KR20180086468A - 형상 변형 약물 전달 장치 및 방법 - Google Patents

형상 변형 약물 전달 장치 및 방법 Download PDF

Info

Publication number
KR20180086468A
KR20180086468A KR1020187017686A KR20187017686A KR20180086468A KR 20180086468 A KR20180086468 A KR 20180086468A KR 1020187017686 A KR1020187017686 A KR 1020187017686A KR 20187017686 A KR20187017686 A KR 20187017686A KR 20180086468 A KR20180086468 A KR 20180086468A
Authority
KR
South Korea
Prior art keywords
carrier
syringe
fibers
coefficient
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020187017686A
Other languages
English (en)
Korean (ko)
Inventor
피터 자렛
미카엘 제이. 맥그래스
티모시 에스. 자렛
라미 엘-하이에크
앤드류 씨. 반슬렛
코트니 에이. 로살레스
찰스 디. 블리자드
아마프리트 에스. 소니
Original Assignee
인셉트, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인셉트, 엘엘씨 filed Critical 인셉트, 엘엘씨
Publication of KR20180086468A publication Critical patent/KR20180086468A/ko
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187017686A 2015-11-25 2016-11-23 형상 변형 약물 전달 장치 및 방법 Abandoned KR20180086468A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562260068P 2015-11-25 2015-11-25
US62/260,068 2015-11-25
US201662319033P 2016-04-06 2016-04-06
US62/319,033 2016-04-06
PCT/US2016/063633 WO2017091749A1 (en) 2015-11-25 2016-11-23 Shape changing drug delivery devices and methods

Publications (1)

Publication Number Publication Date
KR20180086468A true KR20180086468A (ko) 2018-07-31

Family

ID=57590829

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187017686A Abandoned KR20180086468A (ko) 2015-11-25 2016-11-23 형상 변형 약물 전달 장치 및 방법

Country Status (10)

Country Link
US (4) US10420724B2 (enExample)
EP (1) EP3380077A1 (enExample)
JP (1) JP2018536484A (enExample)
KR (1) KR20180086468A (enExample)
CN (1) CN108601725B (enExample)
AU (1) AU2016361579B2 (enExample)
BR (1) BR112018010671A8 (enExample)
CA (1) CA3006303C (enExample)
IL (1) IL259530A (enExample)
WO (1) WO2017091749A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3233058A1 (en) 2014-12-15 2017-10-25 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of glaucoma
CN107921237A (zh) 2015-04-27 2018-04-17 反射医学公司 交感神经心肺神经调节系统和方法
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
WO2017091749A1 (en) * 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
JP7430529B2 (ja) 2016-09-23 2024-02-13 インセプト・リミテッド・ライアビリティ・カンパニー 前房内薬物送達デポ
EP3621654A4 (en) 2017-05-10 2021-02-17 Graybug Vision, Inc. PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY
CN108744048B (zh) * 2018-06-29 2020-11-13 重庆科技学院 一种可实现自卷曲的双层水凝胶及其制备方法
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN117982783A (zh) * 2018-11-09 2024-05-07 塔里斯生物医药公司 用于将药物局部递送到上尿道的药物递送装置和系统
CN109350355B (zh) * 2018-11-30 2023-09-12 西安市第四医院 一种smile手术来源角膜基质透镜泪道栓及其制备方法
US11523896B2 (en) 2019-05-02 2022-12-13 Kevin L. Waltz Ocular protection ring
CN111150545A (zh) * 2020-01-02 2020-05-15 首都医科大学附属北京同仁医院 一种相变降温支架及其制备方法和相变降温组合支架
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
FI3884929T3 (fi) 2020-03-25 2023-08-07 Ocular Therapeutix Inc Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti
CA3177005A1 (en) 2020-04-27 2021-11-04 Michael Goldstein Methods of treating allergic conjunctivitis
EP4344745A3 (en) 2020-09-24 2024-10-09 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
EP4216929A1 (en) 2020-09-24 2023-08-02 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
WO2024064359A2 (en) * 2022-09-25 2024-03-28 Albert Ludwig University Of Freiburg Marine polysaccharide networks
CN120897764A (zh) 2023-04-11 2025-11-04 视尔普斯眼科公司 包含阿西替尼多晶型物iv的眼部植入物

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1014335A (en) 1910-11-10 1912-01-09 Union Typewriter Co Type-writing machine.
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JP3165734B2 (ja) 1992-05-19 2001-05-14 テルモ株式会社 新規な高吸水形状記憶材料
US5304959A (en) 1992-10-16 1994-04-19 Spectrian, Inc. Planar microstrip balun
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
WO1999021512A1 (en) 1997-10-27 1999-05-06 The Regents Of The University Of California Methods and pharmaceutical compositions for the closure of retinal breaks
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
AU2707500A (en) 1998-12-04 2000-06-26 Incept Llc Biocompatible crosslinked polymers
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
AU2001271417B2 (en) * 2000-08-30 2006-10-05 Johns Hopkins University Devices for intraocular drug delivery
CA2438193A1 (en) 2001-02-26 2002-09-06 Duke University Novel dendritic polymers and their biomedical uses
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
WO2005027906A1 (en) * 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US20080287633A1 (en) 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP2396070B1 (en) * 2009-02-12 2024-12-04 Incept Llc Drug delivery through hydrogel plugs
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
WO2012143924A1 (en) 2011-04-21 2012-10-26 Mapi Pharma Ltd. Random pentapolymer for treatment of autoimmune diseases
EP2705182B1 (en) 2011-05-02 2018-10-31 DSM IP Assets B.V. Fiber comprising a biodegradable polymer
ES2912370T3 (es) 2011-09-14 2022-05-25 Forsight Vision5 Inc Aparato para inserción ocular
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP3613413A1 (en) 2011-12-05 2020-02-26 Incept, LLC Medical organogel processes and compositions
CN104884006B (zh) 2012-10-26 2017-12-15 弗赛特影像5股份有限公司 用于持续释放药物到眼睛的眼科系统
EP3858329A1 (en) 2014-12-10 2021-08-04 Incept, LLC Hydrogel drug delivery implants
EP4279064A3 (en) 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
WO2017015591A1 (en) 2015-07-22 2017-01-26 Incept, Llc Coated punctal plug
WO2017091749A1 (en) * 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods

Also Published As

Publication number Publication date
US20200030241A1 (en) 2020-01-30
WO2017091749A1 (en) 2017-06-01
US10786462B2 (en) 2020-09-29
AU2016361579B2 (en) 2022-08-04
EP3380077A1 (en) 2018-10-03
BR112018010671A8 (pt) 2019-02-26
AU2016361579A1 (en) 2018-06-21
BR112018010671A2 (pt) 2018-11-13
JP2018536484A (ja) 2018-12-13
US20170143636A1 (en) 2017-05-25
CA3006303A1 (en) 2017-06-01
IL259530A (en) 2018-07-31
US20220339108A1 (en) 2022-10-27
US11938223B2 (en) 2024-03-26
CN108601725A (zh) 2018-09-28
US11413250B2 (en) 2022-08-16
CA3006303C (en) 2023-11-14
CN108601725B (zh) 2024-03-08
US10420724B2 (en) 2019-09-24
WO2017091749A8 (en) 2017-07-06
US20210128478A1 (en) 2021-05-06

Similar Documents

Publication Publication Date Title
US11938223B2 (en) Shape changing drug delivery devices and methods
JP7599732B2 (ja) ハイドロゲルからの薬物送達
JP7486539B2 (ja) 前房内薬物送達デポ
KR20170117384A (ko) 히드로겔 약물 전달 임플란트
CA2750242A1 (en) Drug delivery through hydrogel plugs
HK1261346A1 (en) Shape changing drug delivery devices and methods
HK1261346B (zh) 形状改变的药物递送装置和方法
BR122024018825A2 (pt) Composição de depósito e uso da mesma para tratamento de uma condição ocular
BR112019005594B1 (pt) Composição de depósito intracameral e uso da mesma para tratamento de uma condição ocular

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PC1902 Submission of document of abandonment before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1902