JP2018536484A5 - - Google Patents
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- Publication number
- JP2018536484A5 JP2018536484A5 JP2018526903A JP2018526903A JP2018536484A5 JP 2018536484 A5 JP2018536484 A5 JP 2018536484A5 JP 2018526903 A JP2018526903 A JP 2018526903A JP 2018526903 A JP2018526903 A JP 2018526903A JP 2018536484 A5 JP2018536484 A5 JP 2018536484A5
- Authority
- JP
- Japan
- Prior art keywords
- xerogel
- hydrogel
- composition
- precursor
- rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 22
- 239000002243 precursor Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 239000007864 aqueous solution Substances 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 9
- 230000008961 swelling Effects 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- 238000012377 drug delivery Methods 0.000 claims 3
- 125000003827 glycol group Chemical group 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 210000001525 retina Anatomy 0.000 claims 3
- 210000003161 choroid Anatomy 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 210000003786 sclera Anatomy 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000004127 vitreous body Anatomy 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960003005 axitinib Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000001851 biosynthetic effect Effects 0.000 claims 1
- 210000005252 bulbus oculi Anatomy 0.000 claims 1
- 210000000795 conjunctiva Anatomy 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260068P | 2015-11-25 | 2015-11-25 | |
| US62/260,068 | 2015-11-25 | ||
| US201662319033P | 2016-04-06 | 2016-04-06 | |
| US62/319,033 | 2016-04-06 | ||
| PCT/US2016/063633 WO2017091749A1 (en) | 2015-11-25 | 2016-11-23 | Shape changing drug delivery devices and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018536484A JP2018536484A (ja) | 2018-12-13 |
| JP2018536484A5 true JP2018536484A5 (enExample) | 2020-01-09 |
Family
ID=57590829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526903A Pending JP2018536484A (ja) | 2015-11-25 | 2016-11-23 | 形状変化する薬物送達デバイス及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10420724B2 (enExample) |
| EP (1) | EP3380077A1 (enExample) |
| JP (1) | JP2018536484A (enExample) |
| KR (1) | KR20180086468A (enExample) |
| CN (1) | CN108601725B (enExample) |
| AU (1) | AU2016361579B2 (enExample) |
| BR (1) | BR112018010671A8 (enExample) |
| CA (1) | CA3006303C (enExample) |
| IL (1) | IL259530A (enExample) |
| WO (1) | WO2017091749A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| CN108601725B (zh) | 2015-11-25 | 2024-03-08 | 因赛普特有限责任公司 | 形状改变的药物递送装置和方法 |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| WO2018005848A1 (en) | 2016-06-29 | 2018-01-04 | Bright, Corinne | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| KR102814241B1 (ko) | 2016-09-23 | 2025-05-29 | 인셉트, 엘엘씨 | 전안방내 약물 전달 데포 |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN108744048B (zh) * | 2018-06-29 | 2020-11-13 | 重庆科技学院 | 一种可实现自卷曲的双层水凝胶及其制备方法 |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| CA3105343A1 (en) | 2018-07-02 | 2020-01-09 | Corinne Bright | Methods and devices for in situ formed nerve cap |
| SG11202103505YA (en) * | 2018-11-09 | 2021-05-28 | Taris Biomedical Llc | Drug delivery devices and systems for local drug delivery to the upper urinary tract |
| CN109350355B (zh) * | 2018-11-30 | 2023-09-12 | 西安市第四医院 | 一种smile手术来源角膜基质透镜泪道栓及其制备方法 |
| US11523896B2 (en) | 2019-05-02 | 2022-12-13 | Kevin L. Waltz | Ocular protection ring |
| CN111150545A (zh) * | 2020-01-02 | 2020-05-15 | 首都医科大学附属北京同仁医院 | 一种相变降温支架及其制备方法和相变降温组合支架 |
| EP4252776A3 (en) | 2020-02-06 | 2023-11-22 | Ocular Therapeutix, Inc. | Compositions and methods for treating ocular diseases |
| WO2021195163A1 (en) | 2020-03-25 | 2021-09-30 | Ocular Therapeutix, Inc. | Ocular implant containing a tyrosine kinase inhibitor |
| WO2021222117A1 (en) | 2020-04-27 | 2021-11-04 | Ocular Therapeutix, Inc. | Methods of treating allergic conjunctivitis |
| WO2022066884A1 (en) | 2020-09-24 | 2022-03-31 | Ocular Therapeutix, Inc. | Sustained release biodegradalbe intracanalicular inserts comprising a hydrogel and cyclosporine |
| US12161753B2 (en) | 2020-09-24 | 2024-12-10 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
| EP4590593A2 (en) * | 2022-09-25 | 2025-07-30 | Albert-Ludwigs-Universität Freiburg | Marine polysaccharide networks |
| EP4583930A1 (en) | 2023-04-11 | 2025-07-16 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
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| US1014335A (en) | 1910-11-10 | 1912-01-09 | Union Typewriter Co | Type-writing machine. |
| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US4002173A (en) | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
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| US5304595A (en) | 1988-11-21 | 1994-04-19 | Collagen Corporation | Collagen-polymer conjugates |
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| IL90193A (en) | 1989-05-04 | 1993-02-21 | Biomedical Polymers Int | Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| JP3165734B2 (ja) | 1992-05-19 | 2001-05-14 | テルモ株式会社 | 新規な高吸水形状記憶材料 |
| US5304959A (en) | 1992-10-16 | 1994-04-19 | Spectrian, Inc. | Planar microstrip balun |
| US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
| WO1999021512A1 (en) | 1997-10-27 | 1999-05-06 | The Regents Of The University Of California | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
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| US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| EP2396070B1 (en) * | 2009-02-12 | 2024-12-04 | Incept Llc | Drug delivery through hydrogel plugs |
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| KR102039468B1 (ko) | 2011-12-05 | 2019-11-01 | 인셉트, 엘엘씨 | 의료용 유기젤 방법 및 조성물 |
| SI2911623T1 (sl) | 2012-10-26 | 2019-12-31 | Forsight Vision5, Inc. | Oftalmični sistem za podaljšano sproščanje zdravila v oko |
| CN120501693A (zh) | 2014-12-10 | 2025-08-19 | 因赛普特有限责任公司 | 水凝胶药物递送植入物 |
| WO2016183296A1 (en) | 2015-05-12 | 2016-11-17 | Incept, Llc | Drug delivery from hydrogels |
| CA2993182A1 (en) | 2015-07-22 | 2017-01-26 | Incept, Llc | Coated punctal plug |
| CN108601725B (zh) * | 2015-11-25 | 2024-03-08 | 因赛普特有限责任公司 | 形状改变的药物递送装置和方法 |
-
2016
- 2016-11-23 CN CN201680078805.5A patent/CN108601725B/zh active Active
- 2016-11-23 JP JP2018526903A patent/JP2018536484A/ja active Pending
- 2016-11-23 EP EP16816493.7A patent/EP3380077A1/en active Pending
- 2016-11-23 CA CA3006303A patent/CA3006303C/en active Active
- 2016-11-23 BR BR112018010671A patent/BR112018010671A8/pt not_active Application Discontinuation
- 2016-11-23 WO PCT/US2016/063633 patent/WO2017091749A1/en not_active Ceased
- 2016-11-23 AU AU2016361579A patent/AU2016361579B2/en active Active
- 2016-11-23 US US15/360,430 patent/US10420724B2/en active Active
- 2016-11-23 KR KR1020187017686A patent/KR20180086468A/ko not_active Abandoned
-
2018
- 2018-05-22 IL IL259530A patent/IL259530A/en unknown
-
2019
- 2019-08-06 US US16/533,331 patent/US10786462B2/en active Active
-
2020
- 2020-08-21 US US16/999,504 patent/US11413250B2/en active Active
-
2022
- 2022-07-07 US US17/859,820 patent/US11938223B2/en active Active
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