BR112018010671A2 - dispositivos e métodos de distribuição de fármaco com mudança de forma - Google Patents

dispositivos e métodos de distribuição de fármaco com mudança de forma

Info

Publication number
BR112018010671A2
BR112018010671A2 BR112018010671A BR112018010671A BR112018010671A2 BR 112018010671 A2 BR112018010671 A2 BR 112018010671A2 BR 112018010671 A BR112018010671 A BR 112018010671A BR 112018010671 A BR112018010671 A BR 112018010671A BR 112018010671 A2 BR112018010671 A2 BR 112018010671A2
Authority
BR
Brazil
Prior art keywords
drug delivery
shape
delivery devices
methods
changing drug
Prior art date
Application number
BR112018010671A
Other languages
English (en)
Other versions
BR112018010671A8 (pt
Inventor
S Sawhney Amarpreet
C Vanslette Andrew
D Blizzard Charles
A Rosales Courtney
J Mcgrath Michael
Jarrett Peter
El-Hayek Rami
S Jarrett Timothy
Original Assignee
Incept Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incept Llc filed Critical Incept Llc
Publication of BR112018010671A2 publication Critical patent/BR112018010671A2/pt
Publication of BR112018010671A8 publication Critical patent/BR112018010671A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a presente invenção refere-se à distribuição de fármaco usando fármacos que afetam o bio, particularmente, com dispositivos de distribuição de fármaco com mudança de forma. as modalidades são incluídas para depósitos para a distribuição de um agente terapêutico que mudam de um estado alongado ex vivo para uma bobina in vivo onde o agente é liberado.
BR112018010671A 2015-11-25 2016-11-23 dispositivos e métodos de distribuição de fármaco com mudança de forma BR112018010671A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562260068P 2015-11-25 2015-11-25
US201662319033P 2016-04-06 2016-04-06
PCT/US2016/063633 WO2017091749A1 (en) 2015-11-25 2016-11-23 Shape changing drug delivery devices and methods

Publications (2)

Publication Number Publication Date
BR112018010671A2 true BR112018010671A2 (pt) 2018-11-13
BR112018010671A8 BR112018010671A8 (pt) 2019-02-26

Family

ID=57590829

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010671A BR112018010671A8 (pt) 2015-11-25 2016-11-23 dispositivos e métodos de distribuição de fármaco com mudança de forma

Country Status (10)

Country Link
US (4) US10420724B2 (pt)
EP (1) EP3380077A1 (pt)
JP (1) JP2018536484A (pt)
KR (1) KR20180086468A (pt)
CN (1) CN108601725B (pt)
AU (1) AU2016361579B2 (pt)
BR (1) BR112018010671A8 (pt)
CA (1) CA3006303C (pt)
IL (1) IL259530A (pt)
WO (1) WO2017091749A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017007873A (es) 2014-12-15 2017-11-06 Univ Johns Hopkins Formulaciones de sunitinib y metodos para uso de las mismas en el tratamiento de trastornos oculares.
WO2016176333A1 (en) 2015-04-27 2016-11-03 Reflex Medical, Inc. Systems and mehtods for sympathetic cardiopulmonary neuromodulation
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
MX2018005932A (es) 2015-11-12 2019-05-20 Graybug Vision Inc Microparticulas aglomerantes para terapia medica.
AU2016361579B2 (en) * 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods
US11246879B2 (en) 2016-02-09 2022-02-15 Tulai Therapeutics, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
EP3478287A4 (en) 2016-06-29 2020-04-08 Tulavi Therapeutics, Inc. TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM
JP7430529B2 (ja) 2016-09-23 2024-02-13 インセプト・リミテッド・ライアビリティ・カンパニー 前房内薬物送達デポ
EP3621654A4 (en) 2017-05-10 2021-02-17 Graybug Vision, Inc. PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY
CN108744048B (zh) * 2018-06-29 2020-11-13 重庆科技学院 一种可实现自卷曲的双层水凝胶及其制备方法
EP3817786A4 (en) 2018-07-02 2022-03-23 Tulavi Therapeutics, Inc. METHODS AND DEVICES FOR IN SITU FORMED NERVE CAP
CN109350355B (zh) * 2018-11-30 2023-09-12 西安市第四医院 一种smile手术来源角膜基质透镜泪道栓及其制备方法
US11523896B2 (en) 2019-05-02 2022-12-13 Kevin L. Waltz Ocular protection ring
CN111150545A (zh) * 2020-01-02 2020-05-15 首都医科大学附属北京同仁医院 一种相变降温支架及其制备方法和相变降温组合支架
AU2021215929A1 (en) 2020-02-06 2022-08-04 Ocular Therapeutix, Inc. Compositions and methods for treating ocular diseases
EP3884929B1 (en) 2020-03-25 2023-06-14 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor
EP3973952B1 (en) 2020-09-24 2024-02-14 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1014335A (en) 1910-11-10 1912-01-09 Union Typewriter Co Type-writing machine.
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JP3165734B2 (ja) * 1992-05-19 2001-05-14 テルモ株式会社 新規な高吸水形状記憶材料
US5304959A (en) 1992-10-16 1994-04-19 Spectrian, Inc. Planar microstrip balun
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
JP2001520979A (ja) 1997-10-27 2001-11-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 網膜傷の閉鎖のための方法及び医薬組成物
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
WO2000033764A1 (en) 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DE60135352D1 (de) 2000-08-30 2008-09-25 Univ Johns Hopkins Vorrichtung zur intraokularen wirkstoffverabreichung
CA2438193A1 (en) 2001-02-26 2002-09-06 Duke University Novel dendritic polymers and their biomedical uses
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
CN1882338A (zh) * 2003-09-18 2006-12-20 马库赛特公司 经巩膜递送
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8409606B2 (en) * 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
EP3960215A1 (en) 2009-12-15 2022-03-02 Incept, LLC Implants and biodegradable fiducial markers
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
ES2601892T3 (es) 2011-04-21 2017-02-16 Mapi Pharma Limited Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes
US20140179802A1 (en) * 2011-05-02 2014-06-26 Dsm Ip Assets B.V. Fiber comprising a biodegradable polymer
RU2740680C2 (ru) 2011-09-14 2021-01-19 Форсайт Вижн5, Инк. Глазное вкладочное устройство и способы
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CN109200013A (zh) 2011-12-05 2019-01-15 因赛普特有限责任公司 医用有机凝胶方法和组合物
US9750636B2 (en) 2012-10-26 2017-09-05 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
AU2015360469B2 (en) 2014-12-10 2021-03-25 Incept, Llc Hydrogel drug delivery implants
US11369591B2 (en) 2015-05-12 2022-06-28 Incept, Llc Drug delivery from hydrogels
KR20180034541A (ko) 2015-07-22 2018-04-04 인셉트, 엘엘씨 코팅된 눈물점마개
AU2016361579B2 (en) * 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods

Also Published As

Publication number Publication date
US20170143636A1 (en) 2017-05-25
US11938223B2 (en) 2024-03-26
WO2017091749A1 (en) 2017-06-01
US20220339108A1 (en) 2022-10-27
WO2017091749A8 (en) 2017-07-06
US10420724B2 (en) 2019-09-24
EP3380077A1 (en) 2018-10-03
JP2018536484A (ja) 2018-12-13
CN108601725A (zh) 2018-09-28
CA3006303C (en) 2023-11-14
US10786462B2 (en) 2020-09-29
IL259530A (en) 2018-07-31
BR112018010671A8 (pt) 2019-02-26
CA3006303A1 (en) 2017-06-01
US20210128478A1 (en) 2021-05-06
US20200030241A1 (en) 2020-01-30
US11413250B2 (en) 2022-08-16
CN108601725B (zh) 2024-03-08
KR20180086468A (ko) 2018-07-31
AU2016361579A1 (en) 2018-06-21
AU2016361579B2 (en) 2022-08-04

Similar Documents

Publication Publication Date Title
BR112018010671A8 (pt) dispositivos e métodos de distribuição de fármaco com mudança de forma
NI201600071A (es) Compuestos de inhibidor de autotaxina
CY1124729T1 (el) Φαρμακοτεχνικες μορφες του ενζαλουταμιδιου
BR112018076601A2 (pt) formulação farmacêutica oral, métodos para tratar um paciente, e, uso de uma formulação
BR112017005693A2 (pt) método para tratar e/ou prevenir uma doença hepática, e, composição farmacêutica.
BR112016020618A8 (pt) oligômero antissentido, composição farmacêutica, e, uso de um oligômero antissentido
CR20150326A (es) Inhibidores de autotaxina
CL2016001609A1 (es) Composiciones farmacéuticas que comprenden azd9291.
NI201600051A (es) Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores
BR112015022625A2 (pt) micromatrizes para entrega de agente terapêutico e métodos de uso
DK3419699T3 (da) Dosisstyresystem til injicerbare lægemiddelafgivelsesindretninger og tilknyttede fremgangsmåder til anvendelse
DK3193981T3 (da) Medikamentadministrationsanordning i form af voluminøst hudplaster med integreret mekanisme til hudsterilisering af injektionssted
BR112016002646A2 (pt) dispositivos e métodos de entrega de fármaco de múltiplas unidades
CL2015002733A1 (es) Composición farmacéutica de clorhidrato de s-cetamina.
MX2020002693A (es) Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina.
EP3354306A4 (en) DRUG DELIVERY DEVICE AND MEDICATION DELIVERY UNIT
NI201600070A (es) Inhibidores tetracíclicos de autotaxina
ZA201508454B (en) Method of applying a composition and pharmaceutical composition with a regimen of administering it, including photo-activating the active component
CO2017002472A2 (es) Formulación de acetato de abiraterona
CL2015002180A1 (es) Terapia de combinación para el tratamiento de neumonía nosocomial
CL2014003148A1 (es) Composición farmacéutica acuosa que contiene un agente terapéutico biológico y guanidina o un derivado de la guanidina y una inyección que incluye la composición.
DK3432970T3 (da) In vivo lægemiddelleveringsindretninger
BR112017012406A2 (pt) formulação com relação fixa de insulina glargina/lixisenatida
ECSP16086247A (es) (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina
BR112017024908A2 (pt) usos terapêuticos da 4-cloroquinurenina

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements