ATE476960T1 - System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges - Google Patents

System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges

Info

Publication number
ATE476960T1
ATE476960T1 AT05025475T AT05025475T ATE476960T1 AT E476960 T1 ATE476960 T1 AT E476960T1 AT 05025475 T AT05025475 T AT 05025475T AT 05025475 T AT05025475 T AT 05025475T AT E476960 T1 ATE476960 T1 AT E476960T1
Authority
AT
Austria
Prior art keywords
eye
polymer
body member
extension
bioactive agent
Prior art date
Application number
AT05025475T
Other languages
English (en)
Inventor
Aron B Anderson
Laurie R Lawin
Byron C Shen
Juan Eugene De
Signe E Varner
Ralph A Chappa
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33435072&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE476960(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of ATE476960T1 publication Critical patent/ATE476960T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00353—Bone cement, e.g. polymethylmethacrylate or PMMA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Prostheses (AREA)
AT05025475T 2003-05-02 2004-04-29 System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges ATE476960T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46741903P 2003-05-02 2003-05-02

Publications (1)

Publication Number Publication Date
ATE476960T1 true ATE476960T1 (de) 2010-08-15

Family

ID=33435072

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05025475T ATE476960T1 (de) 2003-05-02 2004-04-29 System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges

Country Status (8)

Country Link
US (7) US8021680B2 (de)
EP (1) EP1633320A2 (de)
JP (3) JP4824549B2 (de)
AT (1) ATE476960T1 (de)
AU (1) AU2004237774B2 (de)
CA (1) CA2524271C (de)
DE (1) DE602004028638D1 (de)
WO (1) WO2004098565A2 (de)

Families Citing this family (243)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
ATE219693T1 (de) * 1998-04-27 2002-07-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
DE602004028638D1 (de) * 2003-05-02 2010-09-23 Surmodics Inc System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
ATE417637T1 (de) * 2003-08-19 2009-01-15 Polybiomed Ltd Polymerisches arzneimittelfreisetzungssystem für medizinische geräte
CA2535857A1 (en) * 2003-08-29 2005-03-10 Mayo Foundation For Medical Education And Research Hydrogel porogens for fabricating biodegradable scaffolds
EP1663469A4 (de) 2003-09-05 2009-01-07 Univ Massachusetts Kapseln aus amphiphilem polymer und zugehörige verfahren zum grenzflächenfügen
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US20050222613A1 (en) * 2004-02-05 2005-10-06 Edwin Ryan Wound closure device and method for vitrectomy
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
JP2007532187A (ja) * 2004-04-06 2007-11-15 サーモディクス，インコーポレイティド 生物活性物質のためのコーティング組成物
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
WO2006014484A2 (en) 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
CA2572592C (en) 2004-07-02 2015-09-08 Eliot Lazar Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
US8541028B2 (en) 2004-08-04 2013-09-24 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
US20060034891A1 (en) * 2004-08-12 2006-02-16 Laurie Lawin Biodegradable controlled release bioactive agent delivery device
EP1809678B1 (de) * 2004-11-12 2013-05-22 Mayo Foundation for Medical Education and Research Photovernetzbare poly-(caprolacton-fumarate)
US20060134168A1 (en) * 2004-12-07 2006-06-22 Chappa Ralph A Coatings with crystallized active agent(s) and methods
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
AU2006220567A1 (en) * 2005-03-07 2006-09-14 The Regents Of The University Of California Medical implants
JP2008535563A (ja) * 2005-04-06 2008-09-04 サーモディクス，インコーポレイティド 生物活性剤のためのコーティング組成物
US20060228390A1 (en) * 2005-04-07 2006-10-12 Williams David F Intravitreal implant
US8003124B2 (en) * 2005-04-08 2011-08-23 Surmodics, Inc. Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease
ATE511439T1 (de) * 2005-04-29 2011-06-15 Mayo Foundation Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon
US20070027452A1 (en) * 2005-05-18 2007-02-01 Varner Signe E Insertion instrument for non-linear medical devices
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
US7833463B1 (en) * 2005-07-18 2010-11-16 Advanced Neuromodulation Systems, Inc. System and method for removing an organic film from a selected portion of an implantable medical device using an infrared laser
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
ES2441608T3 (es) 2005-08-18 2014-02-05 Zimmer Gmbh Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ulra-alto
ES2380651T3 (es) * 2005-09-01 2012-05-17 Bristol-Myers Squibb Company Biomarcadores y procedimientos para determinar la sensibilidad a moduladores de recpetor 2 del factor de crecimiento endotelial vascular
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
WO2007035865A1 (en) * 2005-09-21 2007-03-29 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
ATE540705T1 (de) 2005-09-21 2012-01-15 Surmodics Inc Überzüge und artikel mit natürlichen biologisch abbaubaren polysacchariden
US8166909B2 (en) * 2005-11-15 2012-05-01 Surmodics, Inc. Apparatus and methods for applying coatings
US8840660B2 (en) * 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
JP5819579B2 (ja) * 2006-01-13 2015-11-24 サーモディクス，インコーポレイティド 薬物送達のためのマトリックスを含む微粒子
WO2007084582A2 (en) * 2006-01-17 2007-07-26 Forsight Labs, Llc Drug delivery treatment device
ES3042426T3 (en) 2006-01-17 2025-11-20 Alcon Inc Glaucoma treatment device
US8089029B2 (en) * 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US7919111B2 (en) * 2006-03-15 2011-04-05 Surmodics, Inc. Biodegradable hydrophobic polysaccharide-based drug delivery implants
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) * 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
SG170806A1 (en) 2006-03-31 2011-05-30 Qlt Plug Delivery Inc Nasolacrimal drainage system implants for drug therapy
US8048150B2 (en) * 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
CA2656191C (en) * 2006-06-28 2015-12-08 Surmodics, Inc. Hydrophilic active agent eluting polymeric matrices with microparticles
US8968782B2 (en) * 2006-06-28 2015-03-03 Surmodics, Inc. Combination degradable and non-degradable matrices for active agent delivery
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
JP2009542359A (ja) * 2006-06-29 2009-12-03 ボストン サイエンティフィック リミテッド 選択的被覆部を備えた医療装置
JP2009545407A (ja) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド 三次元分解制御を備えたエンドプロテーゼ
WO2008022258A2 (en) * 2006-08-16 2008-02-21 Surmodics, Inc. Methods and materials for increasing the adhesion of elution control matrices to substrates
ATE508708T1 (de) 2006-09-14 2011-05-15 Boston Scient Ltd Medizinprodukte mit wirkstofffreisetzender beschichtung
WO2008034048A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663250A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
EP2959925B1 (de) * 2006-09-15 2018-08-29 Boston Scientific Limited Medizinische vorrichtungen und verfahren zu ihrer herstellung
US8002821B2 (en) * 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
WO2008036457A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Controlling biodegradation of a medical instrument
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
WO2008088593A2 (en) * 2006-09-27 2008-07-24 Surmodics, Inc. Additives and methods for enhancing active agent elution kinetics
CA2664879C (en) * 2006-09-29 2015-03-24 Surmodics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
US20080086195A1 (en) * 2006-10-05 2008-04-10 Boston Scientific Scimed, Inc. Polymer-Free Coatings For Medical Devices Formed By Plasma Electrolytic Deposition
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
ATE488259T1 (de) 2006-12-28 2010-12-15 Boston Scient Ltd Bioerodierbare endoprothesen und herstellungsverfahren dafür
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
FR2915087B1 (fr) 2007-04-20 2021-11-26 Corevalve Inc Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant.
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2173289A4 (de) * 2007-07-17 2010-11-24 Transcend Medical Inc Augenimplantat mit hydrogelausdehnungsfähigkeiten
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
US8815273B2 (en) * 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) * 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
WO2009020520A1 (en) * 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
ES2732555T3 (es) 2007-09-07 2019-11-25 Mati Therapeutics Inc Implantes lagrimales y métodos relacionados
MX2010002619A (es) 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Deteccion de implante lagrimal.
CN102670352A (zh) * 2007-09-07 2012-09-19 Qlt股份有限公司 用于泪腺植入物的插入和抽出工具
ES2533359T3 (es) * 2007-09-07 2015-04-09 Mati Therapeutics Inc. Núcleos de fármaco para liberación sostenida de agentes terapéuticos
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090214601A1 (en) * 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8029554B2 (en) * 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US20090143855A1 (en) * 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
US20100008970A1 (en) * 2007-12-14 2010-01-14 Boston Scientific Scimed, Inc. Drug-Eluting Endoprosthesis
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
US8167787B2 (en) 2008-01-03 2012-05-01 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
EP2242520A2 (de) * 2008-01-14 2010-10-27 SurModics, Inc. Vorrichtungen und verfahren zur elution von nukleinsäure-zuführungskomplexen
EP2257250A2 (de) 2008-01-29 2010-12-08 Gilbert H. Kliman Arzneimittelspendevorrichtungen, kits und verfahren dafür
WO2009105178A2 (en) * 2008-02-18 2009-08-27 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
WO2009126830A2 (en) * 2008-04-09 2009-10-15 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
US8496954B2 (en) * 2008-04-18 2013-07-30 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
ES2423504T3 (es) 2008-04-22 2013-09-20 Boston Scientific Scimed, Inc. Dispositivos médicos que tienen un recubrimiento de material inorgánico
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
CN104623741A (zh) 2008-04-30 2015-05-20 马缇医疗股份有限公司 复合泪管植入物及相关方法
CA2723192A1 (en) * 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US7998192B2 (en) * 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
EP2276492A2 (de) * 2008-05-09 2011-01-26 QLT Plug Delivery, Inc. Verzögerte freisetzung von wirkstoffen zur behandlung von glaukom oder okularer hypertonie
WO2009140197A1 (en) 2008-05-12 2009-11-19 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US9439801B2 (en) 2012-06-29 2016-09-13 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2009155328A2 (en) 2008-06-18 2009-12-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
US8459310B2 (en) * 2008-07-24 2013-06-11 Surmodics, Inc. Systems and methods for filling medical device lumen
US7985252B2 (en) * 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) * 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
WO2010096045A1 (en) 2008-10-30 2010-08-26 Nectid, Inc. Novel and potent tapentadol dosage forms
US10842669B2 (en) 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
US10272035B2 (en) 2008-11-13 2019-04-30 Gholam A. Peyman Ophthalmic drug delivery method
US20110125090A1 (en) 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
JP2012509737A (ja) * 2008-11-26 2012-04-26 サーモディクス，インコーポレイティド 埋め込み式の眼薬送達器具および眼薬送達方法
US8231980B2 (en) * 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
AU2010208046B2 (en) 2009-01-29 2014-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
US20100191168A1 (en) * 2009-01-29 2010-07-29 Trustees Of Tufts College Endovascular cerebrospinal fluid shunt
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CA2752645C (en) * 2009-02-23 2017-10-03 Qlt Inc. Lacrimal implants and related methods
WO2010101901A2 (en) * 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) * 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP3412260B1 (de) 2009-05-18 2020-08-26 Dose Medical Corporation Arzneimittelfreisetzendes augenimplantat
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US8802121B2 (en) 2009-06-02 2014-08-12 Surmodics, Inc. Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices for implantation or injection
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
US8586731B2 (en) * 2009-06-11 2013-11-19 Surmodics, Inc. Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20110091518A1 (en) * 2009-09-22 2011-04-21 Danielle Biggs Implant devices having varying bioactive agent loading configurations
US20110166555A1 (en) * 2009-09-30 2011-07-07 Jianbo Zhou Carrier for an insertable medical device, insertion tools, methods of use, and kits
WO2011041517A1 (en) * 2009-09-30 2011-04-07 Surmodics, Inc. Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US8568760B2 (en) * 2009-12-30 2013-10-29 Surmodics, Inc. Hydrophobic polysaccharides with pendent groups having terminal reactive functionalities and medical uses thereof
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
EP2547297A4 (de) 2010-03-19 2014-08-06 Revent Medical Inc Systeme und verfahren zur behandlung von schlafapnoe
CA2793213A1 (en) 2010-03-19 2011-09-22 Revent Medical Inc. Systems and methods for treatment of sleep apnea
WO2011119573A1 (en) * 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
JP2013526392A (ja) 2010-05-21 2013-06-24 レベント メディカル インコーポレイテッド 睡眠時無呼吸を治療するためのシステム及び方法
JP2013538075A (ja) 2010-07-26 2013-10-10 レベント メディカル インコーポレイテッド 睡眠時無呼吸を治療するためのシステム及び方法
EP2600930B1 (de) 2010-08-05 2021-02-17 ForSight Vision4, Inc. Injektionsapparat zur verabreichung von medikamenten
DK2600812T3 (da) 2010-08-05 2021-10-18 Forsight Vision4 Inc Apparat til at behandle et øje
JP6111194B2 (ja) 2010-08-05 2017-04-05 フォーサイト・ビジョン フォー・インコーポレーテッド 組み合わせ薬物送達方法および装置
US20120100187A1 (en) 2010-10-26 2012-04-26 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP2654715B1 (de) 2010-11-24 2017-01-25 Dose Medical Corporation Arzneimittelfreisetzendes augenimplantat
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP4249059B1 (de) 2011-06-28 2025-07-30 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
DK3290024T3 (da) 2011-08-29 2019-06-03 Mati Therapeutics Inc Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
EP2755615B1 (de) 2011-09-14 2022-04-06 Forsight Vision5, Inc. Augeneinsatzvorrichtung
EP2755546A4 (de) * 2011-09-15 2015-08-12 Yoseph Yaacobi Systeme und verfahren zur behandlung von ohrerkrankungen
HUE054578T2 (hu) 2011-09-16 2021-09-28 Forsight Vision4 Inc Fluidumcserélõ berendezés
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US20150031772A1 (en) * 2012-02-17 2015-01-29 Bacterin International, Inc. Adjustable bioactive agent dispersion within a polymeric coating
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
MX351261B (es) 2012-06-01 2017-10-06 Surmodics Inc Aparato y método para recubrir catéteres con globo.
EP2887906B1 (de) * 2012-08-22 2016-12-28 California Institute of Technology Drahtloses stromübertragungssystem mit drei spulen für augenimplantate
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
AU2014256955B2 (en) 2013-04-25 2018-02-22 Innovative Surface Technologies, Inc. Coatings for controlled release of highly water soluble drugs
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
EP3998100A1 (de) 2014-01-15 2022-05-18 Tufts Medical Center, Inc. Endovaskulärer shunt system für rückenmarksflüssigkeit
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
US10184031B2 (en) 2014-03-12 2019-01-22 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4242614A3 (de) 2014-07-01 2023-11-29 Injectsense, Inc. Hermetisch abgedichtete implantatsensoren mit senkrechter stapelarchitektur
JP2017520327A (ja) 2014-07-01 2017-07-27 インジェクトセンス， インコーポレイテッド 眼内圧センサを移植するための方法およびデバイス
EP3679908B1 (de) 2014-07-15 2024-09-04 ForSight Vision4, Inc. Vorrichtung zur einführung von augenimplantaten
CN107106551A (zh) 2014-08-08 2017-08-29 弗赛特影像4股份有限公司 受体酪氨酸激酶抑制剂的稳定且可溶的制剂和其制备方法
BR112017009660A2 (pt) 2014-11-10 2017-12-19 Forsight Vision4 Inc dispositivos de administração de fármacos expansíveis e métodos de utilização
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
EP3299494B1 (de) * 2015-05-21 2021-10-13 Toyo Seikan Group Holdings, Ltd. Metallbleich mit behandelter oberfläche und metallblech mit behandelter oberfläche mit beschichtung aus organischem harz
EP3319553B1 (de) * 2015-08-14 2024-01-31 Willis, Timothy R. Intraokularlinsen (iol) und verwandte anordnungen
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
US11432959B2 (en) 2015-11-20 2022-09-06 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
EP3419682B1 (de) 2016-02-24 2024-04-03 Innovative Surface Technologies, Inc. Kristallisationsinhibitorzusammensetzungen für implantierbare urologische vorrichtungen
US10610669B2 (en) 2016-03-16 2020-04-07 Krishna Rocha-Singh, M.D. Apparatus and method for promoting angiogenesis in ischemic tissue
US10065018B2 (en) 2016-03-16 2018-09-04 Krishna Rocha-Singh Apparatus and method for promoting angiogenesis in ischemic tissue
US11617680B2 (en) 2016-04-05 2023-04-04 Forsight Vision4, Inc. Implantable ocular drug delivery devices
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
CN109562242B (zh) 2016-06-09 2022-03-29 波士顿科学国际有限公司 输注导管
EP3522850B1 (de) * 2016-10-05 2023-12-27 Arizona Board of Regents on behalf of the University of Arizona Verfahren und systeme zur verbesserung der immunsystemreaktionen
CN110267526B (zh) 2016-11-03 2022-06-24 代表亚利桑那大学的亚利桑那董事会 用于在移植前后实时评估包封装置中细胞的方法和系统
CN116919648A (zh) 2016-11-03 2023-10-24 代表亚利桑那大学的亚利桑那董事会 有或无氧气输送的堆叠组织包封装置的系统
EP3534834A4 (de) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Verkapselungsvorrichtungssysteme mit sauerstoffsensoren mit oder ohne exogener sauerstoffzufuhr
JP7314155B2 (ja) 2017-11-21 2023-07-25 フォーサイト・ビジョン４・インコーポレーテッド 膨張可能ポート送達システムのための流体交換装置及びその使用方法
MX2020012458A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11338119B2 (en) * 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
KR20230117119A (ko) 2020-10-30 2023-08-07 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 세포 및 물질을 수용하기 위한 캡슐화 장치에 대한 방법 및 시스템
US11246682B1 (en) * 2020-11-09 2022-02-15 Elliott Jolley Systems and methods for providing an orthodontic spring
US12496612B2 (en) 2021-01-08 2025-12-16 Surmodics, Inc. Coating application system and methods for coating rotatable medical devices
WO2022231930A1 (en) 2021-04-26 2022-11-03 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26176A (en) * 1859-11-22 Sawmill
US273410A (en) * 1883-03-06 Gelatine eye-disk
US21828A (en) * 1858-10-19 Perry g
US31780A (en) * 1861-03-26 Device for forming horseshoes
US120174A (en) * 1871-10-24 Improvement in feather-renovators
US158598A (en) * 1875-01-12 Improvement in culinary vessels
US114823A (en) * 1871-05-16 Improvement in presser-feet for sewing-machines
US168394A (en) * 1875-10-05 Improvement in children s carriages
US165265A (en) * 1875-07-06 Improvement in table-leaf lifters and supporters
US14036A (en) * 1856-01-01 Improvement in grain-binders for harvesters
US32434A (en) * 1861-05-28 Improvement in animal-traps
US188037A (en) * 1877-03-06 Improvement in suspension hooks and clasps
US47911A (en) * 1865-05-30 Improvement in waxed-thread sewing-machines
US22853A (en) * 1859-02-08 John l
US198511A (en) * 1877-12-25 Improvement in harness-saddles
US3416530A (en) * 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US4000745A (en) 1968-08-05 1977-01-04 Goldberg Edward M Electrical leads for cardiac stimulators and related methods and means
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4206756A (en) 1977-03-23 1980-06-10 Murray Grossan Jet ear irrigation system
US4146036A (en) 1977-10-06 1979-03-27 Medtronic, Inc. Body-implantable lead with protector for tissue securing means
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
US4209019A (en) 1979-01-05 1980-06-24 Medtronic, Inc. Stylet insertion guide and rotation control device for use with body implantable lead
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4678466A (en) 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4892736A (en) * 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
GB8527071D0 (en) 1985-11-04 1985-12-11 Biocompatibles Ltd Plastics
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5229128A (en) 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5114719A (en) 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4819661A (en) 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Positive fixation cardiac electrode with drug elution capabilities
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4936825A (en) 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US6514238B1 (en) 1989-08-14 2003-02-04 Photogenesis, Inc. Method for preparation and transplantation of volute grafts and surgical instrument therefor
US4972848A (en) 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
US5002067A (en) 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
US4953564A (en) 1989-08-23 1990-09-04 Medtronic, Inc. Screw-in drug eluting lead
US5003992A (en) 1989-08-23 1991-04-02 Holleman Timothy W Atraumatic screw-in lead
US5525348A (en) 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5255693A (en) 1989-11-02 1993-10-26 Possis Medical, Inc. Cardiac lead
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5076285A (en) 1990-03-30 1991-12-31 Medtronic, Inc. Screw-in lead
US5120312A (en) * 1990-04-20 1992-06-09 Regents Of The University Of Minnesota Method and apparatus for catheterization
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
KR0185215B1 (ko) * 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
AU1579092A (en) 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5364343A (en) 1991-03-06 1994-11-15 D.D. S.R.L. Irrigation device for use in ear canals for therapeutic or hygienic purposes
US5324325A (en) 1991-06-27 1994-06-28 Siemens Pacesetter, Inc. Myocardial steroid releasing lead
US5221698A (en) 1991-06-27 1993-06-22 The Regents Of The University Of Michigan Bioactive composition
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5246867A (en) * 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
EP0625887B1 (de) 1992-02-14 1998-10-14 Smith & Nephew, Inc. Polymere schrauben und beschichtungen zum chirurgischen gebrauch
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
IT1259100B (it) 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
US5447533A (en) 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5314419A (en) 1992-10-30 1994-05-24 Pelling George E Method for dispensing ophthalmic drugs to the eye
US5578075B1 (en) * 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
EP0604022A1 (de) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Mehrschichtiges resorbierbares Stent und Verfahren zu dessen Herstellung
US5300108A (en) 1993-01-05 1994-04-05 Telectronics Pacing Systems, Inc. Active fixation lead with a dual-pitch, free spinning compound screw
US5523092A (en) * 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5673473A (en) * 1993-06-25 1997-10-07 Medtronic, Inc. Method of surface finishing a medical device shield using metallic media
DK0797988T3 (da) 1993-07-19 2009-05-11 Univ British Columbia Anti-angiogene præparater og fremgangsmåder til anvendelse deraf
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US5385148A (en) 1993-07-30 1995-01-31 The Regents Of The University Of California Cardiac imaging and ablation catheter
US5921982A (en) 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
WO1995003843A1 (en) 1993-07-30 1995-02-09 The Regents Of The University Of California Endocardial infusion catheter
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5431649A (en) 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5405376A (en) 1993-08-27 1995-04-11 Medtronic, Inc. Method and apparatus for ablation
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5849843A (en) 1993-11-16 1998-12-15 Baxter International Inc. Polymeric compositions for medical packaging and devices
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5472436A (en) 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5554114A (en) 1994-10-20 1996-09-10 Micro Therapeutics, Inc. Infusion device with preformed shape
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US20020091433A1 (en) 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
DE69623455T2 (de) 1995-04-19 2003-01-16 Schneider (Usa) Inc., Plymouth Beschichteter dilatator zur abgabe eines arzneistoffs
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5731087A (en) * 1995-06-07 1998-03-24 Union Carbide Chemicals & Plastics Technology Corporation Lubricious coatings containing polymers with vinyl and carboxylic acid moieties
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5810836A (en) 1996-03-04 1998-09-22 Myocardial Stents, Inc. Device and method for trans myocardial revascularization (TMR)
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US20030094736A1 (en) 1996-05-03 2003-05-22 Chuan Qin Method of surface modifying a medical tubing
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
ZA978537B (en) * 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6053924A (en) 1996-11-07 2000-04-25 Hussein; Hany Device and method for trans myocardial revascularization
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US20030157187A1 (en) 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
US6547787B1 (en) 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
KR100523199B1 (ko) 1997-03-31 2005-10-21 알자 코포레이션 확산 주입형 투여 시스템 및 투여 방법, 및 그 시스템의 제조 방법
US6214008B1 (en) 1997-04-16 2001-04-10 White Spot Ag Biodegradable osteosynthesis implant
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
AU738338B2 (en) 1997-08-11 2001-09-13 Allergan, Inc. Sterile bioerodible implant device with improved biocompatability and method
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US6214434B1 (en) * 1997-09-02 2001-04-10 Seagate Technology Llc Isolated single-domain high-density magnetic recording media and method of manufacturing the media
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5980548A (en) 1997-10-29 1999-11-09 Kensey Nash Corporation Transmyocardial revascularization system
US6501994B1 (en) 1997-12-24 2002-12-31 Cardiac Pacemakers, Inc. High impedance electrode tip
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6251418B1 (en) 1997-12-18 2001-06-26 C.R. Bard, Inc. Systems and methods for local delivery of an agent
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
DE69838526T2 (de) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Gerät zum Freisetzen eines Medikaments im Herzen
DE69820023T2 (de) 1998-03-26 2004-09-02 Biomat B.V. Endovaskuläre Gefässprothesen mit polymerer Beschichtung
US6091978A (en) 1998-04-07 2000-07-18 Cardiac Pacemakers, Inc. Removable cap for tissue-insertable connections
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
ATE219693T1 (de) * 1998-04-27 2002-07-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
JP2002518141A (ja) 1998-06-22 2002-06-25 ネオヴェイシス インコーポレイテッド 組織内の血流を増大させる方法、インプラントおよび配給システム
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6102887A (en) 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
EP1600125A3 (de) 1998-09-29 2006-08-30 C.R.Bard, Inc. Spiralförmig gewickelter Stent zur Medikamentenabgabe
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
US6399655B1 (en) * 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6530950B1 (en) 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
FR2788955B1 (fr) * 1999-01-28 2001-04-06 Cie Mediterraneenne Des Cafes Dispositif pour l'extraction de cafe
US20040121014A1 (en) 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6298272B1 (en) 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US6719805B1 (en) 1999-06-09 2004-04-13 C. R. Bard, Inc. Devices and methods for treating tissue
JP2003508185A (ja) 1999-08-03 2003-03-04 スミス アンド ネフュー インコーポレーテッド 埋め込み型制御放出装置
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6706023B1 (en) 1999-12-03 2004-03-16 Bionix Development Corporation Device for irrigation of a blind orifice
EP1104681A1 (de) 1999-12-03 2001-06-06 Biomat B.V. Draht, Schlauch oder Katheter mit Feuchthaltemittelbeschichtung
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6360129B1 (en) 1999-12-13 2002-03-19 Cardiac Pacemakers, Inc. Mannitol/hydrogel cap for tissue-insertable connections
AU775590B2 (en) * 2000-01-25 2004-08-05 Edwards Lifesciences Corporation Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia
EP1409058A2 (de) * 2000-01-28 2004-04-21 William Cook Europe ApS Medizinische endovaskuläre vorrichtung mit einer mehrzahl von drähten
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
WO2001078626A1 (en) 2000-04-13 2001-10-25 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20020007214A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007213A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007215A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020005206A1 (en) 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US6506408B1 (en) * 2000-07-13 2003-01-14 Scimed Life Systems, Inc. Implantable or insertable therapeutic agent delivery device
US6743233B1 (en) * 2000-08-02 2004-06-01 Orthopaedic Biosystems, Ltd., Inc. Medical screw and method of installation
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US6613017B1 (en) 2000-08-08 2003-09-02 Scimed Life Systems, Inc. Controlled depth injection device and method
US6595958B1 (en) 2000-08-08 2003-07-22 Scimed Life Systems, Inc. Tortuous path injection device and method
DK1313415T3 (da) * 2000-08-30 2008-10-13 Univ Johns Hopkins Indretninger til intraokulær lægemiddeladministration
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
JP5100951B2 (ja) 2000-09-29 2012-12-19 コーディス・コーポレイション 被覆医用器具
US20020051730A1 (en) 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
DE60129578T2 (de) 2000-10-31 2008-04-03 Med Institute, Inc., West Lafayette Beschichtete, implantierbare medizinische geräte
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6824559B2 (en) 2000-12-22 2004-11-30 Advanced Cardiovascular Systems, Inc. Ethylene-carboxyl copolymers as drug delivery matrices
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US6673453B2 (en) 2001-06-12 2004-01-06 Biocoat Incorporated Coatings appropriate for medical devices
US7485113B2 (en) 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
US20040142013A1 (en) 2001-07-13 2004-07-22 Flow Focusing, Inc. Implantable orthopedic surgical devices with controlled release antimicrobial component
US20050129732A1 (en) 2001-07-13 2005-06-16 Flow Focusing, Inc. Biodegradable, antibiotic, controlled release tape
US6497691B1 (en) 2001-08-24 2002-12-24 Polymer Group, Inc. Structurally durable, drapeable breathable barrier film compositions and articles
US8303651B1 (en) 2001-09-07 2012-11-06 Advanced Cardiovascular Systems, Inc. Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US6916321B2 (en) 2001-09-28 2005-07-12 Ethicon, Inc. Self-tapping resorbable two-piece bone screw
US20030097736A1 (en) * 2001-11-28 2003-05-29 Willis Blankenship Article securing strap assembly
US6764470B2 (en) 2001-12-03 2004-07-20 Roland P. Dimick Ear plug medication administration device
WO2003071986A2 (en) 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
WO2003079936A1 (en) 2002-03-18 2003-10-02 Medtronic Ave Inc. Medical devices for delivering anti-proliferative compositions to anatomical sites at risk for restenosis
EP1505931A1 (de) 2002-05-20 2005-02-16 Orbus Medical Technologies, Inc. Arznei-eluierende implantierbare medizinische vorrichtung
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US20040138695A1 (en) 2002-06-18 2004-07-15 Shu-Tung Li Coatings of implants
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
US20030236513A1 (en) 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7169162B2 (en) 2002-07-03 2007-01-30 Orbusneich Medical, Inc. Balloon catheter
US20040006146A1 (en) 2002-07-06 2004-01-08 Evans Douglas G. Resorbable structure for treating and healing of tissue defects
ATE459380T1 (de) 2002-08-13 2010-03-15 Medtronic Inc Darreichungssysteme von wirkstoffen mit poly(ethylene-co(meth)akrylate, medizinische vorrichtung und verfahren
US6731087B1 (en) * 2002-08-19 2004-05-04 Huang Chin-Cheng Fan motor
JP3642063B2 (ja) * 2002-08-22 2005-04-27 株式会社村田製作所 テルビウム・アルミニウム系常磁性ガーネット単結晶の製造方法
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
WO2004028477A2 (en) 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US7103418B2 (en) 2002-10-02 2006-09-05 Medtronic, Inc. Active fluid delivery catheter
US20040137059A1 (en) 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
DE602004028638D1 (de) 2003-05-02 2010-09-23 Surmodics Inc System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat

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AU2004237774B2 (en) 2009-09-10
US8021680B2 (en) 2011-09-20
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US7976862B2 (en) 2011-07-12
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US20050281863A1 (en) 2005-12-22
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AU2004237774A1 (en) 2004-11-18

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