods
US7592016B2 (en) 2001-06-28 2009-09-22 Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
BR0210494A (pt) 2001-07-23 2004-06-22 Alcon Inc Dispositivo de administração de droga oftálmica
BR0210287A (pt) 2001-07-23 2005-12-13 Alcon Inc Dispositivo de administração de droga oftalmológica
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
EP1420716B1 (en) 2001-08-29 2012-08-15 Ricardo A. P. De Carvalho An implantable and sealable system for unidirectional delivery of therapeutic agents to targeted tissues
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
IN2014DN10834A (enExample) 2001-09-17 2015-09-04 Psivida Inc
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
US20030135201A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
FR2830766B1 (fr) 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese transpalpebrale
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030119000A1 (en) 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
US20080039769A1 (en) 2001-11-07 2008-02-14 Minu Llc Method of medical treatment using controlled heat delivery
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US6802829B2 (en) 2001-11-16 2004-10-12 Infinite Vision, Llc Spray device
ES2348930T3 (es) 2001-11-22 2010-12-17 Eduard Anton Haefliger Procedimiento y dispositivo para realizar operaciones oftalmológicas.
US7348055B2 (en) 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US20060034929A1 (en) 2001-12-27 2006-02-16 Brubaker Michael J Sustained release drug delivery devices with prefabricated permeable plugs
WO2003061625A2 (en) 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
JP2003210513A (ja) 2002-01-23 2003-07-29 Nidek Co Ltd 眼科用治療装置
WO2003073968A2 (en) 2002-02-28 2003-09-12 Gmp Vision Solutions, Inc. Device and method for monitoring aqueous flow within the eye
US20050069893A1 (en) 2002-03-01 2005-03-31 Josef Flammer Diagnostic method for glaucoma
US20060200113A1 (en) 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
KR101191254B1 (ko) 2002-03-11 2012-10-16 알콘, 인코퍼레이티드 이식 가능한 약물 전달 시스템
US20060100408A1 (en) 2002-03-11 2006-05-11 Powell P M Method for forming contact lenses comprising therapeutic agents
AR038926A1 (es) 2002-03-13 2005-02-02 Novartis Ag Materiales con contenido de multiples capas de vesiculas
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
JP4026745B2 (ja) 2002-03-26 2007-12-26 財団法人大阪産業振興機構 医療用システムおよびその製造方法
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20030195438A1 (en) 2002-04-12 2003-10-16 Petillo Phillip J. Method and apparatus to treat glaucoma
US20040024345A1 (en) 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
AU2003217531A1 (en) 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20050159660A1 (en) 2002-05-31 2005-07-21 Valentino Montegrande Intraocular pressure sensor
US20070123767A1 (en) 2002-05-31 2007-05-31 Valentino Montegrande Intraocular pressure sensor and method of use
US8273366B2 (en) 2002-06-05 2012-09-25 University Of Florida Research Foundation, Incorporated Ophthalmic drug delivery system
BR0311585A (pt) 2002-06-05 2005-05-10 Univ Florida Sistema de fornecimento de drogas, método para administrar uma droga oftálmica a um paciente, kit, uso do mesmo, método para preparar o sistema de fornecimento de drogas, e, artigo de fabricação
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US7678827B2 (en) 2002-07-15 2010-03-16 Alcon, Inc. Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use
US20040013702A1 (en) 2002-07-16 2004-01-22 Glover Eugene G. Implantable devices for the controlled release of cytotoxic agents
US7041077B2 (en) 2002-07-19 2006-05-09 Yale University Uveoscleral drainage device
WO2004014218A2 (en) 2002-08-08 2004-02-19 Glaukos Corporation Implantable ocular pump to reduce intraocular pressure
AU2003268169A1 (en) 2002-08-27 2004-03-19 Michigan State University Implantable microscale pressure sensor system
JP4353510B2 (ja) 2002-09-09 2009-10-28 株式会社カネカ 組織再生用支持体及びその製造方法
US7192412B1 (en) 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
EP1539066B1 (en) 2002-09-17 2012-11-07 Iscience Surgical Corporation Apparatus surgical bypass of aqueous humor
US20050261641A1 (en) 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
USRE40722E1 (en) 2002-09-27 2009-06-09 Surmodics, Inc. Method and apparatus for coating of substrates
US7615010B1 (en) 2002-10-03 2009-11-10 Integrated Sensing Systems, Inc. System for monitoring the physiologic parameters of patients with congestive heart failure
US7131945B2 (en) 2002-10-16 2006-11-07 California Institute Of Technology Optically powered and optically data-transmitting wireless intraocular pressure sensor device
WO2004043231A2 (en) 2002-11-06 2004-05-27 Gmp Vision Solutions, Inc. Storage apparatus for surgical implant device
AU2003287666A1 (en) 2002-11-13 2004-06-03 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
US20060039979A1 (en) 2002-12-04 2006-02-23 Kazuhito Yamada Drug delivery system using subconjunctival depot
US7531191B2 (en) 2002-12-17 2009-05-12 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20040137059A1 (en) 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
US20040216749A1 (en) 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
CN100475280C (zh) 2003-02-18 2009-04-08 汉帕尔·卡拉乔济安 用于引流液体和降低眼内压的方法和装置
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
US20040163652A1 (en) 2003-02-25 2004-08-26 Colin Watson Condom with restriction band
USD490152S1 (en) 2003-02-28 2004-05-18 Glaukos Corporation Surgical handpiece
US7483750B2 (en) 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050208102A1 (en) 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
ATE476960T1 (de) 2003-05-02 2010-08-15 Surmodics Inc System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20100222752A1 (en) 2003-05-20 2010-09-02 Collins Jr James F Ophthalmic fluid delivery system
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
WO2004110391A2 (en) 2003-06-16 2004-12-23 Solx, Inc. Shunt for the treatment of glaucoma
WO2005009297A1 (en) 2003-07-10 2005-02-03 Alcon, Inc. Ophthalmic drug delivery device
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
JP4869930B2 (ja) 2003-08-26 2012-02-08 ヴィスタ サイエンティフィック エルエルシー 眼科薬物供給装置
BRPI0413977A (pt) 2003-08-27 2006-11-07 Osi Eyetech Inc método para suprimir um distúrbio neovascular, e para tratar um paciente diagnosticado com ou em risco de desenvolver um distúrbio neovascular, composição farmacêutica, e, embalagem farmacêutica
US20050055075A1 (en) 2003-09-08 2005-03-10 Leonard Pinchuk Methods for the manufacture of porous prostheses
AU2004274026A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
EP1686963A1 (en) 2003-10-27 2006-08-09 PSivida Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US7678089B2 (en) 2003-11-14 2010-03-16 Medical Instill Technologies, Inc. Delivery device and method of delivery
US20050152941A1 (en) 2003-11-20 2005-07-14 Angiotech International Ag Soft tissue implants and anti-scarring agents
US20080058793A1 (en) 2006-06-12 2008-03-06 Pilla Arthur A Electromagnetic apparatus for prophylaxis and repair of ophthalmic tissue and method for using same
US20110112352A1 (en) 2003-12-05 2011-05-12 Pilla Arthur A Apparatus and method for electromagnetic treatment
US20050137538A1 (en) 2003-12-22 2005-06-23 Bausch & Lomb Incorporated Drug delivery device
CN101912325A (zh) 2004-01-12 2010-12-15 i科学外科公司 一种输送粘性材料的注射器
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US20050250788A1 (en) 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
WO2005087314A1 (en) 2004-03-11 2005-09-22 Advanced Neuromodulation Systems, Inc. Brain stimulation system and method
US7513893B2 (en) 2004-03-12 2009-04-07 Abraham Ebbie Soroudi Device and method for treatment of eyelid diseases
WO2005092260A1 (en) 2004-03-26 2005-10-06 Molteno Ophthalmic Ltd Ophthalmic implant for treating glaucoma
US7654985B2 (en) 2004-03-30 2010-02-02 Given Imaging Ltd. Controlled detachment of intra-luminal medical device
US20060083772A1 (en) 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2007534383A (ja) 2004-04-23 2007-11-29 ジーエムピー ヴィジョン ソルーションズ インコーポレイテッド 留置シャント装置及び緑内障のための装置及び方法
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
CN1976732A (zh) 2004-04-29 2007-06-06 i科学外科公司 用于外科手术式改善房水引流的装置和方法
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
WO2005115281A2 (fr) 2004-04-30 2005-12-08 Optis France Dispositif de iontophorese oculaire diminuant les irritations
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244465A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8512738B2 (en) 2004-04-30 2013-08-20 Allergan, Inc. Biodegradable intravitreal tyrosine kinase implants
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US20070212395A1 (en) 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
WO2005110374A1 (en) 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
AU2005240078A1 (en) 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US20050244461A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244500A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US8128954B2 (en) 2004-06-07 2012-03-06 California Institute Of Technology Biodegradable drug-polymer delivery system
US7252006B2 (en) 2004-06-07 2007-08-07 California Institute Of Technology Implantable mechanical pressure sensor and method of manufacturing the same
EP1604697A1 (en) 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
WO2006002366A2 (en) 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable ocular devices, methods and systems
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
JP2008505978A (ja) 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
WO2006015016A2 (en) 2004-07-30 2006-02-09 Massachusetts Eye And Ear Infirmary Photodynamic therapy and compositions for treating ocular glaucoma
US20060032507A1 (en) 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
US7402156B2 (en) 2004-09-01 2008-07-22 Alcon, Inc. Counter pressure device for ophthalmic drug delivery
US20060084952A1 (en) 2004-09-03 2006-04-20 Pallikaris Ioannis G Device for the irradiation of the ciliary body of the eye
US7709049B2 (en) 2004-09-10 2010-05-04 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
ATE413165T1 (de) 2004-09-27 2008-11-15 Sigmoid Pharma Ltd Mikrokapseln mit einem methylxanthin und einem kortikosteroid
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
BRPI0516308A2 (pt) 2004-10-04 2010-06-15 Qlt Usa Inc composição fluida, métodos de tratamento de uma doença ou disfunção, métodos de liberação local ou sistêmica de um agente biológico, implantes, método de formação de um implante, kit de agente biológico e usos de uma composição fluida
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US7226435B2 (en) 2004-10-14 2007-06-05 Alcon, Inc. Drug delivery device
US7958840B2 (en) 2004-10-27 2011-06-14 Surmodics, Inc. Method and apparatus for coating of substrates
US20060089590A1 (en) 2004-10-27 2006-04-27 John Higuchi Methods and devices for sustained in-vivo release of an active agent
EP1814519A1 (en) 2004-11-16 2007-08-08 Université de Liège Active substance delivery system comprising a hydrogel atrix and microcarriers
US20060173397A1 (en) 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
WO2006058189A2 (en) 2004-11-23 2006-06-01 Wong Jr Edward K Medical device for temperature control and treatment of the eye and surrounding tissues
US20060110429A1 (en) 2004-11-24 2006-05-25 Therakine Corporation Implant for intraocular drug delivery
US20070118065A1 (en) 2004-12-03 2007-05-24 Leonard Pinchuk Glaucoma Implant Device
US7837644B2 (en) 2004-12-03 2010-11-23 Innfocus, Llc Glaucoma implant device
BRPI0519171A2 (pt) 2004-12-22 2008-12-30 Alcon Inc dispositivo de administraÇço de medicamento oftÁlmico
MX2007009417A (es) 2005-02-04 2007-08-17 Univ Auburn Sistema de suministro de farmaco de contacto.
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
JP2008530127A (ja) 2005-02-09 2008-08-07 マクサイト， インコーポレイテッド 眼の処置のための処方物
AU2006227116A1 (en) 2005-03-21 2006-09-28 Santen Pharmaceutical Co., Ltd. Drug delivery systems for treatment of diseases or conditions
JP2008535847A (ja) 2005-04-08 2008-09-04 サーモディクス，インコーポレイティド 網膜下に送達するための持続放出インプラント
EP1871890B1 (en) 2005-04-18 2011-06-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and devices for delivering a therapeutic product to the ocular sphere of a subject
US7931909B2 (en) 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
WO2007002184A1 (en) 2005-06-21 2007-01-04 Bausch & Lomb Incorporated Drug delivery device having zero or near zero-order release kinetics
US20070021653A1 (en) 2005-06-27 2007-01-25 Lars-Olof Hattenbach Device for the injection of drugs into microvessels
CN105233349B (zh) 2005-07-15 2019-06-18 胶束技术股份有限公司 包含受控形态的药物粉末的聚合物涂层
JP2009507770A (ja) 2005-07-27 2009-02-26 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド 眼性疾患の治療への、熱ショックの使用
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070038174A1 (en) 2005-08-09 2007-02-15 Hopkins Mark A Ophthalmic injector system
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
ATE540705T1 (de) 2005-09-21 2012-01-15 Surmodics Inc Überzüge und artikel mit natürlichen biologisch abbaubaren polysacchariden
DE602006005826D1 (de) 2005-09-21 2009-04-30 Univ Aston Chronotherapeutisches okulares abgabesystem aus einer kombination von prostaglandinen und einem betablocker zur behandlung von primärem glaukom
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
US20070197957A1 (en) 2005-10-03 2007-08-23 Hunter William L Implantable sensors, implantable pumps and anti-scarring drug combinations
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN101394834A (zh) 2005-10-18 2009-03-25 阿勒根公司 用糖皮质激素衍生物选择性渗透后段组织来治疗眼睛
US20090082321A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
TW200733993A (en) 2005-11-03 2007-09-16 Reseal Internat Ltd Partnership Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein
US8099162B2 (en) 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
WO2007081750A2 (en) 2006-01-06 2007-07-19 The Curators Of The University Of Missouri Ultrasound-mediated transcleral drug delivery
US8143042B2 (en) 2006-01-12 2012-03-27 Massachusetts Institute Of Technology Biodegradable elastomers
EP1978892B1 (en) 2006-01-17 2017-11-15 Novartis Ag Drug delivery treatment device
CN103284833B (zh) 2006-01-17 2016-06-29 创森德医疗设备公司 青光眼治疗装置
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
WO2007106557A2 (en) 2006-03-14 2007-09-20 University Of Southern California Mems device for delivery of therapeutic agents
CA2648066C (en) 2006-03-31 2012-07-03 Forsight Labs, Llc Drug delivery methods, structures, and compositions for nasolacrimal system
JP2009534129A (ja) 2006-04-18 2009-09-24 カスケード オフタルミクス 眼圧減衰装置
ES2396088T3 (es) 2006-04-26 2013-02-19 Eastern Virginia Medical School Sistemas para monitorizar y controlar la presión interna de un ojo o una parte del cuerpo
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
EP2019646A4 (en) 2006-05-04 2013-12-04 Herbert Kaufman METHOD, DEVICE AND SYSTEM FOR THE RELEASE OF A THERAPEUTIC ACTIVE IN THE EYE
US20070260203A1 (en) 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
US7674243B2 (en) 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US20070268340A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US20070270744A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Limited Reuse Assembly For Ophthalmic Injection Device
US7862540B2 (en) 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US20070270768A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Mechanical Linkage Mechanism For Ophthalmic Injection Device
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US20070293873A1 (en) 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US7458953B2 (en) 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US20070298073A1 (en) 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
WO2008005873A2 (en) 2006-06-30 2008-01-10 Aquesys Inc. Methods, systems and apparatus for relieving pressure in an organ
US20080152694A1 (en) 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US9248121B2 (en) 2006-08-21 2016-02-02 Abbott Laboratories Medical devices for controlled drug release
US20080086101A1 (en) 2006-08-25 2008-04-10 David Freilich Ophthalmic insert
WO2008025532A1 (en) 2006-08-30 2008-03-06 Jagotec Ag Controlled release solid oral dosage formulations comprising nisoldipine
US20100241046A1 (en) 2006-09-06 2010-09-23 Innfocus, Llc Apparatus, methods and devices for treatment of ocular disorders
WO2008039749A2 (en) 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
US20080125712A1 (en) 2006-09-26 2008-05-29 Alcon Manufacturing, Ltd. Ophthalmic injection system
US20080097379A1 (en) 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080097390A1 (en) 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
US20080081064A1 (en) 2006-09-28 2008-04-03 Surmodics, Inc. Implantable Medical Device with Apertures for Delivery of Bioactive Agents
JP5694664B2 (ja) 2006-09-29 2015-04-01 サーモディクス，インコーポレイティド 生分解性眼用インプラント及び眼の病気を治療する方法
MX2009003735A (es) 2006-10-05 2009-04-22 Panacea Biotec Ltd Composicion en deposito inyectable y su procedimiento de preparacion.
EP2081632A2 (en) 2006-10-16 2009-07-29 Alcon Research, Ltd. Ceramic chamber with integrated temperature control device for ophthalmic medical device
US20080281292A1 (en) 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US7496174B2 (en) 2006-10-16 2009-02-24 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US7620147B2 (en) 2006-12-13 2009-11-17 Oraya Therapeutics, Inc. Orthovoltage radiotherapy
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US8311624B2 (en) 2006-10-18 2012-11-13 The Cleveland Clinic Foundation Apparatus and method for delivering a therapeutic agent to ocular tissue
US7494487B2 (en) 2006-11-03 2009-02-24 Mobius Therapeutics, Llc Apparatus and method for application of a pharmaceutical to the tympanic membrane for photodynamic laser myringotomy
US8039010B2 (en) 2006-11-03 2011-10-18 Allergan, Inc. Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
US20080114076A1 (en) 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
CA2668954C (en) 2006-11-10 2020-09-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080138408A1 (en) 2006-11-13 2008-06-12 Siddharth Venkatesh Drug delivery system and method
US8143410B2 (en) 2006-11-16 2012-03-27 Allergan, Inc. Kinase inhibitors
US20090036768A1 (en) 2006-11-17 2009-02-05 Boston Scientific Scimed, Inc. Medical devices
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
CA2670990A1 (en) 2006-12-01 2008-06-12 Allergan, Inc. Method for determining optimum intraocular locations for drug delivery systems
US8617143B2 (en) 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
WO2008073576A1 (en) 2006-12-08 2008-06-19 Alcon, Inc. Drug delivery device
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
US20080145405A1 (en) 2006-12-15 2008-06-19 Kunzler Jay F Drug delivery devices
AR063619A1 (es) 2006-12-18 2009-02-04 Alcon Res Ltd Dispositivos y metodos para la administraicion de un farmaco oftalmico
US20080181928A1 (en) 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
WO2008083118A1 (en) 2006-12-26 2008-07-10 Qlt Plug Delivery, Inc. Drug delivery implants for inhibition of optical defects
DE102007004906A1 (de) 2007-01-25 2008-07-31 Universität Rostock Augenimplantat
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US9144516B2 (en) 2007-02-08 2015-09-29 Sharpsight B.V. Device for intraocular administration of a substance, for example a medication, into a human or animal eye by means of a hypodermic needle
JP4799444B2 (ja) 2007-02-26 2011-10-26 パナソニック株式会社 シミュレーションシステム
TW200840554A (en) 2007-02-28 2008-10-16 Alcon Inc Coated medical implants and lenses
US7561085B2 (en) 2007-03-21 2009-07-14 Honeywell International Inc. Systems and methods for improving data converters
WO2008124009A2 (en) 2007-04-02 2008-10-16 The Cleveland Clinic Foundation Treating glaucoma
US8071119B2 (en) 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20090148498A1 (en) 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US20080306429A1 (en) 2007-06-07 2008-12-11 Shields Milton B Uveoscleral drainage device
WO2008157614A2 (en) 2007-06-21 2008-12-24 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
WO2009012406A1 (en) 2007-07-17 2009-01-22 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities reference to priority document
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8475374B2 (en) 2007-08-23 2013-07-02 Purdue Research Foundation Intra-occular pressure sensor
US8303536B2 (en) 2007-08-30 2012-11-06 Sunstorm Research Corp. Implantable delivery device
US8075909B2 (en) 2007-09-04 2011-12-13 University Of Florida Research Foundation, Incorporated Contact lens based bioactive agent delivery system
RU2010112417A (ru) 2007-09-07 2011-10-10 Клт Плаг Диливери, Инк. (Us) Обнаружение лакримальных имплантатов
CA2698508C (en) 2007-09-07 2017-06-06 Alan R. Rapacki Lacrimal implants and related methods
JP5555162B2 (ja) 2007-09-07 2014-07-23 キュー エル ティー インク． 治療薬剤の持続放出のための薬物コア
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8480638B2 (en) 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8109920B2 (en) 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
GB0722484D0 (en) 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
US20090130017A1 (en) 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US20090143752A1 (en) 2007-12-03 2009-06-04 Higuchi John W Passive intraocular drug delivery devices and associated methods
MX2010006840A (es) 2007-12-20 2010-08-12 Univ Southern California Aparato y métodos para suministrar agentes terapeuticos.
US20090162417A1 (en) 2007-12-21 2009-06-25 Cook Incorporated Drug eluting ocular conformer
US20110207987A1 (en) 2009-11-02 2011-08-25 Salutaris Medical Devices, Inc. Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
DK2676701T3 (en) 2008-01-07 2016-05-23 Salutaris Medical Devices Inc Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US20090177182A1 (en) 2008-01-09 2009-07-09 Hickingbotham Dyson W Glass Drug Chamber For Automated Ophthalmic Injection Device
US20090209945A1 (en) 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
EP2257250A2 (en) 2008-01-29 2010-12-08 Gilbert H. Kliman Drug delivery devices, kits and methods therefor
NZ587335A (en) 2008-02-18 2012-05-25 Quadra Logic Tech Inc Lacrimal implants and related methods with implant having drug core
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
US20090274877A1 (en) 2008-03-11 2009-11-05 Edwin Chan Stimuli-responsive surfaces
MX2010010663A (es) 2008-03-28 2010-11-09 Surmodics Inc Dispositivos medicos insertables que tienen substratos elasticos asociados con microparticulas, y metodos de suministro de farmacos.
EP2265293B1 (en) 2008-04-18 2015-11-04 SurModics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
TWI542338B (zh) 2008-05-07 2016-07-21 壯生和壯生視覺關懷公司 用於活性劑之控制釋放的眼用裝置
CN103349803B (zh) 2008-05-08 2016-12-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
ES2534864T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas implantables y cánulas para las mismas
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
WO2009137085A2 (en) 2008-05-09 2009-11-12 Qlt Plug Delivery, Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8702995B2 (en) 2008-05-27 2014-04-22 Dober Chemical Corp. Controlled release of microbiocides
US20100274224A1 (en) * 2008-07-08 2010-10-28 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
US20110125090A1 (en) 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
US20100119519A1 (en) 2008-11-13 2010-05-13 Peyman Gholam A Ophthalmic drug delivery system and method
CN104546669B (zh) 2008-11-14 2018-01-05 得克萨斯大学体系董事会 纳米通道装置和相关方法
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
US20100189765A1 (en) 2008-11-26 2010-07-29 Erickson Signe R Implantable ocular drug delivery device and methods
JP5520962B2 (ja) 2008-12-05 2014-06-11 イバンティス インコーポレイテッド 眼内インプラントを眼球内に送出するための装置
AU2009325061B2 (en) 2008-12-11 2014-05-29 Children's Medical Center Corporation Contact lens drug delivery device
US20100152676A1 (en) 2008-12-16 2010-06-17 Alcon Research, Ltd. Drug Loading Through Plunger
US8070290B2 (en) 2008-12-17 2011-12-06 Glaukos Corporation Gonioscope for improved viewing
US20120257167A1 (en) 2008-12-17 2012-10-11 Glaukos Corporation Gonioscope for improved viewing
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
US20100160870A1 (en) 2008-12-18 2010-06-24 Alcon Research, Ltd. Two Piece Housing For Drug Loading
MX2011006726A (es) 2009-01-02 2011-07-20 Alcon Res Ltd Implante oftalmico recargable in situ.
WO2010088258A2 (en) 2009-01-28 2010-08-05 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
SG173167A1 (en) 2009-01-29 2011-08-29 Forsight Labs Llc Posterior segment drug delivery
WO2010100654A2 (en) 2009-01-30 2010-09-10 Panduranga Revankar Krishna Prasad A device to directly monitor intra ocular pressure by a person based on pattern and colour changes
US8192408B2 (en) 2009-02-10 2012-06-05 Psivida Us, Inc. Ocular trocar assembly
US20100204325A1 (en) 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
US9636255B2 (en) 2009-02-13 2017-05-02 Dose Medical Corporation Uveoscleral drug delivery implant and methods for implanting the same
US8603051B2 (en) 2009-02-17 2013-12-10 Kuvio, Inc. Implantable drug delivery devices
US20100225061A1 (en) 2009-03-09 2010-09-09 Bath David L System and method for gaming with an engagable projectile
WO2010105093A2 (en) 2009-03-12 2010-09-16 Delpor, Inc. Implantable device for long-term delivery of drugs
WO2010105130A2 (en) 2009-03-13 2010-09-16 Vista Scientific Llc Opthalmic drug delivery system and applications
US20100239635A1 (en) 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
US20100247606A1 (en) 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
TWI495459B (zh) 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
WO2010115101A1 (en) 2009-04-03 2010-10-07 Transcend Medical, Inc. Ocular implant delivery systems and methods
EP3412260B1 (en) 2009-05-18 2020-08-26 Dose Medical Corporation Drug eluting ocular implant
US20190021991A9 (en) 2009-05-18 2019-01-24 Glaukos Corporation Ocular implants configured to store and release stable drug formulations
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
WO2011010310A1 (en) 2009-07-22 2011-01-27 Advanced Ophthalmic Pharma Ltd. Device for applying an ophthalmic medicament mist
WO2011021594A1 (ja) 2009-08-18 2011-02-24 国立大学法人東北大学 持続性ドラッグデリバリーシステム
US8808257B2 (en) 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
KR20120047313A (ko) 2009-09-03 2012-05-11 알러간, 인코포레이티드 티로신 키나제 조절인자로서의 화합물
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
WO2011050250A1 (en) 2009-10-22 2011-04-28 On Demand Therapeutics, Inc. Visual indication of rupture of drug reservoir
WO2011053841A1 (en) 2009-10-30 2011-05-05 Aton Pharma, Inc. Ocular drug delivery devices
DE202009018859U1 (de) 2009-11-10 2014-04-01 Fluoron Gmbh Spritze zur Injektion eines chirurgischen Gases
USD645490S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
EP2512389B1 (en) 2009-12-16 2015-09-02 Allergan, Inc. Intracameral devices for sustained delivery
USD645489S1 (en) 2009-12-16 2011-09-20 Glaukos Corporation Gonioscopic system including an optical element attachment
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
EP2515864A4 (en) 2009-12-23 2013-09-11 Psivida Inc DELAYED RELEASE DELIVERY DEVICES
DK3085358T3 (en) 2010-01-22 2018-02-05 Allergan Inc INTRAKAMERAL IMPLANTS WITH DEPOT PREPARATION
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US20130071349A1 (en) 2010-03-02 2013-03-21 Allergan, Inc. Biodegradable polymers for lowering intraocular pressure
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
US9320647B2 (en) 2010-03-31 2016-04-26 Ocuject, Llc Device and method for intraocular drug delivery
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
CA2794956C (en) 2010-04-03 2017-05-02 Praful Doshi Medical devices including medicaments and methods of making and using same
CN102905688B (zh) 2010-04-06 2015-11-25 阿勒根公司 用于前房内药物递送的缓释储库式植入物
US20110251568A1 (en) 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
EP2571526B1 (en) 2010-05-17 2019-03-13 Novaer Holdings, Inc. Drug delivery devices for delivery of ocular therapeutic agents
US8444589B2 (en) 2010-06-09 2013-05-21 Transcend Medical, Inc. Ocular implant with fluid outflow pathways having microporous membranes
KR101180032B1 (ko) 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
US20120022505A1 (en) 2010-07-20 2012-01-26 Bruno Dacquay Closed loop glaucoma drug delivery system
CA2807535C (en) 2010-08-05 2019-03-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
JP5907966B2 (ja) * 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
US8235053B2 (en) 2010-09-08 2012-08-07 Alcon Research, Ltd. Implantable punctal plug
US8864703B2 (en) 2010-10-05 2014-10-21 Alcon Research, Ltd. Drug introduction and placement system
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
US9370444B2 (en) 2010-10-12 2016-06-21 Emmett T. Cunningham, JR. Subconjunctival conformer device and uses thereof
US8915877B2 (en) 2010-10-12 2014-12-23 Emmett T. Cunningham, JR. Glaucoma drainage device and uses thereof
WO2012058274A2 (en) 2010-10-26 2012-05-03 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
JP5917555B2 (ja) 2010-12-16 2016-05-18 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ケモカイン受容体調節因子としてのリン酸誘導体
US20120238994A1 (en) 2010-12-22 2012-09-20 Martin Nazzaro Two-piece injectable drug delivery device with heat-cured seal
EP2668489B1 (en) 2011-01-24 2018-07-11 EMD Millipore Corporation Accelerated mixed gas integrity testing of porous materials
JP2012198134A (ja) 2011-03-22 2012-10-18 Chugoku Electric Power Co Inc:The 事故点標定装置、プログラム
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US20130004651A1 (en) 2011-07-01 2013-01-03 Patty Fu-Giles Sustained drug release from body implants using nanoparticle-embedded polymeric coating materials
US20130018360A1 (en) 2011-07-13 2013-01-17 Marissa Dockendorf Method for delivering ophthalmic drugs
US8486031B2 (en) 2011-07-29 2013-07-16 Allan J. Bogdan Eye treatment apparatus
WO2013030679A2 (en) 2011-08-29 2013-03-07 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
EP4193907A1 (en) 2011-09-13 2023-06-14 Glaukos Corporation Intraocular physiological sensor
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
WO2013040426A2 (en) 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8771220B2 (en) 2011-12-07 2014-07-08 Alcon Research, Ltd. Glaucoma active pressure regulation shunt
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8945214B2 (en) 2011-12-19 2015-02-03 Allergan, Inc. Intravitreal applicator
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
EP2811952A1 (en) 2012-02-07 2014-12-17 On Demand Therapeutics, Inc. Drug delivery devices and methods of use thereof
JP6465490B2 (ja) 2012-03-26 2019-02-06 グローコス コーポレーション インプラント送達装置
US9504603B2 (en) 2012-04-02 2016-11-29 Ocuject, Llc Intraocular delivery devices and methods therefor
WO2014127243A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
AU2014248460B2 (en) 2013-04-01 2019-04-11 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
CA2830555A1 (en) 2013-10-18 2015-04-18 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
HUE050902T2 (hu) 2013-10-31 2021-01-28 Allergan Inc Prosztamidot tartalmazó intraokuláris implantátumok és azok alkalmazási módszerei
CA2950187A1 (en) 2014-05-29 2015-12-03 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
GB2536517B (en) 2014-09-19 2019-05-29 Oxular Ltd Opthalmic drug compositions
CA2980289C (en) 2015-03-20 2024-05-14 Glaukos Corporation Gonioscopic devices
US20180280194A1 (en) 2015-05-20 2018-10-04 Glaukos Corporation Therapeutic drug compositions and implants for delivery of same
KR102268628B1 (ko) 2015-06-03 2021-06-24 아큐시스, 인코포레이티드 안구내 션트의 외부 배치
CA2993407A1 (en) 2015-07-22 2017-01-26 Glaukos Corporation Ocular implants for reduction of intraocular pressure
US20180333296A1 (en) 2015-09-02 2018-11-22 Dose Medical Corporation Drug delivery implants as intraocular drug depots and methods of using same
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20170058811A (ko) 2015-11-19 2017-05-29 글라우코스 코포레이션 전달 장치 시스템 및 녹내장 치료용 임플란트
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
USD833008S1 (en) 2017-02-27 2018-11-06 Glaukos Corporation Gonioscope
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
AU2018338994B2 (en) 2017-09-29 2024-03-28 Glaukos Corporation Intraocular physiological sensor
CN110573117B (zh) 2017-10-06 2021-10-26 格劳科斯公司 用于递送多个眼部植入物的系统和方法
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
US20220119350A1 (en) 2019-02-22 2022-04-21 Glaukos Corporation Compounds for the treatment of ocular disease

Also Published As

Publication number Publication date
JP2024161525A (ja) 2024-11-19
EP3442479A1 (en) 2019-02-20
US20250161110A1 (en) 2025-05-22
US20190125581A1 (en) 2019-05-02
JP7624376B2 (ja) 2025-01-30
CN115120405A (zh) 2022-09-30
WO2017184881A1 (en) 2017-10-26
AU2022201392A1 (en) 2022-03-24
JP7003110B2 (ja) 2022-01-20
AU2017252294B2 (en) 2021-12-02
JP2022024060A (ja) 2022-02-08
US20220313486A1 (en) 2022-10-06
JP2019514640A (ja) 2019-06-06
CN109937025A (zh) 2019-06-25
US11318043B2 (en) 2022-05-03
AU2022201392B2 (en) 2024-02-29
AU2017252294A1 (en) 2018-12-06
CN109937025B (zh) 2022-07-29

Similar Documents

Publication Publication Date Title
AU2022201392B2 (en) Bioresorbable ocular drug delivery device
US12478504B2 (en) Drug eluting ocular implants
US12427057B2 (en) Controlled drug delivery ocular implants and methods of using same
US20240065887A1 (en) Drug delivery implants as intraocular drug depots and methods of using same
US20250375314A1 (en) Drug eluting ocular implant
US20240207091A1 (en) Drug delivery implants with bi-directional delivery capacity and methods of using same
US12478503B2 (en) Implants with controlled drug delivery features and methods of using same
HK40001057B (en) Drug eluting ocular implant
HK40001057A (en) Drug eluting ocular implant

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418

EEER Examination request

Effective date: 20220418