JP2018536484A5 - - Google Patents
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- Publication number
- JP2018536484A5 JP2018536484A5 JP2018526903A JP2018526903A JP2018536484A5 JP 2018536484 A5 JP2018536484 A5 JP 2018536484A5 JP 2018526903 A JP2018526903 A JP 2018526903A JP 2018526903 A JP2018526903 A JP 2018526903A JP 2018536484 A5 JP2018536484 A5 JP 2018536484A5
- Authority
- JP
- Japan
- Prior art keywords
- xerogel
- hydrogel
- composition
- precursor
- rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 22
- 239000002243 precursor Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 239000007864 aqueous solution Substances 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 9
- 230000008961 swelling Effects 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- 238000012377 drug delivery Methods 0.000 claims 3
- 125000003827 glycol group Chemical group 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 210000001525 retina Anatomy 0.000 claims 3
- 210000003161 choroid Anatomy 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 210000003786 sclera Anatomy 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000004127 vitreous body Anatomy 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960003005 axitinib Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000001851 biosynthetic effect Effects 0.000 claims 1
- 210000005252 bulbus oculi Anatomy 0.000 claims 1
- 210000000795 conjunctiva Anatomy 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260068P | 2015-11-25 | 2015-11-25 | |
| US62/260,068 | 2015-11-25 | ||
| US201662319033P | 2016-04-06 | 2016-04-06 | |
| US62/319,033 | 2016-04-06 | ||
| PCT/US2016/063633 WO2017091749A1 (en) | 2015-11-25 | 2016-11-23 | Shape changing drug delivery devices and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018536484A JP2018536484A (ja) | 2018-12-13 |
| JP2018536484A5 true JP2018536484A5 (enExample) | 2020-01-09 |
Family
ID=57590829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526903A Pending JP2018536484A (ja) | 2015-11-25 | 2016-11-23 | 形状変化する薬物送達デバイス及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10420724B2 (enExample) |
| EP (1) | EP3380077B1 (enExample) |
| JP (1) | JP2018536484A (enExample) |
| KR (1) | KR20180086468A (enExample) |
| CN (1) | CN108601725B (enExample) |
| AU (1) | AU2016361579B2 (enExample) |
| BR (1) | BR112018010671A8 (enExample) |
| CA (1) | CA3006303C (enExample) |
| IL (1) | IL259530A (enExample) |
| WO (1) | WO2017091749A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170094793A (ko) | 2014-12-15 | 2017-08-21 | 더 존스 홉킨스 유니버시티 | 수니티닙 제제 및 녹내장의 치료에서의 그의 사용 방법 |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
| MX2018005932A (es) | 2015-11-12 | 2019-05-20 | Graybug Vision Inc | Microparticulas aglomerantes para terapia medica. |
| WO2017091749A1 (en) * | 2015-11-25 | 2017-06-01 | Incept, Llc | Shape changing drug delivery devices and methods |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| WO2018005848A1 (en) | 2016-06-29 | 2018-01-04 | Bright, Corinne | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| US12171869B2 (en) | 2016-09-23 | 2024-12-24 | Incept, Llc | Intracameral drug delivery depots |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| CN108744048B (zh) * | 2018-06-29 | 2020-11-13 | 重庆科技学院 | 一种可实现自卷曲的双层水凝胶及其制备方法 |
| CN117599244A (zh) | 2018-07-02 | 2024-02-27 | 图拉维治疗股份有限公司 | 原位形成神经帽的方法和装置 |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| EP3877034A1 (en) * | 2018-11-09 | 2021-09-15 | TARIS Biomedical LLC | Drug delivery devices and systems for local drug delivery to the upper urinary tract |
| CN109350355B (zh) * | 2018-11-30 | 2023-09-12 | 西安市第四医院 | 一种smile手术来源角膜基质透镜泪道栓及其制备方法 |
| US11523896B2 (en) | 2019-05-02 | 2022-12-13 | Kevin L. Waltz | Ocular protection ring |
| KR20250051157A (ko) | 2019-06-05 | 2025-04-16 | 리제너론 파아마슈티컬스, 인크. | 정밀 투여량 전달을 위한 디바이스 및 방법 |
| CN111150545A (zh) * | 2020-01-02 | 2020-05-15 | 首都医科大学附属北京同仁医院 | 一种相变降温支架及其制备方法和相变降温组合支架 |
| IL295357B1 (en) | 2020-02-06 | 2025-12-01 | Ocular Therapeutix Inc | Travoprost sustained-release biodegradable intracameral implants for use in the treatment of ocular diseases |
| TW202202138A (zh) | 2020-03-25 | 2022-01-16 | 美商歐克萊製藥公司 | 含有酪胺酸激酶抑制劑之眼用植入物 |
| CA3177005A1 (en) | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| WO2022056392A1 (en) | 2020-09-14 | 2022-03-17 | EyePoint Pharmaceuticals, Inc. | Bioerodible ocular drug delivery insert and therapeutic method |
| US12161753B2 (en) | 2020-09-24 | 2024-12-10 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
| US11331267B2 (en) | 2020-09-24 | 2022-05-17 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine |
| EP4590593A2 (en) * | 2022-09-25 | 2025-07-30 | Albert-Ludwigs-Universität Freiburg | Marine polysaccharide networks |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1014335A (en) | 1910-11-10 | 1912-01-09 | Union Typewriter Co | Type-writing machine. |
| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US4002173A (en) | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US4207893A (en) | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
| US4484922A (en) | 1981-06-25 | 1984-11-27 | Rosenwald Peter L | Occular device |
| US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
| US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| IL82834A (en) | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5304595A (en) | 1988-11-21 | 1994-04-19 | Collagen Corporation | Collagen-polymer conjugates |
| IL90193A (en) | 1989-05-04 | 1993-02-21 | Biomedical Polymers Int | Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| JP3165734B2 (ja) * | 1992-05-19 | 2001-05-14 | テルモ株式会社 | 新規な高吸水形状記憶材料 |
| US5304959A (en) | 1992-10-16 | 1994-04-19 | Spectrian, Inc. | Planar microstrip balun |
| US6566406B1 (en) | 1998-12-04 | 2003-05-20 | Incept, Llc | Biocompatible crosslinked polymers |
| US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
| CA2305349A1 (en) | 1997-10-27 | 1999-05-06 | Alexander R. Irvine | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| ATE404140T1 (de) * | 2000-08-30 | 2008-08-15 | Univ Johns Hopkins | Vorrichtung zur intraokularen wirkstoffverabreichung |
| WO2002067908A1 (en) | 2001-02-26 | 2002-09-06 | Duke University | Novel dendritic polymers and their biomedical uses |
| US20040131582A1 (en) | 2002-02-26 | 2004-07-08 | Grinstaff Mark W. | Novel dendritic polymers and their biomedical uses |
| US7129210B2 (en) | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
| AU2004274026A1 (en) * | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| WO2006031358A2 (en) | 2004-08-13 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses |
| WO2006031388A2 (en) | 2004-08-20 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dentritic polymers, crosslinked gels, and their uses in orthopedic applications |
| WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
| WO2007005249A2 (en) | 2005-06-29 | 2007-01-11 | Hyperbranch Medical Technology, Inc. | Nanoparticles and dendritic-polymer-based hydrogels comprising them |
| US8795709B2 (en) | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
| US20080220047A1 (en) | 2007-03-05 | 2008-09-11 | Sawhney Amarpreet S | Low-swelling biocompatible hydrogels |
| US20080287633A1 (en) | 2007-05-18 | 2008-11-20 | Drumheller Paul D | Hydrogel Materials |
| US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| CN102395401B (zh) * | 2009-02-12 | 2015-08-19 | 因赛普特有限责任公司 | 经由水凝胶塞的药物递送 |
| JP5820815B2 (ja) | 2009-12-15 | 2015-11-24 | インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ | インプラントおよび生体分解性基準マーカー |
| US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
| EP2699317B1 (en) | 2011-04-21 | 2016-08-10 | Mapi Pharma Limited | Random pentapolymer for treatment of autoimmune diseases |
| JP6135870B2 (ja) * | 2011-05-02 | 2017-05-31 | ディーエスエム アイピー アセッツ ビー．ブイ． | 生分解性ポリマーを含む繊維 |
| KR102192603B1 (ko) | 2011-09-14 | 2020-12-17 | 포사이트 비젼5, 인크. | 안내 삽입물 장치 및 방법 |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| CN109200013A (zh) | 2011-12-05 | 2019-01-15 | 因赛普特有限责任公司 | 医用有机凝胶方法和组合物 |
| RU2652063C2 (ru) | 2012-10-26 | 2018-04-24 | Форсайт Вижн5, Инк. | Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу |
| AU2015360469B2 (en) | 2014-12-10 | 2021-03-25 | Incept, Llc | Hydrogel drug delivery implants |
| JP2018515529A (ja) | 2015-05-12 | 2018-06-14 | インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ | ハイドロゲルからの薬物送達 |
| KR20180034541A (ko) | 2015-07-22 | 2018-04-04 | 인셉트, 엘엘씨 | 코팅된 눈물점마개 |
| WO2017091749A1 (en) * | 2015-11-25 | 2017-06-01 | Incept, Llc | Shape changing drug delivery devices and methods |
-
2016
- 2016-11-23 WO PCT/US2016/063633 patent/WO2017091749A1/en not_active Ceased
- 2016-11-23 US US15/360,430 patent/US10420724B2/en active Active
- 2016-11-23 KR KR1020187017686A patent/KR20180086468A/ko not_active Abandoned
- 2016-11-23 EP EP16816493.7A patent/EP3380077B1/en active Active
- 2016-11-23 JP JP2018526903A patent/JP2018536484A/ja active Pending
- 2016-11-23 CN CN201680078805.5A patent/CN108601725B/zh active Active
- 2016-11-23 BR BR112018010671A patent/BR112018010671A8/pt not_active Application Discontinuation
- 2016-11-23 CA CA3006303A patent/CA3006303C/en active Active
- 2016-11-23 AU AU2016361579A patent/AU2016361579B2/en active Active
-
2018
- 2018-05-22 IL IL259530A patent/IL259530A/en unknown
-
2019
- 2019-08-06 US US16/533,331 patent/US10786462B2/en active Active
-
2020
- 2020-08-21 US US16/999,504 patent/US11413250B2/en active Active
-
2022
- 2022-07-07 US US17/859,820 patent/US11938223B2/en active Active
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