JP7054211B2 - 涙腺ドラッグ送給デバイス - Google Patents
涙腺ドラッグ送給デバイス Download PDFInfo
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- JP7054211B2 JP7054211B2 JP2018560843A JP2018560843A JP7054211B2 JP 7054211 B2 JP7054211 B2 JP 7054211B2 JP 2018560843 A JP2018560843 A JP 2018560843A JP 2018560843 A JP2018560843 A JP 2018560843A JP 7054211 B2 JP7054211 B2 JP 7054211B2
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- JP
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- Prior art keywords
- drug
- container
- lumen
- feeding device
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
Description
[定義]
1.WO/2014/113384 7/24/2014 KAHOOK, M. 1/14/2014
2.FLEISHER, D. et al. (1996) “Improved oral drug delivery: solubility limitations overcome by the use of prodrugs,” Advanced Drug Delivery Reviews 19(2), 115-130.
3.MOOBERRY, S. L. et al. (1995) “Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect,” Cancer Letters 96(2), 261-266.
4.RO, A. J. et al. (2012) “Morphological and degradation studies of sirolimus-containing poly(lactide-co-glycolide) discs,” Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(3), 767-777.
5.SMITH, C. D. et al (1994) “A sensitive assay for taxol and other microtubule-stabilizing agents,” Cancer Letters 79(2), 213-219.
Claims (13)
- ドラッグを保持するように構成された容器であって、弛緩状態及び膨張状態間で拡張可能な当該容器;
前記容器に流動的に結合されたコネクタ;
前記コネクタ内に形成された管腔であって、前記ドラッグが前記容器から前記管腔を経て送給個所に流れるように設定されている前記管腔;並びに
前記管腔内のヒドロゲルであって、前記ヒドロゲルは前記容器からの前記ドラッグの送給レートを制御するとともに前記ドラッグを前記管腔から前記送給個所に送給するように構成されている前記ヒドロゲル
を具える涙腺ドラッグ送給デバイスであって、前記ヒドロゲルが、使用前には乾燥状態にあり、そして使用中に湿潤状態にあるように構成され、ここで前記デバイスの埋め込み後に、前記ドラッグが、前記容器からヒドロゲルにより吸収される、涙腺ドラッグ送給デバイス。 - 前記コネクタは第2の管腔を有し、送給ガイドが前記第2の管腔の内部に除去可能に配置されている、請求項1に記載の涙腺ドラッグ送給デバイス。
- 前記送給ガイドがガイドワイヤを有している、請求項2に記載の涙腺ドラッグ送給デバイス。
- 前記ガイドワイヤはこれを貫通する開口部を有し、前記ドラッグがこの開口部を通って送給されて前記容器を弛緩状態から膨張状態に転移させるようにした、請求項3に記載の涙腺ドラッグ送給デバイス。
- 前記涙腺ドラッグ送給デバイスが更に、前記第2の管腔内にバルブを有し、前記送給デバイスが除去された際にこのバルブにより前記第2の管腔を封止する、請求項2に記載の涙腺ドラッグ送給デバイス。
- 前記容器を患者の涙嚢内に送給するように前記容器に着脱自在に結合された送給ガイドをさらに具える、請求項1に記載の涙腺ドラッグ送給デバイス。
- 前記ドラッグの流動抵抗が、前記ヒドロゲルの架橋結合により変更可能である、請求項1に記載の涙腺ドラッグ送給デバイス。
- ドラッグ吸収レートが、前記ヒドロゲルの多孔度により少なくとも部分的に制御されており、ここで多孔度が大きくなると、より早い吸収レートを提供する、請求項1に記載の涙腺ドラッグ送給デバイス。
- 前記コネクタに結合されたフィルタをさらに含み、ここで使用中に前記フィルタを介してドラッグが流れることを許容する一方で、前記フィルタが管腔内にヒドロゲルを封止するように構成された、請求項1に記載の涙腺ドラッグ送給デバイス。
- 前記フィルタが、外部物質が前記ヒドロゲルを汚染するのを防止するものである、請求項9に記載の涙腺ドラッグ送給デバイス。
- 前記フィルタが、使用の間に、前記ドラッグの流れを少なくとも部分的に制御するように構成されている、請求項9に記載の涙腺ドラッグ送給デバイス。
- 前記容器が弾性であり、前記容器が膨張状態において、前記容器が前記ドラッグに圧縮力を及ぼすようになっている、請求項1に記載の涙腺ドラッグ送給デバイス。
- 使用中における前記送給箇所が涙点と鼻涙管の少なくとも1であるように前記デバイスが構成されている、請求項1に記載の涙腺ドラッグ送給デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662339258P | 2016-05-20 | 2016-05-20 | |
US62/339,258 | 2016-05-20 | ||
PCT/US2017/033277 WO2017201255A1 (en) | 2016-05-20 | 2017-05-18 | Lacrimal drug delivery device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019516496A JP2019516496A (ja) | 2019-06-20 |
JP2019516496A5 JP2019516496A5 (ja) | 2020-06-25 |
JP7054211B2 true JP7054211B2 (ja) | 2022-04-13 |
Family
ID=60325609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018560843A Active JP7054211B2 (ja) | 2016-05-20 | 2017-05-18 | 涙腺ドラッグ送給デバイス |
Country Status (6)
Country | Link |
---|---|
US (2) | US11207211B2 (ja) |
EP (1) | EP3458030B1 (ja) |
JP (1) | JP7054211B2 (ja) |
AU (1) | AU2017268379A1 (ja) |
CA (1) | CA3024912A1 (ja) |
WO (1) | WO2017201255A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2897197C (en) | 2013-01-15 | 2022-06-07 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system drug delivery device |
AU2016359288C1 (en) | 2015-11-23 | 2022-03-17 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system for drug delivery |
WO2020028022A1 (en) * | 2018-08-03 | 2020-02-06 | The Johns Hopkins University | Lacrimal canalicular delivery system and methods of use |
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2017
- 2017-05-18 JP JP2018560843A patent/JP7054211B2/ja active Active
- 2017-05-18 EP EP17800154.1A patent/EP3458030B1/en active Active
- 2017-05-18 WO PCT/US2017/033277 patent/WO2017201255A1/en unknown
- 2017-05-18 US US16/302,514 patent/US11207211B2/en active Active
- 2017-05-18 AU AU2017268379A patent/AU2017268379A1/en not_active Abandoned
- 2017-05-18 CA CA3024912A patent/CA3024912A1/en active Pending
-
2021
- 2021-11-11 US US17/524,610 patent/US20220062037A1/en active Pending
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JP2009532133A (ja) | 2006-03-31 | 2009-09-10 | キューエルティー プラグ デリバリー,インク. | 鼻涙系用の薬物送達方法、構造および組成物 |
JP2009544355A (ja) | 2006-07-20 | 2009-12-17 | ニューロシステック コーポレイション | 眼科薬物送達のためのデバイス、システム、および方法 |
WO2010092735A1 (ja) | 2009-02-10 | 2010-08-19 | 千寿製薬株式会社 | リング状デバイス |
JP2012517330A (ja) | 2009-02-12 | 2012-08-02 | インセプト エルエルシー | ヒドロゲルプラグによる薬物送達 |
JP2015109990A (ja) | 2009-12-29 | 2015-06-18 | アクラレント インコーポレイテッド | 拡開カテーテル |
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JP2016508064A (ja) | 2013-01-15 | 2016-03-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 涙器系薬剤送達装置 |
Also Published As
Publication number | Publication date |
---|---|
JP2019516496A (ja) | 2019-06-20 |
US20190274877A1 (en) | 2019-09-12 |
EP3458030A4 (en) | 2019-11-20 |
EP3458030A1 (en) | 2019-03-27 |
CA3024912A1 (en) | 2017-11-23 |
WO2017201255A1 (en) | 2017-11-23 |
US20220062037A1 (en) | 2022-03-03 |
AU2017268379A1 (en) | 2018-12-06 |
EP3458030B1 (en) | 2021-05-12 |
US11207211B2 (en) | 2021-12-28 |
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