JP2019514640A - 生体吸収性眼球薬物送達デバイス - Google Patents
生体吸収性眼球薬物送達デバイス Download PDFInfo
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- JP2019514640A JP2019514640A JP2019506601A JP2019506601A JP2019514640A JP 2019514640 A JP2019514640 A JP 2019514640A JP 2019506601 A JP2019506601 A JP 2019506601A JP 2019506601 A JP2019506601 A JP 2019506601A JP 2019514640 A JP2019514640 A JP 2019514640A
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- Prior art keywords
- implant
- drug
- shell
- eye
- ocular
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Abstract
Description
Claims (14)
- 対象の眼に移植するように構成された眼移植片であって、
生侵食性材料を含み、内部管腔を画定する形状である、細長い外殻、
前記内部管腔内に位置し、ヒドロゲルを含む、内部プラグ、及び
前記内部管腔内に位置し、薬物を含む、薬物貯蔵器、
を含み、
前記薬物が、前記外殻を通る前記薬物の溶出を制御する前記内部プラグの少なくとも一部を通過するように構成された、眼移植片。 - 前記薬物貯蔵器が前記内部プラグに隣接して位置する、請求項1に記載の眼移植片。
- 前記内部プラグが前記内部管腔の最遠位端に隣接して位置する、請求項1又は2に記載の眼移植片。
- 前記細長い外殻が、前記外殻の遠位端の近くに位置する1個以上のオリフィスを含み、前記オリフィスが、前記ヒドロゲルを通って前記移植片から出て行く前記薬物の溶出を制御するように構成された、請求項1〜3の何れか一項に記載の眼移植片。
- 前記外殻の少なくとも一部を包囲する被膜を更に含む、請求項1〜4の何れか一項に記載の眼移植片。
- 近位障害物を更に含む、請求項1〜5の何れか一項に記載の眼移植片。
- 前記近位障害物が前記外殻の近位端のエンドキャップを形成する、請求項6に記載の眼移植片。
- 前記近位障害物が前記外殻内の前記薬物貯蔵器の近位側近くに位置する、請求項6に記載の眼移植片。
- 前記外殻が、前記薬物のすべて又はほぼすべてが前記移植片の前記内部管腔から溶出した後に生侵食し始めるように構成された、請求項1〜8の何れか一項に記載の眼移植片。
- 前記外殻が、前記移植片の前記内部管腔から溶出する前記薬物の少なくとも一部が前記内部管腔に残留している間に生侵食し始めるように構成された、請求項1〜8の何れか一項に記載の眼移植片。
- 前記移植片が流体流路を更に含む、請求項1〜10の何れか一項に記載の眼移植片。
- 前記移植片が対象の眼内移植用に構成され、前記流体流路が眼液を生理学的流出空間に排出する、請求項1〜11の何れか一項に記載の眼移植片。
- 前記ヒドロゲルが前記内部管腔内の前記薬物の少なくとも一部を包囲する、請求項1に記載の眼移植片。
- 前記移植片が、送達デバイスの23〜25ゲージ針又はカニューレの管腔内に位置する、請求項1に記載の眼移植片。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021185479A JP2022024060A (ja) | 2016-04-20 | 2021-11-15 | 生体吸収性眼球薬物送達デバイス |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662325378P | 2016-04-20 | 2016-04-20 | |
US62/325,378 | 2016-04-20 | ||
PCT/US2017/028665 WO2017184881A1 (en) | 2016-04-20 | 2017-04-20 | Bioresorbable ocular drug delivery device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021185479A Division JP2022024060A (ja) | 2016-04-20 | 2021-11-15 | 生体吸収性眼球薬物送達デバイス |
Publications (3)
Publication Number | Publication Date |
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JP2019514640A true JP2019514640A (ja) | 2019-06-06 |
JP2019514640A5 JP2019514640A5 (ja) | 2020-05-28 |
JP7003110B2 JP7003110B2 (ja) | 2022-01-20 |
Family
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JP2019506601A Active JP7003110B2 (ja) | 2016-04-20 | 2017-04-20 | 生体吸収性眼球薬物送達デバイス |
JP2021185479A Pending JP2022024060A (ja) | 2016-04-20 | 2021-11-15 | 生体吸収性眼球薬物送達デバイス |
Family Applications After (1)
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JP2021185479A Pending JP2022024060A (ja) | 2016-04-20 | 2021-11-15 | 生体吸収性眼球薬物送達デバイス |
Country Status (7)
Country | Link |
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US (2) | US11318043B2 (ja) |
EP (1) | EP3442479A1 (ja) |
JP (2) | JP7003110B2 (ja) |
CN (2) | CN109937025B (ja) |
AU (2) | AU2017252294B2 (ja) |
CA (1) | CA3022830A1 (ja) |
WO (1) | WO2017184881A1 (ja) |
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